SIF - Societą Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

PHARMACOTOXICOLOGY

 

RESEARCH GROUP MEMBERS:

  1. Barone Domenico, Dir.R.
  2. Fracchia Sergio, C.L.
  3. Fassio Franca, C.L.
  4. Di Giovanni Franca, R.I.
  5. Golzio Lucia, R.I.
  6. Pasquali Emanuela, R.I.
  7. Peroglio Flavio, R.I.

AFFILIATION:

Dipartimento di Biotecnologie

Istituto di Ricerche Biomediche "Antoine Marxer" RBM S.p.A.

ADDRESS: Via Ribes, 1

CITY: Colleretto Giacosa (To)

POSTAL CODE: 10010

TELEPHONE: 0125 - 53746 (r.a.)

FAX: 0125 - 53585, 538079

PUBLICATIONS:

  1. BIANCHI G., BARONE D., LANZAROTTI E., TETTAMANTI R., PORTA R., MOLTRASIO D. AND PRINO G. Defibrotide, a single-stranded polydeoxyribonucleotide acting as an adenosine receptors agonist. Eur. J. Pharmacol., 238 : 327-334, 1993
  2. BARONE D., RAITERI F. AND FERRARA B. An Overview on a new kind of medicine: human somatic gene therapy. Minerva Biotecnologica, 6 : 137-145, 1994
  3. BARONE D., RAITERI F. AND FERRARA B. Human somatic cell therapy and gene therapy: A comparative analysis of USA/EEC regulatory requirements. Minerva Biotecnologica, 6: 159-167, 1994
  4. BARONE D. Toxicokinetics of antitumor drugs. Eur. Bull. Drug Res., 3 : 131-140, 1994
  5. BARONE D., SALVETTI L., DI VADI P. Piperonyl-ranitidine: a gastroprotective agent with a novel pharmacological affinity profile. Eur. Bull. of Drug. Res., 4 :1-16, 1995
  6. DAVICO BONINO L., DE MONTE L.B., SPAGNOLI G.C., VOLA R., MARIANI M., BARONE D., MORO A.M., RIVA P., NICOTRA M.R., NATALI P.G. AND MALAVASI F. Bio-specific monoclonal antibody anti-CD3 x anti-tenascin: an immunotherapeutic agent for human glioma. Int. J. Cancer, 61 : 509-515, 1995
  7. PESCADOR R., TETTAMANTI R., SALVETTI L., CONTO A., BARONE D., PORTA R., MANTOVANI M. AND FERRO L. Effects of Defibrotide on leukocytosis in rabbits with diet-induced atherosclerosis. Life Sci. 57 : 579-589, 1995

RESEARCH GROUP MEMBERS:

  1. Brambilla Giovanni P.O.
  2. Cavanna Marco P.O.
  3. Martelli Antonietta P.A.
  4. Robbiano Luigi R.U.
  5. Mattioli Francesca T.L.
  6. Ghia Marco DR.
  7. Allavena Alessandra DR.
  8. Mereto Eugenio DR.
  9. Canonero Roberta DR.
  10. Brambilla Campart Giulia B.DR.
  11. Angiola Marianna B.

AFFILIATION:

Sezione di Farmacologia e Tossicologia

Dipartimento di Medicina Interna

Facoltą di Medicina e Chirurgia

Universitą di Genova

ADDRESS: Viale Benedetto XV, 2

CITY: Genova

POSTAL CODE: 16132

TELEPHONE: 010-353-8801

FAX: 010-353-8849

PUBLICATIONS:

  1. MARTELLI A., ALLAVENA A., GHIA M., ROBBIANO L., AND BRAMBILLA G. Cytotoxic and genotoxic activity of 1,3-dichloropropene in cultured mammalian cells. Toxicol. Appl. Pharmacol. 120: 114-119, 1993
  2. GHIA M., ROBBIANO L, ALLAVENA A., MARTELLI A., AND BRAMBILLA G. Genotoxic activity of 1,3-dichloropropene in a battery of in vivo short-term tests. Toxicol. Appl. Pharmacol. 120: 120-125, 1993.
  3. MARTELLI A., ALLAVENA A., SOTTOFATTORI E., AND BRAMBILLA G. Low clastogenic activity in vivo of the N-nitrosoderivetives of five b-adrenergic-blocking drugs proved to be potent genotoxins in vitro. Toxicol. Lett. 73: 185-191, 1994.
  4. MARTELLI A., ALLAVENA A., BRAMBILLA CAMPART G., CANONERO R., GHIA M., MATTIOLI F., MERETO E., ROBBIANO L., AND BRAMBILLA G. In vitro and in vivo testing of hydralazine genotoxicity. J. Pharmacol. Exp. Ther. 273: 113-120, 1995.
  5. MARTELLI A., BRAMBILLA CAMPART G., CANONERO R., MATTIOLI F., AND BRAMBILLA G. Testing of metoclopramide and procainamide for their ability to induce genotoxic effects in cultured mammalian cells. Toxicol. Appl. Pharmacol. 131: 185-191, 1995.
  6. MERETO E., ROBBIANO L., GHIA M., ALLAVENA A., MARTELLI A., AND BRAMBILLA G. Evaluation of DNA-damaging, clastogenic and promoting activities of metoclopramide and procainamide in rats. Toxicol. Appl. Pharmacol. 131: 192-197, 1995.
  7. BRAMBILLA G., MARTELLI A., SOTTOFATTORI E. Nitrosation of propranol under simulated gastric conditions. Carcinogenesis 16: 1239-1242, 1995.
  8. MARTELLI A., MATTIOLI F., FAZIO S., ANDRAE U., AND BRAMBILLA G. DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate. Carcinogenesis 16: 1265-1269, 1995.
  9. MARTELLI A., BRAMBILLA CAMPART G., GHIA M., ALLAVENA A., MERETO E., AND BRAMBILLA G. Induction of micronuclei and inhibition of enzyme-altered foci in the liver of female rats trated with cyproterone acetate, chlormadinone acetate or megestrol acetate. Carcinogenesis 17: 551-554, 1996.
  10. MARTELLI A., MATTIOLI F., GHIA M., MERETO E., AND BRAMBILLA G. Comparative study of DNA repair induced by cyproterone acetate, chlormadinone and megestrol acetate in primary cultures of human and rat hepatocytes. Carcinogenesis 17: 1153-1156, 1996.

RESEARCH GROUP MEMBERS:

  1. Cantelli Forti Giorgio,P.O.
  2. Guerra Maria Clelia, P.A.
  3. Paolini Moreno, P.A.
  4. Hrelia Patrizia, R.U.
  5. Maffei Francesca, D.DR.
  6. Pozzetti Laura, D.DR.
  7. Fimognari Carmela, D.DR.
  8. Vigagni Fernanda, B.

AFFILIATION:

Dipartimento di Farmacologia

Universitą degli Studi di Bologna

ADDRESS: Via Irnerio 48

CITY: Bologna

POSTAL CODE: 40126

TELEPHONE: 051-24.31.01, 24.31.51

FAX: 051-24.88.62

E-MAIL: cantelli@biocfarm.unibo.it

PUBLICATIONS:

  1. CANTELLI FORTI, G., PAOLINI, M. AND HRELIA, P. Multiple end point procedure to evaluate risk from pesticides. Environm. Health Perspect. 101: 15-20, 1993.
  2. HRELIA, P., VIGAGNI, F., MOROTTI, M., CANTELLI FORTI, G., BARBIERI, C.L., SPINELLI, D. AND LAMARTINA, L. Mechanism of genotoxicity and electron density distribution by NMR of 5-nitro-3-thiophenecarboxamides, a novel group of direct-acting mutagens in Salmonella typhimurium. Chem.-Biol. Interact. 86:229-254, 1993.
  3. HRELIA, P., VIGAGNI, F., MAFFEI, F., PAOLINI, M., MESIRCA, R., POZZETTI, L. AND CANTELLI FORTI, G. A battery of biomarkers for detecting carcinogenic risk from fungicides. Clinical Chem. 40: 1460-1462, 1994.
  4. RODA, A., PELLICCIARI, R., CERR, C., POLIMENI, C., SADEGHPOUR, B., MARINOZZI, M, CANTELLI FORTI, G. AND SAPIGNI, E. New 6-substituted bile acids: physico-chemical and biological properties of 6-methyl ursodeoxycholic acid and 6-methyl-7-epicholic acid. J. Lipid Research. 35: 2268-2279, 1994.
  5. RODA, A., PELLICCIARI, R., POLIMENI, C., CERRE', C., CANTELLI FORTI, G., SADEGHPOUR, B., SAPIGNI, E., GIOACCHINI, A.M. AND NATALINI, B. Metabolism, pharmacokinetics, and activity of a new 6-fluoro analogue of ursodeoxycholic acid in rats and hamsters. Gastroenterology. 108: 1204-1214, 1995.
  6. VIGAGNI, F., HRELIA, P., CANTELLI FORTI, G., SORSA, M. AND NORPPA, H. An improved assay to detect 6-thioguanine resistant mutants in human lymphocytes. J. Exp. Clin. Cancer Res. 14: 171-173, 1995.
  7. PAOLINI, M., MESIRCA, R., POZZETTI, L., SAPONE, A. AND CANTELLI FORTI, G. Molecular non-genetic biomarkers related to Fenarimol cocarcinogenesis: organ-and sex-specific CYP induction in rat. Cancer Lett. 101: 171-178, 1996.
  8. HRELIA, P., FIMOGNARI, C., MAFFEI, F., VIGAGNI, F., MESIRCA, R., POZZETTI, L., PAOLINI, M. AND CANTELLI FORTI G. The genetic and non-genetic toxicity of the fungicide Vinclozolin. Mutagenesis 11: 445-453, 1996.
  9. HRELIA, P., MAFFEI, F., FIMOGNARI, C., VIGAGNI, F. AND CANTELLI FORTI, G. Cytogenetic effects of Metalaxyl on human and animal chromosomes. Mutation Res. 369: 81-86, 1996.
  10. PAOLINI, M., MESIRCA, R., POZZETTI, L., MAFFEI, F., VIGAGNI, F., HRELIA, P. AND CANTELLI FORTI, G. Genetic and non-genetic biomarkers related to carcinogenesis in evaluating toxicological risk from Fenarimol. Mutation Res. 368: 27-39, 1996.

RESEARCH GROUP MEMBERS:

 

  1. Cantoni Orazio, P.A.
  2. Sestili Piero, R.U.
  3. Brambilla Liliana, D.DR.
  4. Palomba Letizia, B.PDR.
  5. Guidarelli Andrea, T.L.

AFFILIATION:

Istituto di Farmacologia e Farmacognosia

Facoltą di Farmacia

Universitą degli Studi di Urbino

ADDRESS: Via Santa Chiara, 27

CITY: Urbino

POSTAL CODE: 61029

TELEPHONE: 0722-2671, 327670

FAX: 0722-327670

E-MAIL: cantoni@fis.uniurb.it

PUBLICATIONS:

  1. SESTILI, P., CATTABENI F., AND CANTONI, O. Simultaneous determination of DNA double strand breaks and DNA fragment size in cultured mammalian cells exposed to hydrogen peroxide/histidine or etoposide with CHEF electrophoresis. Carcinogenesis. 16: 703-706, 1995.
  2. PALOMBA, L., GUIDARELLI, A., CATTABENI, F., AND CANTONI, O. The effect of hydrogen peroxide/L-Histidine-induced DNA single- vs. DNA double strand breaks on poly(ADP-rybose)polymerase. Eur. J. Pharmacol. 291: 167-173, 1995.
  3. SESTILI, P., CATTABENI F., AND CANTONI, O. The L-Histidine-mediated enhancement of hydrogen peroxide-induced DNA double strand breakage and cytotoxicity does not involve metabolic processes. Biochem. Pharmacol. 50: 1823-1830, 1995.
  4. GUIDARELLI, A., SESTILI, P., CATTABENI, F., AND CANTONI, O. Evidence for a dissimilar mechanism of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-Histidine. J. Pharmacol. Exp. Therap. 275: 1575-1582, 1995.
  5. SESTILI, P., GUIDARELLI, A., CATTABENI, F., MURRAY, D., AND CANTONI, O. AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine. Carcinogenesis. 17: 885-888, 1996.
  6. CANTONI, O., SESTILI, P., PALOMBA, L., GUIDARELLI, A., MURRAY, D., AND CATTABENI, F. Isolation and characterization of a Chinese Hamster Ovary cell line with high-degree resistance to hydrogen peroxide. Biochem. Pharmacol. 51: 1021-1029, 1996.
  7. SESTILI, P., BRANDI, G., BRAMBILLA, L., CATTABENI, F., AND CANTONI, O. Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from co-cultured erythrocytes or fibroblasts. J. Pharmacol. Exp. Therap. 277: 1719-1725, 1996.
  8. GUIDARELLI, A., BRAMBILLA, L., CATTABENI, F., ROTA, C., TOMMASI, A., AND CANTONI, O. The respiratory-chain poison antimycin A promotes the formation of DNA single strand breaks and reduces toxicity in U937 cells exposed to tert-butylhydroperoxide. Biochem. J. 317: 371-375, 1996.
  9. CANTONI, O., BOSCOBOINIK, D., FIORANI, M., STAUBLE, B. AND AZZI, A. The phosphorylation state of MAP-kinases modulates the cytotoxic response of smooth muscle cells to hydrogen peroxide. FEBS Lett. 389: 285-288, 1996.
  10. PALOMBA, L., SESTILI, P., CATTABENI, F., AZZI, A., AND CANTONI, O. Prevention of necrosis and activation of apoptosis in oxidatively injured human myeloid leukemia U937 cells. FEBS Lett. 390: 91-94, 1996.

RESEARCH GROUP MEMBERS :

  1. Chiesara Enzo, P.O.
  2. Marabini Laura, R.U.
  3. Radice Sonia, B.
  4. Cipelletti Barbara, B.
  5. Gervasoni Marco, C.L.

AFFILIATION:

Dipartimento di Farmacologia

Facoltą di Medicina e Chirurgia

Universitą di Milano

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-70146389

FAX: 02-28106260

E-MAIL: tossicol@imiucca.csi.unimi.it

PUBLICATIONS:

  1. DEL PUPPO, M., GALLI KIENLE, M., RATIGLIA, R., GALIMBERTI, D., ACERBI, G., BOERCI, L., MARABINI, L. AND CHIESARA, E. Intraocular and plasma kinetics of tenoxicam in rabbits. Graefeís Arch Clin Exp Ophthalmol. 231: 115-117, 1993.
  2. STANKOV, B., GERVASONI, M., SCAGLIONE, F., PEREGO, R., COVA, D., MARABINI, L. AND FRASCHINI, F. Primary pharmaco-toxicological evaluation of 2-iodomelatonin agonist. Life Sci. 53: 1357-1365, 1993.
  3. CHIESARA, E., BIANCHI, L., ZANNOLI, A., PIZZALA, R.AND STIVALA, L.A. Genotoxicity assay of five pesticides and their mixture in Saccharomyces cerevisiae D7. Mutation Res. 321: 203-211, 1994.
  4. PIATTI, E., MARABINI, L. AND CHIESARA, E. Increase of micronucleus frequency in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl separately and in mixture. Mutation Res. 324: 59-64, 1994.
  5. MARABINI, L., RADICE, S., CIPELLETTI, B. AND CHIESARA, E. Different amounts of cytochrome P-450 dependent monooxygenases in tulip bulbs, pea seedlings and maize endosperm cells. Plant Science. 99: 135-140, 1994.
  6. CORSINI, E., MARINOVICH, M., MARABINI, L., GALLI, C.L. AND CHIESARA, E. Interleukin-1 production after treatment with non-ionic surfactants in a murine keratinocytes cell line. Toxic. in Vitro. 8: 361-369, 1994.
  7. URANI, C., CHIESARA, E., GALVANI, P., MARABINI, L., SANTAGOSTINO, A. AND CAMATINI, M. Benomyl affect the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes. Toxicol. Lett. 76: 135-144, 1995
  8. CHIESARA, E., MARABINI, L. AND BORGHINI, R. Dietary fibre and drug interactions. Eur. J. Clin. Nutr. 49: 123-128, 1995.

RESEARCH GROUP MEMBERS:

  1. Cimino Mauro, R.U.
  2. Balduini Walter, R.U.

AFFILIATION:

Istituto di Farmacologia e Farmacognosia

Facoltą di Farmacia e Scienze Biologiche

Universitą degli Studi di Urbino

ADDRESS: Via S. Chiara, 27

CITY: Urbino

POSTAL CODE: 61029

TELEPHONE: 0722-2671, 2894

FAX: 0722-327670

E-MAIL: farmacol@fis.uniurb.it

PUBLICATIONS:

  1. BALDUINI, W., CIMINO, M., RENO', F., MARINI, P., PRINCIVALLE, A. AND CATTABENI, F. Effects of postnatal or adult chronic acetylcholinestarase inhibition on muscarinic receptors, phosphoinositide turnover and m1 mRNA expression. Eur. J. Pharmacol.- Environmental Toxicology and Pharmacology Section 248: 281-288, 1993.
  2. STANKOV, B., CIMINO, M., MARINI, P., LUCINI, V., FRASCHINI, F., CLEMENTI, F. Identification and functional significance of nicotinic cholinergic receptors in the rat pineal gland. Neurosci. Letters 156 : 131-134, 1993.
  3. CIMINO, M., MARINI, P., COLOMBO, S., CATTABENI, F., MELDOLESI, J. [3H]-CGP 39653 mapping of glutamatergic N-methyl-D-aspartate receptors in the brain of aged rats. Neurosci. Res. Commun. 12 : 31-40, 1993.
  4. BALDUINI, W., RENO', F., COSTA, L.G., AND CATTABENI, F. Developmental neurotoxicity of ethanol: further evidence for an involvement of muscarinic receptor-stimulated phosphoinositide hydrolysis. Eur. J. Pharmacol. - Mol. Pharmacol. Section. 266: 283-289, 1994.
  5. CIMINO, M., MARINI, P., COLOMBO, S., CATTABENI, F., BIANCHI, M., MAGNANI, M. Localization and age-dependent expression of hexokinase mRNA in the rat brain. Mol. Brain Res. 25 : 1-6, 1994.
  6. BALDUINI, W., RENO', F., CATTABENI, F., AND CANTONI O. Oxidative transition of intracellular protein thiols modulates muscarinic receptor-stimulated phosphoinositide breakdown in rat cortical slices. Neurosci. Res. Commun. 15: 125-134, 1994.
  7. BALDUINI, W., RENO', F., COSTA, L.G. Interaction of ethanol and anoxia with muscarinic receptor-stimulated phosphoinositide metabolism during brain development. Life Sci. 57: 1667-1673, 1995
  8. BALDUINI, W., LOMBARDELLI, G., PERUZZI G., AND CATTABENI F. Effect of prenatal treatment with methylazoxymethanol on carbachol-, norepinephrine- and glutamate-stimulated phosphoinositide metabolism in the neonatal, young and adult offspring. Neurochem. Res. 20: 1211-1216, 1995.
  9. CIMINO, M., MARINI, M., COLOMBO, S., ANDENA, M., CATTABENI, M., FORNASARI, D., CLEMENTI, F. Expression of neuronal acetylcholine nicotinic receptor a4 and b2 subunits during postnatal development of the rat brain. J. Neural Transm. 100 : 77-92, 1995.
  10. CIMINO, M., CATTABENI, F., DI LUCA, M., PERUZZI , G., ANDENA, M., TIRASSA, P., ANGELUCCI, F., COZZARI, C., ALOE, L. Levels of NGF, p75NGFR and ChAT immunoreactivity in brain of adult and aged microencephalic rats. Neurobiol. Aging 17 : 137-142, 1996.

RESEARCH GROUP MEMBERS:

  1. Cima Lorenzo, P.O.
  2. Carrara Maria, T.L.

AFFILIATION:

Dipartimento di Farmacologia "E. Meneghetti"

Facoltą di Medicina e Chirurgia

Universitą di Padova

ADDRESS: Largo E. Meneghetti,2

CITY: Padova

POSTAL CODE: 35131

TELEPHONE: 049/827-5078,5103,5099,5076

FAX: 049/827-5093

E-MAIL: cima@ipdunidx.unipd.it

PUBLICATIONS:

  1. CARRARA M., CIMA L., CERINI R., DALLE CARBONARE M. An in vitro method for assessing potential toxicity of cosmetic products. J. Toxicol. - Cutaneous & Ocular Toxicology, 12 : 3-13, 1993.
  2. VALENTI P., DA RE P., RAMPA A., MONTANARI P., CARRARA M., CIMA L. BENZO--pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells. Anti-Cancer Drug Design, 8: 349-360, 1993.
  3. HAIDAR N.H., CARRARA M., ANDRIAMAMPANDRY C., KANFER J.N., FREYSZ L., DREYFUS H., MASSARELLI R. Incorporation of [3H]ethanolamine into acetylcholine by a human cholinergic neuroblastoma clone. Neurochem. Res., 19: 9-13, 1994.
  4. HAIDAR N.H., ANDRIAMAMPANDRY C., CARRARA M., KANFER J.N., FREYSZ L., DREYFUS H., MASSARELLI R. The conversion of ethanolamine and its metabolites to choline in human neuroblastoma clones: effect of differentiation induced by retinoic acid. Neurochem. Res., 19: 457-462, 1994.
  5. BOVA S., TREVISI L., DEBETTO P., CIMA L., FURNARI M., LUCIANI S., PADRINI R.,CARGNELLI G. Vasorelexant properties of norbormide, a selective vasoconstrictor agent for the rat microvasculature. British J. Pharmacol.. 117: 1041-1046, 1996.
  6. VALENTI P., FABBRI G., RAMPA A., BISI A., GOBBI S., DA RE P., CARRARA M. SGEVANO A., CIMA L. Synthesis and antitumor activity of some analogues of flavone acetic acid. Anti-Cancer Drug Design., 11: 243-252, 1996.

RESEARCH GROUP MEMBERS:

  1. Dolara Piero, P.O.
  2. Caderni Giovanna, T.L.
  3. Lodovici Maura, R.U.
  4. Salvadori Maddalena, T.
  5. Luceri Cristina, D.DR.
  6. Casalini Chiara, D.DR.
  7. De Filippo Carlotta, B.
  8. Briani Carla, B.
  9. Lancioni Lorella, B.

AFFILIATION:

Sezione di tossicologia sperimentale e ambientale

Dipartimento di Farmacologia

Facoltą di Farmacia

Universitą di Firenze

ADDRESS: Viale Morgagni 65,

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: (39.55) 4237411 o 413;

FAX: (39.55)4361613

E-MAIL: dolara@stat.ds.unifi.it  farm4@stat.ds.unifi.it

PUBLICATIONS:

  1. CADERNI G., DOLARA P., SPAGNESI M.T., LUCERI C., BIANCHINI F., MASTRANDREA V. AND MOROZZI G. Rats fed high starch diets have lower colonic proliferation and fecal bile acids than high sucrose-fed controls. J. Nutr. 123 : 704-712, 1993.
  2. LA VECCHIA C., FRANCESCA S., DOLARA P., BIDOLI E., BARBONE F. Refined sugar intake and the risk of colorectal cancer in humans.Int. J. Cancer 55 : 1-4, 1993.
  3. CADERNI G., BIANCHINI F., RUSSO A., SPAGNESI M.T., GABBRIELLI M., GIANNESCHI U., LAGI A., MONTIGIANI A., CIPRIANI F., PALLI D., RIZZI M., TONELLI F., VALANZANO R. AND DOLARA P. Mitotic activity in colorectal mucosa of healthy subjects in two italian areas with different dietary habits. Nutr. Cancer 19 : 263-269, 1993.
  4. CADERNI G., LUCERI C., SPAGNESI M.T., GIANNINI A., BIGGERI A. AND DOLARA P. Dietary carbohydrates affect azoxymethane induced intestinal carcinogenesis in rats. J. Nutr. 124 : 517-523, 1994.
  5. SPAGNESI M.T., DOLARA P., CADERNI G., BIANCHINI F., TONELLI F., VALANZANO R. AND ANASTASI A. Rectal proliferation and polyp occurence in patients with familial adenomatous polyposis after sulindac treatment. Gastroenterology 106 : 362-366 1994.
  6. LODOVICI M., DOLARA P., TAITI S., DEL CARMINE P., BERNARDI L., AGATI L. AND CIAPPELLANO S. Polynuclear aromatic hydrocarbons in the leaves of the Evergreen Laurus Nobilis. Science Total Environm. 153: 61-68, 1994.
  7. CADERNI G., GIANNINI A., LANCIONI, L., LUCERI C., BIGGERI A. AND DOLARA P.Characterization of aberrant crypt foci in carcinogen treated rats: association with intestinal carcinogenesis. Brit. J. Cancer 71 : 763-769, 1995.
  8. TONELLI F., DOLARA P., CADERNI G., BATIGNANI G., MONACI I., SPAGNESI M.T., LUCERI C., AND AMOROSI A. Effects of short chain fatty acids on mucosal proliferation and inflamation in patients with ulcerative colitis and familial polyposis. Diseases of Colon and Rectum, 38: 974-978, 1995.

RESEARCH GROUP MEMBERS:

  1. Galli Corrado Lodovico, P.A.
  2. Marinovich Marina, R.U.
  3. Restani Patrizia, R.U.
  4. Viviani Barbara, B.PDR.
  5. Corsini Emanuela, B.DDR.
  6. VelonąTeresa, D.DR.

AFFILIATION:

Sezione di Tossicologia

Istituto di Scienze Farmacologiche

Facoltą di Farmacia

Universitą degli Studi di Milano

ADDRESS: Via G. Balzaretti, 9

CITY: Milano

POSTAL CODE: 20132

TELEPHONE: 02 - 20488.315/225/350/356

FAX: 02 - 20404961

E-MAIL: gallil@isfunix.farma.unimi.it

PUBLICATIONS:

  1. FIOCCHI, P. RESTANI, E. RIVA, R. QUALIZZA, P. BRUNI, A. R. RESTELLI, C. L. GALLI. Meat Allergy: I-Specific IgE to BSA and OSA in atopic, beef sensitive children. J. Amer. College of Nutrition 14: 239-244, 1995.
  2. FIOCCHI, P. RESTANI, E. RIVA, A.R. RESTALLI, G. BIASUCCI, C. L. GALLI AND GIOVANNINI. Meat Allergy. II- Effects of food processing and enzymatic digestion on the allergenicity of bovine and ovine meats. J. Amer. College of Nutrition, 14: 245-250, 1995
  3. RESTANI, T. VELONą, A. PLEBANI, A.G. UGAZIO, C. POIESI, A. MURARO, C. L. GALLI. Evaluation by SDS-PAGE and immunoblotting of residual antigenicity in hydrolysed protein formulas. Clin. Exp. Allergy, 25: 651-658 selected by Infant Nutrition Digest 1995.
  4. MARINOVICH, M. GUIZZETTI, T. ZANELLI, E. CORSINI, C.L. GALLI. Cloning of a new FRTL-5 derived cell line stably expressing active human thyroid peroxidase. Bioch. Bioph. Res. Commun., 212: 602-608, 1995
  5. CORSINI, A. BRUCCOLERI, M. MARINOVICH, C.L. GALLI. Endogenus interleukin-1alpha is required for skin irritation. Toxicol. App. Pharmacol. 138: 268-274, 1996.
  6. RESTANI, T. VELONą, A. CARPEN, M. DURANTI, C.L. GALLI. Gamma Casein as a marker of ripening and/or quality of grana padano cheese. J. Agricultural Food Chem. 44 : 2026-2029, 1996.
  7. MARINOVICH, F. GHILARDI, C. L. GALLI. Effect of pesticide mixture on neural cells in vitro: comparison with single pesticides. Toxicology, 108: 201-206, 1996.
  8. VIVIANI, M. MARINOVICH, C. L. GALLI. Is actin polymerization relevant to neurosecretion? A study on neuroblastoma cells. BBRC, 223:712-717, 1996.
  9. RESTANI, A. PLEBANI, T. VELONą, G. CAVAGNI, A. G. UGAZIO, C. POIESI, A. MURARO, C. L. GALLI. Use of immunoblotting and monoclonal antibodies to evaluate the residual antigenic activity of milk protein hydrolised formulas. Clin. Exp. Allergy, in press, 1996.
  10. MARINOVICH, B. VIVIANI, E. CORSINI, F. GHILARDI AND C. L. GALLI. NF-kB Activation by Triphenyltin Triggers Apoptosis in HL-60 Cells. Exp. Cell Res. 226 : 98-104, 1996.

RESEARCH GROUP MEMBERS:

  1. Manzo Luigi, P.O.
  2. Candura Stefano R.U.
  3. Coccini Teresa C.L.
  4. Locatelli Carlo C.L..
  5. Randine Giovanna B.
  6. Varango Concetta B.
  7. Mattachini Margherita C.L.
  8. Castoldi Anna D.DR
  9. Rossi Anna Maria D.DR.
  10. Butera Raffaella B.
  11. Gandini Cristiano C.L.
  12. Pergami Paola D.DR

AFFILIATION:

Sezione di Farmacologia e Tossicologia

Dipartimento di Medicina Interna e Terapia Medica

Universitą degli Studi di Pavia

ADDRESS: Piazza Botta 10

CITY: Pavia

POSTAL CODE: 27100

TELEPHONE: 0382 - 506.357, 506.365, 26261

FAX: 0382 - 22741

E-MAIL: manzo@ipv36.unipv.it

PUBLICATIONS:

  1. CASTOLDI, A.F., MANZO, L., AND COSTA, L.G. Cyclic GMP formation induced by muscarinic receptors is mediated by nitric oxide synthesis in rat cortical primary cultures. Brain Res.. 610: 57-61, 1993.
  2. ROSSI, A.D., LARSSON, O., MANZO, L., ORRENIUS, S., VAHTER, M., BERGGREN, P.O., AND NICOTERA, P. Modifications of Ca2+ signalling by inorganic mercury in PC12 cells. FASEB Journal. 7: 1507-1514, 1993.
  3. CANDURA, S.M., MANZO L., MARRACCINI, P., COCCINI, T., AND TONINI, M. Investigation into vanadate-induced potentiation of smooth muscle contractility in the rabbit isolated ileum. Life Science. 54: 237-244, 1994.
  4. GREGOTTI, C., KIRBY, Z., MANZO, L., COSTA, L.G., AND FAUSTMAN, E.M. Effects of styrene oxide on differentiation and viability of rodent embryo cultures. Toxicol. Appl. Pharmacol. 128: 25-35, 1994.
  5. MANZO, L., LOCATELLI, C., CANDURA, S.M., AND COSTA, L.G. Nutrition and alcohol neurotoxicity. Neurotoxicol. 15: 555-566, 1994.
  6. BONFOCO, E., CECCATELLI, S., MANZO, L., AND NICOTERA, P. Colchicine induces apoptosis in cerebellar granule cells. Experimental Cellular Research. 218: 189-200, 1995.
  7. COSTA, L.G., AND MANZO, L. Biochemical markers of neurotoxicity. Research strategies and epidemiological applications. Toxicol. Lett. 77: 137-144, 1995.
  8. COCCINI, T., DI NUCCI, A., TONINI, M., MAESTRI, L., COSTA, L.G., LIUZZI, AND MANZO, L. Effects of ethanol administration on cerebral non-protein sulfhydryl content in rats exposed to styrene vapour. Toxicology. 106: 115-122, 1996.
  9. MANZO, L., ARTIGAS, F., MARTINEZ, M., MUTTI, A., BERGAMASCHI, E., NICOTERA, P., TONINI, M., CANDURA, S.M., RAY, D.E., AND COSTA, L.G. Biochemical markers of neurotoxicity: basic issues and a review of mechanistic studies. Human and Exp. Toxicol. 15: 20-35, 1996.
  10. COCCINI, T., MAESTRI, L., ROBUSTELLI, F.S., LI BIN, COSTA, L.G., AND MANZO, L. Urinary mercapturic acid diastereoisomers in rats subchronically exposed to styrene and ethanol. Arch. Toxicol. 70: 736-741, 1996.

RESEARCH GROUP MEMBERS:

  1. Palmery Maura R.U.
  2. Leone Maria Grazia. B. PDR.
  3. Giacomelli Sabrina, B. PDR.
  4. Luzi Anna, D.DR.
  5. Abdel-Haq Hanin, D.DR.

AFFILIATION:

Istituto di Farmacolgia e Farmacognosia

Facoltą di Farmacia

Universitą di Roma 'La Sapienzą

ADDRESS : Piazzale A. Moro, 5

CITY: Roma

POSTAL CODE: 00185

TELEPHONE: 06-49912573

FAX: 06-49912480

E-MAIL: palmery@axrma.uniroma1.it

PUBLICATIONS:

  1. LEONE, M.G., SILVESTRINI, B., PALMERY, M. AND CHENG, C.Y. Identification of multiple biological factors in rabbit serum that modulate dopamine-mediated aortic constriction. Biochem. Int. 26: 1079-1090, 1992.
  2. LEONE, M.G., SASO, L., DEL VECCHIO, A., MO, M.Y., SILVESTRINI B. AND CHENG, C.Y. Micropurification of the two human cerebrospinal fluid proteins by high performance electrophoresis chromatography. J. Neurochem. 61: 533-540, 1993.
  3. SASO, L., SILVESTRINI, B., AND CHENG, C.Y. The use of high performance electrophoresis cromatograhy for the micropurification of cerebrospinal fluid proteins in the rat. Anal. Biochem. 212: 315-324, 1993.
  4. SILVESTRINI, B., PALMERY, M., TOLU, L., BASTA, F., LEONE, M.G. AND CHENG, C.Y ; Facilins , a novel class of biological factors that facilitate the aortic response to dopamine and other biogenic amines. J. Neural Transm. 95: 77-93, 1994.
  5. LI, A.H.Y., SILVESTRINI, B., LEONE, M.G., GIACOMELLI, S. AND CHENG, C.Y. Cerebrin-50, a human cerebrospinal fluid proteins whose mRNA is present in multiple tissues but predominantly expressed in the lymphoblastoid cells and the brain. Biochem. Mol. Int. 35: 135-144, 1995.
  6. PIMPINELLA G., PALMERY M. ; Interaction of beta-carbolines with central dopaminergic transmission in mice: structure-activity relationships. Neurosci. Lett. 189: 121-124, 1995.
  7. GIACOMELLI, S., BRAGHIROLI, L., PONZIANELLI, A., KOPPENAAL, D.W. AND DE FEO G. A sensitive assay for the study of dopaminergic activity with pituitary cell culture. J. Pharm. Pharmacol., in press, 1996.

RESEARCH GROUP MEMBERS:

  1. Preziosi Paolo, P.O.
  2. Martire Maria, P.A.
  3. Tempesta Enrico, P.A.
  4. Minotti Giorgio, R.U.
  5. Ragazzoni Enzo, R.U.
  6. Mores Nadia, R.U.

AFFILIATION:

Istituto di Farmacologia

Facoltą di Medicina e Chirurgia

Universitą Cattolica del Sacro Cuore

ADDRESS: Largo Francesco Vito, 1

CITY: Roma

POSTAL CODE: 00168

TELEPHONE: 06-3015 4253

FAX: 06-3050159, 3051343

PUBLICATIONS:

  1. MARTIRE, M., PISTRITTO, G., MORES, N., AGNATI, L.F. AND FUXE, K. Regional specific inhibition of potassium-evoked 3H-noradrenaline release by NPY13-36 from rat brain synaptosomes. Involvement of NPY receptors of the Y2 type. Eur. J. Pharmacol. 230: 231-234, 1993.
  2. CIABATTONI, G., MONTUSCHI, P., CURRO', D., TOGNA, G., PREZIOSI, P. Effects of vasoactive intestinal polypeptide on antigen-induced bronchocostriction and thromboxane release in guinea-pig lung. Brit. J. Pharmacol. 109: 243-250, 1993.
  3. CURRO', D., PREZIOSI, P., RAGAZZONI, E., CIABATTONI, G. Peptide hystidine isoleucine-like immunoreactivity release from the rat gastric fundus. Brit. J. Pharmacol. 113: 541-549, 1994.
  4. GRIMALDI, M., POZZOLI, G., NAVARRA, P., PREZIOSI, P., SCHETTINI, G. Vasoactive intestinal peptide and forskolin stimulate interleukin 6 production by rat cortical astrocytes in culture via a cyclic AMP-dependent, prostaglandin-independent mechanism. J. Neurochem. 63: 344-350, 1994.
  5. MARTIRE, M., PISTRITTO, G., MORES, N., AGNATI, L.F. AND FUXE, K. Presynaptic 2-receptors and neuropeptide Y Y2-receptors inhibit 3H-noradrenaline release from rat hypothalamic synaptosomes via different mechanisms. Neurosci. Lett. 188: 9-12, 1995.
  6. MINOTTI, G., CAVALIERE, A.F., MORDENTE, A., ROSSI, M., SCHIAVELLO, R., ZAMPARELLI, R., POSSATI, G.F. Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines. J. Clin. Invest. 95: 1595-1605, 1995.
  7. MINOTTI, G., MANCUSO, C., FRUSTACI, A., MORDENTE, A., SANTINI, A., CALAFIORE, A.M., LIBERI, G., GENTILONI, N. Paradoxical inhibition of cardiac lipid peroxidation in cancer patients treated with doxorubicin. J. Clin. Invest. 98: 650-661, 1996.
  8. MONTUSCHI, P., TRINGALI, G., MIRTELLA, A., PARENTE, L., RAGAZZONI, E., PREZIOSI, P. AND NAVARRA, P. Interleukin-1 release from rat gastric fundus. Amer. J. Physiol. 271 (Gastrointest. Liver Physiol. 84): G275-G281, 1996.
  9. CURRO', D., VOLPE, A.R. AND PREZIOSI, P. Nitric oxide synthase activity and non-adrenergic non-cholinergic relaxation in the rat gastric fundus. Brit. J. Pharmacol. 117: 717-723, 1996.
  10. NAVARRA, P., GROHMANN, U., NOCENTINI, G., TRINGALI, G., PUCCETTI, P., RICCARDI, C. AND PREZIOSI, P. Hydroxyurea induces the gene expression and synthesis of proinflammatory cytokines in vivo.. J. Pharmacol Exp. Ther. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Santagostino Angela, P.A.*
  2. Colleoni Mariapia, R.U.#
  3. Galvani Pietro, D.D.R.*
  4. Fumagalli Pietro, T.L.#
  5. Costa Barbara, B.#
  6. Conte Massimo, B.*
  7. Zanolli Luisa, B.*

AFFILIATION:

* Dipartimento di Scienze dell'ambiente e del Territorio ed

# Istituto di Farmacologia,

Facoltą di Scienze MM.FF.NN. Universitą degli Studi di Milano

ADDRESSES: *via Emanueli,15

# via Vanvitelli, 32/A

CITY: Milano

POSTAL CODE: * 20126 e # 20129

FAX: *02 64474500 e # 02-70002270

E-MAIL: * angela@alpha.disat.unimi.it   # gori@imiucca.csi.unimi.it

PUBLICATIONS:

  1. URANI C., BRAMBILLA E., SANTAGOSTINO A., CAMATINI M.: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes actin stress fibers disorganization and calcium elevation in Swiss 3T3 mouse fibroblasts. Toxicology. 91: 117-126, 1994.
  2. URANI C., CHIESARA E., GALVANI P., MARABINI L., SANTAGOSTINO A., CAMATINI M.: Benomyl affects the microtubule cytosckeleton and glutathione level of mammalian primary cultured hepatocytes. Toxicol. Lett. 76: 135-144, 1995.
  3. COLLEONI M, COSTA B., PAROLARO D., SALA M., GORI E.: Effects of repeated administrations of CP 55,940 on liver microsomal and liver and brain mitochondrial activities in the rat. Behav. Pharmacol. 6: 51-52, 1995.
  4. GALVANI P.,FUMAGALLI P., SANTAGOSTINO A.:Vulnerability of mitochondrial complex I in PC12 cells exposed to manganese.Eur. J. Pharmacol., Environ. Toxicol and Pharmacol. section. 293: 377-383, 1995.
  5. GALVANI P., COLLEONI M., ORIGGI M., SANTAGOSTINO A.: Mitochondria toxicity of iron and the protective role of ferritin on dopaminergic PC12 cell line. Toxicol. in vitro. 9 :365-368, 1995.
  6. COLLEONI M, COSTA B.,GORI E, SANTAGOSTINO A.:Biochemical characterization of the effects of the benzodiazepine, midazolam on mitochondrial electron transfer. Pharmacol. Toxicol. 78: 69-76, 1996.
  7. COSTA B., PAROLARO D. AND COLLEONI M.: Chronic cannabinoid, CP-55,940, administration alters biotransformation in the rat Eur. J. Pharmacol. 313, 17-24,1996.

RESEARCH GROUP MEMBERS:

  1. Valeri Pacifico, P.A.
  2. Romanelli Luca, B.PDR.
  3. Amico Maria Carmela, B.PDR.
  4. Mattioli Francesca, D.DR.

AFFILIATION:

Istituto di Farmacologia e Farmacognosia

Facoltą di Farmacia

Universitą di Roma 'La Sapienzą

ADDRESS: P.le Aldo Moro, 5

CITY: Roma

POSTAL CODE: 00185

TELEPHONE: 06-49912670

FAX: 06-49912480

E-MAIL: valeri@axrma.uniroma1.it

PUBLICATIONS:

  1. MORRONE, L.A., ROMANELLI, L. AND VALERI, P. Withdrawal contractures of guinea-pig isolated ileum after acute activation of k opioid receptors. Brit. J. Pharmacol., 109: 48-52, 1993.
  2. VALERI, P., MORRONE, L.A., ROMANELLI, L. AND AMICO, M.C. Effect of non-steroidal anti-inflammatory drugs on withdrawal responses in guinea-pig ileum after a brief exposure to morphine. J. Pharmacol. Exp. Ther., 264: 1028-1032, 1993.
  3. NENCINI, P. AND VALERI, P. The role of opioid mechanisms in the anoretic effect of stimulants: U-50,488H enhances amphetamine inhibition of free feeding in rats. Pharmacol. Bioch. Behav., 48: 63-68, 1994.
  4. VALERI, P., MORRONE, L.A., ROMANELLI, L. AND AMICO, M.C. Acute withdrawal after bremazocine and the interaction between Mu and Kappa opioid receptors in isolated gut tissues. Brit. J. Pharmacol., 114: 1206-1210, 1995.
  5. VALERI, P., ROMANELLI, L., MORRONE, L.A., AMICO, M.C. AND MATTIOLI, F. Mu and Kappa opioid system interactions in the expression of acute opioid dependence in isolated guinea-pig ileum. Neuropharmacology, 35: 377-84, 1996.
  6. ROMANELLI L., MORRONE L.A., AMICO M.C., MATTIOLI F., STATTI, G. AND VALERI, P. Ineractions of Centaurea deusta and Crepis lacera methanolic extracts with stimulatory peptides in isolated guinea-pig ileum. Phytother Res. In press, 1996.

 

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