SIF - Società Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

ANTINEOPLASTIC CHEMOTHERAPY

 


RESEARCH GROUP MEMBERS :

  1. Baggio Giosuè Gabriele, P.O.
  2. Castelli Mario, P.A.
  3. Rossi Tiziana, R.U.
  4. Malagoli Monica, D.DR.

AFFILIATION :

Sezione di Farmacologia, Dipartimento di Scienze Biomediche

Facoltà di Medicina e Chirurgia

Università degli Studi di Modena

ADDRESS: Via Campi, 287

CITY: Modena

POSTAL CODE: 41100

TELEPHONE: 059/428411/50

FAX: 059/372653

E-MAIL: farmacol@unimo.it

PUBLICATIONS :

  1. ROSSI ,T., VAMPA , G., BENVENUTI , S., PINI , L.A., GALATULAS , I., BOSSA , R., CASTELLI , M., RUBERTO, A.I., AND BAGGIO, G. Glycyrrhizin and 18-glycyrrhetinic acid : a comparative study of the pharmacological effects induced in the rat after prolonged oral treatment. IN VIVO 8: 317-320, 1994.
  2. CASTELLI , M., BAGGIO , G., RUBERTO , A.I., ROSSI , T., PROVVISIONATO , A., MALAGOLI , M., BOSSA , R., AND GALATULAS , I. In vitro activity of trimethoprim in association with sulphimidazole against aerobic Gram-negative and Gram-positive microorganisms and Clostridia. Chemotherapy 41: 337-344, 1995.
  3. ROSSI , T., GALATULAS , I., BOSSA , R., TAMPIERI , A., TARTONI , P.L., BAGGIO , G., RUBERTO , A.I., AND CASTELLI , M. Influence of glycyrrhizin on the evolution and respiration of Ehrlich ascites tumour cells. IN VIVO 9: 183-186, 1995.
  4. BOSSA , R., CHIERICOZZI , M., GALATULAS , I., SALVATORE , G., TELI , M., BAGGIO , G., AND CASTELLI , M. The effects of roxatidine on neuromuscolar transmission. IN VIVO 9: 113-116, 1995.
  5. CASTELLI , M., BAGGIO , G., RUBERTO , A.I., TAMPIERI ,P., TARTONI , P.L., ROSSI , T., BOSSA , M.R., AND GALATULAS , I. Influence of antimalarials chloroquine, quinine, primaquine and mepacrine on the evolution of Ehrlich ascites tumour . Anticancer Res. 16 : 1-3, 1996.

RESEARCH GROUP MEMBERS:

  1. Baldini Luciano, P.O.
  2. Bartoli Klugmann Fiora, P.A.
  3. Decorti Giuliana, R.U.
  4. Candussio Luigi, R.U.
  5. Strohmayer Antonella, B.

AFFILIATION:

Sezione di Farmacologia Medica, Dipartimento di Scienze Biomediche

Facoltà di Medicina e Chirurgia

Università di Trieste

ADDRESS: Via Giorgieri, 7

CITY: Trieste

POSTAL CODE: 34127

TELEPHONE: 040 6763537

FAX: 040 55477

E-MAIL: farmed@univ.trieste.it

PUBLICATIONS:

  1. DECORTI G., CANDUSSIO L., BARTOLI KLUGMANN F., BALDINI L. Effect of neomycin and other aminoglycosides on adriamycin uptake in rat peritoneal mast cells. Pharmacol. Toxicol. 73: 341-343, 1993.
  2. BARTOLI KLUGMANN F., DECORTI G., CANDUSSIO L, SOTTOCASA G.L., BALDINI L. Adriamycin induced histamine release in rat peritoneal mast cells: evidence for the involvement of G protein. Cell. Pharmacol. 4: 1-5; 1994.
  3. CANDUSSIO L., BARTOLI KLUGMANN F., DECORTI G., BALDINI L. Effect of sodium nedocromil on histamine release and toxicity induced by adriamycin. Curr. Ther. Res. 55: 1238-1246, 1994.
  4. DECORTI G., BARTOLI KLUGMANN F., CANDUSSIO L., BALDINI L. Effect of paclitaxel and cremophor EL on mast cell histamine secretion and their interaction with adriamycin. Anticancer Res.16: 317-320, 1996.
  5. DECORTI G., CANDUSSIO L., BARTOLI KLUGMANN F., BALDINI L. Binding of aminoglycoside antibiotics by degranulating mast cells. Chemotherapy, In press, 1996.
  6. CRIVELLATO E., CANDUSSIO L., DECORTI G., BARTOLI KLUGMANN F. Adriamycin binds to the matrix of secretory granules during mast cell exocytosis. Biotechnic-Histochem, In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Bonmassar Enzo, P.O.
  2. De Vecchis Liana, P.A.
  3. Aquino Angelo, R.U.
  4. Graziani Grazia, R.U.
  5. Macchi Beatrice, R.U.
  6. Franchi Annibale, R.U.
  7. Tentori Lucio, T.L.
  8. Prete Salvatore P., T.L.
  9. Giuliani Anna, Dir. R.
  10. Turriziani Mario, T.L.
  11. Gilberti Sara, Sp.
  12. Cantagallo Daniela, Sp.
  13. Minchella Ida, Sp.
  14. Orlando Laura, Sp.
  15. Comandini Alessandro, Sp.
  16. Masci Giovanna, Sp.
  17. Benincasa Elena, Sp.
  18. Franzese Ornella, B.PDR.
  19. Faraoni Isabella, B.PDR.
  20. Lacal Pedro M., B.PDR.
  21. D'Atri Stefania, B.PDR.
  22. Tricarico Maria, Dir. R.
  23. Fuggetta Maria Pia, T.L.
  24. Alvino Ester, T.L.

AFFILIATION:

Cattedra di Farmacologia

Dipartimento di Medicina Sperimentale e Scienze Biochimiche

Facoltà di Medicina e Chirurgia

Università degli Studi di Roma "Tor Vergata"

ADDRESS: Via Tor Vergata, 135

CITY: Roma

POSTAL CODE: 00133

TELEPHONE: 06-7259-6322, 6315, 6340

FAX: 06-7259-6323

E-MAIL: disperim@utovrm.it

PUBLICATIONS:

  1. FUGGETTA M.P., ALVINO E., PEPPONI R., DE FILIPPI R., MARINI S., BONMASSAR E.: In vitro tumor cell growth inhibition: a comparative study between allosensitized cytotoxicity T lymphocytes and lymphokine activated killer cells. Cell Proliferation 26:305-316, 1993.
  2. GRAZIANI G., FARAONI I., ZHANG J., CARONTI B., LAURO G., BONMASSAR E., MACCHI B.: Transient HTLV-I infection of a human glioma cell line following cell-free exposure. Virology 197:767-769, 1993.
  3. LACAL P.M., PUGLIANIELLO A., BONMASSAR E., D'ONOFRIO C.: Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. Cell differentiation determines sensitivity to prostaglandins and virus infection. J. Pharmacol. Exper. Ther. 271:1086-1095, 1994.
  4. LACAL P.M., AMICI C., BONMASSAR E. AND D'ONOFRIO C.: Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. J. Pharmacol. Exper. Ther. 271:1096-1102, 1994.
  5. D'ATRI S., PICCIONI D., CASTELLANO A., TUORTO V., FRANCHI A., LU K., CHRISTIANSEN N., FRANKEL S., RUSTUM Y.M., PAPA G., MANDELLI F., BONMASSAR E.: Chemosensitivity to triazene compounds and O6-alkylguanine-DNA-alkyltransferase levels: studies with blasts of leukaemic patients. Ann. Oncol. 6:389-393, 1995.
  6. D'ONOFRIO C., PUGLIANIELLO A., AMICI C., FARAONI I., LANZILLI G. AND BONMASSAR E.: HSP70 production and inhibition of cell proliferation in MOLT-4-T-cells after cell-to-cell transmission of HTLV-I: effect of PGA1. Leukemia Res. 19:345-356, 1995.
  7. TENTORI L., GRAZIANI G., GILBERTI S., LACAL P.M., BONMASSAR E., D'ATRI S.: Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines. Leukemia 9:1888-1895, 1995.
  8. GRAZIANI G., FARAONI I., GROHMANN U., BIANCHI R., BINAGLIA L., MARGISON G.P., WATSON A.J., ORLANDO L., BONMASSAR E., D'ATRI S.: O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia. Cancer Res. 55:6231-6236, 1995.
  9. TENTORI L., LEONETTI C., LOZUPONE F., BONMASSAR E.: Antitumor and antimetastatic effects of Dacarbazine combined with cyclophosphamide and IL-2 in Lewis Lung Carcinoma (3LL). Cancer Immunol. Immunother. 41(6):375-383, 1995.
  10. LACAL P.M., D'ATRI S., ORLANDO L., BONMASSAR E. AND GRAZIANI G.: In vitro inactivation of human O6-alkylguanine DNA alkyltransferase by antitumor triazene compounds. J. Pharmacol. Exper. Ther., In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Chieco Pasquale, Dir. R.
  2. Stecca Barbara A., D.DR.
  3. Suozzi Anna, B.
  4. Pagano Katia, B.
  5. Capri Isabella, B.

AFFILIATION :

Istituto di Oncologia "F. Addarii"

Policlinico S. Orsola- Malpighi - Bologna

ADDRESS : Viale Ercolani 4/2

CITY: Bologna

POSTAL CODE: 40138

TELEPHONE: 051/6363312

FAX : 051/397244

E-MAIL : set3264@iperbole.bologna.it

PUBLICATIONS :

  1. CHIECO P., JONKER A., MELCHIORRI C., VANNI G., VAN NOORDEN C.J.F. A user's guide for avoiding errors in absorbance image cytometry : a review with original experimental observations. Histochem. J. 26 : 1-19, 1994.
  2. TRERE' D., MELCHIORRI C., CHIECO P., MARABINI A., DERENZINI M. Interphase AgNOR quantity and DNA content in endometrial adenocarcinoma. Gynecol. Oncol. 52 : 202-207, 1994.
  3. DERENZINI M., TRERE' D., CHIECO P., MELCHIORRI C. Interphase AgNOR quantity is not related to DNA content in 11 established human cancer cell lines. Exp. Cell Res. 211 : 282-285, 1994.
  4. MELCHIORRI C., BOLONDI L., CHIECO P., PAGNONI M., GRAMANTIERI L., BARBARA L. Diagnostic and prognostic value of DNA ploidy and cell nuclearity in ultrasound-guided liver biopsy specimens. Cancer 74 : 1713-1719, 1994.
  5. CHIECO P., STECCA B., BOLONDI L., MELCHIORRI C., GAIANI S., BARBARA L. Cytochemical detection of a class 3 aldehyde dehydrogenase in human hepatocellular carcinoma. Liver 15 : 87-92, 1995.
  6. CECCARELLI C., SANTINI D., CHIECO P., TUFFARELLI M., MARRANO D., MANCINI A.M. Multiple expression patterns of biopathological markers in primary invasive breast carcinoma : A useful tool for elucidating its biological behaviour. Ann. Oncol. 6 : 275-282, 1995.
  7. FACCIOLI S., CHIECO P., GRAMANTIERI L., STECCA B.A., BOLONDI L. Cytometric measurement of cell proliferation in echo-guided biopsies from focal lesions of the liver. Mod. Pathol. 9 : 120-125, 1996.
  8. BOLONDI L., GRAMANTIERI L., CHIECO P., MELCHIORRI C., TRERE' D., STECCA B., DERENZINI M., BARBARA L. Enzymatic cytochemistry, DNA ploidy and AgNOR quantitation in hepatocellular nodules of uncertain malignant potential in liver cirrhosis. Digest. Dis. Sci. 41 : 800-808, 1996.

RESEARCH GROUP MEMBERS:

  1. D'Alessandro Natale, P.O.
  2. Flugy Papè Anna Maria, R.U.
  3. Crescimanno Marilena, T.L.
  4. Flandina Carla, T.L.
  5. Borsellino Nicolò, B.
  6. Leonardi Vita, B.

AFFILIATION :

Cattedra di Farmacologia CLOPD

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università di Palermo

ADDRESS: Policlinico P. Giaccone, Via del Vespro 129

CITY: Palermo

POSTAL CODE: 90127

TELEPHONE: 091-6553258

FAX: 091-6553249

E-MAIL: nadales@mbox.vol.it

PUBLICATIONS:

  1. N. BORSELLINO, M. CRESCIMANNO, C. FLANDINA, V. LEONARDI, L. RAUSA, N. D'ALESSANDRO. Antiproliferative and chemomodulatory effects of interferon-gamma on doxorubicin-sensitive and -resistant tumour cell lines. Anti-Cancer Drugs 4: 265-272, 1993.
  2. V. LEONARDI, N. BORSELLINO, M. CRESCIMANNO, C. FLANDINA, A. FLUGY, N. D'ALESSANDRO. Combinative growth inhibitory effects of interferon-alpha on multidrug resistant tumor cell lines. Oncology Reports 1: 161-164, 1994.
  3. N. BORSELLINO, M. CRESCIMANNO, V. LEONARDI, N. D'ALESSANDRO. Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug resistant tumour cell lines. Pharmacol. Res. 30: 81-90, 1994.
  4. M. CRESCIMANNO, N. BORSELLINO, V. LEONARDI, C. FLANDINA, A. FLUGY, L. RAUSA, N. D'ALESSANDRO. Effect of buthionine sulfoximine on the sensitivity to doxorubicin of parent and MDR tumor cell lines. J. Chemother. 6: 343-348, 1994.
  5. N. BORSELLINO, M. CRESCIMANNO, C. FLANDINA, A. FLUGY, N. D'ALESSANDRO. Combined activity of Interleukin-1alpha or TNF- alpha and doxorubicin on multidrug resistant cell lines: evidence that TNF and DXR have synergistic antitumor and differentiation-inducing effects. Anticancer Res. 14: 2643-2648, 1994.
  6. A. FLUGY, N. BORSELLINO, N. D'ALESSANDRO. TNF-induced apoptosis in multidrug resistant Friend erythroleukemia is not influenced by the P-glycoprotein and glutathione status of the cell line. Oncol. Res. 7: 559-564, 1995.
  7. N. BORSELLINO, A. BELLDEGRUN, B. BONAVIDA. Endogenous Interleukin 6 is a resistance factor for cisiamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Cancer Res. 55: 4633-4639, 1995.
  8. N. D'ALESSANDRO, N. BORSELLINO. In vivo effects of tumor necrosis factor-alpha or flavone acetic acid in combination with doxorubicin on multidrug-resistant B16 melanoma. Anti-Cancer Drugs 7: 281-287, 1996.
  9. C. FLANDINA, A. FLUGY, N. BORSELLINO, N. D'ALESSANDRO. Development and partial characterization of a human T-lymphoblastic leukaemic (CCRF-CEM) cell line resistant to etoposide. Analysis of possible circumventing approaches. J. Chemother. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Esposito Mauro, Dir.R.
  2. Viale Maurizio, A.L.
  3. Vannozzi Maria Ornella, A.L.
  4. Pellecchia Caterina, T.
  5. Tolino Giuseppina, Contrattista

AFFILIATION:

Sezione di Farmacologia Tossicologica

Dipartimento di Oncologia Preclinica

Istituto Nazionale per la Ricerca sul Cancro (IST)

ADDRESS: Largo Rosanna Benzi, 10

CITY: Genova

POSTAL CODE: 16132

TELEPHONE: 010-5600-660, 923, 936, 523

FAX: 010-5600-659, 501

E-MAIL: esposito@hp380.ist.unige.it

PUBLICATIONS:

  1. ESPOSITO, M., VANNOZZI, M.O., VIALE, M., FULCO, R.A., COLLECCHI, P., MERLO, F., DECIAN, F., ZICCA, A., CADONI, A., AND POIRIER, M.C. Para-aminobenzoic acid suppression of cis-diamminedichloroplatinum(II) nephrotoxicity. Carcinogenesis. 12: 2595-2599, 1993.
  2. RATTO, G.B., ESPOSITO, M., LEPRINI, A., CIVALLERI, D., DECIAN, F., VANNOZZI, M.O., ROMANO, P., CANEPA, M., AND ZACCHEO, D. "In situ" lung perfusion with cisplatin: an experimental study. Cancer. 71: 2962-2970, 1993.
  3. LERZA, R., ESPOSITO, M., VANNOZZI, M., BOTTINO, G.B., BOGLIOLO, G, AND PANNACCIULLI, I. High doses of intrapleural cisplatin in a case of malignant pleural mesothelioma: clinical observations and pharmacokinetic analyses. Cancer. 73: 79-84, 1994.
  4. VIALE, M., MELIOLI, G., PASQUETTI, W., META, M., CAFAGGI, S., AND ESPOSITO, M. Modifications of cell cycle induced by DPR, a new platinum-triamine complex containing procaine. Int. J. Oncol. 4: 1047-1051, 1994.
  5. VIALE, M., CAFAGGI, S., PARODI, B., AND ESPOSITO, M. Cytotoxicity and cellular accumulation of a new cis-diammineplatinum(II) complex containing procaine in murine L1210 cells sensitive and resistant to cis-diamminedichloroplatinum(II). Cancer Chemother. Pharmacol. 35: 371-376, 1995.
  6. PARODI, B., ESPOSITO, M., VIALE, M., CAFAGGI, S., AND VANNOZZI, M. Chemical and biological properties of a new cis-diammineplatinum(II) complex containing para-aminobenzoic acid as amino ligand. Anticancer Res. 15: 895-899, 1995.
  7. ESPOSITO, M., VANNOZZI, M., VIALE, M., PELLECCHIA, C., CIVALLERI, D., AND GOGIOSO L. Effect of para-aminobenzoic acid on the pharmacokinetics and urinary excretion of cis-diamminedichloroplatinum(II) in rats. Anticancer Res. 15: 2541-2548, 1995.
  8. ZHANG, J.G., ESPOSITO, M., CAFAGGI, S., AND LINDUP, W.E. Comparison of the toxicities of cisplatin and a new cisplatin-procaine complex to rat renal cortical slices. Hum. Exp. Toxicol. 15: 59-63, 1996.
  9. ESPOSITO, M., VIALE, M., VANNOZZI, M.O., ZICCA, A., AND GOGIOSO, L. Effect of antiarrhytmic drug procainamide on the toxicity and antitumor activity of cisplatin. Toxicol. Appl. Pharmacol. 140, In press, 1996.
  10. VANNOZZI, M.O., NOBILE, M.T., SANGUINETI, O., BARZACCHI, C., VIALE, M., NUMICO, G., AND ESPOSITO, M. Pharmacokinetics of (6S)-Leucovorin and 5-Methyltetrahydrofolate after 4-hour continuous intravenous infusion followed by repeated oral doses of (6S)-Leucovorin in patients with colorectal cancer treated with 5-fluorouracil. Clin. Drug Invest.. 12: 39-45, 1996.

RESEARCH GROUP MEMBERS :

  1. Favoni Roberto E., Dir. R.
  2. de Cupis Alessandra, B.
  3. Pirani Paolo, T.
  4. Caci Emanuela, S.I.
  5. Ferrera Alessandra, Biotecnologo

AFFILIATION :

Dipartimento di Oncologia Preclinica

Laboratorio di Farmacologia Sperimentale

Istituto Nazionale per la Ricerca sul Cancro

ADDRESS : Largo Rosanna Benzi, 10

CITY : Genova

POSTAL CODE: 16132

TELEPHONE: 010-5600-931,932

FAX : 010-355503

PUBLICATIONS :

  1. RAVERA F., MIGLIETTA L., PIRANI P., FAVONI R.E. Suramin- induced growth inhibition and IGF-I binding blockade on human breast carcinoma cell lines : potentially realted events. Eur. J. Cancer, 29A : 225-230, 1993.
  2. FAVONI R.E., DE CUPIS A., RAVERA F., CANTONI C., PIRANI P., ARDIZZONI A., NOONAN D., AND BIASSONI R. Expression and function of the insulin-like growth factor-I system in human non-small-cell lung cancer and normal lung cell lines. Int. J. Cancer, 56 : 858-866, 1994.
  3. FAVONI R.E., RAVERA F., PIRANI P., ARDIZZONI A., NOONAN D., DE CUPIS A. Suramin interferes with auto/paracrine insulin-like growth factor-I-controlled proliferative loop on human lung cancer cell lines. Eur. J. Pharmacol. 264 : 199-206, 1994.
  4. FAVONI R.E., SFORZINI S., AMOROSO D., DE CUPIS A., PENSA F., PERROTTA A., MIGLIETTA L. IGF-I and IGF-binding proteins blood serum levels in women with early- and late stage- breast cancer : mutual relationship and possible correlation with patients hormonal status. J. Cancer Res. Clin. Oncol. 121 : 674-682, 1995.
  5. DE CUPIS A., NOONAN D., PIRANI P., FERRERA A., CLERICO L., FAVONI R.E. Comparison between novel steroidal-like and conventional nonsteroidal antiestrogens in inhibiting oestradiol- and IGF-I-induced proliferation of human breast cancer-derived cells. Brit. J. Pharmacol. 116 : 2391-2400, 1995.

RESEARCH GROUP MEMBERS:

  1. Mazzanti Gabriela, P.A.
  2. Piccinelli Dario, P.O.
  3. Braghiroli Laura, B.PDR.
  4. Cometa Francesca, D.DR.

AFFILIATION :

Istituto di Farmacologia e Farmacognosia

Facoltà di Farmacia

Università di Roma 'La Sapienza'

ADDRESS: P.le Aldo Moro, 5

CITY: Roma

POSTAL CODE: 00185

TELEPHONE: 06-49912903

FAX: 06-49912480

E-MAIL: mazzanti@axrma.uniroma1.it

PUBLICATIONS :

  1. SEVERINI, C., TITA, B. AND BOLLE, P. Pumiliotoxin B-like alkaloid in extracts of the skin of the australian myobatrachid frog Pseudophryne coriacea: effects on blood pressure and heart of the rabbit. Arch. Int. Pharmacodyn. Ther., 317: 56-66, 1992
  2. MAZZANTI, G., AND BRAGHIROLI, L. Anti-inflammatory action of Pfaffia paniculata (Martius) Kuntze. Phytother. Res. 8: 413-6, 1994.
  3. BONSI, P., PALMERY, M., AND AUGUSTI-TOCCO, G. Aflatoxin B1 cytotoxicity on neurons in culture. Atla., 24: 533-40, 1996.
  4. BRAGHIROLI , L., MANGANARO, M., MASCELLINO, M.T., MAZZANTI, G. AND VESPERTILLI, T. Antimicrobial activity of Calluna Vulgaris. Phytother. Res. 10 : In press, 1996.
  5. COMETA, M.F., GALEFFI, C. AND PALMERY, M. Acute effect of alkaloids from Hydrastis canadensis L. on guinea-pig ileum: structure activity relationships. Phytother. Res. 10 : In press, 1996.
  6. MAZZANTI, G., BRAGHIROLI, L., BOLLE, P., SAIJA, A. AND SASO, L. Effects of Panax ginseng and Ginkgo biloba on in vitro prolactin sectretion. Phytother. Res. 10 : In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Pagnini Giuseppe, P.O.
  2. Florio Salvatore, R.U.
  3. Filosa Stefania, B. PDR.
  4. Crispino Antonio, C.L.

AFFILIATION :

Sezione di Farmacologia, Dipartimento di Strutture, Funzioni e Tecnologie Biologiche

Facoltà di Medicina Veterinaria

Università Federico II

ADDRESS: Via Veterinaria, 1

CITY: Napoli

POSTAL CODE: 80137

TELEPHONE: 081-290665

FAX: 081-440120

PUBLICATIONS:

  1. PAGNINI D., PAINO G., FLORIO S., PACILIO G., IODICE G., SCALA G., PAGNINI U. Influence of thymic factors on the transplacental cis-platinum toxicity in rats. Acta Med. Vet. 39: 137-144, 1993.
  2. AVALLONE L, LOMBARDI P., FLORIO S., CRISPINO A., POTENA M.I.,TORTORA G., VOLPE P., ROMANELLI G., PAPPARELLA S. Steroid receptors distribution in canine mammary tumour. Acta Med. Vet. 40: 105-112, 1994.
  3. SEVERINO L., FLORIO S., DONATO A. Influence of Fenclor 64 on the product of conception and on some parameters correlated to the reproductive function of the rat. Acta Toxicol. Ther. 15 : 181-193, 1994.
  4. PAGNINI G., FLORIO S., PAGNINI U., CRISPINO A. Effect of cis-diamminedichloroplatinum (II) on thymocyte membrane potential of the rat. J. Chemother. 8: 147-153, 1996.
  5. FLORIO S., PAGNINI D., CRISPINO A., AVALLONE L., LOMBARDI P., ZUCCARO S., LANNI P., PELAGALLI A. Preliminary observations on the interference of antiblastic agents on membrane fluidity and potential in leukocytes. J. Chemother. 8: 55-58, 1996.
  6. DI CARLO R., MELI R. , FLORIO S. , MATTACE RASO G. , GUALILLO O. , PAGNINI G. The effect of age and sex on the expression of prolactin binding activity in the chicken Bursa of Fabricius. Life Sci. In press, 1996
  7. AVALLONE L., LOMBARDI P., FLORIO S., D'ANGELO D., BOGIN E. Age-dependent variations of lactic dehydrogenase and creatine kinase activities in water buffalo calves serum. Eur. J. Clin. Chem. Clin Biochem., In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Pezza Barzi Anna Maria, P.A.
  2. Rufini Stefano, P.A.
  3. Nocentini Giuseppe, B.
  4. Flaviani Miriam, B.

AFFILIATION :

Sezione di Farmacologia, Tossicologia e Chemioterapia

Dipartimento di Medicina Clinica, Patologia e Farmacologia

Facoltà di Medicina e Chirurgia

Università di Perugia

ADDRESS : Via del Giochetto

CITY : Perugia

POSTAL CODE : 06100

TELEPHONE: 075-585-3470, 3474, 3593, 3467

FAX: 075-585-3405

E-MAIL : farmaco@teseo.unipg.it

PUBLICATIONS :

  1. NOCENTINI G., FEDERICI F., FRANCHETTI P., BARZI A. 2,2'-Bipyridyl-6-carbothioamide and its ferrous complex : their in vitro antitumoral activity related to the inhibition of ribonucleotide reductase R2 subunit. Cancer Res. 53 : 19-26, 1993.
  2. SPOSITO M., SABALICH I., RUFINI S., Importance for evaluating growth hormone defects. Med Surg. Ped. 15 : 67-71, 1993.
  3. SAVINI L., MASSARELLI P., SEGA A., PELLERANO C., BARZI A., NOCENTINI G. Chelating agents as potential antitumorals. 2-Quinoylhydrazones and bis-2-Quinolylhydrazones. Eur. J. Med. Chem. 30 : 547-552, 1995.
  4. NOCENTINI G., AND BARZI A. A predictive screening model for in vitro selection of agents with potential antitumor activity. Arzneim-Forsch Drug Res. 45 : 1306-1311, 1995.
  5. FRANCHETTI P., CAPPELLACCI L., GRIFANTINI M., BARZI A., NOCENTINI G., YANG H., O'CONNOR A., JAYARAM H.N., CARRELL C., GOLDSTEIN B.M. Furanfurin and thiofenfurin : two novel tiazofurin analogues. Synthesis, Structure, Antitumor activity and interactions with inosine monophosphate deydrogenase. J. Med. Chem. 38 : 3829-3837, 1995.
  6. NOCENTINI G., AND BARZI A. . 2,2'-Bipyridyl-6-carbothioamide copper (II) complex differs from the iron leading to cytotoxicity. Biochem. Pharmacol. 52 : 65-71, 1996.
  7. NOCENTINI G. Ribonucleotide reductase inhibitors : new strategies for cancer chemotherapy. Critical Rev. in Oncol/Hematol. 22 : 89-126, 1996.
  8. SPOSITO M., RUFINI G. Serum IGPB3 levels in GHD children after rGH therapy. Ped. Med. Chir. 17 : 41-44, 1995.

RESEARCH GROUP MEMBERS:

  1. Piccinini Francesco, P.O.
  2. Monti Elena, R.U.
  3. Maria Bonfà, T.L.
  4. Luisa Paracchini, T.L.
  5. Gianpaolo Perletti, T.L.
  6. Marzia Gariboldi, T.L.

AFFILIATION:

Sezione di Farmacologia Applicata, Istituto di Farmacologia

Facoltà di Scienze Matematiche, Fisiche e Naturali

Università degli Studi di Milano

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-7010-0131, 0391

FAX: 02-7000-2270

E-MAIL: pharmapp@imiucca.csi.unimi.it

PUBLICATIONS:

  1. MONTI, E., MIMNAUGH, E.G., AND SINHA, B.K. Synergistic antiproliferative action of etoposide and interleukin-1 is not due to DNA damage in human melanoma cells. Biochim. Biophys. Acta 1180: 231-235, 1993.
  2. LA PORTA, C., PERLETTI, G., PICCININI, F., AND COMOLLI, R. Analysis of calcium dependent protein kinase C isoforms in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis. Mol. Carcinogenesis 8: 255-263, 1993.
  3. BRADAMANTE, S., JOTTI, A., PARACCHINI, L., AND MONTI, E. The hydrophilic spin trap 5,5-dimethyl-1 pyrroline-1-oxide (DMPO) does not protect the rat heart from reperfusion injury. Eur. J. Pharmacol. 234: 113-116, 1993.
  4. MONTI, E., MIMNAUGH, E.G., AND SINHA, B.K. Synergistic antiproliferative effects of interleukin-1 and doxorubicin on a human ovarian carcinoma cell line (NIH:OVCAR-3) do not involve interleukin-1a receptor modulation. Biochem. Pharmacol. 45: 2099-2107, 1993.
  5. JOTTI, A., MAIORINO, M., PARACCHINI, L., PICCININI, F., AND URSINI, F. Protective effect of dietary selenium supplementation on delayed cardiotoxicity of adriamycin in rat: is PHGPX but not GPX involved? Free Radical Biology & Medicine 16: 283-288, 1994.
  6. TESSITORE, L., PERLETTI, G., SESCA, E., PANI, P., DIANZANI, M.U. AND PICCININI, F. Protein Kinase C isoenzyme pattern in liver hyperplasia. Biochem. Biophys. Res. Comm. 205: 208-214, 1994.
  7. BRADAMANTE, S., PICCININI, F., DELU', C., HUITZER, T., AND DE JONG JW. Changes in phosphorylation potential and purine release durihng recurrent ischemia. Biochim. Biophys. Acta 1243: 1-8, 1995.
  8. PERLETTI, G., FOLINI, M., LIN, H., MISCHAK, H., PICCININI, F., AND TASHJIAN, A.H. Jr. Overexpression of Protein Kinase C epsilon is oncogenic in rat colonic epithelial cells. Oncogene 12: 847-854, 1996.
  9. PERLETTI, G., TESSITORE, L., SESCA, E., PANI, P., DIANZANI, M.U., PICCININI, F. PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture. Biochem. Biophys. Res. Comm. 221: 688-691, 1995.
  10. MONTI, E., COVA, D., GUIDO, E., MORELLI, R., AND OLIVA, C. Protective effect of the nitroxide TEMPOL against the cardiotoxicity of adriamycin. Free Radical Biology & Medicine, 21: 463-470, 1996.

RESEARCH GROUP MEMBERS:

  1. Sanguedolce Rosario, P.A.
  2. Vultaggio Giuseppe, B.
  3. Randazzo Giuseppe, B.
  4. Gancitano Rosalba, D.DR.
  5. Porretto Ferdinando, D.DR.

AFFILIATION :

Istituto di Farmacologia

Policlinico Palermo

ADDRESS: via del Vespro 120

CITY: Palermo

POSTAL CODE: 90127

TELEPHONE: 091, 6553273

FAX: 091, 6553249

E-MAIL: farmapa@mbox.vol.it

PUBLICATIONS:

  1. R. SANGUEDOLCE, C. FLANDINA, T. CUCCHIARA,F. VARVARA E L. RAUSA. Morphological changes in the hearths of CD1 mice following chronic treatment with Doxorubicin and Lonidamine.. Res Comm in Chem Path and Pharm. 82 :81-89, 1993.
  2. R. SANGUEDOLCE, I. BRUMARESCU, G. DARDANONI, A. GRASSADONIA, G. VULTAGGIO AND L. RAUSA. Thymidylate synthase level and DNA-ploidy pattern as possible prognostic factors in human colorectal cancer: a preliminary study. Anticancer Res. 15 : 1800-1801, 1995.
  3. R. SANGUEDOLCE, G. VULTAGGIO, G. DARDANONI, A. GRASSADONIA, F. SANGUEDOLCE, G. DI GIOVANNI E L. RAUSA. Valore prognostico dei livelli di timidilato sintetasi in pazienti con carcinoma colo-rettale. Giornale italiano di Chemioterapia, 42 : 23-30, 1995.

RESEARCH GROUP MEMBERS :

  1. Sava Gianni, P.A.
  2. Pacor Sabrina, B.PDR.
  3. Gagliardi Renato, C.L.
  4. Cocchietto Moreno, R.I.
  5. Bergamo Alberta, B.
  6. Capozzi Ilaria, B.
  7. Clerici Katiuscia, B.
  8. Giovanni Salerno, B.

AFFILIATION:

Sezione di Farmacologia

Dipartimento di Scienze Biomediche

Università degli Studi di Trieste

ADDRESS: Via L. Giorgieri, 7

CITY: Trieste

POSTAL CODE: 34127

TELEPHONE: 040-676-3541

FAX: 040-577435

E-MAIL: gsava@fc.univ.trieste.it

PUBLICATIONS:

  1. SAVA, G., PACOR, S., VRANESIC, B., AND TOMASIC, J., COCCHIETTO M. Modification of the growth of MCa mammary carcinoma of CBA mouse by new adamantylpeptides. Int. J. Oncol.. 2: 607-612, 1993.
  2. COLUCCIA, M., SAVA, G., LOSETO, F., NASSI, A., BOCCARELLI, A., GIORDANO, D., ALESSIO, E., AND MESTRONI G. Anti-leukaemic action of RuCl2(DMSO)4 isomers and prevention of brain involvement on P388 leukaemia and on P388/DDP subline. Eur. J. Cancer. 29A: 1873-1879, 1993.
  3. PACOR, S., FRANZ, C., GAGLIARDI, R., AND SAVA G. Lysozyme induced recovery of the response to ConA on mononuclear cells harvested from mice bearing MCa mammary carcinoma. Int. J. Oncology. 4: 877-883, 1994.
  4. GAGLIARDI, R., SAVA, G., PACOR, S., MESTRONI, G., AND ALESSIO E. Antimetastatic action and toxicity on healthy tissues of Na[trans-RuCl4(DMSO)Im] in the mouse. Clin. Exp. Metastasis. 12: 93-100, 1994.
  5. DASIC, G., PACOR, S., BERGAMO, A., SALERNO, G., VRANESIC, B., JUKIC., R, TOMASIC., J, AND SAVA G. Effects of L-(adamant-2-yl)glycyl-L-alanyl-D-isoglutamine on the antitumor action of cyclophosphamide, 5-FU, cisplatin and dacarbazine on advanced carcinomas of the mouse. Int. J. Oncology. 5: 275-284, 1994.
  6. SAVA, G., PACOR, S., COLUCCIA, M., MARIGGIO', M., COCCHIETTO, M., ALESSIO, E., AND MESTRONI G. Response of MCa mammary carcinoma to cisplatin and to Na[trans-RuCl4(DMSO)Im]. Selective inhibition of spontaneous lung metastases by the ruthenium complex. Drug Invest. 8: 150-161, 1994.
  7. SAVA, G., PACOR, S., BERGAMO, A., COCCHIETTO, M., MESTRONI, G., AND ALESSIO E. Effects of ruthenium complexes on experimental tumors: irrelevance of cytotoxicity for metastasis inhibition. Chem.-Biol. Interact. 95: 109-126, 1995.
  8. SAVA, G., PACOR, S., DASIC, G., AND BERGAMO A. Lysozyme stimulates lymphocyte response to ConA and IL-2 and potentiates 5-fluorouracil action on advanced carcinomas. Anticancer Res. 15: 1883-1888, 1995.
  9. PACOR, S., GIACOMELLO, E., BERGAMO, A., GAGLIARDI, R., COCCHIETTO, M., AND SAVA G. Cytofluorimetric analysis of gut-intraepitelial and mesenteric lymph node lymphocytes of tumour bearing mice fed with egg-white lysozyme. Anticancer Res. 16: 145-150, 1996.
  10. SAVA, G., SALERNO, G., BERGAMO, A., COCCHIETTO, M., GAGLIARDI, R., ALESSIO, E., AND MESTRONI G. Reduction of lung metastases by Na[trans-RuCl4(DMSO)Im] is not coupled with the induction of chemical xenogenization. Metal Based Drugs. 3: 67-73, 1996.

RESEARCH GROUP MEMBERS:

  1. Viano Ilario, P.O.
  2. Brunelleschi Sandra, R.U.
  3. Guidotto Stefania, D.DR.
  4. Colangelo Donato, B.PDR.
  5. Tommasino Enrica, B.

AFFILIATION :

Dipartimento di Scienze Mediche

II Facoltà di Medicina

Università di Torino

ADDRESS: Via Solaroli, 17

CITY: Novara

POSTAL CODE: 28100

TELEPHONE: 0321- 660- 648, 600, 601.

FAX: 0321- 620421

E-MAIL: viano@no.unipmn.it

PUBLICATIONS:

  1. DA COL, R., SILVESTRO, L., BAIOCCHI, C., GIACOSA, D. AND VIANO I. High-performance liquid chromatography-mass spectrometric analysis of cis-dichlorodiamine platinum-DNA complexes using a ion spray interface. J. Chromatogr. 633: 119-128, 1993.
  2. DA COL, R., SILVESTRO, L., NAGGI, A., TORRI, G., BAIOCCHI, C., MOLTRASIO, D., CEDRO, A. AND VIANO I. Characterization of the chemical structure of sulphated glycosaminoglycans after enzymatic digestion. Application of liquid chromatography-mass spectrometry with an atmospheric pressure interface. J. Chromatogr. 647:289-300, 1993.
  3. DIANZANI, C., BRUNELLESCHI, S., VIANO, I. AND FANTOZZI, R.. Adenosine modulation of primed human neutrophils. Eur. J. Pharmacol. 263:223-226, 1994.
  4. SILVESTRO, L., SANFILIPPO, O., ZAFFARONI, N., DA COL, R., LA SALA, L., MERLACH, P., VIANO, I. AND SILVESTRINI, R. In vitro modulation of cisplatin activity by interferon-beta on the K562 leukemia cell line. Cell. Pharmacology 1:73-76, 1994.
  5. DIANZANI, C., COLANGELO, D., TONSO, E., GUIDOTTO, S. AND VIANO, I. In vivo antiviral effect of Pidotimod. Arzneim-Forsch Drug Res. 44:1431-1433, 1994.
  6. BRUNELLESCHI, S., GUIDOTTO, S., TONSO, E., VIANO, I. AND FANTOZZI, R. Modulation by protein Kinase C (PKC) of the enhanced responsiveness to tachychinins in ovalbumin sensitized guinea pig macrophages. Neuropeptides 30:249-260, 1996.
  7. BRUNELLESCHI, S., GUIDOTTO, S., VIANO, I., FANTOZZI, R., POZZI, E., GHIO, P., AND ALBERA C.Tachykinin activation of human alveolar macrophages in tobacco smoke and sarcoidosis: a phenotypical and functional study. Neuropeptides 30: In press, 1996.

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