6° Congresso Monotematico SIF 2002

Farmacologia Cardiovascolare dei Donatori di Ossido di Azoto (NO): Prospettive Terapeutiche

P-01	Nitric-oxide donating anti-inflammatory drugs: a new class of effective and safe agents F. BENEDINI, V. CHIROLI, E. ONGINI, P. DEL SOLDATO NicOx Research Institute, via Ariosto 21, 20091 Bresso, Milan, Italy
P-02	S-nitrosothiols: a promising class of nitric oxide donors. The kinetic of nitric oxide release L. GROSSI Dipartimento di Chimica Organica "A. Mangini" - Università di Bologna Viale Risorgimento 4, 40136 Bologna
P-03	Esteri nitrici dell'eparina *A. NAGGI, S. VENTURINI, G. MAZZONI, G. TORRI, B. CASU, A. MONOPOLI, M. BOLLA, M. GUZZETTA, P. DEL SOLDATO, P. GRESELE#, M. LEONE#, A. M. MEZZASOMA* # Istituto G. Ronzoni Milano; *NicOx, Bresso (MI); #Università di Perugia
P-04	Proprietà antiinfiammatorie, gastroprotettive e antiaggreganti di nuovi esteri NO-donatori dell'aspirina C. CENAa, L. LAZZARATOa, L. TOMATISa, G. MORINIb, I.L. MEGSONc, R. FRUTTEROa, A. GASCOa aUniversità degli Studi di Torino, Dipartimento di Scienza e Tecnologia del Farmaco, Via Pietro Giuria 9, I-10125, Torino, Italy; bUniversità degli Studi di Parma, Istituto di Farmacologia, via Volturno 39, 43100 Parma, Italy; cUniversity of Edinburgh, Centre for Cardiovascular Science, Biomedical Sciences, Edinburgh EH8 9XD, UK.
P-05	Copper induces the production of nitric oxide and peroxynitrite in vivo S. CUZZOCREA-1, L. DUGO-1, T. PERSICHINI-2, L. PALOMBA-3, O. CANTONI-3, M. COLASANTI-2, G. MUSCI-4 1-Dipartimento Clinico-Sperimentale di Medicina e Farmacologia, Università di Messina; 2-Dipartimento di Biologia, Università Roma Tre; 3-Istituto di Farmacologia e Farmacognosia, Universita di Urbino; 4-Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Università di Messina
P-06	Il nitrossido regola la via del segnale di trasduzione attivato dagli estrogeni, attraverso la generazione di GMP ciclico *S. FALCONE°, L. MAURO, G. DE ROSE, C. SCIORATI§, S. ANDÒ, E. CLEMENTI§* °Dipartimento di Farmacologia, Università di Milano, *Dipartimento di Biologia cellulare e Farmaco-Biologico, Università della Calabria, §DIBIT-Istituto Scientifico H San Raffaele, Via Olgettina 58, 20132 Milano
P-07	Nitric oxide activates phospholipase A2 in the vascular smooth muscle, through a cGMP-independent pathway V. CALDERONE, L. TESTAI, P. NIERI, M.C. BRESCHI, E. MARTINOTTI Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie Università degli Studi di Pisa; Via Bonanno, 6 - 56126 Pisa
P-08	Effect of a nitric oxide-releasing aspirin derivative, NCX 4016, on endothelial dysfunction occurring in diabetic rats: a biochemical and morphological study *M.V. AMBROSINI§, G. MARIUCCI§, M.G. RAMBOTTI§, M. TANTUCCI§, G. BASTA, C. COVARELLI#, L. DE ANGELIS#, A. MONOPOLI1 , P. DEL SOLDATO1** §Dept. Exp. Med. & Biochem. Sci., *DIMISEM, University of Perugia, #Perugia General Hospital, Perugia, Italy; 1NicOx Research Institute, Milano, Italy
P-09	The role of cytosolic phospholipase A2 in peroxynitrite-induced U937 cell death I. TOMMASINI, P. SESTILI, A. GUIDARELLI, O. CANTONI Istituto di Farmacologia e Farmacognosia, Università degli Studi di Urbino. Via S. Chiara 27, 61029 Urbino (PU)
P-10	Endogenous peroxynitrite promotes activation of mitochondrial phospholipase A2 and this response is causally-linked to PC12 cell death induced by tert-butylhydroperoxide L. PALOMBA, O. CANTONI Istituto di Farmacologia e Farmacognosia, Università degli Studi di Urbino, Urbino
P-11	The basic fibroblast growth factor stimulates nitric oxide production in CHO-K1 cells: role of ceramide S. ARENA-1, A. PATTAROZZI-1, S. THELLUNG-1, A. CORSARO-1, G. SPOTO-2, A. MASSA, F. DIANA, G. DAMONTE-3, U.BENATTI-3, G. SCHETTINI-1, T. FLORIO-1,2 1-Pharmacology and Neurosciences, IST-CBA and Dept. Oncology, Univ. Genova; 2-Dept. Biomedical Sci. Univ. G. D'Annunzio of Chieti; 3-Dept. Experimental Medicine, Univ. of Genova, Italy
P-12	Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independent of cellular glutathione status F. VISIOLI-1,2, A. SMITH-1, W. ZHANG-1, J. F. KEANEY JR-3, T. HAGEN-1, B. FREI-1 1 Linus Pauling Institute, Oregon State University, Corvallis, OR; 2 Department of Pharmacological Sciences, University of Milan, Italy and the College of Pharmacy, Oregon State University; and 3 Whitaker Cardiovascular Institute, Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, MA
P-13	Effect of nitric oxide (NO)-donating agents on monocyte COX-2 *M. LEONE, T. CORAZZI, P. DEL SOLDATO, P. GRESELE** Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; *NicOx Research Institute, Milan, Italy
P-14	Modulation of ventricular calcium current by NO/O2-donors D. MALAN, R.C. LEVI, G. ALLOATTI, A. MARCANTONI, M.P. GALLO Department of Animal and Human Biology, University of Torino, Via Accademia Albertina 13, I-10123, Torino, and the I.N.F.M., Italy
P-15	Cardioprotective effects of N-acetylcysteine (NAC) and isosorbide-5-mononitrate (IS5MN) after ischemia and reperfusion in a rat model M. SALIO, N. DE ANGELIS, L. CALVILLO, L. POLLICINO, E. MARTINOLI, G. JEREMIC, S. MASSON, R. LATINI Department of Cardiovascular Research, Istituto "Mario Negri", Milan, Italy
P-16	NCX 4016, a nitric oxide-releasing aspirin, modulates adrenergic vasoconstriction in the perfused rat tail artery B. MANFREDI-1, G. ROSSONI-2,1, P. DEL SOLDATO-3 , F. BERTI-4 1-Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy; 2-Department of Pharmacological Sciences University of Milan, Milan, Italy; 3-NicOx S.A., Valbonne-Sophia Antipolis, France; 4-Department of Experimental Medicine, Environmental and Biotechnology, University of Milano-Bicocca, Monza, Italy
P-17	Protective effects of manidipine/delapril combination on myocardial hypertrophy and endothelial dysfunction in SHR-rats F. PASTORE, M. RIUNNO, R. RAZZETTI, T. BACHETTI, E. PASINI Chiesi Farmaceutici. Parma (Italy) and *Laboratorio di Fisiopatologia Cardiovascolare "S. Maugeri". Fondazione " S. Maugeri", IRCCS
P-18	Effects of nitric oxide (NO)-timolol on the blood pressure and heart rate of L-NAME-induced hypertension in the rats M. D'AMICO, C. DI FILIPPO, E. LAMPA, S. ROSSI, A. FILIPPELLI, L. BERRINO, F. ROSSI Department of Experimental Medicine, Section of Pharmacology, Faculty of Medicine and Surgery, 2nd University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
P-19	ACE inhibitors improve endothelial vasodilator function in rats with chronic nitric oxide deficiency *V. DE GENNARO COLONNA, G. ROSSONI, A. RIGAMONTI, S. BONOMO, B. MANFREDI, E.E. MULLER, F. BERTI** Department of Pharmacology, Chemotherapy and Medical Toxicology University of Milan, Via Vanvitelli 32, 20129 Milan, Italy; *Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
P-20	Characterization of new nitric oxide donor drugs as endothelial-protective agents *L. MORBIDELLI, S. DONNINI, V. D'AMORE, L. CASELLA, M. ZICHE** Inst. of Pharmacological Sciences, Univ. Siena, Via Aldo Moro 2, 53100 Siena; *Dept. General Chemistry, Univ. Pavia, Pavia
P-21	Nitric oxide up-regulates metalloproteinases and down-regulates tissue inhibitor of metalloproteinases in vascular endothelial growth factor-induced angiogenesis S. DONNINI, L. MORBIDELLI, S. CANTARA, M. ZICHE Inst. of Pharmacological Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena
P-22	Antioxidant treatment affects vascular responses in the aorta of short-term diabetic rats C. PINNA, L. PUGLISI Department of Pharmacological Sciences, via Balzaretti 9, 20133 Milan, Italy
P-23	Effect of the combination of NCX 4016, aspirin (ASA) and clopidogrel in a model of pulmonary thromboembolism in mice *S. MOMI, A.M. MEZZASOMA, M. LEONE, P. DEL SOLDATO, P. GRESELE** Dept of Int. Med., Sect. of Int. and Cardiovasc. Med, Univ. Perugia; *NicOx Research Institute, Milan, Italy
P-24	Metabolic profile of nitroflurbiprofen (HCT 1026) in rat plasma and brain: a LC-MS study G.C ALDINIa, M. CARINIa, M. ORIOLIa, G. ROSSONIb, R. MAFFEI FACINOa, G. L. WENKc aIstituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, Milan, Italy; bDipartimento di Scienze Farmacologiche, University of Milan, Via Balzaretti 9, Milan, Italy; c Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, 384 Life Sciences North Building, Tucson, AZ 85724 USA
P-25	Molecular mechanisms of nitric oxide-mediated down-regulation of brain-derived neurotrophic factor secretion *E. GIORDANO, S. CAPPELLO^, M. CARBONI, T. BACHETTI°, C. GUARNIERI, S. FERRI^, C.M. CALDARERA, M. CANOSSA^* Depart. of Biochemistry* "G.. Moruzzi" and of Pharmacology^, University of Bologna; °Cardiovascular Research Center, Fondazione Salvatore Maugeri, IRCCS, Gussago
P-26	Constitutive nitric oxide synthase (cNOS): a possible key point in pathogenesis of secondary lesion after spinal cord injury M. MISCUSI-1, M. MENEGAZZI-2, A. BRICOLO-1, H. SUZUKI-2 Department of Neuroscience and Vision, 1-Section of Neurosurgery, 2-Section of Biochemestry, University of Verona, Italy
P-27	Nitric oxide-releasing nonsteroidal anti-inflammatory drugs abrogate immune dysfunctions caused by myeloid suppressor cells in tumor-bearing mice P. SERAFINI-1, C. DE SANTO-1, I. MARIGO-1, S. CINGARLINI-1, P. DEL SOLDATO-2, P. ZANOVELLO-1, V. BRONTE-1 1 Department of Oncology and Surgical Sciences, 35128 Padova; 2 NicOx S.A., 06906 Sophia Antipolis, France
P-28	Contrasting effects of nitric oxide on food-intake and gh secretion stimulated by a GH-releasing peptide (GHRP) in young-adult rats A.E. RIGAMONTI, S. BONOMO, S.G. CELLA, E.E. MULLER Dip. di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Milano
P-29	In vitro metabolism of the nitric oxide-donating derivative of aspirin (NCX 4016) by rat liver: LC and LC-MS studies M. CARINI-1, G. ALDINI-1, A. PICCOLI-1, R. MAFFEI FACINO-1, P. DEL SOLDATO-2 1 Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy; 2 NicOx S.A., Sophia Antipolis, France