SIF - Società Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

CLINICAL PHARMACOLOGY
AND PHARMACOKINETICS

 

RESEARCH GROUP MEMBERS:

  1. Biagi Gian Luigi, P.O.
  2. Barbaro Anna Maria, P.A.
  3. Sapone Andrea, D.DR.

AFFILIATION:

Dipartimento di Farmacologia

Università di Bologna

ADDRESS: Via Irnerio, 48

CITY: Bologna

POSTAL CODE: 40126

TELEPHONE: 051-24-9561, 3101, 3151

FAX: 051-248862

PUBLICATIONS:

  1. PAOLINI M., MESIRCA R., POZZETTI L., SAPONE A., SAPIGNI E., BIAGI G.L., TRIEFF N.M., CANTELLI FORTI G. Correlation between cytochrome P450 2B1 induction by barbiturates and toxicity in the chick embryo in ovo, Toxicol. Environ. Chem. 44: 43-53, 1994
  2. PAOLINI M., BIAGI G.L. BAUER C., CANTELLI FORTI G. Cocktail Strategy : complications and limitations. J. Clin. Pharmacol. 33 : 1011-1012, 1993.
  3. PAOLINI M., MESIRCA R., POZZETTI L., SAPONE A., BIAGI G.L., TRIEFF N.M., CANTELLI FORTI G. Correlation between murine liver cytochrome P450 2B1 induction by halogenated hydrocarbons and toxicity, Toxicol. Environ. Chem. 44: 55-64, 1994
  4. PAOLINI M., BIAGI G.L., BAUER C., CANTELLI FORTI G. On the procedures for isolation of S9 fractions from induced rodents in in vitro genotoxicity assays. Teratogen. Carcin. Mut., 14: 101-103, 1994
  5. BIAGI G.L., BARBARO A.M., SAPONE A., RECANATINI M. Determination of lipophilicity by means of reversed-phase thin-layer chromatography I. Basic aspects and relationship between slope and intercept of TLC equations, J. Chromatogr. A, 662: 341-361, 1994
  6. BIAGI G.L., BARBARO A.M., SAPONE A., RECANATINI M. Determination of lipophilicity by means of reversed-phase thin-layer chromatography II. Influence of the organic modifier on the slope of the thin-layer chromatographic equation, J. Chromatogr. A, 669: 246-253, 1994
  7. BIAGI G.L., BARBARO A.M., RECANATINI M. Determination of lipophilicity by means of reversed-phase thin-layer chromatography III. Study of the TLC equations for a series of ionizable quinolone derivatives, J. Chromatogr. A, 678: 127-137, 1994
  8. PAOLINI M., MESIRCA R., GIALLUCA N., BAUER C., BIAGI G.L., CANTELLI FORTI G. On cancer chemoprevention. Complications and limitations of some proposed strategies. Cancerogenesis 14: 971-973, 1995.
  9. BIAGI G.L., BARBARO A.M., SAPONE A., BOREA P.A., VARANI K., RECANATINI M. Study of lipophilic character of serotonergic ligands, J. Chromatogr., 723: 135-143,. 1996.

RESEARCH GROUP MEMBERS:

  1. Borgese Nica, P.O.
  2. Barbera Massimo, B.
  3. Bulbarelli Alessandra, B.
  4. Pedrazzini Emanuela, D.DR.
  5. Perego Carla, B.P.DR.
  6. Pietrini Grazia T.L.

AFFILIATION:

Facoltà di Farmacia

Università di Reggio Calabria

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Università di Milano

Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare

ADDRESS: Via Vanvitelli 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 01-70146-254, 262, 266, 256

FAX: 02-7490574

E-MAIL: segreteria@farma5.csfic.mi.cnr.it  Nica@Farma1.csfic.mi.cnr.it

PUBLICATIONS:

  1. BORGESE N., D'ARRIGO A., DE SILVESTRIS M., AND PIETRINI G. NADH-cytochrome b5 reductase and cytochrome b5: the problem of post-translational targeting to the endoplasmic reticulum. FEBS Lett. 325: 70-75, 1993.
  2. GOTTARDI C. J., PIETRINI G., ROUSH D.L., AND CAPLAN M. J. Sorting of ion transport proteins in polarized cells. J. Cell Sci. 17: 13-30, 1993.
  3. D'ARRIGO A., MANERA E., LONGHI R., AND BORGESE N. The specific subcellular localization of two isoforms of cytochrome b5 suggests novel targeting pathways. J. Biol. Chem. 268: 2802-2808, 1993.
  4. PIETRINI G., SUH Y. J., EDELMANN L., RUDNICK G., AND CAPLAN M. J. The axonal GABA transporter is sorted to the apical membranes of polarized epithelial cells. J. Biol. Chem. 269: 4668-4674, 1994.
  5. SHIRABE K., LANDI M.T., TAKESHITA M., UZIEL G. FEDRIZZI E., AND BORGESE N. A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impared NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia. Amer. J. Human Genetics 57: 302-310, 1995
  6. DE SILVESTRIS M., D'ARRIGO A., AND BORGESE N. The targeting information of the outer mitochondrial membrane isoform of cytochrome b5 is contained within the carboxyl-terminal region. FEBS Lett. 370: 69-74, 1995
  7. PEDRAZZINI E., VILLA A., AND BORGESE N. A mutant cytochrome b5 with a lengthened membrane anchor escapes from the endoplasmic reticulum and reaches the plasma membrane. Proc. Nat. Acad. Sci. USA 93: 4207-4212, 1996.
  8. BORGESE N., AGGUJARO D., CARRERA P., PIETRINI G., AND BASSETTI M. A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not endoplasmic reticulum membranes. J. Cell Biol., in press, 1996.

RESEARCH GROUP MEMBERS:

  1. Castelli Mariagrazia, C.L.
  2. Ghiglieri Alberto, R. I.
  3. Salgarollo Giuliana, R.I.
  4. Castello Renato,T.
  5. Cucchi Fabrizio, T.

AFFILIATION:

Sezione Drug Disposition

Dipartimento di Farmacocinetica e Metabolismo

Pharmacia & Upjohn, Nerviano (Mi)

ADDRESS: Via per Pogliano

CITY: Nerviano

POSTAL CODE: 20014

TELEPHONE: 02-4838-3169

FAX: 02-4838-3174

E-MAIL: MariaGrazia.Castelli@eu.pnu.com

PUBLICATIONS:

  1. STROLIN BENEDETTI M, FRAIER D., PIANEZZOLA E., CASTELLI M.G., DOSTERT P. AND GIANNI L. Stereoselectivity of iododoxorubicin reduction in various animal species and humans. Xenobiotica. 23: 115-121,1993.
  2. BATTAGLIA R. , STROLIN BENEDETTI M., MANTEGANI S., CASTELLI M.G., COCCHIARA G. AND DOSTERT P. Disposition and urinary metabolic pattern of cabergoline, a potent dopaminergic agonist, in rat, monkey and man. Xenobiotica. 23: 1377-89,1993.
  3. STROLIN BENEDETTI M., MARRARI P., COLOMBO M., CASTELLI M.G., ARAND M., OESCH F., DOSTERT P. The new anticonvulsivant FCE 26743 is a selective and short-acting MAO-B inhibitor devoid of inducing properties towords cytochrome P-450-dependent testosterone hydroxylation. J. Pharmacol. 46: 814-819,1994.
  4. DOSTERT P., CASTELLI M.G., CICIONI P. AND STROLIN BENEDETTI M. Reboxetine prevents the tranilcypromine-induced increase in tyramine levels in rat heart. J. Neural. Trasm. Suppl. 41: 149-153, 1994.
  5. STROLIN BENEDETTI M., PIANEZZOLA E., BRUGHERA M., FRAIER D., CASTELLI M. G. Concentration of refabutin in plasma and cerobrospinal fluid in Cynomolgus monkeys. J. Antimicrob. Chemother. 34: 600-603, 1994.
  6. STROLIN BENEDETTI M., FRIGERIO E., TOCCHETTI P.,BRIANCESCHI G., CASTELLI M. G., PELLIZONI C. AND DOSTERT P. Stereoselective and species-dependent kinetics of reboxetine in mouse and rat. Chirality. 7: 285-289,1995.
  7. EDWARDS D.M. F. , PELLIZONI C., BREUEL H.P., BERARDI A., CASTELLI M.G., FRIGERIO E. ET AL. Pharmacokinetics of reboxetine in healty volunteers. Single oral doses, linearity and plasma protein binding. Biopharmaceutics drug disposition. 16: 443-460, 1995.
  8. OESCH F., ARAND M., STROLIN BENEDETTI M. CASTELLI M.G. AND DOSTERT P. Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P-450 and UDP-glucuronosyltransferase superfamilies in female rat liver. J. Antimicrobial Chemotherapy . 37: 1111-1119, 1996.

RESEARCH GROUP MEMBERS:

  1. Ferrari Mariano, P.O.
  2. Padrini Roberto, P.A. *
  3. Piovan Donatella, A.M.
  4. Magnolfi Gianna, A.M.
  5. Spolaore Paolo, F.T.
  6. Zordan Rossella, T.

AFFILIATION:

Cattedra di Farmacologia Clinica e Servizio di Farmacologia Medica

Dipartimento di Medicina Clinica e Sperimentale

Facoltà di Medicina e Chirurgia

* Dipartimento di Farmacologia "E. Meneghetti"

Facoltà di Medicina e Chirurgia

ADDRESS: Via Giustiniani 2

CITY: Padova

POSTAL CODE: 35128

TELEPHONE: 049-821-2340,2341, 2343, 2349

FAX: 049-8754179

*ADDRESS: Via Largo Meneghetti 2

CITY: Padova

POSTAL CODE: 35100

TELEPHONE: 049-8275085,5098,5096

FAX: 049-8275093

E-MAIL: padrini@dfem.unipd.it

PUBLICATIONS:

  1. PADRINI R., PIOVAN D., BUSA M., AL-BUNNI M., MAIOLINO P., AND FERRARI M. Pharmacodynamic variability of flecainide assessed by QRS changes.Clin. Pharmacol. Ther. 53: 59-64, 1993.
  2. ZEPPELLINI R., BOLOGNESI R., JAVERNARO A., DE DOMENICO R., LIBARDONI M., TSIALTAS D., PIOVAN D., PADRINI R., AND CUCCHINI F. Effect of dobutamine on left ventricular relaxation and filling phase in patients with ischemic heart disease and preserved systolic function. Cardiovasc. Drug Ther. 7: 325-331, 1993.
  3. PADRINI R., PIOVAN D., JAVERNARO A., CUCCHINI F., AND FERRARI M. Pharmacokinetics and electrophysiological effects of i.v. ajmaline. Clin. Pharmacokin. 25: 1-8, 1993.
  4. ZORDAN R., PADRINI R., BERNINI V., PIOVAN D., AND FERRARI M. Influence of age and gender on the "in vitro" serum protein binding of flecainide. Pharmacol. Res. 28: 259-264, 1993.
  5. NICOLETTO M.O., PADRINI R., FERRAZZI E., NASCIMBEN O., VISONà E., TUMOLO S., PALUMBO M., COSTA L., VINANTE O., MONFARDINI S., AND FIORENTINO M.V. Phase I-II intraperitoneal Mitoxantrone in advanced pretreated ovarian cancer. Eur. J. Cancer 29A: 1242-1248, 1993.
  6. PIOVAN D., PADRINI,R., SVALUTO MOREOLO G., MAGNOLFI G., ZORDAN R., PELLEGRINO P.A., AND FERRARI M. Verapamil and norverapamil plasma levels in infants and children during chronic oral treatment. Therap. Drug. Monitor. 17: 60-67, 1995.
  7. YANG Q., PADRINI R., BOVA S., PIOVAN D., AND MAGNOLFI G. Electrophysiological interactions between pinacidil, a potassium channel opener, and class 1 antiarrhythmic agents in guinea-pig perfused heart. Brit. J. Pharmacol. 114: 1745-1749, 1995.
  8. PADRINI R., BUTROUS G., CAMM A.J., AND MALIK M. Algebraic decomposition of the TU-wave morphology patterns. PACE 18: 2209-2215, 1995.
  9. LATINI R., MAGNOLFI G., ZORDAN R., FERRARI M., PADRINI R., PIOVAN D., PECORARI T., AND BOTTAZZI L. Antiarrhythmic drug plasma concentrations in ambulatory patients. Ann. Pharmac. 30: 298-300, 1996.
  10. BOVA S., TREVISI L., DEBETTO P., CIMA L., FURNARI M., LUCIANI S., PADRINI R., AND CARGNELLI G. Vasorelaxant properties of norbormide, a selective vasoconstrictor agent for the rat microvasculature. Brit. J. Pharmacol. 117: 1040-1046, 1996.

RESEARCH GROUP MEMBERS:

  1. Furlanut Mario, P.O.
  2. Baraldo Massimo, R.U.
  3. Pea Federico, A.O.

AFFILIATION:

Cattedra di Farmacologia Speciale

Dipartimento di Patologia e Medicina Sperimentale e Clinica

Istituto di Farmacologia Clinica e Tossicologia

Facoltà di Medicina e Chirurgia

Università di Udine

ADDRESS: P.le S.M. della Misericordia 3

CITY: Udine

POSTAL CODE: 33100

TELEPHONE: 0432-559833

FAX: 0432-559833

E-MAIL: furlanut@hydrus.cc.uniud.it

PUBLICATIONS:

  1. BENETELLO P., FURLANUT M., ZARA G., BARALDO M., AND HASSAN E. Plasma levels of levodopa and its main metabolites in parkinsonian patients after conventional and controlled-release levodopa-carbidopa associations. Eur. Neurol. 33: 69-73, 1993.
  2. FURLANUT M., BENETELLO P., AND SPINA E. Pharmacokinetic optimisation of tricyclic antidepressant therapy. Clin. Pharmacokinet. 24: 301-318, 1993.
  3. FERRACCIOLI G.,GUERRA P., RIZZI V., BARALDO M., SALAFFI F., FURLANUT M., AND BARTOLI E. Somatomedin C (Insulin-Like Growth Factor 1) levels decrease during acute changes of stress related hormones. Relevance for fibromyalgia. J. Rheumatol. 21: 1332-1334, 1994.
  4. GALLA F., MARZOCCHI V., CROATTINO L., POZ D., BARALDO M., AND FURLANUT M. Oral and intravenous disposition of cyclosporine in psoriatic patients. Ther. Drug Monit. 17: 302-304, 1995.
  5. DAMIANI D., MICHIELI M., MICHELUTTI A., PEA F., BARALDO M., FANIN R., RUSSO D., FURLANUT M., AND BACCARANI M. P170 - related multidrug resistance. Enhancement of idarubicin content in leukemic cells with cyclosporine in vivo: a report of two cases. Leukemia 9: 1792-1795, 1995
  6. WU G., BARALDO M., AND FURLANUT M. Calculating percentage prediction error: a user's note. Pharmacol. Res. 32: 241-248, 1995.
  7. WU G., BARALDO M., PEA F., COSSETTINI P., AND FURLANUT M. Effects of different sampling strategies on predictions of blood cyclosporine concentrations in haematological patients with multidrug resistance by bayesian and nonlinear least squares method. Pharmacol. Res. 32: 355-362, 1995.
  8. FURLANUT M., BARALDO M., GALLA F., MARZOCCHI V., AND PEA F. Cyclosporin nephrotoxicity in relation to its metabolism in psoriasis. Pharmacol. Res. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Leone Luciana, P.A.
  2. Ferrante Luigi, R.U.
  3. Bompadre Stefano, T.L.

AFFILIATION:

Istituto di Scienze Biomediche

Facoltà di Medicina e Chirurgia

Università di Ancona

ADDRESS: Monte d'Ago

CITY: Ancona

POSTAL CODE: 60131

TELEPHONE: 071-220-4637

FAX: 071-220-4622

E-MAIL: biomat@popcsi.unian.it

PUBLICATIONS:

  1. RIPA S., FERRANTE L., PRENNA M. Pharmacokinetics of fluconazole in normal volunteers. Chemotherapy, 39: 6-12, 1993
  2. BRUNI C., FERRANTE L., KOCH G., SCOGLIO C., STARACE G. A stochastic model for cell debris in flow cytometry. J. Theor. Biol. 161: 157-74, 1993.
  3. DUBINI B., FERRANTE L., LEONARDI M., MESSINA G., MONTECCHIA F. The freezing and thawing of water in poultry meat and vegetables irradiated by electrons at doses of 0.1-0.4 KGy. Int. J. Rad. Biol. 63: 687 - 92, 1993.
  4. FERRANTE L., BOMPADRE S., CINGOLANI ML., LEONE L. A bayesan approach to drug disposition evaluation: application to teicoplanin. Int. J. Clin. Pharmacol. Ther. 33: 410-14, 1995
  5. BOMPADRE S., FERRANTE L., ALO' FP., LEONE L. On-line solid-phase extraction of ceftazidime in serum and determination by high-performance liquid chromatography. J. Chromatogr. B.:, 669: 265-69, 1995.
  6. BOMPADRE S., LEONE L., FERRANTE L. Determination of cefodizime in human plasma by high-performance liquid chromatography with column-switching. J. Liq. Chromatogr. 18: 2895-909, 1995
  7. FERRANTE L., BOMPADRE S., CINGOLANI ML., LEONE L. RIPA S. Bioavailability study of two different formulations of azithromycin. Curr. Ther. Res. 57: 288-98, 1996
  8. BOMPADRE S., FERRANTE L., LEONE L., ALO' FP., IOANNIDIS G. Extractionless high-performance liquid chromatographic method for determination of cefazolin in human serum. J. Liq. Chromatogr.,1996 (in press)
  9. BOMPADRE S., FERRANTE L., LEONE L., MONTESI M., POSSATI L. Column-switching high-performance liquid chromatographic assay for minocycline in nude mouse serum.. J. Liq. Chromatogr. 1996 (in press).

RESEARCH GROUP MEMBERS:

  1. Lucisano Antonia, P.O.
  2. Amorena Michele, R.U.
  3. Severino Lorella, R.U.
  4. Pelagalli Alessandra, D.DR
  5. Ferrante Maria Carmela, D.DR
  6. Cavaliere Maria, D.DR

AFFILIATION:

Sezione di Tossicologia Veterinaria

Dipartimento di Patologia Profilassi ed Ispezione degli alimenti

Facoltà di Medicina Veterinaria

Università di Napoli Federico II

ADDRESS: Via F. Delpino n°1

CITY: Napoli

POSTAL CODE: 80137

TELEPHONE: 081/297122

FAX: 081/297122

E-MAIL: Lucisano@ds.unina.it

PUBLICATIONS:

  1. MONTESISSA C., HUUVENEERS M.B.M., HOOGENBOMM L.A.P., AMORENA M., DE LIGUORO M., LUCISANO A. The oxidative metabolism of aldicarb in pigs: in vivo - in vitro comparison. Drug Metab. Drug Interact. 11 :127-38,1994.
  2. MONTESISSA C., DE LIGUORO M., AMORENA M., LUCISANO A., CARLI S. In vitro oxidation of Aldicarb by various food producing animal species. Vet. Hum. Toxicol. 37 : 333-336,1995
  3. RE G., BADINO P., NOVELLI A., DI RENZO G.F., SEVERINO L., DE LIGUORO M., FERONE M.R. Distribution of cytosolic oestrogen (ER) and progesterone (PgR) receptors in the genital tract of the mare. Res. Vet. Sci. 59 :214-218, 1995
  4. DE LIGUORO M., LUONGO F., BRAMBILLA G., CINQUINA A., BOCCA A., LUCISANO A. Distribution of the anthelmintic drug albendazole and its major metabolites in ovine milk and milk products after a single oral dose. J. Dairy Res. 63 : 533-542, 1996

RESEARCH GROUP MEMBERS:

  1. Montesissa Clara, P.A.
  2. De Liguoro Marco, R.U.

AFFILIATION:

Istituto di Patologia e Igiene Veterinaria

Facoltà di Medicina Veterinaria

Università di Padova

ADDRESS: Agripolis

CITY: Legnaro, Padova

POSTAL CODE: 35020

TELEPHONE: 049-8272604

FAX: 049-8272602

E-MAIL: monty@agripolis.unipd.it

PUBLICATIONS:

  1. CARLI S., SONZOGNI O., VILLA R., MONTESISSA C. Pharmacokinetic profile of sulphamonomethoxine and trimethoprim in horses after intravenous, intramuscolar and oral administration. Res. Vet. Sci., 54 :184-188, 1993.
  2. ANFOSSI P., RONCADA P., STRACCIARI G.L., MONTANA M., PASQUALUCCI C., AND MONTESISSA C. Toxicokinetics and metabolism of linuron in the rabbit: in vivo-in vitro studies. Xenobiotica, 23 :1113-1123, 1993.
  3. MONTESISSA C., HUUVENEERS M.B.M., HOOGENBOOM L.A.P., AMORENA M., DE LIGUORO M., LUCISANO A. The oxidative metabolism of aldicarb in pigs: in vivo - in vitro comparison. Drug Metab. Drug Interact. 11 :127-138,1994.
  4. MONTESISSA C., VILLA R., SONZOGNI O., BELLOLI C., CARLI S. Comparative Pharmacokinetics of ampicillin - sulbactam combination in calves and sheep Vet. Pharmacol. and Therap. 17 : 359-364, 1994.
  5. BELLOLI C., CECI L., CARLI S., TASSI P., MONTESISSA C., DE NATALE G., MARCOTRIGIANO G., ORMAS P. Disposition of Antimony and Aminosidine administered separately and in combination to the dog: implication for antileishmania therapy. Res. Vet. Sci., 58 : 123-127, 1995.
  6. RONCADA P., TOMASI L., MONTESISSA C., GROSSI G., STRACCIARI G.L., ANFOSSI P. Absorption and dosage of theophylline in the horse after single and repeated administration of a microincapsulated preparation. Equine Vet.J., 27 :13-18, 1995.
  7. MONTESISSA C., DE LIGUORO M., AMORENA M. , LUCISANO A., CARLI S. In vitro oxidation of Aldicarb by various food producing animal species. Vet.Hum. Toxicol., 37 : 333-336, 1995.
  8. RE G., BADINO P., NOVELLI A., DI RENZO G.F., SEVERINO L., DE LIGUORO M., FERONE M.R. Distribution of cytosolic oestrogen (ER) and progesterone (PgR) receptors in the genital tract of the mare. Res. Vet. Sci., 59 : 214-218, 1995.
  9. ANFOSSI P., MONTESISSA C., PEZZI P., FORMIGONI A. Bioavalability of microgranulated sulphamethazine in veal calves. Vet. Pharmacol. and Therap. 19 : 300-305, 1996.
  10. DE LIGUORO M., LUONGO F., BRAMBILLA G., CINQUINA A., BOCCA A., LUCISANO A. Distribution of the anthelmintic drug albendazole and its major metabolites in ovine milk and milk products after a single oral dose. J. Dairy Res. 63 : 533-542 1996.

RESEARCH GROUP MEMBERS:

  1. Pacifici Gian Maria, P.A.

AFFILIATION:

Dipartimento di Biomedicina Sperimentale, Infettiva e Pubblica

Facoltà di Medicina e Chirurgia

Università di Pisa

ADDRESS: Via Roma, 55

CITY: Pisa

POSTAL CODE: 56126

TELEPHONE: 050-554851, 554866

FAX: 050-554929

E-MAIL: pacifici@biomed.unipi.it

PUBLICATIONS:

  1. PACIFICI G.M., BIGOTTI R., MARCHI G., AND GIULIANI L. Minoxidil sulphation in human liver and platelets: a study on the interindividual variability. Eur. J. Clin. Pharmacol. 45: 337-341, 1993.
  2. PACIFICI G.M., AND MARCHI G. Phenol and catechol sulphotransferases in platelets from adult subjects and newborns: a study on the interindividual variability. Brit. J. Clin. Pharmacol. 36 : 593-597, 1993.
  3. PACIFICI G.M., BIGOTTI R., AND GIULIANI L. The intestine is the primary site of the in vitro sulphation of (+) and (-) terbutaline. Eur. J. Clin. Pharmacol. 45 : 483-487, 1993.
  4. PACIFICI G.M., FERRONI MA., TEMELLINI A., GUCCI A., MORELLI M.C., GIULIANI L. Human liver budesonide sulphotransferase is inhibited by testosterone and correlates with testosterone sulphotransferase, Eur. J. Clin. Pharmacol. 46 : 49-54, 1994.
  5. DONATELLI P., MARCHI G., GIULIANI L., GUSTAFSSON L. AND PACIFICI G.M. Stereochemical inhibition of histamine N-methyltransferase by chloroquine. Eur. J. Clin. Pharmacol. 47 : 345-349, 1994.
  6. PACIFICI G.M., AND NOTTOLI R. Transplacental transfer of drugs administered to the mother. Clin. Pharmacokin. 28 : 235-269, 1995.
  7. PACIFICI G.M., DE'SANTI C., MUSSI A., ANGELETTI C.A. Interindividual variability in the rate of salbutamol sulphation in the human lung. Eur. J. Clin. Pharmacol. 49 : 299-303, 1996.
  8. PACIFICI G.M., EVANGELISTI L., AND GIULIANI L. Zidovudine glucuronosyl transferase is not normally distributed in human liver. Int. J. Clin. Pharmacol. Ther. 34 : 329-334, 1996.
  9. FERRONI M.A., GIULIANOTTI P.C., PIETRABISSA A., MOSCA F., GOMENI R., AND PACIFICI G.M. Captopril methylation in human liver and kidney: interindividual variability. Xenobiotica 26 : 877-882, 1996.
  10. FERRONI M.A., MARCHI G., SANSONE E., ROMEO P., GIULIANOTTI P.C., PIETRABISSA A., MOSCA F. AND PACIFICI G.M. Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney of an an Italian population. Eur. J. Clin. Pharmacol. 51 : 23-26, 1996.

RESEARCH GROUP MEMBERS:

  1. Perucca Emilio, P.A.
  2. Gatti Giuliana, R.U.
  3. Bartoli Anna, B.
  4. Fattore Cinzia, B.

AFFILIATION:

Sezione di Farmacologia e Tossicologia

Dipartmento di Medicina Interna e Terapia Medica

I Facoltà di Medicina e Chirurgia

Università di Pavia

ADDRESS: Piazza Botta 10

CITY: Pavia

POSTAL CODE: 27100

TELEPHONE: 0382-506 360 / 370

FAX: 0382-22741

PUBLICATIONS:

  1. TARTARA A., GALIMBERTI C.A., MANNI R., MORINI R., LIMIDO G., GATTI G., BARTOLI A., STRADA G. AND PERUCCA E. The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid. Brit. J. Clin. Pharmacol. 36: 366-368, 1993.
  2. PISANI F., HAJ-YEHIA A., FAZIO A., ARTESI C., OTERI G., PERUCCA E., KROETZ D.L., LEVY R.H., AND BIALER M. Pharmacokinetics of valnoctamide in epileptic patients and its interaction with carbamazepine: In vitro/in vivo correlation. Epilepsia 34: 954-959, 1993.
  3. PATRINI C., PERUCCA E., REGGIANI C., AND RINDI G. Effects of phenytoin on the in vivo kinetics of thiamine and its hosphoesters in rat nervous tissue. Brain Res. 628: 179-186, 1993.
  4. GATTI G., BARTOLI A., MARCHISELLI R., MICHELUCCI R., TASSINARI C.A., PISANI F., ZACCARA G., TIMMINGS, P., RICHENS, A., AND PERUCCA, E. Vigabatrin-induced decrease in serum phenytoin concentration does not involve a change in phenytoin bioavailability. Brit. J. Clin. Pharmacol. 36: 603-606, 1993.
  5. PERUCCA E., GATTI G., CIPOLLA G., SPINA E., BAREL S., SOBACK S., GIPS M., AND BIALER M. Inhibition of diazepam metabolism by fluvoxamine: A pharmacokinetic study in normal volunteers. Clin. Pharmacol. Ther. 56: 471-476, 1994.
  6. GATTI G., BARTOLI A., BERTIN D., STROLIN-BENEDETTI M., AND PERUCCA E. Pharmacokinetic and pharmacodynamic studies following single and multiple doses of rolafragel, a novel inhibitor of thromboxane synthase, in normal volunteers. Eur. J. Clin. Pharmacol. 47: 275-280, 1994.
  7. PERUCCA E., GATTI G. AND SPINA E. Clinical pharmacokinetics of fluvoxamine. Clinical Pharmacokinetics 27: 175-190, 1994.
  8. SPINA E., AVENOSO A., CAMPO G.M., CAPUTI A.P., AND PERUCCA E. Phenobarbital induces the CYP2D6-mediated 2-hydroxylation of desipramine. Ther. Drug Monit. 18: 60-64, 1996.
  9. GIACCONE M., BARTOLI A, GATTI G., MARCHISELLI R. PISANI F., AND PERUCCA E. Effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetics in epileptic patients. Brit. J. Clin. Pharmacol. 41: 575-579, 1996.
  10. PERUCCA E. AND BIALER M. The clinical pharmacokinetics of the newer antiepileptic drugs. Focus on Topiramate, zonisamide and tiagabine. Clinical Pharmacokinetics 31: 29-46, 1996.

RESEARCH GROUP MEMBERS:

  1. Pisanti Nicola, P.A.
  2. De Marino Vincenzo, P.A.
  3. Basile Vincenzo, P.A.
  4. Gentile Antonio, R.U.
  5. Capone Domenico, CPE

AFFILIATION:

Sezione di Farmacologia, Dipartimento di Neuroscienze

Facoltà di Medicina e Chirurgia

Università di Napoli Federico II

ADDRESS: Via Pansini,5

CITY: Napoli

POSTAL CODE: 80131

TELEPHONE: 081-746-3312, 3317, 3330

FAX: 081- 7463323

E-MAIL : farmacol@unina.it

PUBLICATIONS :

  1. CAPONE, D., DE MARINO, V., PISANTI, N., AND DE MARINO, V. New dry chemistry immunoassay: Comparison with a fluorescence polarization system. Eur. Rev. Med. Pharmacol. Sci. 91- 94, 1994.
  2. CAPONE, D., DE MARINO, V., FONTANA, R., DE MARINO, V., AND PISANTI, N. Effects of different routes of cyclosporin A administration on blood levels in patients undergoing bone marrow transplantion. Bone Marrow Transplantation, In press, 1996.
  3. CAPONE, D., AIELLO, C., SANTORO, G.A., GENTILE, A, STANZIALE, P., D'ALESSANDRO, R., IMPERATORE, P., AND BASILE, V. Drug interaction between cyclosporine and two antimicrobial agents, josamycin and rifampicin, in organ transplanted patients. Int. J. Clin. Pharmacol. Res., In press, 1996.
  4. PISANTI, N., STANZIALE, P., IMPERATORE, P., D'ALESSANDRO, R., DE MARINO, V., CAPONE, D.,AND DE MARINO, V. Lack of effect of gemfibrozil on cyclosporine blood concentrations in kidney transplanted patients. Amer. J. Nephrol., in press, 1996.

RESEARCH GROUP MEMBERS:

  1. Sternieri Emilio, P.O.
  2. Pini Luigi Alberto, R.U.
  3. Vitale Giovanni, D.DR.
  4. Stefani Marina, B.

AFFILIATION:

Servizio di Tossicologia e Farmacologia Clinica

Dipartimento di Medicina Interna

Facoltà di Medicina e Chirurgia

Università di Modena

ADDRESS: via del Pozzo, 71

CITY: Modena

POSTAL CODE: 41100

TELEPHONE: 059 372001, 424064, 422098

FAX: 059 424069

PUBLICATIONS:

  1. PINI L.A., VITALE G., SANDRINI M. The role of serotonin brain receptors in the analgesic effect of phenazone. Drugs Exptl. Clin. Res. 19: 13-17, 1993
  2. SANDRINI M., VITALE G., PINI L.A., STERNIERI E., BERTOLINI A. Effects of chronic treatment with phenazone on the hot-plate test and [3H]-Serotonin binding sites in pons and Cortex membranes of the rat. Pharmacology 47: 84-90, 1993.
  3. VITALE G., SANDRINI M., PINI L.A. Lack of activity of ketorolac in hot-plate test and serotonin binding capacity of brain membranes in rats. Agents Actions 41: 184-187, 1994.
  4. SANDRINI M, VITALE G, DONDI M, PINI L.A. Effects of Acetylsalicylic Acid on Serotonin Brain Receptor Subtypes. Gen. Pharmacol. 26: 737-741, 1995.
  5. PINI LA, SANDRINI M, VITALE G. Lack of activity of Azapropazone in the hot-plate test and in 5-HT1A and 5-HT2 receptor subtype in rat brain memebranes. Drugs Exptl. Clin. Res. 181-186, 1995.
  6. PINI L.A., SANDRINI M, VITALE G. Involvement of brain serotonergic system in the antinociceptive action of acetylsalicylic acid in the rat. Inflamm. Res. 44: 30-35, 1995.
  7. PINI L.A., BIGARELLI, M, VITALE, G, STERNIERI, E. Headaches associated with chronic use of analgesics: a therapeutic approach.. Headache 36: 433-439, 1996
  8. PINI L.A., VITALE G, SANDRINI M. The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. Eur. J. Pharmacol. 308: 31-40, 1996

RESEARCH GROUP MEMBERS:

  1. Velo Giampaolo, P.O.
  2. Milanino Roberto, R.U.
  3. Marrella Mauro, T.L.
  4. Gasperini Roberta, B.
  5. Pasqualicchio Mara, B.
  6. Valdo Paola, B.

AFFILIATION:

Istituto di Farmacologia,

Facoltà di Medicina e Chirurgia

Università di Verona

ADDRESS: c/o Policlinico Borgo Roma

CITY: Verona

POSTAL CODE: 37134

TELEPHONE: 045-8098611, 8074244

FAX: 045-581111

E-MAIL: GPVelo@farma.univr.it

PUBLICATIONS:

  1. MILANINO R., FRIGO A., BAMBARA L.M., MARRELLA M., MORETTI U., PASQUALICCHIO M., BIASI D., GASPERINI R., MAINENTI L., VELO G.P. Copper and zinc status in rheumatoid arthritis: studies on plasma, erythrocytes and urine, and relationship with disease activity markers and pharmacological treatment. Clinical and Experimental Rheumatology, 11 : 271-281, 1993.
  2. MILANINO R., MARRELLA M., GASPERINI R., PASQUALICCHIO M., VELO G.P. Copper and zinc body levels in inflammation: an overview of the data obtained from animal and human studies. Agents Actions, 39 : 195-209, 1993.
  3. MARRELLA M., GUERRINI F., SOLERO P.L., TREGNAGHI P.L., SCHENA F., VELO G.P. Blood copper and zinc changes in runners after a marathon. J. Trace Elem. Electrolytes Health Dis. 7 : 248-250, 1993.
  4. MILANINO R., MARRELLA M., VELO G.P. Copper in the treatment of arthritic conditions : myth or reality ? La Clinica e l'Industria, 76 : 138-143, 1994.
  5. PASQUALICCHIO M., DAVIES M.E., VELO G.P. Effects of copper and zinc on chondrocyte - PBMC adhesion via ICAM-1/CD18 interactions. Inflammopharmacology, 3 : 35-48, 1995.
  6. PASQUALICCHIO M., GASPERINI R., VELO G.P., DAVIES M.E. Effects of copper and zinc on proteoglycan metabolism in articular cartilage. Mediators of Inflammation, 5 : 95-99, 1996.

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