SIF - Societą Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

PHARMACOLOGY OF THE LIPID METABOLISM

  


RESEARCH GROUP MEMBERS:

  1. Catapano Alberico L., P.A.
  2. Maggi Franco M., R.U.
  3. Roma Paola, B.PDR.
  4. Zanelli Tiziano, B.PDR.
  5. Grignaffini Paola, D.DR.
  6. Zoppo Adele, D.DR.
  7. Pirillo Angela, B.

AFFILIATION:

Istituto di Scienze Farmacologiche

Universitą degli Studi di Milano

ADDRESS: Via Balzaretti, 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02 - 20 488 302

FAX: 02 - 20 488 386

E-MAIL: catapano@isfunix.farma.unimi.it

PUBLICATIONS:

  1. FUNKE, A., VON ECKARDSTEIN, A., PRITCHARD, P.H., HORNBY, A.E., WIEBUSCH, H., MOTTI, C., HAYDEN, M.R., DACHET, C., JACOTOT, B., GERDES, U., FAEGERMAN, O., ALBERS, J.J., COLLEONI, N., CATAPANO, A.L., FROHLICH, J., AND ASSMANN, G. Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. J. Clin. Invest. 91: 677-683, 1993.
  2. ZANELLI, T., CATAPANO, A.L., AVERNA, M.R., BARBAGALLO, C.M., MOTTA, A., AND NOTARBARTOLO, A. A new case of apo C-II deficiency with a nonsense mutation in the apo C-II gene. Clin. Chim. Acta. 224: 111-118, 1994.
  3. ZHU, W., ROMA, P., PELLEGATTA, F., AND CATAPANO, A.L. Oxidized-LDL induce the expression of heat shock protein 70 in human endothelial cells. Biochem. Biophys. Res. Commun. 200: 389-394, 1994.
  4. FIELDING, P.E., KAWANO, M., CATAPANO, A.L., ZOPPO, A., MARCOVINA, M., AND FIELDING, C.J. A unique epitope of apolipoprotein A-I expressed in preß-1 high density lipoprotein and its role in the catalysed efflux of cellular cholesterol. Biochemistry. 33: 6981-6985, 1994
  5. MAGGI, F.M., PIGLIONICAM, M.R., DE MICHELE, L., BARONI, S., GIONCHETTA, C., BIASI, G.M., AND CATAPANO, A.L. Bezafibrate lowers elevated plasma levels of fibrinogen and Lp(a) in patients with type IIa and b dyslypoproteinaemia. Nutr. Metab. Cardiovasc. Dis. 4: 215-220, 1994.
  6. CORSINI, A., MAGGI, F.M., AND CATAPANO, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol. Res. 31: 9-27, 1995.
  7. ZHU, W., ROMA, P., PIRILLO, A., PELLEGATTA, F., AND CATAPANO, A.L. Oxidized LDL induce hsp70 expression in human smooth muscle cells. FEBS Lett. 372: 1-5, 1995.
  8. SOMA, M.R., DONETTI, E., PAROLINI, C., BARBERI, L., FUMAGALLI, R., PAOLETTI, R., AND CATAPANO, A.L. Effect of lacidipine on fatty and proliferative lesions induced in hypocholesterlemic rabbits. Brit. J. Pharmacol., 118 : 215-219, 1996.
  9. ZHU, W., ROMA, P., PIRILLO, A., PELLEGATTA, F., AND CATAPANO, A.L. Human endothelial cells exposed to oxidized LDL express hsp70 only when proliferating. Arterioscler. Thromb. Vasc. Biol. 16: 1104-1111, 1996.

RESEARCH GROUP MEMBERS:

  1. Franceschini Guido, P.A.
  2. Calabresi Laura, B.PDR.
  3. Chiesa Giulia, B.PDR.
  4. Parolini Cinzia, D.DR.

AFFILIATION:

Istituto di Scienze Farmacologiche

Centro E. Grossi Paoletti

Facoltą di Farmacia

Universitą degli Studi di Milano

ADDRESS: via Balzaretti 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-6471690

FAX: 02-6470594

E-MAIL: francesc@isfunix.farma.unimi.it

PUBLICATIONS:

  1. CHIESA G., MICHELAGNOLI S., CASSINOTTI M., GIANFRANCESCHI G., WERBA J.P., PAZZUCCONI F., SIRTORI C.R., AND FRANCESCHINI G. Mechanisms of HDL reduction after probucol treatment: changes in plasma cholesterol esterification/transfer and lipase activities. Metabolism 42: 229-235, 1993.
  2. CALABRESI L., CASSINOTTI M., GIANFRANCESCHI G., SAFA O., SIRTORI C.R., AND FRANCESCHINI G. Increased postprandial lipemia in the apolipoprotein A-IMilano carriers. Arterioscl. Thromb. 13:521-528, 1993.
  3. FRANCESCHINI G., WERBA J.P., AND CALABRESI L. Drug control of reverse cholesterol transport. Pharmacol. Ther. 61:289-324, 1994.
  4. FRANCESCHINI G., CASSINOTTI M., VECCHIO G., GIANFRANCESCHI G., PAZZUCCONI F., MURAKAMI T., SIRTORI M., D'ACQUARICA A.L., AND SIRTORI C.R. Pravastatin effectively lowers LDL cholesterol in familial combined hyperlipidemia without changing LDL subclass pattern. Arterioscler. Thromb. 14:1569-1575, 1994.
  5. CALABRESI L., VECCHIO G., LONGHI R., GIANAZZA E., PALM G., WADENSTEN H., HAMMARSTRÖM A., OLSSON A., KARLSTRÖM A., SEJLITZ T., AGELAND H., SIRTORI C.R., AND FRANCESCHINI G. Molecular characterization of native and recombinant apolipoprotein A-IMilano dimer. The introduction of an interchain disulfide bridge remarkably alters the physicochemical properties of apolipoprotein A-I. J. Biol. Chem. 269:32168-32174, 1994.
  6. FRISONI G.B., GOVONI S., GEROLDI C., BIANCHETTI A., CALABRESI L., FRANCESCHINI G., AND TRABUCCHI M. Gene dose of the 4 allele apolipoprotein E and disease progression in sporadic late-onset alzheimer's disease. Ann. Neurol. 37:596-604, 1995.
  7. MURAKAMI T., MICHELAGNOLI S., LONGHI R., GIANFRANCESCHI G., PAZZUCONI F., CALABRESI L., SIRTORI C.R., AND FRANCESCHINI G. Triglycerides are major determinants of cholesterol esterification/transfer and HDL remodeling in human plasma. Arterioscl. Thromb. Vasc. Biol. 15:1819-1828, 1995.
  8. BERNINI F., CALABRESI L., BONFADINI G., AND FRANCESCHINI G. The molecular structure of apolipoprotein A-II modulates the capacity of HDL to promote cell cholesterol efflux. Biochim. Biophys. Acta 1299:103-109, 1996.
  9. CALABRESI L., LUCCHINI A., VECCHIO G., SIRTORI C.R., AND FRANCESCHINI G. Human apolipoprotein A-II inhibits the formation of pre- high density lipoproteins. Biochim. Biophys. Acta; In press, 1996.
  10. FRANCESCHINI G. Apolipoprotein function in health and disease: insights from natural mutations. Eur. J. Clin. Invest., In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Fumagalli Remo P.O.
  2. Corsini Alberto R.U.
  3. Soma Maurizio R.U.
  4. Bellosta Stefano B.PDR.
  5. Donetti Elena D.DR.
  6. Baetta Roberta D.DR.
  7. Quarato Pierangelo B.
  8. Canavesi Monica B.

AFFILIATION:

Istituto di Scienze Farmacologiche

Facoltą di Farmacia

Universitą degli Studi di Milano

ADDRESS: Via Balzaretti, 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02 - 20488321/322/346

FAX: 02 - 29404961

E-MAIL: corsiniaisfunix.farma.unimi.it

PUBLICATIONS:

  1. SOMA MR, DONETTI E, PAROLINI C, MAZZINI G, FERRARI C, FUMAGALLI R, PAOLETTI R. HMGCoA reductase inhibitors: in vivo effects on carotid intimal thickening in normocholesterolemic rabbits. Arterioscler. Thromb. 13: 571-578. 1993
  2. BERNINI F, DIDONI G, BELLOSTA S, FUMAGALLI R. Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages. Atherosclerosis. 104: 19-26, 1993
  3. CORSINI A, MAZZOTTI M, RAITERI M, SOMA MR, GABBIANI G, FUMAGALLI R, AND PAOLETTI R. Relationship between mevalonate pathway and arterial myocyte proliferation: "in vitro" studies with inhibitors of HMG-CoA reductase. Atherosclerosis. 101: 117-125, 1993
  4. SOMA MR, BAETTA R, BERGAMASCHI S, DE RENZIS MR, DAVEGNA C, BATTAINI F, FUMAGALLI R, GOVONI S. PKC activity in rat C6 glioma cells: changes associated with cell cycle and simvastatin treatment. Biochem. Biophys. Res. Commun. 200: 1143-1149, 1994
  5. SOMA MR, BAETTA R, DE RENZIS R, MAZZINI G, DAVEGNA C, MAGRASSI L, BUTTI G, PEZZOTTA S, PAOLETTI R, FUMAGALLI R. In vitro and in vivo enhanced anti-tumor activity of carmustine (BCNU) by simvastatin, a hypocholesterolemic drug. Cancer Res. 55: 597-602, 1995
  6. SOMA MR, DONETTI E, PAROLINI C, SIRTORI C, FUMAGALLI R, FRANCESCHINI G. Recombinant apolipoprotein A-IMilano dimer inhibits carotid intimal thickening induced by perivascular manipulation in rabbits. Circ. Res. 76: 405-411, 1995
  7. CORSINI A, VERRI D, RAITERI M, QUARATO P, PAOLETTI R, FUMAGALLI R. Effect of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes. Arterioscler. Thromb. Vasc. Biol. 15:420-428, 1995
  8. BERNINI F, SCURATI N, BONFADINI G, FUMAGALLI R. HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages. Arterioscl., Thromb. Vasc. Biol. 15: 1352-1358, 1995
  9. SOMA MR, DONETTI E, PAROLINI C, BARBERI L, FUMAGALLI L, PAOLETTI R, CATAPANO AL. Effect of lacidipine on fatty and proliferative lesions induced in hypercholesterolemic rabbits. Brit. J. Pharmacol. 118: 215-219, 1996.
  10. CORSINI A, BONFATTI M, QUARATO P, RAITERI M, SARTANI A, TESTA R, PAOLETTI R, FUMAGALLI R. Effect of the new calcium antagonist lercanidipine and its enantiomers on the migration and proliferation of arterial myocytes. J. Cardiovasc. Pharmacol. 28 : In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Galli Claudio, P.O.
  2. Petroni Anna, R.U.
  3. Visioli Francesco, B.PDR.
  4. Marangoni Franca, B.PDR.
  5. Risé Patrizia, D.DR.
  6. Papini Nadia, Spec.
  7. Colombo Claudio, T.
  8. Blasevich Milena, T.

AFFILIATION:

Istituto di Scienze Farmacologiche

Facoltą di Farmacia

Universitą degli Studi di Milano

ADDRESS: Via Balzaretti, 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-20488309-307

FAX: 02-29404961

E-MAIL: gallic@isfunix.farma.unimi.it.

PUBBLICATIONS:

  1. GALELLA, G., MARANGONI, F., RISÆ, P., COLOMBO, C., GALLI, G. AND GALLI, C. n-6 and n-3 fatty acid accumulation in THP-1 cell phospho-lipids. Biochim. Biophys. Acta, 1169: 280-290, 1993
  2. F. MARANGONI, M.T. ANGELI, S. COLLI, S. ELIGINI, E. TREMOLI, C.R. SIRTORI, C. GALLI. Changes of n-3 and n-6 fatty acids in plasma and circulating cells of normal subjects, after prolonged administration of 20:5 (EPA) and 22:6 (DHA) ethyl esters and prolonged washout. Biochim Biophys Acta, 1210: 55-62, 1993.
  3. A. PETRONI, M. SALAMI, M. BLASEVICH, N. PAPINI, G. GALELLA, C. COLOMBO, C. GALLI. Eicosanoid and inositol phosphate response to platelet-activating factor (PAF) and to a PAF antagonist in rat astroglial cells. Dev Brain Res., 1-6, 1993.
  4. D. CARUSO, P.RISÉ, G.GALELLA, C.REGAZZONI, A.TOIA, G.GALLI AND C.GALLI. Formation of 22 and 24 carbon 6-desaturated fatty acids from exogenous deuterated arachidonic acid is activated in THP-1 cells at high substrate concentrations. FEBS Letters, 343:195-199, 1994.
  5. F. VISIOLI AND C. GALLI. Oleuropein protects low density lipoprotein from oxidation. Life Sciences, 55:1965-71,1994
  6. E.TREMOLI, P.MADERNA, F.MARANGONI, S.COLLI, S.ELIGINI, I. CATALANO, MT ANGELI, F PAZZUCCONI, G GIANFRANCESCHI, G DAVI, E STRAGLIOTTO, CR SIRTORI, C GALLI. Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl ester ingestion by healthy volunteers. Am. J. Clin. Nutr. 61: 1-7, 1995.
  7. VISIOLI F, BELLOMO G, MONTEDORO GF AND GALLI C. Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents. Atherosclerosis 117: 25-32, 1995.
  8. A. PETRONI, M. BLASEVICH, N. PAPINI, P. LA SPADA AND C. GALLI. Changes in arachidonic acid levels and formation and in lipid synthesis in the human neuroblastoma SK-NBE during retinoic acid-induced differentiation. J Neurochem 67:549-556, 1996
  9. P. PAULETTO, PUATO M, CAROLI MG, CASIGLIA E, MUNHAMBO AE, CAZZOLATO G, BITTOLO BON G, ANGELI MT, GALLI C, AND PESSINA A. Blood pressure and atherogenic lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania : the Lugalawa Study. Lancet, 348:784-88, 1996.

RESEARCH GROUP MEMBERS:

  1. Sirtori Cesare, P.O.
  2. Lovati Maria Rosa, R.U.
  3. Gianazza Elisabetta, R.U.
  4. Gianfranceschi Gemma, R.U.
  5. Bertoli Marina, R.U.
  6. Manzoni Cristina, T.L.
  7. Pazzucconi Franco, T.L.
  8. Battistin Paolo, T.L.

AFFILIATION:

Istituto di Scienze Farmacologiche

Facoltą di Farmacia

Universitą degli Studi di Milano

Centro E. Grossi Paoletti, Ospedale Niguarda Cą Granda

ADDRESS: Via Balzaretti, 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02/20.488.311, 303

FAX: 02 - 29.404.961

E-MAIL: sirtori@isfunix.farma.unimi.it

PUBLICATIONS:

  1. BEKAERT E.D., ALAUPOVIC P., KNIGHT-GIBSON C.S., FRANCESCHINI G., AND SIRTORI C.R. Apolipoprotein A-1Milano: sex related differences in the concentration and composition of apo A-I and apoB-containing lipoprotein particles. J. Lipid Res. 34: 111-123, 1993.
  2. ROMA P., GREGG R.E., MENG M.S., RONAN R., ZECH L.A., FRANCESCHINI G., SIRTORI C.R., AND BREWER H. B. Jr. In vivo metabolism of a mutant form of apolipoprotein A-I, apo A-IMilano, associated with familial hypoalphalipoproteinemia. J. Clin. Invest. 91: 1445-1452, 1993.
  3. PAZZUCCONI F., FRANCESCHINI G., GIANFRANCESCHI G., BRAMBILLA E., AND SIRTORI, C.R. Lipoprotein structure in male subjects during in vivo lipolysis: effect of an antilipolytic treatment with acipimox. J. Lipid Res. 34: 1465-1472, 1993.
  4. MARANGONI F., ANGELI M.T., COLLI S., ELIGINI S., TREMOLI E., SIRTORI C.R., AND GALLI C. Changes of n-3 and n-6 fatty acids in plasma and circulating cells of normal subjects, after prolonged administration of 20:5 (EPA) and 22:6 (DHA) ethyl esters and prolonged washout. Biochim. Biophys. Acta 1210: 55-62, 1993.
  5. FRANCESCHINI G., CASSINOTTI M., VECCHIO G., GIANFRANCESCHI G., PAZZUCCONI, F., MURAKAMI T., SIRTORI M., D'ACQUARICA A.L., AND SIRTORI C.R. Pravastatin effectively lowers LDL cholesterol in familial combined hyperlipidemia without changing LDL subclass pattern. Arterioscler. Thromb. 14: 1569-1575, 1994.
  6. SOMA M.R., DONETTI E., PAROLINI C., SIRTORI C.R., FUMAGALLI R., AND FRANCESCHINI, G. Recombinant apolipoprotein A-IMilano dimer inhibits carotid intimal thickening induced by perivascular manipulation in rabbits. Circ. Res. 76: 405-411, 1995.
  7. FRANCESCHINI G., WERBA J.P., D'ACQUARICA A.L., GIANFRANCESCHI G., MICHELAGNOLI S., AND SIRTORI C.R. Microsomal enzyme inducers raise plasma HDL-cholesterol levels in healthy controls but not in patients with primary hypoalphalipoproteinemia. Clin. Pharmacol. Ther. 57: 434-440, 1995.
  8. SIRTORI C.R. New targets for lipid lowering and atherosclerosis prevention. Pharmacol. Ther. 67: 433-447, 1995
  9. BALDASSARRE D., GIANFRANCESCHI G., PAZZUCCONI F., AND SIRTORI C.R. Non-invasive assessment of unstimulated forearm arterial compliance in human subjects. Impaired vasoreactivity in hypercholesterolaemia. Eur. J. Clin. Invest. 25: 859-866, 1995.
  10. PAZZUCCONI F., BARBI S., BALDASSARRE D., COLOMBO N., DORIGOTTI F., AND SIRTORI C.R. Iron-ovotransferrin preparation does not interfere with ciprofloxacin absorption. Clin. Pharmacol. Ther. 59: 418-422, 1996.

RESEARCH GROUP MEMBERS:

  1. Tacconi Maria Teresa, C.L..
  2. Sciarretta Birolo Roberto B.
  3. Tsankova Virginia, visiting scientist

AFFILIATION:

Istituto di Ricerche Farmacologiche "Mario Negri" Milano

ADDRESS: Via Eritrea, 62

CITY: Milano

POSTAL CODE: 0157

TELEPHONE: O2-39014464

FAX: 02-3546277

E-MAIL: tacconi@irfmn.mnegri.it

PUBLICATIONS:

  1. PELLEGRINI G, TOTANI L, DISANTO A, PICCOLI A, TACCONI MT, DONATI MB AND LORENZET R, Supplementation-induced changes in polyunsaturated fatty acid membrane and plasma composition do not modify mononuclear cell procoagulant activity , Thromb. Res., 71: 95-101, 1993.
  2. LLIGONA TRULLA LLUIS, MAGISTRELLI A. , M SALMONA AND TACCONI MT Effect of cell density on cytotoxicity of Ether lipids analogues in variants of B16 murine melanoma; Lipids, 28, 403-406,1993.
  3. M VISENTIN, M SALMONA AND MT TACCONI. Reye's and Reye-like syndrome: drug-related deseases? Causative agents, etiology, pathogenesis and therapeutic approach, Drug Metab. Rev. 27: 517-539, 1995.
  4. A MAGISTRELLI, P VILLA, E BENFENATI, M SALMONA, E J MODEST AND MT TACCONI.The fate of 1-O-octadecyl-2-O-methyl -rac-glycero-3-phosphocholine (ET18OMe) in malignant cells, normal cells and isolated and perfused rat liver. Drug Metab. Disposition, 23 : 113-118, 1995.
  5. M VISENTIN, M SALMONA AND MT TACCONI. Reye syndrome model in rat:protection against liver abnormalities by L-carniytine and L-acetylcarnitine J. Pharmacol. Exp. Ther., 275:1069-1075, 1995.
  6. TSANKOVA, A MAGISTRELLI, L CANTONI, AND MT TACCONI. Peripheral benzodiazepine receptor ligands in rat liver: Effect on mitochondrial cholesterol translocation, Eur. J. Pharmacol., 294:601-607, 1995.
  7. LUSUARDI M, CAPELLI A, SALMONA M, TACCONI MT, CERUTTI CG, DONNER CF. Intraluminal inflammationin airways of patients with chronic bronchitis after treatment with ambroxol. Monaldi Arch. Chest Dis. 50:346-351, 1995.
  8. TSANKOVA, M VISENTIN, M CARELLI, L CANTONI, AND MT TACCONI. Peripheral benzodiazepine receptor ligands in rat liver: Effect on 27- hydroxylation of cholesterol, Eur. J. Pharmacol., 299:197-203, 1996.

 

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