SIF - Società Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

PHARMACOLOGY OF INFLAMATION
AND IMMUNOMODULATION

 

RESEARCH GROUP MEMBERS:

  1. Benoni Giuseppina, R.U.
  2. Cuzzolin Laura, T.L.
  3. Adami Alessandra, B.
  4. Crivellente Federica, D.DR.

AFFILIATION:

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università di Verona

ADDRESS: Policlinico Borgo Roma

CITY: Verona

POSTAL CODE: 37134

TELEPHONE: 45-8098609

FAX: 045-581111

E-MAIL: Laura@Farma.Univr.it

PUBLICATIONS:

  1. CONFORTI, A., SCHINELLA, M., BENONI, G., DONINI, M., AND CUZZOLIN, L. Efficacy and nephrotoxicity of cyclosporin alone and associated to methylprednisolone in adjuvant arthritis. Int. J. Immunopathol. Pharmacol. 6: 193-198, 1993.
  2. BENONI, G., BELLAVITE, P., ADAMI, A., CHIRUMBOLO, S., LIPPI, G., BROCCO, G., GIULINI, G.M., AND CUZZOLIN, L. Changes in several neutrophil functions in basketball players before, during and after the sports season. Int. J. Sport. Med. 16: 34-37, 1995.
  3. BENONI, G., BELLAVITE, P., ADAMI, A., CHIRUMBOLO, S., LIPPI, G., BROCCO, G., AND CUZZOLIN, L. Effect of acute exercise on some haematological parameters and neutrophil functions in trained and untrained subjects. Eur. J. Appl. Physiol. 70: 187-191, 1995.
  4. BENONI, G., TERZI, M., ADAMI, A., GRIGOLINI, L., DEL SOLDATO, P., AND CUZZOLIN, L. Plasma concentrations and pharmacokinetic parameters of nitrofenac, using a simple and sensitive HPLC method. J. Pharmaceut. Sci. 84: 93-95, 1995.
  5. MARIOTTO, S., CUZZOLIN, L., ADAMI, A., DEL SOLDATO, P., SUZUKI, H., AND BENONI, G. Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils. Brit. J. Pharmacol. 114: 1105-1106, 1995.
  6. MARIOTTO, S., CUZZOLIN, L., ADAMI, A., DEL SOLDATO, P., SUZUKI, H., AND BENONI, G. Effect of a new non-steroidal antiinflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils. Brit. J. Pharmacol. 115: 225-226, 1995.
  7. MARIOTTO, S., MENEGAZZI, M., CARCERERI DE PRATI, A., CUZZOLIN, L., ADAMI, A., SUZUKI, H., AND BENONI G. Protective effect of NO on gastric lesions and inhibition of expression of gastric inducible NOS by flurbiprofen and its nitro-derivative, nitroflurbiprofen. Brit. J. Pharmacol. 116: 1713-1714, 1995.
  8. MINUZ, P., LECHI, C., TOMMASOLI, R., GAINO, S., DEGAN, M., ZULIANI, V., BONAPACE, S., BENONI, G., ADAMI, A., CUZZOLIN, L., AND LECHI, A. Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid. Thromb. Res. 80: 367-376, 1995.
  9. CUZZOLIN, L., ADAMI, A., DEGAN, M., CRIVELLENTE, F., BONAPACE, S., MINUZ, P., AND BENONI, G. Effect of single and repeated doses of a new nitroderivative of acetylsalicylic acid on platelet TXA2 production in rats. Life Sci. 58: 207-210, 1996.

RESEARCH GROUP MEMBERS:

  1. Bruni Alessandro, P.O.
  2. Cusinato Federico T.L.
  3. Carrara Marisa T.L.

AFFILIATION:

Dipartimento di Farmacologia "E. Meneghetti"

Facoltà di Medicina e Chirurgia

Università di Padova

ADDRESS: Largo E. Meneghetti, 2

CITY: Padova

POSTAL CODE: 35131

TELEPHONE: 049 8275081

FAX: 049 8275093

PUBLICATIONS:

  1. VIOLA G., MIETTO L., SECCHI F.E., PING L. AND BRUNI A. Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route. J. Lipid Res. 34: 1843-1851, 1993.
  2. SANTAMBROGIO L., LIPARTITI M., BRUNI A. AND DAL TOSO R. Dopamine receptors on human T and B lymphocytes. Neuroimmunol., 45: 113-120, 1993.
  3. BELLINI F. AND BRUNI A. Role of a serum phospholipase A1 in the phosphatidylserine-induced T cell inhibition. FEBS Lett. 316: 1-4, 1993.
  4. MONASTRA G., CROSS A.H., BRUNI A. AND RAINE C.S. Phosphatidylserine, a putative inhibitor of tumor necrosis factor, prevents autoimmune demyelination. Neurology 43: 153-163, 1993.
  5. BRUNI A., MIETTO L., SECCHI F.E. AND CHIZZOLINI C. Lipid mediators of immune reactions: effect of a linked phosphorylserine group. Immunol. Lett. 42: 87-90, 1994.
  6. BRUNI A., MIETTO L., SECCHI F.E., PONZIN D., MONASTRA G., KIRSCHNER G., CUSINATO F. AND CHIZZOLINI C. Inhibition by cholesterylphosphorylserine of T cell-mediated immune responses in mice. Int. J. Immunopharmacol. 17: 517-521, 1995.

RESEARCH GROUP MEMBERS:

  1. Caprino Luciano, P.O.
  2. Togna Giuseppina Ines, P.A.
  3. Togna Anna Rita, T.L.
  4. Graziani Manuela, T.L.
  5. Russo Pierluigi, B

AFFILIATION:

Istituto di Farmacologia Medica (IV Cattedra)

Facoltà di Medicina e Chirurgia

Università "La Sapienza"

ADDRESS: P.le Aldo Moro, 5

CITY: Roma

POSTAL CODE: 00185

TELEPHONE: 06-4991/2920, 2905

FAX: 06-4991/2393

PUBLICATIONS:

  1. CAPRINO L., AND TOGNA G. The problems of the safety evaluation of biotechnology derived drugs. Biomed. Environ. Sci. 6: 413-418, 1993.
  2. CIABATTONI G., MONTUSCHI P., CURRO' D., TOGNA G., PREZIOSI P. Effects of VIP on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung. Brit. J. Pharmacol. 109: 243-250, 1993.
  3. CAPRINO L., TOGNA A.R., STELLA C., TOGNA G. An in vitro method for evaluating vascular endothelial ADPase activity. J. Pharmacol. Toxicolog. Met. 35: 153-157, 1996.
  4. TOGNA G., GRAZIANI M., SORRENTINO C., CAPRINO L. Prostanoid production in in the presence of platelet activation in hypoxic cocaine-treated rats. Haemostasis, 26 : In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Di Rosa Massimo, P.O.
  2. Carnuccio Rosa, P.A.
  3. Sautebin Lidia, R.U.
  4. Ialenti Armando, R.U.
  5. Iuvone Teresa, R.U.
  6. Ianaro Angela, B.PDR.
  7. Rombolà Laura, D.DR.

AFFILIATION:

Dipartimento di Farmacologia Sperimentale

Facoltà di Farmacia

Università di Napoli Federico II

ADDRESS: Via Domenico Montesano, 49

CITY: Napoli

POSTAL CODE: 80131

TELEPHONE: 081-7486-414, 422

FAX: 081-7486-403

PUBLICATIONS:

  1. IALENTI, A., MONCADA, S., AND DI ROSA M. Modulation of adjuvant arthritis by endogenous nitric oxide. Brit. J. Pharmacol. 101: 701-706, 1993.
  2. IUVONE, T., CARNUCCIO, R., AND DI ROSA, M. Characterization of vasocortin-like proteins induced by dexamethasone in endothelial cells. Eur. J. Pharmacol. 243: 163-167, 1993.
  3. IANARO, A., O'DONNELL, C.A., DI ROSA, M., AND LIEW, F.Y. A nitric oxide synthase inhibitor reduces inflammation, down-regulates inflammatory cytokines and enhances interleukin-10 production in carrageenin-induced oedema in mice. Immunology. 82: 370-375, 1994.
  4. SAUTEBIN, L., AND DI ROSA, M. Nitric oxide modulates prostacyclin biosynthesis in the lung of endotoxin-treated rats. Eur. J. Pharmacol. 264: 193-196, 1994.
  5. IUVONE, T., CARNUCCIO, R., AND DI ROSA, M. Modulation of granuloma formation by endogenous nitric oxide. Eur. J. Pharmacol. 265: 89-92, 1994.
  6. IANARO, A., O'DONNELL, C.A., DI ROSA, M. AND LIEW, F.Y. Expression of TGF- in attenuated Salmonella tiphimurium: oral administration leads to the reduction of inflammation, IL-2 and INF-, but enhancement of IL-10, in carrageenin oedema in mice. Immunology. 84: 8-15, 1995.
  7. SAUTEBIN, L., IALENTI, A., IANARO, A., AND DI ROSA, M. Modulation by nitric oxide of prostaglandin biosynthesis in the rat. Brit. J. Pharmacol. 114: 323-328, 1995.
  8. SAUTEBIN, L., IALENTI, A., IANARO, A., AND DI ROSA, M. Endogenous nitric oxide increase prostaglandin biosynthesis in carrageenin rat paw oedema. Eur. J. Pharmacol. 286: 219-222, 1995.
  9. DI ROSA, M., IALENTI, A., IANARO, A., AND SAUTEBIN, L. Interaction between nitric oxide and cyclooxygenase pathways. Prostagland. Leuk. Essent. Fatty 54: 229-238, 1996.
  10. IUVONE, T., D'ACQUISTO, F., CARNUCCIO, R., AND DI ROSA, M. Nitric oxide inhibits LPS-induced tumor necrosis factor synthesis in vitro and in vivo. Life Sci. 59: PL207-PL211, 1996.

RESEARCH GROUP MEMBERS:

  1. Fantozzi Roberto, P.O.
  2. Cassone Chiara, P.A.
  3. Dianzani Chiara, R.U.
  4. Lombardi Grazia, R.U.
  5. Ferrara Cinzia, D.DR.
  6. Pisterna Alessia, B.

AFFILIATION:

Sezione di Farmacologia-Dipartimento di Anatomia, Farmacologia e Medicina Legale

Facoltà di Farmacia

Università degli Studi di Torino

ADDRESSES:

Turin: Via Pietro Giuria, 9

CITY: Torino

POSTAL CODE: 10126

TELEPHONE: 011-670-7688-7689

FAX: 011-670-7688

Novara: Viale F. Ferrucci, 35

CITY: Novara

POSTAL CODE: 28100

TELEPHONE: 0321-629028

FAX: 0321-611043

PUBLICATIONS:

  1. BRUNI, F., COSTANZO, A., SELLERI, S., GUERRINI, G., FANTOZZI, R., PIRISINO, R., BRUNELLESCHI, S. Synthesis and study of the anti-inflammatory properties of some pyrazolo [1,5-]pyrimidine derivatives. J. Pharmaceut. Sci. 82: 480-486, 1993.
  2. LOMBARDI, G., SZEKELY, A.M., BRISTOL, L.A., GUIDOTTI, A., MANEV, H. Induction onithine decarboxylase by N-methyl-D-aspartate receptor activation is unrelated to potentiation of glutamate excitotoxicity by polyamines in cerebellar granule neurons. J. Neurochem. 60: 1317-1324, 1993.
  3. CASSONE, M.C., LOMBARD, A., ROSSETTI, V., URCIUOLI, R., ROLFO, M. Effect of in vivo He-Ne laser irradiation on biogenic amine levels in rat brain. J. Photochem. Photobiol. B: Biology. 18: 291-294, 1993.
  4. DIANZANI, C., BRUNELLESCHI, S., VIANO, I., FANTOZZI, R. Adenosine modulation of primed human neutrophils. Eur. J. Pharmacol. 263: 223-226, 1994.
  5. MIAN, M., BENETTI, D., ALOISI, R., ROSINI, S., FANTOZZI, R. Effects of bisphosphonate derivatives on macrophage function. Pharmacology. 49: 336-342, 1994.
  6. SILVESTRO, L., VIANO, I., MACARIO, M., COLANGELO, D., MONTRUCCHIO, G., PANICO, S., FANTOZZI, R. Effects of heparin and its desulfated derivatives on leukocytes-endothelial adhesion. Seminars Thromb. Hemostasis. 20: 254-258, 1994.
  7. BRUNELLESCHI, S., GUIDOTTO, S., TONSO, E., VIANO, I., FANTOZZI, R. Modulation by protein kinase C of enhanced responsiveness to tachykinins in ovalbumin-sensitized guinea pig alveolar macrophages. Neuropeptides. 30: 249-260, 1996.
  8. DIANZANI, C., PARRINI, M., FERRARA, C., FANTOZZI, R. Effect of 4-hydroxynonenal on superoxide anion production from primed human neutrophils. Cell Biochem Funct. 14: In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Fioretti Maria Cristina, P.O.
  2. Contessa Anna Rita, P.O.
  3. Pucetti Paolo, P.O.
  4. Allegrucci Massimo, R.U.
  5. Campanile Franca, R.U.
  6. Giampietri Antonio, R.U.
  7. Grohmann Ursula, R.U.
  8. Bianchi Roberta, T.L.
  9. Belladonna Maria Laura, D.D.R.
  10. Fallarino Francesca, D.D.R.
  11. Silla Silvia, D.D.R.

AFFILIATION :

Sezione di Farmacologia

Dipartimento di Medicina Sperimentale e Scienze Biochimiche

Facoltà di Farmacia

Università di Perugia

ADDRESS: Via del Giochetto

CITY: Perugia

POSTAL CODE: 06100

TELEPHONE: 075/585 3472-96-63

FAX : 075/585-3473

PUBLICATIONS :

  1. CAMPANILE F., GIAMPIETRI A., GROHMANN U., BINAGLIA L., FIORETTI M.C., AND PUCCETTI P. Accelerated hematopoietic recovery and protective effect of the cyclooxygenase inhibitor indomethacin in bacterial infection of neutropenic mice. Cell. Immunol. 147 : 341-352, 1993.
  2. GROHMANN U., BINAGLIA L., PUCCETTI P., AND FIORETTI M.C. Cell-mediated immunity to chemically xenogenized tumors-VI. The effect of cell treatment with retroviral env antisense oligonucleotides. Int. J. Immunopharmac. 15 : 567-572, 1993.
  3. GROHMANN U., FIORETTI M.C., BINAGLIA L., BELLADONNA M.L., BIANCHI R., AND PUCCETTI P. Immunogenic properties of retroviral protein P15E from drug-treated murine mastocytoma P815. Int. J. Cancer 55 : 344-350, 1993.
  4. PUCCETTI P., BIANCHI R., FIORETTI M.C., AYROLDI E., UYTTENHOVE C., VAN PEL A., BOON T., AND GROHMANN U. Use of a skin test assay to determine tumor-specificCD8+T cell reactivity. Eur. J. Immunol. 24 : 1446-1452, 1994.
  5. GROHMANN U., BELLADONNA M.L., ALLEGRUCCI M., SILLA S., SCHIAFFELLA E., FIORETTI M.C., AND PUCCETTI P. Endogenous retroviral gp70 genes of the murine lymphoma L5178Y : analysis of restriction fragment polymorphism upon induction of drug-mediated immunogenicity. Viral Immunol. 7 :155-167, 1994.
  6. GROHMANN U., PUCCETTI P., BELLADONNA M.L., FALLARINO F., BIANCHI R., BINAGLIA L., SAGAKUCHI K., MAGE M.G., APPELLA E., AND FIORETTI M.C. Multiple point mutations in an endogenous retroviral gene confer high immunogenicity on a drug-treated murine tumor. J. Immunol. 154 : 4630-4641, 1995.
  7. GROHMANN U., BIANCHI R., FIORETTI M.C., FALLARINO F., BINAGLIA L., UYTTENHOVE C., VAN PEL A., BOON T., AND PUCCETTI P. CD8+ cell activation to a MAjor mastocytoma rejection antigen, P815AB : requirement for tumor helper peptides in priming for skin test reactivity to a P815AB-related peptide. Eur. J. Immunol. 25 : 2797-2802, 1995.
  8. CAMPANILE F., GIAMPIETRI A., GROHMANN U., BELLADONNA M.L., FIORETTI M.C., AND PUCCETTI P. Evidence for tumor necrosis factor asa mediator of the toxocity of a cyclooxygenase inhibitor in Gram-negative sepsy. Eur. J. Pharmacol. 307 : 191-199, 1996.
  9. BIANCHI R., GROHMANN U., BELLADONNA M.L.,SILLA S., FALLARINO F., AYROLDI E., FIORETTI M.C., AND PUCCETTI P. IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells. J. Immunol. 157 : 1589-1597, 1996.

RESEARCH GROUP MEMBERS :

  1. Geppetti Pierangelo, R.U.
  2. Emanueli Costanza, D.DR.
  3. Figini Michela, D.DR.

AFFILIATION:

Sezione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale

Facoltà di Medicina e Chirurgia

Università di Ferrara

ADDRESS: Via Fossato di Mortara 19

CITY: Ferrara

POSTAL CODE: 40100

TELEPHONE: (0532) 291-226

FAX: (0532) 291-205

E-MAIL: gpp@ifeuniv.unife,it

PUBLICATIONS :

  1. BERTRAND C, NADEL JA, YAMAWAKI I, GEPPETTI P. Role of kinins in the vascular extravasation evoked by antigen and mediated by tachykinins in guinea pig trachea. J. Immunol., 151:4902-4907,1993.
  2. HUBER O, BERTRAND C, BUNNETT NW, PELLEGRINI CA, DEBAS HT, NADEL JA, GEPPETTI P. Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors. Gastroenterology, 105:981-987, 1993.
  3. BEVAN S, GEPPETTI P. Protons, small stimulants of capsaicin-sensitive sensory nerves. Trends Neurosci., 17:509-512, 1994.
  4. FAHY JV, WONG HH, GEPPETTI P, REIS JM, HARRIS SC, MACLEAN DB, NADEL JA, BOUSHEY HA. Effect of an NK-1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects. Amer. J. Respir. Crit. Care Med.152:879-884, 1995.
  5. FUSCO BM, MARABINI S, MAGGI CA, GEPPETTI P. Preventive effect of repeated nasal applications of capsaicin in cluster headache. Pain, 59:321-325, 1995.
  6. FIGINI M, RICCIARDOLO FLM, JAVDAN P, NJIKAMP FP, EMANUELI C, PRADELLES P, FOLKERTS G, GEPPETTI P. Evidence that epithelium-derived relaxing factor released by bradykinin in the guinea pig trachea is nitric oxide. Amer. J. Respir. Crit. Care Med. 153:918-923, 1996.
  7. RICCIARDOLO FLM, GEPPETTI P, MISTRETTA A, NADEL JA, BELLOFIORE S, SAPIENZA MA, DI MARIA GU. Inhibition of nitric oxide biosynthesis potentiates bradykinin-induced bronchoconstriction in asthmatics. Lancet 348:374-377, 1996.
  8. FIGINI M, EMANUELI C, BETRAND C, JAVDAN P, GEPPETTI P. Evidence that tachykinins relax the guinea-pig trachea via nitric oxide release and by stimulation of a septide-insensitive NK1 receptor. Brit. J. Pharmacol. 117:1270-1276, 1996.
  9. ROSENECKER J, HONG K, ZHANG W, LAUSIER J, GEPPETTI P, YOSHIHARA S, PAPAHADJOPUOLOS D, NADEL JA. Increased liposome extravasation in selected tissues: effect of substance P. Proc. Nat. Acad. Sci. USA 93:7236-7241, 1996.
  10. BERTRAND C, GEPPETTI P. Tachykinin and kinin receptor antagonists: therapeutic perspectives in allergic airway disease. Trends Pharmacol. Sci., 17:255-259, 1996.

RESEARCH GROUP MEMBERS:

  1. Parente Luca, P.O. (1)
  2. Biondi Filippo, R.U.
  3. Vetri Piera, R.U.
  4. Perretti Mauro, R.I.
  5. Solito Egle, R.I.

AFFILIATION:

Istituto di Farmacologia e Farmacognosia

Facoltà di Farmacia

Università di Palermo

ADDRESS: Via Forlanini, 1

CITY: Palermo

POSTAL CODE: 90134

TELEPHONE: 091-651-2262, 2425

FAX: 091-6512469

E-MAIL: l.parente@mbox.netway.it

PUBLICATIONS:

  1. PALLA, G. BENSI, E. SOLITO, D. TORNESE BUONAMASSA, G. FASSINA, G. RAUGEI, F. SPANO, C. GALEOTTI, M. MORA, M. DOMENIGHINI, M. ROSSINI, E. GALLO, V. CARINCI, M. BUGNOLI, F. BERTINI, L. PARENTE, M. Melli, Loop substitution as a tool to identify active sites of interleukin­1 . J. Biol. Chem. 268: 13486-13492, 1993.
  2. DE CATERINA, R. SICARI, D. GIANNESSI, P.L. PAGGIARO, P. PAOLETTI, G. LAZZERINI, W. BERNINI, E. SOLITO, L. PARENTE, Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids. J. Appl. Physiol. 75: 2368-2375, 1993.
  3. SOLITO, S. NUTI, L. PARENTE, Dexamethasone induces the translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells. Brit. J. Pharmacol. 112: 347-348, 1994.
  4. PALMI, M. FROSINI, C. BECHERUCCI, G.P. SGARAGLI, L. PARENTE, Increase of extracellular brain calcium is involved in interleukin-1 -induced pyresis in the rabbit; antagonism by dexamethasone. Brit. J. Pharmacol. 112: 449-452, 1994.
  5. GO, F. ZUIDERVEN, L. DE LEY, J.G. TER HAAR, L. PARENTE, E. SOLITO, W.M. MOLENAAR, Effects of steroids on brain lipocortin immunoreactivity. Acta Neurochir. 60: 101-103, 1994.
  6. PARENTE, E. SOLITO, Association between glucocorticoids and lipocortin-1. Trends Pharmacol. Sci. 15: 362, 1994.
  7. MIRTELLA, G. POZZOLI, G. GUERRIERO, P. GHIARA, L. PARENTE, P. PREZIOSI, P. NAVARRA, Evidence that the interleukin-1 -induced prostaglandin E2 release from rat hypothalamus is mediated by type I and type II interleukin-1 receptors. J. Neuroimmunol. 61: 171-177, 1995.
  8. AMBROSETTI, E. PALLA, A. MIRTELLA, C. GALEOTTI, E. SOLITO, P. NAVARRA, L. PARENTE, M. MELLI, Synthetic alleles at position 121 define a functional domain of human interleukin-1 . Eur. J. Biochem. 238: 308-316, 1996.
  9. MONTUSCHI, G. TRINGALI, A. MIRTELLA, L. PARENTE, E. RAGAZZONI, P. PREZIOSI, P. NAVARRA, Interleukin-1 release from rat gastric fundus. Amer. J. Physiol. 271: G275-G281,1996.
  10. CIFONE, L. CIRONI, P. RONCAIOLI, S. MARTINOTTI, E. TONIATO, L. CILENTI, D. BOTTI, E. SOLITO, L. PARENTE, A. SANTONI Phospholipase A2 activity and calpactin I levels in rat lymphokine-activated killer cells: correlation with the cytotoxic activity. Cell. Immunol. 170: 274-282, 1996.

RESEARCH GROUP MEMBERS:

  1. Patrono Carlo, P.O.
  2. Patrignani Paola, T.L.
  3. Panara Maria Rosaria, DDR
  4. Santini Giovanna, B.
  5. Sciulli Maria Gina, B
  6. Padovano Roberto, B.

AFFILIATION:

Cattedra di Farmacologia I, Istituto di Fisiopatologia Medica

Facoltà di Medicina e Chirurgia

Università di Chieti "G. D'Annunzio"

ADDRESS: Via dei Vestini, 31

CITY: Chieti

POSTAL CODE: 66013

TELEPHONE: 0871-355-775, 701, 772, 773, 748

FAX: 0871-355-718

E-MAIL: ppatrignani@unich.it

PUBLICATIONS:

  1. CIABATTONI, G., SHAHROM UJANG, SRITARA, P., ANDREOTTI, F., DAVIES, G., SIMONETTI, B.M., PATRONO, C., AND MASERI, A. Aspirin, but not heparin, suppresses the transient increase in thromboxane biosynthesis associated with cardiac catheterisation or coronary angioplasty. J. Amer. Coll. Cardiol., 21:1377-1382, 1993.
  2. FABBRINI, M.S., VITALE, A., PEDRAZZINI, E., NITTI, G., ZAMAI, M., TAMBURIN, M., CAIOLFA, V.R., PATRONO, C., AND BENATTI, L. In vivo expression of mutant preproendothelins: hierarchy of processing events but no strict requirement of Trp-Val at the processing site. Proc. Nat. Acad. Sci. USA, 90:3923-3928, 1993.
  3. DE FERRARI, G..M, SALVATI, P., GROSSONI,. M, UKMAR, G., VAGA, L., PATRONO, C., AND SCHWARTZ, P.J. Pharmacologic modulation of the autonomic nervous system in the prevention of sudden cardiac death. A study with propranolol, methacoline and oxotremorine in conscious dogs with a healed myocardial infarction. J. Amer. Coll. Cardiol., 21:283-288,1993.
  4. DI MINNO, G., DAVI', G., MARGAGLIONE, M., CIRILLO, F., GRANDONE, E., CIABATTONI, G., CATALANO, I., STRISCIUGLIO, P., ANDRIA, G., PATRONO, C., AND MANCINI, M. Abnormally high thromboxane A2 biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism. J. Clin. Invest., 92:1400-1405,1993.
  5. DAVI', G., PATRONO, C., CATALANO, I., CUSTRO, N., GIAMMARRESI, C., GANCI, A., COSENTINO, F., AND NOTARBARTOLO, A. Inhibition of thromboxane biosynthesis and platelet function by indobufen in type II diabetes mellitus. Arterioscler. Thromb., 13:1346-1351, 1993.
  6. PATRONO, C. Aspirin as an antiplatelet drug. N. Engl. J. Med., 330: 1287-1292, 1994.
  7. NOTARBARTOLO, A., DAVI', G., AVERNA, M., BARBAGALLO, M.B., GANCI, A., GIAMMARRESI, C., LA PLACA, F.P., AND PATRONO, C. Inhibition of thromboxane biosynthesis and platelet function by simvastatin in type IIa hypercholesterolemia. Arterioscler. Thromb., 15:247-252, 1995.
  8. BARBUI, T., DE GAETANO, G., FINAZZI, G., LANDOLFI, R., MARCHIOLI, R., PATRONO, C., TOGNONI, G., AND THE GRUPPO ITALIANO STUDIO POLICITEMIA (GISP). Polycythemia Vera: the natural history of 1213 patients followed for 20 years. Ann. Intern. Med., 123:656-661, 1995.
  9. PANARA, M.R., GRECO, A., SANTINI, G., SCIULLI, M.G., ROTONDO, M.T., PADOVANO, R., DI GIAMBERARDINO, M., CIPOLLONE, F., CUCCURULLO, F., PATRONO, C., AND PATRIGNANI, P. Effects of the novel antiinflammatory compounds NS-398 and L-745,337 on the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. Brit. J. Pharmacol., 116:2429-2434, 1995.
  10. PATRIGNANI, P., SANTINI, G., PANARA, M.R., SCIULLI, M.G., GRECO, A., ROTONDO, M.T., DI GIAMBERARDINO, M., MACLOUF, J., CIABATTONI, G., AND PATRONO, C. Induction of prostaglandin endoperoxide synthase-2 in human monocytes is associated with cyclooxygenase-dependent F2-isoprostane formation. Brit. J. Pharmacol., 118:1285-1293, 1996.

RESEARCH GROUP MEMBERS :

  1. Pinto Aldo, P.A.
  2. Autore Giuseppina, R.U.
  3. Capasso Anna, R.U.

AFFILIATION :

Sezione di Farmacologia

Dipartimento di Scienze Farmaceutiche

Facoltà di Farmacia

ADDRESS: Piazza Vittorio Emanuele 9

CITY: Penta, Salerno

POSTAL CODE: 84084

TELEPHONE: 089/968950-968909-988916

FAX: 089/968937

PUBLICATIONS:

  1. SORRENTINO, L. SORRENTINO AND A. PINTO Effect of some products of protein catabolism on endothelium-dependent and independent relaxation of rabbit thoracic aorta rings. J. Pharmacol. Exp. Ther. 266 : 626-633, 1993.
  2. CAPASSO, N. MASCOLO, A.A. IZZO, G. AUTORE, G. DI CARLO Effect of Senna is not mediated by platelet activating factor. Pharmacology, 47 :58-63, 1993.
  3. MASCOLO, A.A. IZZO, G. AUTORE, F. BARBATO, F. CAPASSO Nitric oxide and castor oil induced diarrhoea. J. Pharmacol. Exper. Ther. 68 : 291-295, 1994.
  4. CAPASSO, L. SORRENTINO, A. DI GIANNUARIO, S. PIERETTI, A. LOIZZO Des-tyrosine-g-endorphin effect on neocortical spike and wave spindling in DBA/2J mice. Eur. J. Pharmacol. 261 : 209-212, 1994.
  5. LOIZZO, S. PIERETTI, A. DI GIANNUARIO, M.R. DOMENICI, S. SAGRATELLA, A. CAPASSO, L. SORRENTINO The synthetic glucocorticoid dexamethasone induces selective inhibition of the central m opioid receptor: functional in vivo and in vitro evidence in rodents. Brit. J. Pharmacol. 113 : 1416-1422, 1994.
  6. MASCOLO, A.A. IZZO, G. AUTORE, F.M. MAIELLO, F. CAPASSO Acetic acid induced colitis in normal and essential fatty acid deficient rats. J. Pharmacol. Exp. Ther. 272 : 469-475, 1995.
  7. R. SORRENTINO AND A. PINTO Effect of methylguanidine on rat bood pressure: role of endothelial nitric oxide synthase. Brit. J. Pharmacol. 115 : 510-514, 1995.
  8. IUVONE, A. CAPASSO, F. D'ACQUISTO, R. CARNUCCIO Opioids inhibit the induction of nitric oxide synthase in J774 macrophages. Biochem. Bioph. Res. Comm. 212 : 975-980, 1995.
  9. CIRINO, R. SORRENTINO, C. CICALA, L. SORRENTINO AND A. PINTO Indimetacin and thrombossane A2/Prostaglandin H2 antagonist SQ29,548, impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats. J. Lipid Mediator Cell Signal. 13 : 177-187, 1996.
  10. CAPASSO, A. DI GIANNUARIO, A. LOIZZO, S. PIERETTI, S. SAGRATELLA AND L. SORRENTINO Dexamethasone selective inhibition of opioid acute physical dependence in isolated tissues. J. Pharmacol. Exp. Ther. 276 : 743-751, 1996.

RESEARCH GROUP MEMBERS:

  1. Pinza Mario, Dir. R.
  2. Prosdocimi Marco, C.P.E.
  3. Campana Alberto, C.L.
  4. Marchetti Marcello, C.L.
  5. Milanese Claudio, C.L.
  6. Rossi Vilma, C.L.
  7. Capezzone de Joannon Alessandra, R.I.
  8. Coletta Isabella, R.I.
  9. D'Onofrio Eutimio, R.I.
  10. Guglielmotti Angelo, R.I.
  11. Jovicevic Ljuba, R.I.
  12. Mangano Giorgina, R.I.
  13. Martinelli Biancangela, R.I.
  14. Panei Marina, R.I.
  15. Soldo Lucia, R.I.

AFFILIATION:

Angelini Ricerche S.p.A.

ADDRESS: P.le della Stazione snc

CITY: S. Palomba - Pomezia (Rm)

POSTAL CODE: 00040

TELEPHONE: 06 - 910451

FAX: 06 - 91984597

PUBLICATIONS:

  1. GUGLIELMOTTI, A., SILVESTRINI, B., SASO, L., ZWAIN, I. AND CHENG, C.Y. Chronic inflammatory response in the rat can be blocked by bindarit. Biochem. Mol. Biol. Int. 29: 747-756, 1993.
  2. SASO, L., SILVESTRINI, B., GUGLIELMOTTI, A., LAHITA, R. AND CHENG, C.Y. Abnormal glycosilation of alpha 2-macroglobulin, a non-acute-phase protein, in patients with autoimmune diseases. Inflammation. 17: 465-479, 1993.
  3. PERI, G., MILANESE, C., MATTEUCCI, C., RUCO, L., DAN, Z., SOZZANI, S., COLETTA, I. AND MANTOVANI, A. A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemiotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells. J. Immun. Meth. 174: 249-257, 1994.
  4. WOODWARD, R.M., POLENZANI, L. AND MILEDI, R. Effects of fenamates and other non-steroidal anti-inflammatory drugs on rat brain GABA A receptors expressed in Xenopous oocytes. J. Pharmacol.Exp. Ther. 268: 806-817, 1994.
  5. GUGLIELMOTTI, A., CAPEZZONE DE JOANNON, A., CAZZOLLA, N., MARCHETTI, M., SOLDO, L., CAVALLO, G. AND PINZA, M. Radical scavenger activity of bendazac, an anticataract non-steroidal antiinflammatory agent. Pharmacol. Res. 32: 369-373, 1995.
  6. MILEO A.M., PALMA E., POLENZANI L., LIMATOLA C., GRASSI F. AND EUSEBI F. Protein kinases C modulates exogenous acetylcholine receptors currents in Xenopus oocytes. J.Neurosci.Res. 41: 443-451 1995.
  7. CAPEZZONE, A., MANGANO, G., PERI, G., ROSSI, V. AND MILANESE, C. A flow-cytometric method to evaluate drug anti-aggregating effect on polymorphonuclear cells. J.Pharmacol. Toxicol. Met. 36: 21-28, 1996.
  8. DELPINO A., MILEO A.M., LAPENTA V., PISELLI P., VERDINA A. AND POLENZANI L. Characterization of a new high temperature-induced mammalian heat shock protein (HSP 66), antigenically related to heat shock protein 72. J.Cell.Biochem. 63: 51-60 1996.
  9. SIRONI, M., POZZI, P., POLENTARUTTI, N., BENIGNI, F., COLETTA, I., GUGLIELMOTTI, A., MILANESE, C., GHEZZI, P., VECCHI, A., PINZA, M. AND MANTOVANI, A. Inhibition of inflammatory cytokine production and protection against septic shock by benzydamine. Cytokine. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Regoli Domenico, P.O.
  2. Calò Girolamo, R.U.
  3. Rizzi Anna, D. DR.
  4. Bogoni Giovanni, D. DR.

AFFILIATION:

Istituto di Farmacologia

Università di Ferrara.

ADDRESS: Via Fossato di Mortara, 17-19

CITY: Ferrara

POSTAL CODE: 44100

TELEPHONE: 0532-291203

FAX: 0532-291205

E-MAIL: fmc@ifeuniv.unife.it

PUBLICATIONS:

  1. LOPES P., KAR S., TOUSIGNANT C., REGOLI D., QUIRION R., AND COUTURE R. Autoradiographic localization of [125I-Tyr8]-bradykinin receptor binding sites in the guinea pig spinal cord. Synapse 15:48-57 1993.
  2. BASCANDS J.L., PECHER C., ROUAUD S., EMOND C., TACK J.L., BASTIE M.J., BURCH R., REGOLI D., AND GIROLAMI J.P. Evidence for existence of two distinct bradykinin receptors on rat mesangial cells. Amer. J. Physiol., 264:0002-9513 1993.
  3. CHAHINE R., ADAM A., YAMAGUCHI N., GASPO R., REGOLI D., AND NADEAU R.. Protective effects of bradykinin on the ischaemic heart: implication of the B1 receptor. Brit. J. Pharmacol. 108:318-22 1993.
  4. PICARD P., BOUCHER S., REGOLI D., GITTER B.D., HOWBERT J.J., AND COUTURE R. Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat. Eur .J. Pharmacol. 232:255-61 1993.
  5. RIBUOT C., GODIN D., COUTURE R., REGOLI D., AND NADEAU R. In vivo B2-receptor-mediated negative chronotropic effect of bradykinin in canine sinus node. Amer. J. Physiol. 265:0002-9513 1993.
  6. REGOLI D., BOUDON A., AND FAUCHERE J.L.. Receptors and antagonists for substance P and related peptides. Pharmacol. Rev. 46:551-99 1994.
  7. REGOLI D., GOBEIL F., NGUYEN Q.T., JUKIC D., SEOANE P.R., SALVINO J.M., AND SAWUTZ D.G.. Bradykinin receptor types and B2 subtypes. Life Sci. 55:735-49 1994.
  8. PICARD P., REGOLI D., AND COUTURE R. Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists. Brit. J. Pharmacol. 112:240-9 1994.
  9. CROWTHER R., JUKIC D., REGOLI D., AND RANGACHARI P.K. Functional subtyping of neurokinin receptors on canine proximal colonic mucosa. J. Pharmacol. Exp. Ther. 268:1374-80 1994.
  10. BERTHIAUME N., CLAING A., REGOLI D., WARNER T.D., AND D'ORLEANS-JUSTE P. Characterization of receptors for kinins and neurokinins in the arterial and venous mesenteric vasculatures of the guinea-pig. Brit. J. Pharmacol. 115:1319-25 1995.

RESEARCH GROUP MEMBERS:

  1. Riccardi Carlo, P.O.
  2. Delfino Domenico, R.U.
  3. Ronchetti Simona, D.DR.
  4. Migliorati Graziella, T.L.
  5. Ayroldi Emira, T.L.
  6. D'Adamio Francesca, T.L.

AFFILIATION:

Sezione di Farmacologia, Tossicologia e Chemioterapia

Dipartimento di Medicina Clinica, Patologia e Farmacologia

Facoltà di Medicina e Chirurgia

Università degli Studi di Perugia

ADDRESS: Via del Giochetto

CITY: Perugia

POSTAL CODE: 06122

TELEPHONE: 075-585-3467-3471-3492-3464

FAX: 075-585-3405

E-MAIL: farmaco@unipg.it;  riccardi@unipg.it

PUBLICATIONS:

  1. MIGLIORATI, G., NICOLETTI, I., PAGLIACCI, M.C., D'ADAMIO, L., RICCARDI C. Interleukin-4 protects double-negative and CD4 single-positive thymocytes from dexamethasone-induced apoptosis. Blood, 81:1352-1358, 1993.
  2. MIGLIORATI, G., NICOLETTI, I., D'ADAMIO, F., SPRECA, A., PAGLIACCI, C., RICCARDI, C. Dexamethasone induces apoptosis in mouse natural killer cells and cytotoxic T lymphocytes. Immunology, 81: 21-26, 1994.
  3. DELFINO, D.V., PATRENE, K.D., DE LEO, A.B., DE LEO, R., HERBERMANN, R.B., BOGGS, S.S. Role of CD44 in the development of NK cells from precursors in long-term cultures of mouse bone marrow. J. Immunol. 154: 5171-5179, 1994.
  4. NOCENTINI, G., RONCHETTI, S., BARTOLI, A., TESTA, G., D'ADAMIO, F., RICCARDI, C., MIGLIORATI, G. T cell receptor an alternatively spliced product of the T cell receptor gene. Eur. J. Immunol. 25: 1405-1409, 1995.
  5. AYROLDI, E., CANNARILE, L., MIGLIORATI, G., BARTOLI, A., NICOLETTI, I., RICCARDI, C. CD44(Pgp-1) inhibits CD3 and dexamethasone-induced apoptosis. Blood, 86: 2672-2678, 1995.
  6. SPINOZZI, F., NICOLETTI, I., AGEA, E., BELIA, S., MORACA, R., MIGLIORATI, G., RICCARDI, C., GRIGNANI, F., BERTOTTO, A. IL-4 is able to reverse the CD2-mediated negative apoptotic signal to CD4- CD8- and/or T lymphpocytes. Immunology, 86: 379-384, 1995.
  7. FIORUCCI, S., SANTUCCI, L., MIGLIORATI, G., RICCARDI C., AMOROSI, A., MANCINI, A., ROBERTI, R., MORELLI, A. Isolated guinea pig gastric chief cells express tumor necrosis factor receptors coupled with the sphingomyelin pathway. Gut, 38: 182-189, 1996.
  8. SPINOZZI, F., AGEA, E., BISTONI, O., FORENZA, N., MONACO, A., BASSOTTI, G., NICOLETTI, I., RICCARDI, C. Increased allergen-specific, steroid-sensitive T cells in bronchoalveolar lavage fluid from patients with asthma. Ann. Intern. Med. 124: 223-227, 1996.
  9. DELFINO, D.V., PATRENE, K.D., LU, J., DE LEO, A., DE LEO, R., HERBERMAN ,R.B., BOGGS, S.S. Natural killer cell precursors in the CD44neg/dim T-cell receptorneg population of mouse bone marrow. Blood, 87, 2394-2400, 1996.
  10. SANTUCCI, L., FIORUCCI, S., CHIOREAN, M., BRUNORI, P.M., DI MATTEO, F.M., SIDONI, A., MIGLIORATI, G., MORELLI, A. Interleukin 10 reduces lethality and hepatic injury induced by lipopolysaccharide in galactosamine-sensitized mice. Gastroenterology, 111: 736-744, 1996.

RESEARCH GROUP MEMBERS:

  1. Saso Luciano, R.U.
  2. Casini Maria Luisa, D.DR.

AFFILIATION :

Istituto di Farmacologia e Farmacognosia

Facoltà di Farmacia

Università di Roma 'La Sapienzà

ADDRESS: P.le Aldo Moro, 5

CITY: Roma

POSTAL CODE: 00185

TELEPHONE: 06-49912481

FAX: 06-49912480

E-MAIL: saso@axrma.uniroma1.it

PUBLICATIONS:

  1. GUGLIELMOTTI, A., SILVESTRINI, B., SASO, L., ZWAIN, I.H. AND CHENG ,C.Y. Chronic inflammatory response in the rat can be blocked by bindarit. Biochem. Mol. Biol. Int. 29: 747-756, 1993.
  2. SASO, L., SILVESTRINI, B. AND CHENG, C.Y. The use of high performance electrophoresis chromatography for the micropurification of cerebrospinal fluid proteins in the rat. Anal. Biochem. 212: 315-324, 1993.
  3. SASO, L., SILVESTRINI, B., GUGLIELMOTTI, A., LAHITA, R. AND CHENG, C.Y. Abnormal glycosylation of a2-macroglobulin, a non-acute-phase protein, in patients with autoimmune diseases. Inflammation 17: 465-479, 1993.
  4. SASO L., SILVESTRINI B., LAHITA R., AND CHENG C.Y. Changes of immunoreactivity in a1-antitrypsin in patients with autoimmune diseases. Inflammation 17: 383-400, 1993.
  5. LI, A.H.Y., ZWAIN, I.H., PINEAU, C., CAZZOLLA, N., SASO, L., SILVESTRINI, B., BARDIN, C.W. AND CHENG, C.Y. Response of 2-macroglobulin messenger ribonucleic acid expression to acute inflammation in the testis is different from the response in the liver and brain. Biol. Reprod. 50: 1287-1296, 1994
  6. GIACOMELLI, S., LEONE, M.G., GRIMA, J., SILVESTRINI, B. AND CHENG, C.Y. Astrocytes synthesize and secrete prostaglandin D synthetase in vitro. Biochim. Biophys. Acta 1310: 269-276, 1996
  7. SASO, L., CASINI, M.L., MATTEI, E., VALENTINI, G. AND MAZZANTI, G. . -Hydroxy acids, anti-aging compounds, protect albumin against heat-induced denaturation. Phytother. Res. 10 : In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Sorrentino Ludovico, P.O.
  2. Calignano Antonio, R.U:
  3. Cirino Giuseppe, R.U.
  4. Cicala Carla, B.PDR.
  5. Sorrentino Raffaella, B.PDR.
  6. Mancuso Franca, B.PDR

AFFILIATION :

Dipartimento di Farmacologia Sperimentale

Facoltà di Farmacia

Università di Napoli Federico II

ADDRESS: Via Domenico Montesano 49

CITY: Napoli

POSTAL CODE: 80131

TELEPHONE: 081-7486402

FAX: 081-7486403

PUBLICATIONS :

  1. CIRINO G., CICALA C., SORRENTINO L. AND J.L. BROWNING. Human recombinant non pancreatic secreted platelet phospholipase A2 has anticoagulant activity in vitro on human plasma. Thromb. Res. 70 : 337-342, 1993.
  2. CALIGNANO A., PERSICO P., MANCUSO F., SORRENTINO L. Endogenous nitric oxide modulates morphine-induced changes in locomotion and food intake in mice. Eur. J. Pharmacol. 231 : 415-419, 1993.
  3. CIRINO G., CICALA C., SORRENTINO L., SORRENTINO R., BROWNING J.L. AND PAGE C.P. Human recombinant secreted phospholipase A2 has antiaggregatory effect in vivo and in vitro in rat and guinea pig. Eur. J.Pharmacol. 252 : 147-154, 1994.
  4. CIRINO G., CICALA C., SORRENTINO L., FRANCESCO M. MAIELLO AND J.L. BROWNING. Human recombinant secreted phospholipase A2 induces a synovitis-like inflammation in rat air pouch. J. Rheumatol. 21 : 824-829, 1994.
  5. WALLACE J.L., REUTER B., CICALA C., MCKNIGHT W., GRISHAM M., CIRINO G. Novel NSAID derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology 107 : 173-179, 1994.
  6. MANCUSO F., CALIGNANO A., SORRENTINO L. Endogenous nitric oxide modulates behavioural effects elicited by substance P in rat. Eur. J. Pharmacol. 271 : 329-333, 1994.
  7. WALLACE, J.L., MCKNIGHT W., DEL SOLDATO, P., BAYDOUN A.R. AND G. CIRINO. Anti-thrombotic effect of a nitric-oxide releasing, gastric-sparing aspirin derivative. J. Clin. Invest. 96 : 2711-2718, 1995.
  8. MANCUSO F., FLOWER R.J., PERRETTI M. Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. J. Immunol. 155 : 377-386, 1995.
  9. CIRINO,G., CICALA C., BUCCI, M.R., MARAGANORE J.M.. AND STONE S.R. Thrombin functions as an inflammatory mediator through activation of its receptor. J. Exp. Med. 183 : 821-827, 1996.

RESEARCH GROUP MEMBERS :

  1. Zilletti Lucilla, P.O.
  2. Ciuffi Mario P.A.
  3. Franchi-Micheli S. T.L.
  4. Mugnai Sabrina. D.DR.
  5. D'Alfonso Caterina B.

AFFILIATION :

Dipartimento di Farmacologia Preclinica e Clinica "Mario Aiazzi Mancini"

Facoltà di Medicina e Chirurgia

Università degli Studi di Firenze

ADDRESS: Viale G.B. Morgagni 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237-411,407,423

FAX: 055-4361613

PUBLICATIONS:

  1. CIUFFI M., GENTILINI G., FRANCHI-MICHELI S., ZILLETTI L. Effect of 21-amanosteroid U74500A (pregna-1,4,9(11) triene-3,20-dione,21-(4-(5,6-bisdietylamino)-2-pyridinyl)-16-methyl,HCl(16 alpha)), on rat brain cortex lipid peroxidation induced "in vivo" by iron-carbohydrate. Biochem. Pharmacol. 47:2181-2186,1994.
  2. CIUFFI M., TARLINI L., MUGNAI S., FRANCHI-MICHELI S., ZILLETTI L. Hemoglobin affects lipid peroxidation and prostaglandin E2 formation in rat corticocerebral tissues in vitro. Biochem. Pharmacol. 52:97-103,
  3. FAILLI P., CECCHI E., RUOCCO C., FAZZINI A., GIOTTI A. Effects of L-and D-arginine and some related esters on the cytosolic mechanisms of a-thrombin-induced human platelet activation. Brit. J. Pharmacol. 110:213,218, 1993.
  4. FAILLI P., RUOCCO C., DE FRANCO R., CALIGIURI A., GENTILINI A., GIOTTI A., GENTILINI P., PINZANI M. The mito-genic effect of platelet-derived growth factor in human hepatic stellate cells requires calcium influx. Amer. J. Physiol. Cell Physiol. 269:C1133-C1139, 1995.
  5. FAILLI P., TESCO G., RUOCCO C., GINESTRONI A., AMADUCCI L., GIOTTI A., SORBI S. The effect of tetraethylammonium on intracellular calcium concentration in Alzheimer's disease fibroblasts with APP, A182 and E5-1 missense mutations. Neurosci. Lett. 208:216-218, 1996.
  6. GENTILINI G., FRANCHI-MICHELI S., MUGNAI S., BINDI D., ZILLETTI L. GABA-mediated inhibition of the anaphylactic response in the guinea-pig trachea. Brit. J. Pharmacol.. 115:389-394, 1995.
  7. ZILLETTI L., CIUFFI M., FRANCHI-MICHELI S., FUSI F., GENTILINI G., MONETI G., VALOTI M., SGARAGLI G. P. Cyclooxygenase activity of hemoglobin. Methods-Enzymology. 30: 562-573,1994.

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