SIF - Societą Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

 

PHARMACOLOGY OF THE
CENTRAL NERVOUS SYSTEM II

 

RESEARCH GROUP MEMBERS:

  1. Corradetti Renato, P.A.
  2. Pugliese Anna Maria, B.PDR.
  3. Passani Maria Beatrice, B.PDR.

 

AFFILIATION:

Dipartimento di Farmacologia Preclinica e Clinica

"Mario Aiazzi-Mancini"

Facoltą di Medicina e Chirurgia

Universitą di Firenze

ADDRESS: Viale G.B. Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237-411, 429, 455

FAX: 055-4361-613

E-MAIL: neuroef@stat.ds.unifi.it

PUBLICATIONS:

  1. PASSANI, M.B., PUGLIESE, A.M., AZZURRINI, M. AND CORRADETTI, R. Effects of DAU 6215, a novel 5-hydroxytryptamine3 (5-HT3) antagonist on electrophysiological properties of the rat hippocampus. Brit. J. Pharmacol. 112: 695-703, 1994.
  2. BALLERINI, L., CORRADETTI, R., NISTRI, A., PUGLIESE, A.M. AND STOCCA, G. Electrophysiological interactions between 5-hydroxytryptamine and thyrotropin releasing hormone on rat hippocampal CA1 neurons. Eur. J. Neurosci. 6: 953-960, 1994.
  3. PUGLIESE, A.M., BALLERINI, L., PASSANI, M.B. AND CORRADETTI, R. EPSP-Spike potentiation during primed burst-induced long-term potentiation in the CA1 region of rat hippocampal slices. Neuroscience 62: 1021-1032, 1994.
  4. FLETCHER, A., FORSTER, E.A., BILL, D.J., BROWN, G., CLIFFE, I.A., HARTLEY, J.E., JONES, D.E., MCLENACHAN, A., STANHOPE, K.J., CRITCHLEY, D.J.P., CHILDS, K.J., MIDDLEFELL, V.C., LANFUMEY, L., CORRADETTI, R., LAPORTE, A.M., GOZLAN, H., HAMON, M., DOURISH, C. Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective, and silent 5-HT1A receptor antagonist. Behav. Brain Res. 73: 337-353, 1995.
  5. PASSANI, B.M. AND CORRADETTI, R. Therapeutic potentials of DAU 6215 (Itasetron), a novel 5-HT3 receptor antagonist, in the treatment of central nervous disorders. CNS Drug Reviews 2: 195-213, 1996.
  6. CORRADETTI, R., LE POUL, E., LAARIS, N., HAMON, M. AND LANFUMEY, L. Electrophysiological effects of WAY 100635 (N-(2-(-4(2metoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cycloexane carboxamide) on dorsal raphe serotoninergic neurones and CA hippocampal pyramidal cells in vitro. J. Pharmacol. Exp. Ther. 278: 679-688. 1996.
  7. PUGLIESE, A.M. AND CORRADETTI, R. Effects of the antiepileptic drug felbamate on long-term potentiation in the CA1 region of rat hippocampal slices. Neurosci. Lett. 215: 21-24, 1996.
  8. PUGLIESE, A.M., PASSANI, M.B., PEPEU, G. AND CORRADETTI, R. Felbamate decreases synaptic potentials and CA1 pyramidal cells in rat hippocampal slices. J. Pharmacol. Exp. Ther. 279: In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Corsini Giovanni Umberto, P.O.
  2. Vaglini Francesca,T.L.
  3. Maggio Roberto, R.U.
  4. Fornai Francesco, C.L.

 

AFFILIATION:

Istituto di Farmacologia

Facoltą di Medicina e Chirurgia

Universitą degli Studi di Pisa

ADDRESS: Via Roma, 55

CITY: Pisa

POSTAL CODE: 56100

TELEPHONE: 050-560109,560509

FAX: 050-551434

E-MAIL: gcorsini@drugs.med.unipi.it   r.maggio@drugs.med.unipi.it

PUBLICATIONS:

  1. VAGLINI F., FASCETTI F., FORNAI F., MAGGIO R. AND CORSINI G.U. (+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice. Brain Res. 668:194-203, 1994.
  2. FORNAI F., DYBDAL D.J., PROCTOR M.R., GALE K. Focal intracerebral elevation of L-lactate is anticonvulsivant. Eur. J. Pharmacol. 254 : R1-R2, 1994.
  3. BARBIER P., RENZETTI A.R., TURBANTI L., DI BUGNO C., FORNAI F., VAGLINI F., MAGGIO R. AND CORSINI G.U. Stereoselective inhibition of muscarinic receptor subtypes by the stereoisomers related to rociverine. Eur. J. Pharmacol.290:125-132, 1995.
  4. FORNAI F., ALESSANDRI' M.G., FASCETTI F., VAGLINI F. AND CORSINI G.U. Clonidine Suppresses 1-Methyl-4-Phenyl-1,2,3,6-Tethrahydropyridine-Induced Reductions of Striatal Dopamine and Tyrosine Hydroxylase Activity in Mice. J. Neurochem. 65: 704-709, 1995.
  5. FORNAI F., BASSI L., TORRACCA M.T., SCALORI V. AND CORSINI G.U. Norepinephrine loss exacerbates methamphetamine-induced striatal dopamine depletion in mice. Eur. J. Pharmacol. 283: 99-102 1995.
  6. MAGGIOR., BARBIER P., TOSO A., BARLETTA D. AND CORSINI G.U. Sodium nitroprusside induces internalizazion of muscarinic receptors stably expressed in cho cell line. J. Neurochem. 65: 943-946, 1995.
  7. VAGLINI F., PARDINI C., MAGGIO R. AND CORSINI G.U. Role of excitatory amino-acids in diethyldithiocarbamate-induced cell death in mesencephalic cultures. Brain Res. 674: 127-132, 1995.
  8. VAGLINI F., FASCETTI F. ,TEDESCHI D., CAVALLETTI M., FORNAI F. AND CORSINI G.U. Striatal MPTP levels do not necessarily correlate with striatal DA levels after different combined treatments in mice. Neurodegeneration 5:129-136 1996.
  9. FORNAI F., VAGLINI F., MAGGIO R., BONUCCELLI U. AND CORSINI G.U. Excitatory aminoacids and MPTP toxicity Adv. Neurol. 69:167-176, 1996.
  10. MAGGIO R., BARBIER P., FORNAI F. AND CORSINI G.U. Functional role of the third cytoplasmatic loop in muscarinic receptor dimerization. J. Biol. Chem. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Cuomo Vincenzo, P.O.
  2. Cagiano Raffaele, P.A.
  3. Cortese Ida, P.A.
  4. Renna Giuseppe, P.A.
  5. Siro Brigiani Giovanni, P.A.
  6. Carratł Maria Rosaria, R.U.
  7. Giustino Arcangela, R.U.
  8. Trabace Luigia, R.U.
  9. De Salvia Maria A., T.L.
  10. Di Giovanni Vincenzo, T.L.

AFFILIATION:

Istituto di Farmacologia

Facoltą di Medicina e Chirurgia

Universitą di Bari

ADDRESS: Policlinico, Piazza Giulio Cesare

CITY: Bari

POSTAL CODE: 70124

TELEPHONE: 080/5478448 - 5478439

FAX: 080/5478444

E-MAIL: cuomo@cimedoc.uniba.it

PUBLICATIONS:

  1. CARRATU' M.R., RENNA G., GIUSTINO A., DE SALVIA M.A. AND V. CUOMO, Changes in peripheral nervous system activity produced in rats by prenatal exposure to carbon monoxide, Arch. Toxicol., 67 : 297-301, 1993.
  2. DI GIOVANNI V., CAGIANO R., DE SALVIA M.A., GIUSTINO A., LACOMBA C., RENNA G. AND V. CUOMO, Neurobehavioral changes produced in rats by prenatal exposure to carbon monoxide, Brain Res., 616 : 126-131, 1993.
  3. DI GIOVANNI V., CAGIANO R., CARRATU' M.R., DE SALVIA M.A., GIUSTINO A. AND V. CUOMO, Alteration in the ontogeny of rat pup ultrasonic vocalization produced by prenatal exposure to nitrogen dioxide, Psychopharmacology, 116 : 423-427, 1994.
  4. ROBERTS A.C., DE SALVIA M.A., WILKINSON L.S., COLLINS P. MUIR J.L., EVERITT B.J., ROBBINS T.W., 6- Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine, J. Neurosci., 14 : 2531-2544, 1994.
  5. CARRATU' M.R., LABATE M., DE SANTIS S., GIUSTINO A., DE SALVIA M.A. AND V. CUOMO, Lectin binding pattern of Schwann cells and macrophages in 2,5-hexanedione-induced axonal degeneration in rats, Arch. Toxicol., 69 : 160-164, 1995.
  6. DE SALVIA M.A., CAGIANO R., CARRATU' M.R., DI GIOVANNI V., TRABACE L. AND V. CUOMO, Irreversible impairment of active avoidance behavior in rats prenatally exposed to mild concentration of carbon monoxide, Psychopharmacology, 122 : 66-71, 1995.
  7. STEARDO L., MONTELEONE P., D'ISTRIA M., MAJ M. AND V. CUOMO, (+) N-allylnormetazocine (SKF-10047) enhances N-acetyltransferase activity and melatonin synthesis: preliminary evidence for a functional role of sigma receptors in the rat pineal gland, J. Pharmacol. Exp. Ther., 275 : 845-849, 1995.
  8. POZZI L., TRABACE L., INVERNIZZI R., SAMANIN R., Intranigral GR-113808, a selective 5-HT4 receptor antagonist, attenuates morphine-stimulated dopamine release in the rat striatum, Brain Res., 692 : 265-268, 1995.
  9. GIUSTINO A., BECKETT S., BALLARD T., CUOMO V. AND MARSDEN C.A., Perinatal cocaine reduces responsiveness to cocaine and causes alteration exploratory behavior and visual discrimination in young-adult rats, Brain Res., 728 : 149-156, 1996.
  10. STEARDO L., MONTELEONE P., D'ISTRIA M., SERINO I., MAJ M. AND CUOMO V., Sigma receptor modulation of noradrenergic-stimulated pineal melatonin biosynthesis in rats, J. Neurochem., 67 : 287-293, 1996.

RESEARCH GROUP MEMBERS:

  1. De Caro Giuseppe, P.O.
  2. Massi Maurizio, P.O.
  3. Polidori Carlo, R.U.
  4. Pompei Pierluigi, R.U.
  5. Ciccocioppo Roberto, D.DR.

AFFILIATION :

Dipartimento di Scienze Farmacologiche e Medicina Sperimentale

Facoltą di Farmacia

Universitą di Camerino

ADDRESS: Via Scalzino, 3

CITY: Camerino

POSTAL CODE: 62032

TELEPHONE: 0737-40700, 40701, 40761, 40763, 633242, 632538, 633015

FAX: 0737-630618

E-MAIL: decaro@cambio.unicam.it; massi@cambio.unicam.it; polidori@cambio.unicam.it;

pompei@cambio.unicam.it

PUBLICATIONS:

  1. PANOCKA, I., POMPEI, P., AND MASSI, M. Suppression of alcohol preference in rats following risperidone, a serotonin 5-HT2 and dopamine D2 receptor antagonist. Brain Res. Bull. 31: 595-599, 1993.
  2. PANOCKA, I., CICCOCIOPPO, R., POLIDORI, C., AND MASSI, M. The nucleus accumbens is a site of action for the inhibitory effect of ritanserin on ethanol intake in rats. Pharmacol. Biochem. Behav. 46: 857-862, 1993.
  3. CICCOCIOPPO, R., PANOCKA, I., POMPEI, P., DE CARO, G., AND MASSI, M. Selective agonists at NK3 tachykinin receptors inhibit alcohol intake in Sardinian alcohol-preferring rats. Brain Res. Bull. 33: 71-78, 1994.
  4. CICCOCIOPPO, R., POLIDORI, C., POMPEI, P., DE CARO, G., AND MASSI, M. Inhibition of isotonic sodium chloride intake in the rat by selective tachykinin agonists. Pharmacol. Biochem. Behav. 47: 609-615, 1994.
  5. POLIDORI, C., CICCOCIOPPO, R., EPSTEIN, A.N., DE CARO, G., AND MASSI, M. Effect of tachykinins of the need-free sodium intake of female rats: a continuous intracerebroventricular infusion study. Physiol. Behav. 56: 877-882, 1994.
  6. CICCOCIOPPO, R., PANOCKA, I., STEFANINI, E., GESSA, G.L., AND MASSI, M. Low responsiveness to agents evoking 5-HT2 receptor-mediated behaviours in Sardinian alcohol-preferring rats. Pharmacol. Biochem. Behav. 51: 21-27, 1995.
  7. CICCOCIOPPO, R., PANOCKA, I., POMPEI, P., POLIDORI, C., DE CARO, G., AND MASSI, M. Subcutaneous injections of the tachykinin senktide reduce alcohol intake in alcohol-preferring rats. Peptides 16: 533-537, 1995.
  8. POMPEI, P., RIFTINA, F., AND MCEWEN, B.S. Effect of adrenal steroids on preproneurokinin-A gene expression in discrete regions of the rat brain. Mol. Brain Res. 33:209-216, 1995.
  9. PANOCKA, I., CICCOCIOPPO, R., MOSCA, M., POLIDORI, C., AND MASSI, M. Effects of the dopamine D1 receptor antagonist SCH 39166 on the ingestive behaviour of alcohol-preferring rats. Psychopharmacology 120: 227-235, 1995.
  10. POLIDORI, C., CICCOCIOPPO, R., POMPEI, P., CIRILLO, R., AND MASSI, M. Functional evidence for the ability of angiotensin AT1 receptor antagonists to cross the blood-brain barrier in rats. Eur. J. Pharmacol. 307: 259-267, 1996.

RESEARCH GROUP MEMBERS:

  1. De Carolis Scotti Arsenia, Dir. R.
  2. Sagratella Stefano, 1° R.
  3. Popoli Patrizia, 1° R.
  4. Frank Claudio, R.
  5. Domenici M. Rosaria, B.
  6. Pčzzola Antonella, T.

AFFILIATION:

Laboratorio di Farmacologia

Istituto Superiore di Sanitą

ADDRESS: Viale Regina Elena, 299

CITY: Roma

POSTAL CODE: 00161

TELEPHONE: 06 49902387, 49902482

FAX: 06 49387104

E- MAIL: sagrat@iss.it

PUBLICATIONS:

  1. DOMENICI, M.R., LONGO, R., FRANK, C., SCOTTI DE CAROLIS, A., SAGRATELLA, S. Protective action of 21-aminosteroids and MK 801 on Hypoxia-induced electrophysiological changes in rat hippocampal slices. Eur. J. Pharmacol.. 233:291-293, 1993.
  2. BRONZETTI, E., CAPORALI, M.G., FELICI, L., NIGLIO, T., SCOTTI DE CAROLIS, A., AMENTA, F. Muscarinic cholinoceptor subtypes in the rat frontoparietal cortex after ipsilateral lesions of the nucleus basalis magnocellularis. Pharmacology. 46:301-307, 1993.
  3. SAGRATELLA, S., SCOTTI DE CAROLIS, A., DIANA, G., DOMENICI, M.R., POPOLI, P. Selective reduction of hippocampal dentate frequency-potentiation in striatally-lesioned rats with impaired place learning. Brain Res. 660: 66-77, 1994.
  4. POPOLI, P., PEZZOLA, A., DOMENICI, M.R., SAGRATELLA, S., DIANA, G., CAPORALI, M.G., BRONZETTI, E., VEGA, S., SCOTTI DE CAROLIS, A. Behavioural and electrophysiological correlates of the quinolinic acid model of Huntington's disease in rats. Brain Res. Bull. 35: 329-335, 1994.
  5. FERRÉ, S., POPOLI P., GIMENEZ-LLORT, L., FINNMAN, U.B., MARTINEZ, E., SCOTTI DE CAROLIS, A., FUXE, K. Postsynaptic antagonistic interaction between adenosine A1 and dopamine D1 receptors. Neuroreport. 6: 73-76, 1994.
  6. POPOLI, P., REGGIO, R., PEZZOLA, A., SCOTTI DE CAROLIS, A. The stimulation of cholecystokinin receptors in the rostral nucleus accummbens significantly antagonized the EEG and behavioural effects induced by phencyclidine in rats. Psychopharmacology. 120: 156-161, 1995.
  7. LONGO, R., ZENG, Y.C., SAGRATELLA, S. Opposite modulation of 4-aminopyridine and hypoxic hyperexcitability by A1 and A2 adenosine ligands in rat hippocampal slices. Neurosci. Lett. 200: 21-24, 1995.
  8. FRANK, C., ENGERT, F., TOKUTOMI, N., LUX, H.D. Different effects of baclofen and GTPS on voltage - activated (Ca++ currents in rat hippocampal neurons in vitro. Eur. J. Pharmacol.. 295: 87-92, 1996.
  9. DOMENICI, M.R., SCOTTI DE CAROLIS, A., SAGRATELLA, S., Block by N6-phenyl-isopropil-adenosine of the electrophysiological and morphological correlates of the hippocampal ischemic injury in the gerbil. Brit. J. Pharmacol. 118: 1551-1559, 1996.
  10. POPOLI, P., FERRÉ, S., PEZZOLA, A., REGGIO, R., SCOTTI DE CAROLIS, A., FUXE, K. Stimulation of adenosine A1 receptors prevents the EEG arousal due to dopamine D1 receptor activation in rabbits. Eur. J. Pharmacol. 305: 123-126, 1996.

RESEARCH GROUP MEMBERS:

  1. De Sarro Giovambattista, P.A.
  2. Donato Di Paola Eugenio, R.U.
  3. Rizzo Milena, R.U.
  4. Gratteri Santo, T.L.
  5. Gareri Pietro, B.

 

AFFILIATION:

Sezione di Farmacologia

Dipartimento di Medicina Sperimentale e Clinica

Facoltą di Medicina e Chirurgia di Catanzaro

Universitą di Reggio Calabria

ADDRESS: Via T. Campanella

CITY: Catanzaro

POSTAL CODE: 88100

TELEPHONE: 0961-7123-22, 23, 24

FAX: 0961-774424

E-MAIL: desarro@the brain.net

PUBLICATIONS:

  1. DE SARRO G.B., BAGETTA G., SPAGNOLO C., NISTICO' G. Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine into the deep prepiriform cortex. Neuropharmacol. 32: 43-50, 1993.
  2. DE SARRO G.B., DE SARRO A. Anticonvulsant properties of non-competitive antagonists of NMDA receptor in genetically epilepsy prone rats. Comparison with CPPene. Neuropharmacol. 32: 51-58, 1993.
  3. DE SARRO G.B., DONATO DI PAOLA E., DE SARRO A., VIDAL M.J. L-Arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex. Eur. J. Pharmacol. 230: 151-158, 1993.
  4. DE SARRO A., ZAPPALą M., CHIMIRRI A., GRASSO S., DE SARRO G.B. Quinolones potentiate cefazolin-induced seizures in DBA/2 mice. Antim. Age. Chemother. 37: 1497-1503, 1993.
  5. DE SARRO G.B., ONGINI E., BERTORELLI R., AGUGLIA U., DE SARRO A. Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. Eur. J. Pharmacol. 262: 11-19, 1994.
  6. DE SARRO A., AMMENDOLA D., ZAPPALą M., GRASSO S., DE SARRO G.B. Structure and convulsant properties relationship of some b-lactam derivatives following intracerebroventricular microinjection in rats. Antim. Age. Chemother., 39: 232-237, 1995.
  7. DE SARRO G.B., AMMENDOLA D., NAVA F., DE SARRO A. Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice. Brain Res., 671: 131-140, 1995.
  8. DE SARRO G.B., CHIMIRRI A., DE SARRO A., GITTO R., GRASSO S., GIUSTI P., CHAPMAN A.G. GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice. Eur. J. Pharmacol. 294: 411-422, 1995.
  9. DE SARRO G.B., NAVA F., AGUGLIA U., DE SARRO A. Lamotrigine potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice. Neuropharmacology 35: 153-158, 1996.
  10. DE SARRO G.B., DE SARRO A., AMMENDOLA D, PATEL S. Lack of development of tolerance to anticonvulsant activity of CGP 37849 and CGP 39551 in genetically epilepsy-prone rats. Brain Res. 692: 11-19, 1996.

RESEARCH GROUP MEMBERS:

  1. De Pasquale Anna, P.O.
  2. Saija Antonella, R.U.
  3. Rapisarda Antonio, R.U.
  4. Trombetta Domenico, B.PDR.
  5. Tomaino Antonio, B.

AFFILIATION:

Dipartimento Farmaco-Biologico

Settore di Farmacologia

Facoltą di Farmacia, Universitą di Messina

ADDRESS: Contrada Annunziata

CITY: Messina

POSTAL CODE: 98168

TELEPHONE: 090/358178-6766530

FAX: 090/355703

PUBLICATIONS:

  1. RAPISARDA, A., RAGUSA , S. AND DE PASQUALE, A. Hepatotoxic effect of the leaves of some Cordia species. Acta Horticolturae. 332: 237-42, 1993.
  2. SAIJA, A., PRINCI, P., CASUSCELLI, F., LANZA, M., SCALESE, M., TROMBETTA, D., COSTA, G. AND DE SARRO, G.B. Genetically epilepsy-prone rodents show some changes of ion levels in the brain. Brain Res. Bull. 33: 1-6, 1994.
  3. SAIJA, A., PRINCI, P., PISANI, A., LANZA, M., SCALESE, M., ARAMNEJAD, E., CESERANI, R. AND COSTA, G. Protective effects of glutathione on kainic acid-induced neuropathological changes in the rat brain. Gen. Pharmacol.. 25: 97-102, 1994.
  4. TRIMARCHI, G.R., IMPERATORE, C., ARCADI, F.A., SAIJA, A., DE SARRO, A., DE SARRO, G.B. AND COSTA G. Increased cardiovascular responsiveness to central cholinergic stimulation in the genetically epilepsy-prone rat. J. Pharm. Pharmacol. 46: 497-502, 1994.
  5. SAIJA, A., PRINCI, P., LANZA, M., SCALESE, M., ARAMNEJAD, E. AND DE SARRO A. Systemic cytokine administration can affect blood-brain barrier permeability in the rat. Life Sci. 56: 775-84, 1995.
  6. SAIJA, A., SCALESE, M., LANZA, M., MARZULLO, D., BONINA, F. AND CASTELLI, F. Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radicals in Biology and Medicine. 19: 481-486, 1995.
  7. SAIJA, A., BONINA, F., TROMBETTA, D., TOMAINO, A., MONTENEGRO, L., SMERIGLIO, P., CASTELLI, F. Flavonoid-biomembrane interactions: a calorimetric study on dipalmitoylphosphatidylcholine vesicles. Int. J. Pharmaceut. 124: 1-8, 1995.
  8. BONINA, F., LANZA, M., MONTENEGRO, L., SALERNO, L., SMERIGLIO, P., TROMBETTA, D. AND SAIJA, A. Transport of alpha-tocopherol and its derivatives through erythrocyte membranes. Pharmaceut. Res. 13: 1342-6, 1996.
  9. SAIJA, A., RAPISARDA, A., TOMAINO, A., TROMBETTA, D. AND DE FEO, G. Flavonoid interactions with biomembranes. Phytother. Res. In press, 1996.
  10. BONINA, F., LANZA, M., MONTENEGRO, L., PUGLISI, C., TOMAINO, A., TROMBETTA, D., CASTELLI, F. AND SAIJA, A. Flavonoids as potential protective agents against photooxidative skin damages. Int. J. Pharmaceut. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Del Zompo Maria, P.A.
  2. Bocchetta Alberto, T.L.
  3. Piccardi Maria Paola, T.L.
  4. Ruiu Stefania, D.DR.

AFFILIATION:

Dipartimento di Neuroscienze "B.B. Brodie"

Facoltą di Medicina e Chirurgia

Universitą di Cagliari

ADDRESS: Via Porcell, 4

CITY: Cagliari

POSTAL CODE: 09124

TELEPHONE: 070 - 6092438

FAX: 070 - 669242

E-MAIL: delzompo@unica.it

PUBLICATIONS:

  1. DEL ZOMPO, M., PICCARDI, M.P., RUIU, S., QUARTU, M., GESSA, G.L., ANS VACCARI, A. Selective MPP+ uptake into synaptic dopamine vesicles: possible involvement of MPTP neurotossicity. Brit. J. Pharmacol. 109: 411-414, 1993.
  2. BOCCHETTA, A., BERNARDI, F., BURRAI, C., PEDDITZI, M., AND DEL ZOMPO, M. A double-blind study of L-sulpiride versus amitryptiline in lithium-maintained bipolar depressives. Acta Psychiatrica Scandinavica 88: 434-439, 1993.
  3. DEL ZOMPO, M., LAI, M., LOI, V., AND PISANO, M.R. Dopamine hypersensitivity in migraine: role of apomorphine syncope. Headache 35: 222-224, 1995.
  4. DEL ZOMPO M., BOCCHETTA A., LOVISELLI A., MARTINO E., POST R.M., AND KETTER T.A. Thyroid function during carbamazepine. Biol. Psych. 36 : 135-136, 1994.
  5. BOCCHETTA, A., CHERCHI, A., LOVISELLI, A., MOSSA, P., VELLUZZI, F., DERAI, R, AND DEL ZOMPO, M. Six-year follow-up of thyroid function during lithium treatment. Acta Psychiatrica Scandinavica 94: 45-48, 1996

RESEARCH GROUP MEMBERS :

  1. Della Corte Laura, P.A.
  2. Colivicchi Alessandra, D.DR.
  3. Bianchi Loria, B.PDR.
  4. Galeffi Francesca, B.
  5. Bartolini Petra, B.

AFFILIATION :

Dipartimento di Farmacologia Preclinica e Clinica M. Aiazzi Mancini

Universitą di Firenze

ADDRESS: Viale Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237411, 412, 440, 454, 456

FAX: 055-4361613

E-MAIL: d-corte@stat.ds.unifi.it

PUBLICATIONS:

  1. DELLA CORTE, L., VALOTI, M., PALMI, M., GIOVANNINI, M.G. AND SGARAGLI, G.P. Pharmacokinetics of chlorimipramine, chlorpromazine and their N-dealkylated metabolites in plasma of healthy volunteers after a single oral dose of the parent compounds. J. Pharm. Pharmacol. 45: 825-829, 1993.
  2. DELLA CORTE, L., BIANCHI, L., COLIVICCHI, A. AND TIPTON, K.F. The effect of ethanol on rat brain monoamine oxidase activities. J. Neural Transmission, 41: 51-55, 1994.
  3. BIANCHI, L., SHARP, T., BOLAM, J.P. AND DELLA CORTE, L. The effect of kainic acid on the release of GABA in rat neostriatum and substantia nigra. Neuroreport: 5, 1233-1236, 1994.
  4. SGARAGLI, G.P., FROSINI, M., PALMI, M., BIANCHI, L. AND DELLA CORTE, L. Calcium and taurine interaction in mammalian brain metabolism. Adv Exp Med Biol 359: 299-308, 1994.
  5. GIOVANNINI, M.G., MUTOLO, D., BIANCHI, L., MICHELASSI, A. AND PEPEU, G. NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study. J. Neurosci. 14: 1358-1365, 1994.
  6. SGARAGLI, G.P., VALOTI, M., PALMI, M., FROSINI, M., GIOVANNINI, M.G., BIANCHI, L. DELLA CORTE, L. Rat tissue concentrations of chlorimipramine, chlorpromazine and their N-demethylated metabolites after a single oral dose of the parent compounds. J. Pharm. Pharmacol. 47: 782-790, 1995.
  7. BIANCHI, L., COLIVICCHI, M.A. AND DELLA CORTE, L., VALOTI, M., SGARAGLI, G.P. AND BECHI, P. Measurement of synthetic phenolic antioxidants in human tissues by High-Performance Liquid Chromatography with coulometric electrochemical detection. J. Chromatogr., In press, 1996.
  8. CORSI, C., PAZZAGLI, M., BIANCHI, L., DELLA CORTE, L., PEPEU, G. AND PEDATA, F. Excitatory amino acids and GABA release from the striatum of aging rats: adenosine modulation. Neurobiol. Aging, In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Desole M.Speranza, P.A.
  2. Fresu Luigia, R.U.
  3. Sciola Luigi, R.U.
  4. Piras Giovanna, D.DR.
  5. Migheli Rossana, D.DR.
  6. Delogu M.Rosaria, D.DR.
  7. Sircana Sara, D.DR.
  8. Zangani Danilo, D.DR.

AFFILIATION:

Istituto di Farmacologia

Facoltą di Medicina e Chirurgia

Universitą di Sassari

ADDRESS: Viale S.Pietro 43B

CITY: Sassari

POSTAL CODE: 07100

TELEPHONE: 079-228519

FAX: 079-228525

E-MAIL: desole@ssmain.uniss.it

PUBLICATIONS:

  1. DESOLE M.S.,ESPOSITO G.,ENRICO P.,MIELE M.,FRESU L.,DE NATALE MIELE E. AND GRELLA G. Effects of ageing on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxic effects on striatum and brainstem in the rat. Neurosci. Lett. 159:143-146, 1993.
  2. DESOLE M.S.,ESPOSITO G.,FRESU L.,MIGHELI R., ENRICO P.,MIELE M.,DE NATALE G. AND MIELE E. Correlation between 1-methyl-4-phenylpyridinium ion (MPP+) levels, ascorbic acid oxidation and glutathione levels in the striatal synaptosomes of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated rat. Neurosci. Lett. 161: 121-123,1993.
  3. BRACOLLA A., SHIN C.-K., ROSE M.J., PIRAS G., WARREN T.C., GRYGON C.A., INGRAHAM R.H., GREENWOOD D.J., COUSIN R.C., RICHMAN D., CHENG Y.-C. AND GRIFFIN J.A. Amino acid substitutions in HIV-reverse transcritase with corresponding residues from HIV-2: effect on kinetic constants and inhibition by nonnucleoside analogs. Biol. Chem. 268: 16571-16577, 1993
  4. DESOLE M.S., KIM W.-K., RABIN R.A. AND LAYCHOCK S.G. Nitric oxide reduces depolarization-induced calcium mobilization in PC12 vells by a cyclic GMP-mediated mechanism. Neuropharmacology 33: 193-198, 1994.
  5. DESOLE M.S., MIELE M., ESPOSITO G., MIGHELI R., FRESU L., DE NATALE G. AND MIELE E. Dopaminergic system activity and cellular defense mechanisms in the striatum and striatal synaptosomes of the rat subchronically exposed to manganese. Arch. Toxicol. 68: 566-570, 1994.
  6. DESOLE M.S., MIELE M., ESPOSITO G., MIGHEL R., FRESU L., ENRICO P., DE NATALE G. AND MIELE E. Monoaminergic systems activity and cellular defense mechanisms in the brainstem of young and aged rats subchronically exposed to manganese. Neurosci. Lett. 177: 71-74, 1994.
  7. DESOLE M.S.,ESPOSITO G.,MIGHELI R., FRESU L., SIRCANA S., ZANGANI D., MIELE M. AND MIELE E. Cellular defense mecanisms in the striatum of young and aged rats subchronically exposed to manganese. Neuropharmacology 34:289-295,1995.
  8. PIRAS G., DUTSCHMAN G.E., IM G.J., PAN B.C., CHU S.H. AND CHENG Y.C. The action of uracil analogues of human imunodeficiency virus type 1 (HIV-1) and its reverse transcriptase. Antimicrob. Agents. Chemother. 39: 539-541, 1995.
  9. DESOLE M.S., ESPOSITO G., FRESU L.G., MIGHELI R., SIRCANA S., DELOGU P. M. R., MIELE M. AND MIELE E. Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brainstem of the rat. Pharmacol. Biochem. Behav. 54:377-383,1996.
  10. DESOLE M.S., SCIOLA L., DELOGU M.R., SIRCANA S. AND MIGHELI R. Manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine induce apoptosis in PC12 cells. Neurosci. Lett. 209:193-196,1996.

RESEARCH GROUP MEMBERS:

  1. Di Renzo Gianfranco, P.O.
  2. Canzoniero Lorella, B.P.D:R.
  3. Caporaso Roberta, B

AFFILIATION:

Facoltą di Farmacia

Universitą degli Studi di Reggio Calabria

ADDRESS: Complesso Ninģ Barbieri

CITY: Roccelletta di Borgia (CZ)

POSTAL CODE: 88021

TELEPHONE: 0961-391157

FAX: 0961-391490

PUBLICATIONS:

  1. AMOROSO S., SENSI S., DI RENZO G.F. AND ANNUNZIATO L.The inhibition of tha Na+-Ca2+ exchanger enhances anoxia and glucopenia-induced 3H aspartate release in hippocampal slices. J. Pharmacol. Exp. Ther. 264:515-529,1993.
  2. CANZONIERO L.M.T., TAGLIALATELA M., DI RENZO,G.F. AND ANNUNZIATO L.:Gadolinium and Neomycin block voltage-sensitive Ca2+ channels without interfering with the Na+-Ca2+ antiporter in brain nerve endings.Eur. J. Pharmacol.; Molecular Pharmacology Section. 245: 97-103,1003.
  3. CSERNANSKY C.A., CANZONIERO L.M.T., SENSI S., YU S.P. AND CHOI D.W.Delayed application of Aurintricarboxylic acid reduced glutamate neurotoxicity. J. Neurosci. Res. 38: 101-108,1994.
  4. FATATIS A., CAPORASO R., IANNOTTI E., BASSI A., DI RENZO G.F. AND ANNUNZIATO L.Relationship between time of activation of Phospholipase C.linked plasma membrane receptors and reloading of intracellular Ca2+ stores in LAN-1 human neuroblastoma cells. J. Biol. Chem. 269:18021-18027,1994.
  5. LYNCH J.J., YU S.P., CANZONIERO L.M.T., SENSI S. AND CHOI D.W- Sodium channels blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists. J. Pharmacol. Exp. Ther. 273: 554-560,1995.
  6. DUGAN.L.L., SENSI S., CANZONIERO L.M.T., HANDRAN S.H., ROTHMAN S.M, GOLDBERG M.P. AND CHOI D.W. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-Daspartate. J. Neurosci.:15:6377-6388, 1995.
  7. DI RENZO G.F., AMOROSO S., BASSI A., FATATIS A., CATALDI M., COLAO A.M., LOMBARDI G. AND ANNUNZIATO L.Role of the Na+-Ca2+ and Na+-H+ antiporters in prolactin release from anterior pituitary cells in primary culture. Eur. J. Pharmacol. 204:11-15, 1995.
  8. AMOROSO S., IANNOTTI E., SAGGESE M.L., DI RENZO G.F. AND ANNUNZIATO L. The A1 agonist CCPA reduced bisoxonol-monitored membrane potential depolarization elicited by high K+ in cerebrocortical nerve endings. Biochim. Biophys. Acta. 1239:67-73.1995.
  9. CANZONIERO L.M.T., SENSI S, AND CHOI D.W. Recovery from NMDA-induced intracellular acidification is slow and dependent on extracellular bicarbonate. Amer. J. Physiol. 270:C593-C599,1996.
  10. AMOROSO S., DE MEIO M., RUSSO G.M., BASSI A., MENTAGNANI S., DI RENZO G.F., AND ANNUNZIATO L. The Na+-Ca2+ exchanger operates as a Na+ efflux and Ca2+ influx pathway during in vitro ischemia in C6 glioma cells. Brit. J. Pharmacol. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Drago Filippo, P.A.
  2. Villareale Giuseppe, D.DR.
  3. Marino Vittorio, D.DR.
  4. D'Agata Velia, B.
  5. Di Leo Francesco, B.
  6. Busą Lina, B.

AFFILIATION:

Istituto di Farmacologia

Facoltą di Medicina e Chirurgia

Universitą degli Studi di Catania

ADDRESS: Viale A. Doria, 6

CITY: Catania

POSTAL CODE: 95125

TELEPHONE: 095-330709, 330533 (int. 264)

FAX: 095-333219

E-MAIL: fdrago@mbox.vol.it

PUBLICATIONS:

  1. D'AGATA, V., AND DRAGO F., SERAPIDE F., CICIRATA F. Effects of cerebellectomy on motivation-related behavior: a time-course study. Physiol. Behav. 53: 173-176, 1993.
  2. DRAGO, F., MAUCERI F., NARDO L., VALERIO C., GENAZZANI A.A., AND GRASSI M. Effects of cytidine-diphosphocholine on acetylcholine-mediated behaviors in the rat. Brain Res. Bull. 31: 485-489, 1993.
  3. GRASSI, M., AND DRAGO F. Effects of oxytocin on emotional stress and strees-induced gastric lesions. J. Physiol. 87: 261-264, 1993.
  4. DRAGO, F., GRASSI M., AND GENAZZANI A.A. Neuromediators in aging and gastric mucosal injury. J. Physiol. 87: 379-383, 1993.
  5. DRAGO, F., DAL BELLO A., MARINO V., PISATI R., LODOLA E., AND BARBIERI P. Evaluation of the effects of thymoxamine solution 0.5% on mydriasis induced by ibopamine solution 1%. Eur. J. Clin. Pharmacol. 44: 477-480, 1993.
  6. DRAGO, F., COPPI G., ANTONUZZO P.A., VALERIO C., GENAZZANI A.A., GRASSI M., RAFFAELE R., AND SCAPAGNINI U. Effects of RGH 2202 on cognitive and motor behavior of the rat. Neurobiol. Aging 17: 67-71, 1996.
  7. DRAGO, F., MUSCO S., NARDO L., VALERIO C., GRASSI M., AND RAMPELLO L. Behavioral and neurochemical alterations induced by reversible conductive hearing loss in aged male rats. Neurosci. Lett. 205: 1-4, 1996.
  8. DRAGO, F., DI LEO F., IKONOMOU S., ANZALLO C., BUSą L., AND LO PRESTI L. Behavioral and endocrine effects of growth hormone administration in aged female rats. Psychoneuroendocrinology 21: 401-410, 1996.
  9. DRAGO, F., NARDO L., RAMPELLO L., AND RAFFAELE R. Vestibular compensation in aged rats with unilateral labyrinthectomy treated with dopaminergic drugs. Pharmacol. Res. 33: 135-140, 1996.
  10. CLEMENTI, G., VALERIO C., EMMI I., PRATO A., AND DRAGO F. Behavioral effects of amylin injected intracerebroventricularly in the rat. Peptides 17: 324-326, 1996.

RESEARCH GROUP MEMBERS:

  1. Ferrari Francesca, P.O.
  2. Giuliani Daniela, D. DR.

AFFILIATION:

Sezione di Farmacologia

Dipt. di Scienze Biomediche

Universitą di Modena

ADDRESS: Via G. Campi, 287

CITY: Modena

POSTAL CODE: 41100

TELEPHONE: 0039-59-428419

FAX: 0039-59-372653

E-MAIL: farmacol@.unimo.it

PUBLICATIONS:

  1. FERRARI F., PELLONI F. AND GIULIANI D. Behavioural profile in chicken of CQ 32-084 and CQP 201-403, two dopamine agonists. Pharmacol. Biochem. Behav. 45: 117-122, 1993.
  2. FERRARI F. AND GIULIANI D.: Behavioural effects induced in rats and chicks by D2 dopamine agonists. Physiol. Behav. 54: 695-700, 1993.
  3. FERRARI F., PELLONI F. AND GIULIANI D. Behavioural evidence that different neurochemical mechanisms underly stretching-yawning and penile erection induced in male rats by SND 919, a new selective D2 dopamine receptor agonist. Psychopharmacology, 113: 172-176, 1993.
  4. FERRARI F. AND GIULIANI D. Influence of idazoxan on the dopamine D2 receptor agonist-induced behavioural effects in rats. Eur. J. Pharmacol. 250: 51-57, 1993.
  5. FERRARI F. AND GIULIANI D. The selective D2 dopamine receptor antagonist (-)eticlopride counteracts the ejaculatio preacox induced by the selective D2 dopamine agonist SND 919 in the rat. Life Sci. 55: 1155-1162, 1994.
  6. FERRARI F. AND GIULIANI D. Sexual attraction and copulation in male rats: effects of the dopamine agonist SND 919. Pharmacol. Biochem. Behav. 50: 29-34, 1995.
  7. FERRARI F. AND GIULIANI D.: Effect on rat feeding behavior of two selective D2 dopamine agonists. Physiology and Behav. 56:921-926, 1995.
  8. FERRARI F. AND GIULIANI D.: Influence of Eticlopride on cocaine- and DA D2 agonist-induced behavioral effects in rats. Pharmacol. Biochem. Behav. 53: 525-530, 1996.
  9. FERRARI F. AND GIULIANI D.: Behavioral effects induced by the dopamine D3 agonist 7-OH-DPAT in sexually-active and inactive male rats. Neuropharmacology 35: 279-284, 1996 .
  10. GIULIANI D. AND FERRARI F. Differential behavioral response to dopamine D2 agonists by sexually naive, sexually active and sexually inactive male rats. Behav. Neurosci. 110 : In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Ferri Sergio, P.O.
  2. Candeletti Sanzio, T.L.
  3. Romualdi Patrizia, R.U.
  4. Lesa Giovanni, T.L.
  5. Donatini Alessandra, D.DR.

AFFILIATION:

Dipartimento di Farmacologia

Facoltą di Farmacia

Universitą degli Studi di Bologna

ADDRESS: Via Irnerio, 48

CITY: Bologna

POSTAL CODE: 40126

TELEPHONE: 051 - 242025 / 243101

FAX: 051 - 248862

E-MAIL: ferri@biocfarm.unibo.it

PUBLICATIONS:

  1. MELCHIORRE, C., ROMUALDI, P., BOLOGNESI, M.L., DONATINI, A., FERRI, S. Binding profile of benextramine at neuropeptide Y receptor subtypes in rat brain areas. Eur. J. Pharmacol.. 265: 93-98, 1994.
  2. AROIAN, R.V., LESA, G., STERNBERG, P.W. Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function. EMBO J. 13: 360-366, 1994.
  3. CANDELETTI, S., FERRI, S. Cerebrospinal alterations of immunoreactive dynorphin A after unilateral rhizotomy in the rat. Brain Res.. 670: 289-296, 1995.
  4. ROMUALDI, P., LESA, G., DONATINI, A., FERRI, S. Long-term exposure to opioid antagonists up-regulates prodynorphin gene expression in rat brain. Brain Res.. 672: 42-47, 1995.
  5. ROMUALDI, P., DONATINI, A., BREGOLA, G. BIANCHI, C., BEANI, L., FERRI, S., SIMONATO, M. Early changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures in the rat. Eur. J. Neurosci. 7: 171-177, 1995.
  6. ROMUALDI, P., DONATINI, A., FERRI, S. Prodynorphin gene expression regulation by chronic methamphetamine in rat brain. Analgesia, 1: 679-682, 1995.
  7. STERNBERG, P.W., LESA, G., LEE, J.H., KATZ, W.S., YOON, C., CLANDININ, T.R., HUANG, L.S., CHAMBERLIN, H.M., JONGEWARD, G. LET-23 -mediated signal transduction during Caenorhabditis elegans development. Mol. Reprod. Develop.. 42: 523-528, 1995.
  8. ROMUALDI, P., DONATINI, A., IZENWASSER, S., COX, B.M., FERRI, S. Chronic intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat hypothalamus and caudate-putamen. Mol. Brain Res.. 40: 153-156, 1996.
  9. SIMONATO, M., BREGOLA, G., DONATINI, A., BIANCHI, C., BEANI, L., FERRI, S., ROMUALDI, P. Kindled seizure-induced c-Fos and prodynorphin mRNA expressions are unrelated in the rat brain. Eur. J. Neurosci. 16: In press, 1996.

 

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