SIF - Societā Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

PHARMACOLOGY OF THE
CENTRAL NERVOUS SYSTEM I

 

RESEARCH GROUP MEMBERS:

  1. Annunziato Lucio, P.O.
  2. Amoroso Salvatore, P.A.
  3. Taglialatela Maurizio, R.U.(*)
  4. Fatatis Alessandro, D.R.
  5. Cataldi Mauro, D.R.
  6. Iossa Silvana, DDR.
  7. Gioielli Anna, DDR.
  8. Castaldo Pasqualina, B.
AFFILIATION:

Sezione di Farmacologia,

Dipartimento di Scienza della Comunicazione Umana

Facoltā di Medicina e Chirurgia

Universitā Federico II

ADDRESS: Via Pansini, 5

CITY: Napoli

POSTAL CODE: 80131

TELEPHONE: 081-746-3323, 3318, 3330, 3315

FAX: 081-746-3323

E-MAIL: farmacol@unina.it;

(*) mtaglial@unina.it

PUBLICATIONS:

  1. BERNARDI H., DE WEILLE J.R., EPELBAUM J., MOURRE C., AMOROSO S., SLAMA A., FOSSET M., AND LAZDUNSKI M.: ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release. Proc. Nat. Acad. Sci. USA. 90 :1340-1344, 1993.
  2. AMOROSO S., SENSI S., DI RENZO G.F., AND ANNUNZIATO L.: The inhibition of the Na +-Ca2+ exchanger enhances anoxia and glucopenia-induced [3H] aspartate release in h ippocampal slices. J. Pharmacol. Exp. Ther. 264: 515-520, 1993.
  3. CANZONIERO L.M.T., TAGLIALATELA M., DI RENZO G.F., AND ANNUNZIATO L.: Gadolinium and Neomycin block voltage-sensitive Ca2+ channels without interfering with the Na+-Ca2+ antiporter in brain nerve endings. Eur. J. Pharmacol., Molecular Pharmacology Section. 245: 97-103, 1993.
  4. TAGLIALATELA M., WIBLE B., CAPORASO R., AND BROWN A.M: Specification of pore properties by the carboxyl-terminus of inwardly-rectifying K+ channels. Science. 264: 844-847, 1994.
  5. FATATIS A., BASSI A., IANNOTTI E., CASO N., MITA G.D., DI RENZO G.F., AND ANNUNZIATO L.: Appearance of depolarization and maitotoxin induce [Ca2+]i elevation in LAN-1 human neuroblastoma cells upon exposure to retinoid acid. J. Neurochem.. 63: 1900-1907, 1994.
  6. FATATIS A., HOLTZCLAW L.A., AVIDOR R., BRENNEMAN D.E., AND RUSSEL J.T.: VIP increases intracellular calcium in astroglia: synergism with a-adrenergic receptors. Proc. Nat. Acad. Sci. USA. 61- 2036-2040, 1994.
  7. FATATIS A., CAPORASO R., IANNOTTI E., BASSI A., DI RENZO G.F., AND ANNUNZIATO L.: Relationship between time of activation of PhosPholipase C-linked plasma membrane receptors and reloading of intracellular Ca2+ strores in LAN-1 human neuroblastoma cells. J. Biol. Chem. 269: 18021-18027, 1994.
  8. AMOROSO S., IANNOTTI E., SAGGESE M.L., DI RENZO G.F., AND ANNUNZIATO L.: The A1 agonist CCPA reduced bisoxonol-monitored membrane potential depolarization elicited by high K+ in cerebrocortical nerve endings. Biochim. Biophys. Acta. 1239: 67-73, 1995.
  9. CATALDI, M., TAGLIALATELA, M., GUERRIERO, S., AMOROSO, S., LOMBARDI, G., DI RENZO, G.F. , and ANNUNZIATO, L. : Protein tyrosine kinases activate while proetin tyrosine phosphatases inihibit L-type calcium channel activity in pituitary GH3 cells. J. Biol. Chem.. 271: 9441-9446, 1996.

    10. TAGLIALATELA, M., ONGINI, E., BROWN, A.M., DI RENZO, G.F., and ANNUNZIATO, L. Felbamate inhibits voltage-dependent Na+ channels from human and rat brain. Eur. J. Pharmacol. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Arrigo Reina Rosa, P.A.
  2. Nicoletti Ferdinando, P.A.
  3. Scoto Giovanna Maria, P.A.
  4. Spadaro Concetta, P.A.
  5. Chiechio Santina, D.DR.
  6. Parenti Carmela, D.DR.
  7. Gentile Michele, D.DR.
AFFILIATION:

Istituto di Farmacologia e Farmacognosia,

Facoltā di Farmacia

Universitā Catania

ADDRESS: Cittā Universitaria, Viale A. Doria, 6

CITY: Catania

POSTAL CODE: 25125

TELEPHONE: 095 - 330533 (int. 222, 285),

095 - 338378

FAX: 095 - 338378

PUBLICATIONS:

  1. ARRIGO-REINA, R., CATTI, T. AND CHIECHIO, S. Increased analgesic potency of morphine following repeated anaphylactoid reaction by C48/80 involves cyclooxygenase products of arachidonic acid. Agents Actions. 38: 269-271, 1993.
  2. SCOTO, G.M. AND PARENTI, C. Prevention of stress-induced gastric ulcers by and opioid agonists in the rat. J. Physiol. 87: 385-388, 1993.
  3. ARRIGO-REINA, R. AND CHIECHIO, S. Histaminergic mechanisms in clonidine induced analgesia in rat tail-flick test. Inflammation Res. 44: 21-23, 1995.
  4. SCOTO, G.M. AND PARENTI, C. Central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats. Pharmacology. 52 : 56-60, 1996.
  5. CHIECHIO, S., SPADARO, C., AND ARRIGO-REINA, R. H3-histamine receptors and clonidine analgesia in rats. Inflamm. Res. In press, 1996.
  6. NICOLETTI, F., BRUNO, V., COPANI, A., CASABONA, G., KNOEPFEL, T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends in Neurosci. 19: 267-271, 1996.
  7. THOMSEN C., BRUNO V., NICOLETTI F., MARINOZZI M., PELLICCIARI R. (2S, 1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl) glycine, a potent and selective antagonist of type II metabotropic glutamate receptors. Mol. Pharmacol. 50 : 6-9, 1996.

RESEARCH GROUP MEMBERS:

  1. Bartolini Alessandro, P.O.
  2. Malmberg-Aiello Petra, R.U.
  3. Ghelardini Carla, R.U.
  4. Galeotti Nicoletta, D.DR.
  5. Lamberti Claudia, B.
  6. Ipponi Alessandra, B.
AFFILIATION :

Dipartimento di Farmacologia Preclinica e Clinica "M. Aiazzi Mancini"

Universitā di Firenze

ADDRESS: Viale Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237-432, 437, 415

FAX: 055-4361613

E-MAIL: bartolin@stat.ds.unifi.it

PUBLICATIONS:

  1. ROMANELLI, M.N., GHELARDINI, C., DEI, S., MATUCCI, R., MORI, F., SCAPECCHI, S., TEODORI, E., BARTOLINI, A., GALLI, A. AND GUALTIERI F. Synthesis and biological activity of a series of aryl tropanyl esters and amides chemically related to 1H-indole-3-carboxylic acid endo 8-methyl-8-azabicyclo[3.2.1.]oct-3-yl ester: development of a 5-HT4 agonist endowed with potent antinociceptive activity. Arzeneim-Forsch Drug Res., 43: 913-918, 1993.
  2. FRANCHINI, C., CHIAIA NOJA, F., CORBO, F., LENTINI, G., TORTORELLA, V., BARTOLINI, A., GHELARDINI, C., MATUCCI, R. AND GIOTTI, A. Stereoselectivity in central analgesic action of tocainide and its analogs. Chirality. 5: 135-142, 1993.
  3. MALMBERG-AIELLO, P., LAMBERTI, C., GHELARDINI, C., GIOTTI, A. AND BARTOLINI, A. Role of histamine in rodent antinociception. Brit. J. Pharmacol. 111: 1269-1279, 1994.
  4. GUALTIERI, F., CONTI, G., DEI, S., GIOVANNONI, M.P., NANNUCCI, F., ROMANELLI, M. N., SCAPECCHI, S., TEODORI, E., FANFANI, L., GHELARDINI, C., GIOTTI, A., BARTOLINI, A. Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. I. Tropic and 2-phenylpropinic acid esters, J. Med. Chem. 37: 1704- 1711, 1994.
  5. GUALTIERI, F., BOTTALICO, C., CALANDRELLA, A., DEI, S., GIOVANNONI, M.P., MEALLI, S., ROMANELLI, M.N., SCAPECCHI, S., TEODORI, E., GALEOTTI, N., GHELARDINI, C., GIOTTI, A. AND BARTOLINI A. Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. II. 2-phenoxy-, 2-(phenylthio)- and 2-(phenylamino) alkanoic acid esters, J. Med. Chem. 37 : 1712- 1719, 1994.
  6. GHELARDINI, C., BARTOLINI, A., GALEOTTI, N., TEODORI, E. AND GUALTIERI, F. S-(-)-ET 126: a potent and selective M1 antagonist in vitro and in vivo. Life Sci. 58: 991-1000, 1996.
  7. LAMBERTI, C., BARTOLINI, A., GHELARDINI, C. AND MALMBERG-AIELLO, P. Investigation into the role of histamine receptors in rodent antinociception. Pharmacol. Biochem. Behav. 53:567-574, 1996
  8. GHELARDINI, C., GALEOTTI, N., CASAMENTI, F., MALMBERG-AIELLO, P., PEPEU, G., GUALTIERI, F. AND BARTOLINI, A. Central cholinergic antinociception induced by 5-HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 58: 2297-2309, 1996.
  9. GALEOTTI, N., GHELARDINI, C. AND BARTOLINI, A. Piracetam and Aniracetam antagonism of centrally-active drugs-induce antinociception, Pharmacol. Biochem. Behav. 53 (4): 943-950, 1996.
  10. GALEOTTI, N., GHELARDINI, C., BARTOLINI, A. Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception.., Eur. J. Pharmacol 308: 125-133, 1996.

RESEARCH GROUP MEMBERS:

  1. Battaini Fiorenzo, R.U. *
  2. Pascale Alessia, D.DR. #
  3. Lucchi Laura, T.#
AFFILIATION:

* Dipartimento di Medicina Sperimentale e Scienze Biochimiche

Facoltā di Medicina e Chirurgia

Universitā di Roma Tor Vergata

# Istituto di Scienze Farmacologiche

Facoltā di Farmacia

Universitā di Milano

ADDRESS: Via di Tor Vergata, 135

CITY: Roma

POSTAL CODE: 00133

TELEPHONE: 06/7259 6310

FAX: 06/7259 6302

PUBLICATIONS :

  1. LUCCHI L., PASCALE A., BATTAINI F., GOVONI S. AND TRABUCCHI M.: Cognition stimulating drugs modulate PKC activity in cerebral cortex and hippocampus of adult rats. Life Sci., 53: 1821-1832, 1993.
  2. MARTINI A., BATTAINI F., GOVONI S. AND VOLPE P.: Inositol 1,4,5 tris-phosphate receptor and ryanodine receptor in the aging brain of Wistar rats. Neurobiol. Aging, 15: 203-206,1994.
  3. BATTAINI F., GARBILLO G., BERGAMASCHI S., PARENTI M., WETSEL W.C., GOVONI S. AND TRABUCCHI M.: Regulation of protein kinase C in NG 108-15 cell differentiation. Biochem. Biophys. Res. Comm. 201: 135-142, 1994.
  4. BATTAINI F., PASCALE A., LUCCHI L., RACCHI M., BERGAMASCHI S., PARENTI M., WETSEL W.C., GOVONI S. AND TRABUCCHI M.: Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation. Biochem. Biophys. Res. Comm. 203: 1423-1431, 1994.
  5. PASCALE A., MILANO S., CORSICO N., LUCCHI L., BATTAINI F., ARRIGONI E., TRABUCCHI M., GOVONI S. Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: "in vitro" and "in vivo" studies. Eur. J. Pharmacol., 265: 1-7, 1994. .
  6. BATTAINI F., ELKABES S., BERGAMASCHI S., LADISA V., LUCCHI L., DE GRAAN P.N.E., SCHUURMAN T., WETSEL W.C., TRABUCCHI M. AND GOVONI S.: Protein kinase C activity, translocation and conventional isoforms in aging rat brain. Neurobiol. Aging, 16: 137-148, 1995.
  7. BERGAMASCHI S., BATTAINI F., TRABUCCHI M., PARENTI M. LOPEZ C.M. AND GOVONI S. Neuronal differentiation modifies the effect of ethanol exposure on voltage-dependent calcium channels in NG108-15 cells. Alcohol, 12: 324-327, 1995.
  8. PINTOR A., FORTUNA S., LORENZINI P., PASCALE A., BATTAINI F., AVELLINO C., MALVEZZI CAMPEGGI L., SALVATI S. Influence of hypothyroidism on lipid composition, responsiveness of inositol lipid-linked receptors and protein kinase C activity in the cerebral cortex of Lewis rats. Neurochem. Res.21: 539-543, 1996 .
  9. PASCALE A., FORTINO I., GOVONI S., TRABUCCHI M., WETSEL W.C., AND BATTAINI F. Differential isoform-specific regulation of calcium-independent protein kinase C in rat cerebral cortex. Neurosci. Lett. 214 : 99-102, 1996.
  10. PASCALE A., FORTINO I., GOVONI S., TRABUCCHI M., WETSEL W.C., AND BATTAINI F. Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase) deficiency in aged rat brain cortex. J. Neurochem. 67 : 2471-2477, 1996.

RESEARCH GROUP MEMBERS:

  1. Beani Lorenzo P.O.
  2. Bianchi Clementina P.O.
  3. Antonelli Tiziana P.A.
  4. Siniscalchi Anna P.A.
  5. Simonato Michele R.U.
  6. Morari Michele R.U.
  7. Ferraro Luca T.L.
  8. Barbieri Mario B.PDR.
  9. Badini Irene D.DR.
  10. Bregola Gianni D.DR.
  11. Tomasini Cristina D.DR.
  12. Sbrenna Simone D.DR.
AFFILIATION:

Sezione di Farmacologia

Dipartimento di Medicina Clinica e Sperimentale

Facoltā di Medicina e Chirurgia

Universitā di Ferrara

ADDRESS: Via Fossato di Mortara 17-19

CITY: Ferrara

POSTAL CODE: 44100

TELEPHONE: 0532-291204, 291202, 291201

FAX: 0532-291205

E-MAIL: fma@ifeuniv.unife.it

PUBLICATIONS:

  1. FERRARO, L., CALO', G., ANTONELLI, T., FABRIZI, A., ACCIARRI, N., BIANCHI, C., BEANI, L., AND SIMONATO, M. Noradrenergic modulation of Gamma-aminobutyric acid outflow from the human cerebral cortex. Brain Res. 629: 103-108, 1993.
  2. MORARI, M., O'CONNOR, W.T., UNGERSTEDT, U., AND FUXE, K. N-methyl-D-aspartate acid differentially regulates extra-cellular dopamine, GABA and glutamate levels in the dorsolateral neostriatum of the halothane-anesthetized rat: An in vivo microdialysis study. J. Neurochem. 60: 1884-1893, 1993
  3. SINISCALCHI, A., BADINI, I., BIANCHI, C., AND BEANI, L. Monoamines modulates the electrically-evoked efflux of 3H-choline from slices of guinea pig nucleus basalis magnocellularis. Naunyn-Schmied. Arch. Pharmacol. 350: 10-14, 1994.
  4. TANGANELLI, S., O'CONNOR, W.T., FERRARO, L., BIANCHI, C., BEANI, L., UNGERSTEDT, U., AND FUXE, K. Facilitation of GABA release by neurotensin is associated with reduction of dopamine release in rat nucleus accumbens. Neurosci. 69 : 649-657, 1994.
  5. BIANCHI, C., FERRARO, L., TANGANELLI, S., MORARI, M., SPALLUTO, G., SIMONATO, M., AND BEANI, L. 5-hydroxytryptamine-mediated effects of nicotine on endogenous GABA efflux from guinea pig cortical slices. Brit. J. Pharmacol. 116: 2724 - 2728, 1995.
  6. HOSFORD, D.A., SIMONATO, M., CAO, Z., GARCIA CAIRASCO, J.M., SILVER, J.M., BUTLER, L., SHIN, C., AND MCNAMARA, J.O. Differences in the anatomic distribution of immediate early gene expression in amigdala and angular bundle kindling development. J. Neurosci. 15: 2513-2523, 1995.
  7. ROMUALDI, P., DONATINI, A., BREGOLA, G., BIANCHI C., BEANI, L., FERRI, S., AND SIMONATO, M. Early changes in pro-dynorphin mRNA and ir-dynorphin A levels after kindled seizures in the rat. Eur. J. Neurosci. 7: 1850-1856, 1995.
  8. FERRARO, L., O'CONNOR, W. T., LI, X.M., RIMONDINI, R., BEANI, L., UNGERSTED, U., FUXE, K., AND TANGANELLI, S. Evidence for a differential CCKB and CCKA receptor regulation of GABA release in the nucleus accumbens mediated via opaminergic and cholinergic mechanisms. Neurosci. 73: 941-950, 1996.
  9. MORARI, M., O'CONNOR, W.T., UNGERSTED, U., AND BIANCHI, C. Functional neuroanatomy of the nigrostriatal pathways as studied with dual microdialysis probe in the awake rat I. Effects of perfusion with tetrodotoxin and low-calcium. Neurosci. 72: 79-88, 1996.
  10. MORARI, M., O'CONNOR, W.T., UNGERSTED, U., AND BIANCHI, C. Functional neuroanatomy of the nigrostriatal pathways as studied with dual microdialysis probe in the awake rat. II. Evidence for striatal N-methyl-D-aspartate receptor regulation of striatonigral gabaergic transmission and motor function. Neurosci. 72: 89-97, 1996

RESEARCH GROUP MEMBERS:

  1. Benzi GianMartino, P.O.
  2. Moretti Antonio, B.
  3. Viganotti Carla, P.A.
  4. Marzatico Fulvio, R.U.
  5. Bertorelli Laura, D.DR.
  6. Guallini Paola, B.
  7. Finotti Nicoletta, B.
  8. Curti Daniela, R.U.
  9. Cattaneo Achille, B.
  10. Rognoni Francesca, B.
  11. Cuccia Mariaclara, P.A.
  12. Pastoris Ornella, R.U.
  13. Dossena Maurizia, B.PDR.
  14. Catapano Mariana D.DR.
  15. Foppa Paola D.DR.
  16. Pagani Sara, B.
  17. Villa Roberto Federico, R.U.
  18. Gorini Antonella, B.PDR.
  19. Canosi Umberto, D.DR.
  20. D'angelo Angela, B.
  21. Maggi Anna, B.
AFFILIATION:

Istituto di Farmacologia

Facoltā di Scienze

Universitā di Pavia

ADDRESS: Piazza Botta, 11

CITY: Pavia

POSTAL CODE: 27100

TELEPHONE: 0382 506 381,384

FAX: 0382 506 385

E-MAIL: carla@ipv36.unipv.it;

curtid@ipv36.unipv.it;

fulviomk@ipv36.unipv.it;

orpast@ipv36.unipv.it;

rfvilla@ipv36.unipv.it

PUBLICATIONS:

  1. BENZI G.,GORINI A., ARNABOLDI R., GHIGINI B. AND VILLA R.F. Age-related changes by hypoxia and TRH analogue treatment on synaptosomal non-mitochondrial ATPase activities. J. Neurosci.Res. 34: 654-663, 1993
  2. BENZI G., GORINI A., ARNABOLDI R., GHIGINI B. AND VILLA R.F. Effect of intermittent mild hypoxia and drug treatment on synaptic non-mitochondrial ATPase activities. Neurobiol. Aging. 15:409-417, 1994
  3. PASTORIS O., DOSSENA M., FOPPA P., ARNABOLDI R., GORINI A., VILLA R., AND BENZI G. Modifications by chronic intermittent hypoxia and drug treatment on skeletal muscle metabolism. Neurochem. Res. 20: 143-150, 1995.
  4. CAFE' C., TORRI C., BERTORELLI L., TARTARA F., TANCIONI F., GAETANI P., RODRIGUEZ Y BAENA R., MARZATICO F. Oxidative events in neuronal and glial cell-enriched fractions of rat cerebral cortex. Free Rad. Biol. Med. 19: 853-857, 1995
  5. BENZI G. AND MORETTI, A. Age-and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Rad. Biol. Med. 77 :77-101, 1995
  6. BENZI G. AND MORETTI A Are reactive oxygen species involved in Alzheimer's disease? Neurobiol. Aging 16: 661-674, 1995
  7. CAFÉ C., TORRI C., BERTORELLI L., ANGERETTI N., LUCCA E., FORLONI G., MARZATICO F. Oxidative stress after acute and chronic apllication of b-amyloid fragment 25-35 in cortical neurons. Neurosci. Lett. 203: 61-65, 1996
  8. OPASICH C., AQUILANI R., DOSSENA M., FOPPA P., CATAPANO M., PAGANI S., FERRARI R., PASINI E., TAVAZZI L. AND PASTORIS O. Skeletal metabolism of the muscle in resting and fasting patients with severe chronic heart failure. Eur. Heart J. 17: 1686-1693, 1996
  9. WHATLEY S.A., CURTI D. AND MARCHBANKS R.M. Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem. Res. 21:1001-1010, 1996.
  10. CURTI D., MALASPINA A., FACCHETTI G., CAMANA C., MAZZINI L., TOSCA P., ZERBI F. AND CERONI M. Amyotrophic lateral sclerosis: oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes. Neurology 47: 1060-1064, 1996.

RESEARCH GROUP MEMBERS:

  1. Bertolini Alfio, P.O.
  2. Bernardi Mara, P.A.
  3. Genedani Susanna, P.A.
  4. Benelli Augusta, R.U.
  5. Cavazzuti Elena, D.DR.
AFFILIATION:

Sezione di Farmacologia

Dipartimento di Scienze Biomediche

Facoltā di Medicina e Chirurgia

Universitā di Modena

ADDRESS: Via G. Campi, 287

CITY: Modena

POSTAL CODE: 41100

TELEPHONE: 059-428-440, 412, 417, 416

FAX: 059-372653

E-MAIL: farmacol@.unimo.it

PUBLICATIONS:

  1. GENEDANI, S. AND BERNARDI, M. ACTH-(11-24) antagonizes ACTH-(1-24)-induced behavioral syndrome. Neuropeptides 26: 241-244, 1994.
  2. GENEDANI, S., BERNARDI, M. AND BERTOLINI, A. Influence of ifenprodil on the ACTH-induced behavioral syndrome in rats. Eur. J. Pharmacol. 252: 77-80, 1994.
  3. GENEDANI, S., BERNARDI, M., OTTAVIANI, E., FRANCESCHI, C., LEUNG, M.K., AND STEFANO, G.B. Differential modulation of invertebrate hemocyte motility by CRF, ACTH, and its fragments. Peptides 15: 203-206, 1994.
  4. POGGIOLI, R., BENELLI, A., ARLETTI, R., VERGONI, A.V., MENOZZI, B., AND BERTOLINI, A. Old rats are unresponsive to the behavioral effects of adrenocorticotropin. Eur. J. Pharmacol. 271: 253-257, 1994.
  5. POGGIOLI, R., BENELLI, A., ARLETTI, R., CAVAZZUTI, E., AND BERTOLINI, A. K+ channel openers delay intestinal transit and have antidiarrheal activity. Eur. J. Pharmacol. 287: 207-209, 1995.
  6. VERGONI, A.V., SANDRINI, M., FILAFERRO, M., AND BERTOLINI, A. Opening of brain potassium-channel inhibits the ACTH- induced behavioral syndrome in the male rat. Neurosci. Lett. 188: 29-32, 1995.
  7. POGGIOLI, R., BENELLI, A., ARLETTI, R., CAVAZZUTI, E., AND BERTOLINI, A. Nitric Oxide is involved in the ACTH-induced behavioral syndrome. Peptides 16: 1263-1268, 1995.
  8. BERTOLINI, A. The opioid/anti-opioid balance in shock: a new target for therapy in resuscitation. Resuscitation 30: 29-42, 1995.
  9. BENELLI, A., BERTOLINI, A., POGGIOLI, R., CAVAZZUTI, E., CALZā, L., GIARDINO, L., AND ARLETTI, R. Nitric Oxide is involved in male sexual behavior of rats. Eur. J. Pharmacol. 294: 505-510, 1995.
  10. BERNARDI, M., BERTOLINI, A., SZCZAWINSKA, K., AND GENEDANI, S. Blockade of the polyamine site of NMDA receptors produces antinociception and enhances the effect of morphine in mice. Eur. J. Pharmacol. 298: 51-55, 1996.

RESEARCH GROUP MEMBERS:

  1. Borea Pier Andrea, P. O.
  2. Guerra Laura, D.DR
  3. Gessi Stefania, D.DR.
  4. Varani Katia, B.
  5. Dalpiaz Alessandro, B.
AFFILIATION:

Sezione di Farmacologia

Dipartimento di Medicina Clinica e Sperimentale

Facoltā di Medicina e Chirurgia

Universitā di Ferrara

ADDRESS: Via Fossato di Mortara, 17/19

CITY: Ferrara

POSTAL CODE: 44100

TELEPHONE: 0532-291214

FAX: 0532-291205

E-MAIL: bpa@ifeuniv.unife.it

PUBLICATIONS:

  1. GILLI P., FERRETTI V., GILLI G. AND BOREA P.A. Enthalpy-entropy compensation in drug-receptor binding. J. Phys. Chem. 98: 1515-1518, 1994.
  2. VARANI K., GUERRA L., BOREA P.A., DIONISOTTI S., ZOCCHI C. AND ONGINI E. Binding characteristics of the adenosine A2 receptor ligand [3H]-CGS 21680 to human platelet membranes. Biochem. Pharmacol. 48:1658-1661, 1994.
  3. IJZERMAN A.P., VAN DERWENDEN A.M., VONFRIJTAG J.K., DRABBE KUNZEL, MATHOT R.A.A., DANHOF M., BOREA P.A. AND VARANI K. Partial agonism of theophylline-7-riboside on adenosine receptors. Naunyn-Schmied. Arch. Pharmacol. 350: 638-645, 1994.
  4. BOREA P.A., VARANI K., DALPIAZ A., CAPUZZO A., FABBRI E. AND IJZERMAN A.P. Full and partial agonistic behaviour and thermodynamic binding parameters of adenosine A1 receptor ligands. Eur. J. Pharmacol., Molecular Pharmacology Section. 267: 55-61, 1994.
  5. BOREA P.A., DALPIAZ A., VARANI K., GUERRA L. AND GILLI G. Binding thermodynamics of adenosine A2a receptor ligands. Biochem. Pharmacol. 49: 461-469, 1995.
  6. DALPIAZ A., VARANI K., BOREA P.A., MARTINI C., CHIELLINI G. AND LUCACCHINI A. Biochemical and pharmacological characterization of periodate-oxidized adenosine analogs at adenosine A1 receptors. Biochim. Biophys. Acta. 1267: 145-151, 1995.
  7. DALPIAZ A., GESSI S., BOREA P.A. AND GILLI G. Discrimination of rat brain 5HT1A, 5HT2A and 5HT3 receptors by serotonin binding thermodynamics. Life Sci. 57: PL 141-146, 1995.
  8. VARANI K., GESSI S., DALPIAZ A. AND BOREA P.A. Biochemical and pharmacological characterization of purified A2a adenosine receptors in human platelet membranes by [3H]- CGS 21680 binding. Brit. J. Pharmacol.. 117: 1693-1701, 1996.
  9. BOREA P.A., DALPIAZ A., GESSI S. AND GILLI G. Thermodynamics of 5-HT3 receptor binding discriminates agonistic from antagonistic behaviour. Eur. J. Pharmacol.. 298: 329-334, 1996.
  10. BOREA P.A., VARANI K., GESSI S., DALPIAZ A. AND GILLI G. Binding Thermodynamics at Adenosine A1 and A2a Receptors. Life Sci. 59: 1373-1388, 1996.

RESEARCH GROUP MEMBERS:

  1. Borsini Franco, Capo Dipartimento
  2. Brambilla Alessandro, Capo Sezione
  3. Ceci Angelo, Capo Sezione
  4. Giraldo Ettore, Capo Sezione
  5. Monferini Eugenia, Capo Sezione
  6. Sagrada Angelo, Capo Sezione
  7. Cesana Raffaele, C.L.
  8. Pitsikas Nikolaus, C.L.
  9. Schiavi Giovanni Battista, C.L.
  10. Volonté Marina, C.L.
  11. Ciprandi Clara, R.I.
  12. Scandroglio Alessandro, R.I.
  13. Targa Roberta, R.I.
  14. Stefani Rita, R.I.
AFFILIATION:

Dipartimento di Biologia

Divisione Ricerca e Sviluppo

Boehringer Ingelheim Italia

ADDRESS: Via Lorenzini, 8

CITY: Milano

POSTAL CODE: 20139

TELEPHONE: 02-5355.252

FAX: 02-5355.205

PUBLICATIONS:

  1. PITSIKAS, N., BRAMBILLA, A., AND BORSINI, F. Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task. Pharmacol. Biochem. Behav. 47: 95-99, 1994.
  2. CECI, A., BASCHIROTTO A., AND BORSINI, F. The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotonergic neurons in rats is attenuated by lesion of the frontal cortex. Neuropharmacology 33: 709-713, 1994.
  3. CECI, A., FODRITTO, F., AND BORSINI, F.. Repeated treatment with fluoxetine decreases the number of spontaneously active cells per track in frontal cortex. Eur. J. Pharmacol. 271: 231-234, 1994.
  4. BORSINI, F., GIRALDO, E., MONFERINI, E., ANTONINI, G., PARENTI, M., BIETTI, G., AND DONETTI, A. BIMT 17, a 5-HT2A antagonist and 5-HT1A receptor full agonist, in rat cerebral cortex. Naunyn-Schmied. Arch. Pharmacol. 352: 276-282, 1995.
  5. BORSINI, F., CECI, A., BIETTI, G., AND DONETTI, A.. BIMT 17 a 5-HT1A agonist/5-HT2A antagonist, directly activates postsynaptic 5-HT inhibitory responses in the cortex. Naunyn-Schmied. Arch. Pharmacol. 352: 283-290, 1995.
  6. VOLONTÉ, M., CECI, A., AND BORSINI, F. Effect of the 5-hydroxytryptamine3 receptor antagonist itasetron (DAU 6215) on (+)-N-allylnormetazocine-induced dopamine release in the nucleus accumbens and in the corpus striatum of the rat: an in vivo microdialysis study. J. Pharmacol. Exp. Ther. 275: 358-367, 1995.
  7. CESANA, R., CIPRANDI, C., AND BORSINI, F., The effect of BIMT 17, a new potential antidepressant, in the forced swimming test in mice. Behav. Pharmacol. 6: 688-694, 1995.
  8. BRAMBILLA, A., PRUDENTINO, A., GRIPPA, N., AND BORSINI, F. Pharmacological characterization of AMPA-induced biting behaviour in mice. Eur. J. Pharmacol. 305: 115-117, 1996.
  9. PITSIKAS, N., AND BORSINI, F. The 5-HT3 antagonist itasetron (DAU 6215) prevents discrete memory impairment in the aged rat in a multiple choice avoidance task. Eur. J. Pharmacol. 311: 115-119, 1996.
  10. CECI A., AND BORSINI, F. Effects of desipramine and maprotiline on the coeruleus-cortical noradrenergic system in anaesthetized rats. Eur. J. Pharmacol. 312: 189-193, 1996.

RESEARCH GROUP MEMBERS:

  1. Buffoni Franca, P.O. (fuori ruolo)
  2. Ignesti Giovanni, P.A.
  3. Cambi Sandro, T.
AFFILIATION:

Dipartimento di Farmacologia preclinica e clinica "M. Aiazzi Mancini"

Universitā di Firenze

ADDRESS: Viale G.B. Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237411,405,400

FAX: 055-4361613

E-MAIL: buffoni@stat.ds.unifi.it

PUBLICATIONS:

  1. BUFFONI F., BANCHELLI G., CAMBI S., IGNESTI G., PIRISINO R., RAIMONDI L., AND VANNELLI G. Skin wound healing, some biochemical parameters in guinea pig skin. J. Pharm. Pharmacol. 45: 784-790, 1993
  2. IGNESTI G., BANCHELLI G., PIRISINO R., RAIMONDI L., AND BUFFONI F. Some problem with the diamine oxidase (DAO) assay using putrescine as substrate in rat liver. Agents Actions. 39: 6-17, 1993
  3. BUFFONI F. Properties, distribution and physiological role of semicarbazide-sensitive amine oxidases. Curr. Topics Pharmacol. 2: 33-50, 1993
  4. BUFFONI F., CAMBI S., BANCHELLI G., IGNESTI G., PIRISINO R., AND RAIMONDI L. Semicarbazide-sensitive amine oxidase activity of guinea-pig dorsal skin. J.Neural.Transm. 41: 421-426, 1994
  5. BUFFONI F. Isolation and identification by GC-MS of the carbonyl active site of pig kidney diamine oxidase. Anal. Biochem. 220: 185-191,1994
  6. BUFFONI F., BANCHELLI G., IGNESTI G., PIRISINO R., AND RAIMONDI L. The role of semicarbazide-sensitive amine oxidase with high affinity for benzylamine (Bz.SSAO) in the catabolism of histamine in the mesenteric arterial bed of the rat. Agents Actions. 42: 1-6, 1994
  7. BUFFONI F., PIERACCINI G. Isolation and identification in rat tissues by gas chromatography-mass spectrometry of a metabolite of 3,5-diethoxy-4-aminomethylpyridine (B24), a specific inhibitor of the semicarbazide-sensitive amine oxidases with high affinity for benzylamine. Pharmaceut. Sci. 1: 83-85, 1995
  8. BUFFONI F., MONETI G., PIERACCINI G., AND BERTINI V. Identification by gas chromatography- mass spectrometry of an adduct between pure pig plasma benzylamine oxidase and the inhibitor 3,5-diethoxy-4-aminomethylpyridine. J. Enz. Inhib. 8: 267-179,1995
  9. BUFFONI F. Semicarbazide-sensitive amine oxidases. Some biochemical properties and general considerations. Progress. Brain Res. 106: 323-331, 1995
  10. BUFFONI F., PINO R., AND DAL POZZO A. Effect of tripeptide-copper complexes on the process of skin healing and on cultured fibroblasts. Arch. Int. Pharmacodyn. 330: 345-360, 1995

RESEARCH GROUP MEMBERS:

  1. Caciagli Francesco, P.O.
  2. Ciccarelli Renata, R.U.
  3. Di Iorio Patrizia, R.U.
  4. Ballerini Patrizia, R.U.
  5. Giuliani Patricia, T.L.
  6. D'Alimonte Iolanda, B.
  7. Ambrosini Grazia, B.
  8. Renzetti Alessandro, B.
  9. Tiboni Gian Mario, B.PDR.
  10. Chimisso Michele, T.L.
AFFILIATION:

Istituto di Farmacologia e Tecnologie Bio-Mediche

Facoltā di Medicina e Chirurgia

Universitā "G. D'Annunzio"

ADDRESS: Via dei Vestini, 31

CITY: Chieti

POSTAL CODE: 66013

TELEPHONE: 0871 - 355259

FAX: 0871 - 355224

E-MAIL: isphar@phobos.unich.it

PUBLICATIONS:

  1. PORRECA E., CICCARELLI R., DI FEBBO C., CUCCURULLO F. Protein kinase C pathway and proliferative responses in adult and young rat vascular smooth muscle cells. Atherosclerosis, 104: 137-145, 1993.
  2. BALLERINI P., CICCARELLI R., DI IORIO P., GIULIANI P., FRANCANO D., CACIAGLI F. TMB-8 and thapsigargin modulate purine release from dissociated primary cultures of rat brain astrocytes. Res. Commun. Chem. Pathol. Pharmacol. 82: 167-174, 1993.
  3. CHUANG TT., SALLESE M., AMBROSINI G., PARRUTI G., DE BLASI A. Molecular mechanisms of receptor regulation: cloning and expression of the gene for the beta-adrenergic receptor kinase.J. Biol. Chem. 267: 563-571, 1993.
  4. CASABONA G., L'EPISCOPO M.R., DI IORIO P., CICCARELLI R., DE BERNARDIS E., SHINOZAKI H., NICOLETTI F., CACIAGLI F. Interaction between metabotropic receptors and purinergic transmission in rat hippocampal slices. Brain Res. 645: 13-18, 1994
  5. CICCARELLI R., DI IORIO P., BALLERINI P., AMBROSINI G., GIULIANI P., TIBONI G.M., CACIAGLI F. Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes. J. Neurosci. Res. 39: 556-566; 1994.
  6. BALLERINI P., CICCARELLI R., DI IORIO P., GIULIANI P., CACIAGLI F. Influence of Ca2+ channel modulators on 3H-purine release from rat cultured glial cells. Neurochem. Res. 20: 697-704; 1995
  7. DI IORIO P., BATTAGLIA G., CICCARELLI R., BALLERINI P., GIULIANI P., POLI A., NICOLETTI F., CACIAGLI F. Interaction between A1 adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices. J. Neurochem., 67: 302-309, 1996.
  8. AMBROSINI G., ALTIERI D.C. Molecular dissection of effector cell protease receptor-1 recognition of factor Xa. Assignment of critical residues involved in antibody reactivity and ligand binding. J. Biol. Chem. 271: 1243-1248, 1996.
  9. BALLERINI P., RATHBONE M.P., DI IORIO P., RENZETTI A., GIULIANI P., D'ALIMONTE I., TRUBIANI O., CACIAGLI F., CICCARELLI R. Rat astroglial P2Z receptors regulate intracellular calcium and purine release. NeuroReport, 7 : In press, 1996.
  10. HERMANN M., REED J., CICCARELLI R., DI IORIO P., RATHBONE M.P. Trophic effects of purines in neurons and glial cells. Prog. Neurobiology, In press, (invited review) 1996.

RESEARCH GROUP MEMBERS :

  1. Cannizzaro Gaspare, P.O.
  2. Beninati Francesco
  3. Flugy Anna, R.U.
  4. Gagliano Mauro
AFFILIATION:

Istituto di Farmacologia

Facoltā di Medicina e Chirurgia

Universitā degli Studi di Palermo

ADDRESS: Via del Vespro, 129

CITY: Palermo

POSTAL CODE: 90127

TELEPHONE: 091-655-3259, 3215, 3274, 3257

FAX : 091- 6553212

PUBLICATIONS:

  1. KLIMEK, V., ZAK-KNAPIK, S., CANNIZZARO, C. Changes in the rat brain 5-HT1a and 5-HT2 receptors after chronic administration of levoprotiline, (+) oxaprotiline and other antidepressant drugs. Polish J. Pharmacol. 44: 549-560, 1993.
  2. CANNIZZARO, G., FLUGY, A., CANNIZZARO, C., GAGLIANO, M., SABATINO, M. Effects of desipramine and alprazolam in the forced swim test in rats after long lasting termination of chronic exposure to picrotoxin and pentylenetetrazol. Eur. Neuropsychopharmacol. 3: 477-484, 1993.
  3. SABATINO, M., CANNIZZARO, C., FLUGY, A., GAGLIANO, M. AND CANNIZZARO, G. NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms. Eur. Neuropsychopharmacol. 4: 103-109, 1994.
  4. CANNIZZARO, C., CANNIZZARO, E., GAGLIANO, M., MINEO, M., SABATINO, M. AND CANNIZZARO, G. Effects of desipramine and alprazolam in forced swimming behaviour of adult rats exposed to prenatal diazepam. Eur. J. Pharmacol. 273: 239-245, 1995.
  5. CANNNIZZARO G., C. CANNIZZARO, E. GAGLIANO, M., MANGIAPANE, N. Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists. Eur. Neuropsychopharmacol. 5: 523-526, 1995.
  6. CANNIZZARO, C., CANNIZZARO E. , GAGLIANO, M. Motor and antidepressant-like effects of 5-HT(1A) agonist LY 228729 in prenatally benzodiazepine-exposed rats. Eur. Neuropsychopharmacol. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Carruba Michele, P.O.
  2. Briscini Luca, D. DR.
  3. Nisoli Enzo, B.
  4. Tonello Cristina, B.
AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Facoltā di Medicina e Chirurgia

Universitā degli Studi di Milano

ADDRESS: Via Vanvitelli 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-70146370, 332

FAX: 02-70146371

E-MAIL: Carruba@imiucca.csi.unimi.it

PUBLICATIONS:

  1. NISOLI E., TONELLO C., IMHOF R., SCHERSCHLICHT R., DA PRADA M., AND CARRUBA M.O. Neurochemical and behavioral evidence that Ro 41-9067 is a selective presynaptic dopamine receptor agonist. J. Pharmacol. Exp. Ther.. 266: 97-105, 1993
  2. NISOLI E., TONELLO C., AND CARRUBA M.O. SR 58611A: a novel thermogenetic -adrenoceptor agonist. Eur. J. Pharmacol., 259: 181-186, 1994
  3. GAROSI V.L., NISOLI E., BLUNDELL J.E., AND CARRUBA M.O. Pharmacological antagonism of lipoprivic feeding induced by sodium mercaptoacetate. Eur. J. Pharmacol., 276: 285-289, 1995
  4. NISOLI E. Adaptive events. Nature, 374: 671, 1995
  5. NISOLI E., TONELLO C., BENARESE M., AND CARRUBA M.O. Rat frontal cortex 1-adrenoceptors are activated by the 3- adrenoceptor agonist SR 58611A and SR 58878A but not by BRL 37344 or ICI 215,001. J. Neurochem., 65: 1580- 1587, 1995
  6. NISOLI E., TONELLO C., AND CARRUBA M.O. Differential relevance of -adrenoceptor subtypes in modulating the rat brown adipocytes function. Archives Internationales de Pharmacodynamie et de Thérapie, 329: 436-453, 1995
  7. NISOLI E., TONELLO C., LANDI M., AND CARUBA M.O. Functional Studies of the first selective 3- adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Mol. Pharmacol. 49: 7-14, 1996
  8. NISOLI E., TONELLO C., BENARESE M., LIBERINI P., AND CARRUBA M.O. Expression of nerve growth factor in brown adipose tissue: implications for thermogenesis and obesity. Endocrinology, 137: 495-503, 1996
  9. NISOLI E., GAROSI V.L., BLUNDELL J. E., AND CARRUBA M.O. Salbutamol antagonizes insulin - and sodium mercaptoacetate-induced but not 2-deoxy-D-glucose-induced hyperphagia. Pharmacol. Biochem. Behav. 54: 409-413, 1996

RESEARCH GROUP MEMBERS:

  1. Cattabeni Flaminio, P.O.
  2. Abbracchio Maria Pia, R.U.
  3. Di Luca Monica, R.U.
  4. Brambilla Roberta, D.DR.
  5. Caputi Antonio, D.DR.
  6. Ceruti Stefania, D.DR.
  7. Pastorino Lucia, D.DR.
AFFILIATION:

Laboratorio di Farmacologia della Plasticitā Sinaptica

Istituto di Scienze Farmacologiche

Facoltā di Farmacia

Universitā di Milano

ADDRESS: Via Balzaretti 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-20488.314, .374, .355, .265, .253

FAX: 02-2940.4961

E-MAIL: cattaben@isfunix.farma.unimi.it

PUBLICATIONS:

  1. DI LUCA M., CAPUTI A., CINQUANTA M., CIMINO M., MARINI P., PRINCIVALLE A. DE GRAAN P.N.E., GISPEN W.H. AND CATTABENI F. Changes in protein kinase C and its presynaptic substrate B-50/GAP-43 after intrauterine exposure to methylazoxy-methanol, a treatment inducing cortical and hippocampal damage and cognitive deficit. Eur. J. Neurosci., 7: 899-906, 1995.
  2. ABBRACCHIO M.P., BRAMBILLA R., CERUTI S., KIM H.O., VON LUBITZ D.K.J.E., JACOBSON K.A. AND CATTABENI F. G-protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain. Mol. Pharmacol., 48: 1038-1045, 1995.
  3. ABBRACCHIO M.P., CERUTI S., BARBIERI D., FRANCESCHI C., MALORNI W., BIONDO L., BURNSTOCK G. AND CATTABENI F. A novel action for Adenosine: apoptosis of astroglial cells in rat brain primary cultures. Biochem. Biophys. Res. Commun., 213: 908-915, 1995.
  4. ABBRACCHIO M.P., CERUTI S., LANGFELDER R., CATTABENI F., SAFFREY M.J. AND BURNSTOCK G. Effects of ATP analogues and basic Fibroblast Growth Factor on astroglial cell differentiation in primary cultures of rat striatum. Int. J. Develop. Neurosci., 13: 685-693, 1995.
  5. DI LUCA M., PASTORINO L., RAVERDINO V., DE GRAAN P.N.E., CAPUTI A., GISPEN W.H. AND CATTABENI F. Determination of the endogenous phosphorylation state of B-50/GAP-43 and neurogranin in different brain regions by electrospray-mass spectrometry. FEBS Lett. 389: 303-313, 1996.
  6. CAPUTI A., RURALE S., PASTORINO L., CIMINO M., CATTABENI F. AND DI LUCA M. Differential translocation of Protein Kinase C isozymes in rats characterized by a chronic lack of LTP induction and cognitive impairment. FEBS Lett. 393: 121-123,1996.
  7. NEARY J.T., RATHBONE M.P., CATTABENI F., ABBRACCHIO M.P. AND BURNSTOCK G. Trophic actions of extracellular nucloetides and nucleosides on glial and neuronal cells. Trends Neurosci. 19: 13-18, 1996.
  8. DI LUCA M., PASTORINO L., CATTABENI F., ZANARDI R., SCARONE S., RACAGNI G., SMERALDI E. AND PEREZ J. Abnormal pattern of platelet APP isoforms in Alzheimer's disease and Down's syndrome. Arch. Neurol. In press, 1996.
  9. DI LUCA M., CAPUTI A., CATTABENI F., DE GRAAN P.N.E., GISPEN W.H., RAITERI M., FASSIO A., SCHMID G AND BONANNO G.B. Increased presynaptic protein kinase C activity and glutamate release in rats with a prenatally induced hippocampal lesion. Eur. J. Neurosci. In press, 1996.
  10. CERUTI S., BARBIERI D., VERONESE E., CATTABENI F., COSSARIZZA A., GIAMMARIOLI A.M., MALORNI W., FRANCESCHI C. AND ABBRACCHIO M.P. Different pathways of apoptosis revealed by 2-Chloro-adenosine and deoxy-D-ribose in mammalian astroglial cells. J. Neurosci. Res. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Cattaneo Elena, R.U.
  2. De Fraja Claudio,B.
  3. Conti Luciano,B.
AFFILIATION :

Istituto di Scienze Farmacologiche

Facoltā di Farmacia

Universitā Statale di Milano

ADDRESS: Via Balzaretti,9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02/20488349

FAX: 02/29404961

E-MAIL: Cattaneo@isfunix.farma.unimi.it

PUBLICATIONS:

  1. CATTANEO E., MAGRASSI L., BUTTI G., SANTI L., GIAVAZZI A., PEZZOTTA S. A short t term of the behaviour of conditionali immortalized neuronal progenitors and primary neuroepithelial cells implanted into the fetal rat brain. Develop. Brain Res. 83 :197-208, 1994.
  2. CATTANEO E., REINACH B., CAPUTI A., CATTABENI F., DI LUCA M. Selective in vitro blockade of neuroepithelial cells proliferation by methylazoxymethanol,a molecul capable of enducing long lasting functional impairments. J. Neurosci. Res. 41 :640-647, 1995.
  3. CATTANEO E., DE FRAJA C., REINACH B., BOLIS L., GOVONI S., LIBOI E.Activation of the JAK/STAT pathway leads to proliferation of ST14A central nervous system progenitor cells. J. Biol. Chem..271 : 23374-23379, 1996.
  4. SALVIETTI N., CATTANEO E., GOVONI S., RACCHI M. Changes in beta-amyloid precursor protein secretion associated with the proliferative status of CNS derived progenitors cells. Neurosci. Lett. 212 :199-203, 1996.
  5. MAGRASSI L., PEZZOTTA S., BUTTI G., CONTI L., GOVONI S., CATTANEO E. Scattered primary and conditionally immortalized neuroepithelial cells trnsplanted into the embryonic rat brain differentiate into neurons and glial cells.Neurosci. Res. Comm. 18 :175-183, 1996.
  6. CATTANEO E., CONTI L., GRITTI A., FROLICHSTHAL P., GOVONI S., VESCOVI A. Non viral mediated gene transfer into human central nervous system precursors cells. Mol. Brain Res., In press, 1996.
  7. CORTI O., HORELLOU P., COLIN P., CATTANEO E., MALLET J.Intracerebral tetracycline-dependent regulation of gene expression in grafts of neural precursors. Neuroreport. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Clementi Francesco, P.O.
  2. Balestra Barbara, D.D.R.
  3. Battaglioli Elena, D.D.R.
  4. Flora Adriano, B.
  5. Fornasari Diego, R.CNR
  6. Gotti Cecilia, R.CNR
  7. Moretti Milena, T.L.
  8. Terzano Susanna, D.DR.
AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Universitā di Milano

Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare

ADDRESS: Via Vanvitelli 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 01-70146-254, 262, 266, 256

FAX: 02-7490574

E-MAIL: segreteria@farma5.csfic.mi.cnr.it

PUBLICATIONS:

  1. GOTTI, C., MORETTI, M., LONGHI, R., MANERA, E. AND CLEMENTI, F. Anti-peptide specific antibodies for the characterization of different a-subunits of a-Bungarotoxin receptors present in chick optic lobe. J. Receptor Res. 13: 453-465, 1993.
  2. GOTTI, C., HANKE, W., MAURY, K., MORETTI, M., BALLIVET, M., CLEMENTI, F. AND BERTRAND, D. Pharmacological and biophysical properties of a7 and a7-a8 a-Bungarotoxin receptor subtypes immunopurified from chick optic lobe. Eur. J. Neurosci. 6: 1281-1291, 1994.
  3. GOTTI, C., BRISCINI, L., VERDERIO, C., OORTGISIEN, M., BALESTRA, B. AND CLEMENTI, F. Native nicotinic acetylcholine receptors in human IMR32 neuroblastoma cells: functional, immunological and pharmacological properties. Eur. J. Neurosci.7: 2083-2092, 1995.
  4. RUBBOLI, F., COURT, J.A., SALA, C., MORRIS, C., CHINI, B., PERRY, E. AND CLEMENTI, F. Distribution of neuronal nicotinic receptors in the human hippocampus and thalamus. Eur. J. Neurosci. 6: 1596-1604, 1994.
  5. RUBBOLI, F., COURT, J.A., SALA, C., MORRIS, C., CHINI, B., PERRY, E. AND CLEMENTI, F. Distribution of neuronal nicotinic receptor subunits in human brain. Neurochem. Int. 25: 69-71, 1994.
  6. CIMINO, M., MARINI, P., COLOMBO, S., CATTABENI, F., FORNASARI, D. AND CLEMENTI, F. Expression of neuronal acetylcholine nicotinic receptor a4 and b2 subunits during postnatal development of the rat brain. J. Neural Trans. 100: 77-92, 1995.
  7. COURT J., PERRY, E.K., SPURDEN, D., GRIFFITHS, M., KERWIN, J.M., MORRIS, C.M., JOHNSON, M., OAKLEY, A.E., BIRDSALL, N.J.M., CLEMENTI, F. AND PERRY, R.H. The role of cholinergic system in the development of the human cerebellum.Develop. Brain Res. 90: 159-167, 1995.
  8. ZAHLER, R., SUN, W., LUFBURROW, M., FORNASARI, D., ROMANA, M. AND BRINES, M. Selective inhibition of Na, K-ATPase isoform expression using antisense oligodeoxynucleotide: possible functional differences between human a1 and a3 isoforms. J. Cell Physiol., In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Corona Gian Luigi, P.O.
  2. Santagostino Barbone Giuseppe, P.A.
  3. Frattini Pietro, P.A.
  4. Cucchi Maria Laura, P.A.
  5. Schinelli Sergio, R.U.
  6. Paolillo Mayra, B.PDR.
  7. Preda Stefania, D.DR.
AFFILIATION:

Istituto di Farmacologia

Facoltā di Farmacia

Universitā di Pavia

ADDRESS: Viale Taramelli, 14

CITY: Pavia

POSTAL CODE: 27100

TELEPHONE: 0382-507395

FAX: 0382-507405

E-MAIL: mcs@chifar.unipv.it

PUBLICATIONS:

  1. SCHINELLI, S., PAOLILLO, M., QUARTIERI, M., AND SANTAGOSTINO, G. Dopamine synthesis, uptake and metabolism in embryonic rat mesencephalic cell cultures. Pharmacol. Res. 28: 265-237, 1993.
  2. PAOLILLO, M., PREDA, S., CORONA, G.L., AND SCHINELLI, S. Measurement of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in cultured rat mesencephalic neurons by high performance liquid chromatography with electrochemical detection. J. Chromatogr. 613: 231-237, 1993.
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