SIF - Società Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

PHARMACOLOGY OF THE
CENTRAL NERVOUS SYSTEM III

 

RESEARCH GROUP MEMBERS:

  1. Fratta Walter , P.O.
  2. Fadda Paola*, R.CNR
  3. Martellotta M. Cristina, B.PDR
  4. Porcella Anna, B.
  5. Pani Luca*, R.CNR
  6. Fattore Liana, B.
  7. Cossu Gregorio, B.

AFFILIATION:

Dipartimento di Neuroscienze "B.B.Brodie"

*Centro di Studio per la Neurofarmacologia (C.N.R.)

Facoltà di Medicina e Chirurgia

Università di Cagliari

ADDRESS: Via Porcell, 4

CITY: Cagliari

POSTAL CODE: 09124

TELEPHONE: 070-6758421

FAX: 070-657237

E-MAIL: wfratta@unica.it

PUBLICATIONS:

  1. FADDA, M.C. MARTELLOTTA, G.L. GESSA AND W. FRATTA Dopamine and opioids interactions in sleep deprivation. Prog. Neuropsychopharmacol. Biol Psychiat. 17 :pp.269-278; 1993.
  2. M.KOLMER, H.ALHO, E.COSTA, L.PANI Cloning and tissue specific functional characterization of the rat Diazepam Binding Inhibitor promoter. 90 : 8439-8443; 1993.
  3. M.C.MARTELLOTTA, A.KUZMIN, P.MUGLIA, G.L.GESSA AND W. FRATTA Effect of the calcium antagonist Isradipine on cocaine intravenous self-administration in rats. Psychopharmacology 113 : 378-380; 1994.
  4. M.C.MARTELLOTTA, A.KUZMIN, E.ZVARTAU, G.COSSU, G.L.GESSA AND W.FRATTA Isradipine inhibits nicotine intravenous self-administration in drug-naive mice. Pharmacol. Biochem. Behav. 52 :271-274; 1995
  5. P.FADDA, L.PANI, A.PORCELLA AND W.FRATTA Chronic imipramine, L-sulpiride and mianserin decrease Corticotropin releasing Factor levels in the rat brain. Neurosci. Lett. 192 :121-123; 1995
  6. G.L.GESSA, L.PANI, P.FADDA AND W.FRATTA Sleep deprivation in the rat: an animal model of mania. Eur. Neuropsychopharmacol. 89-93; 1995
  7. U.SAMADANI, A.PORCELLA, L.PANI, P.F.JOHNSON, J.BURCH, R.PINE, R.H.COSTA Cytokine Regulation of the Liver Transcription Factor HNF-3 is mediated by the C/EBP Family and Interferon Regulatory Factor 1. Cell Growth Diff. 6 :879-890; 1995.
  8. F.MARROSU, M.GIAGHEDDU, W.FRATTA Failure of naloxone to modify EEG interictal seizure discharges in primary generalized epilepsy after sleep deprivation. Epilepsia, 37 :56-59; 1996
  9. A.KUZMIN, M.C.MARTELLOTTA, W.FRATTA, G.L.GESSA AND E.ZVARTAU. Effect of Isradipine, a Dihydropyridine-calcium antagonist on i.v. self-administration of morphine in rats. Life Sci. 59 :159-164; 1996

RESEARCH GROUP MEMBERS:

  1. Frigo Gianmario, P.O.
  2. Lecchini Sergio, P.O.
  3. Cosentino Marco, R.U.
  4. Marino Franca, T.
  5. Giaroni Cristina, D.DR.
  6. Leoni Olivia, B.

AFFILIATION:

Dipartimento di Medicina Interna e Terapia Medica

II Facoltà di Medicina e Chirurgia

Università degli Studi di Pavia

ADDRESS: Via Ottorino Rossi, 9

CITY: Varese

POSTAL CODE: 21100

TELEPHONE: 0332 811601

FAX: 0332 811601

E-MAIL: phrm2fmc@ipv36.unipv.it

PUBLICATIONS:

  1. DE PONTI F, GIARONI C., COSENTINO M., LECCHINI S., FRIGO G.M. Calcium channel blockers and gastrointestinal motility: basic and clinical aspects. Pharmacol. Ther. 60: 121-148, 1993.
  2. MARINO F., MARCOLI M., DE PONTI F., COSENTINO M., LECCHINI S., FRIGO G.M. Effect of desipramine-induced blockade of neuronal uptake mechanisms on adrenoceptor-mediated responses in the guinea-pig colon. Naunyn-Schmied. Arch. Pharmacol. 350: 499-506, 1994.
  3. COSENTINO M., DE PONTI F., MARINO F., GIARONI C., LEONI O., LECCHINI S., FRIGO G.M. N-methyl-D-aspartate receptors modulate neurotransmitter release and peristalsis in the guinea-pig isolated colon. Neurosci. Lett. 183: 139-142, 1995.
  4. COSENTINO M., MARINO F., DE PONTI F., GIARONI C., SOMAINI L., LEONI O., LECCHINI S., FRIGO G.M. Tonic modulation of neurotransmitter release in the guinea-pig myenteric plexus: effect of mu and kappa opioid receptor blockade and of chronic sympathetic denervation. Neurosci. Lett. 194: 185-8, 1995.
  5. DE PONTI F., GIARONI C., COSENTINO M., LECCHINI S., FRIGO G.M. Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications. Pharmacol. Ther. 69: 59-78, 1996.
  6. COSENTINO M., LEONI O., RISPOLI L., PELLEGRINI C., FINAVERA L., LECCHINI S. FRIGO G.M. A one-year study of drug prescriptions and adverse drug reactions in psychiatric hospital practice. Pharmacoepidemiology and drug safety, In press, 1996.
  7. COSENTINO M., FIETTA AM., CALDIROLI E., MARINO F., RISPOLI L., COMELLI M., LECCHINI S., FRIGO GM. Assessment of lymphocyte subsets and neutrophil leukocyte function in chronic psychiatric patients on long-term drug therapy. Prog. Neuro-Psychopharmacol. Biol. Psychiat., In press, 1996.
  8. COSENTINO M., LEONI O., BANFI F., LECCHINI S. FRIGO G.M. Attitudes to adverse drug reaction reporting by medical practitioners in a northern italian district. Pharmacol. Res. In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Fumagalli Guido, P.O.
  2. Sala Carlo, D.DR.
  3. Sava Anna, D.DR.
  4. Mion Silvia, B.
  5. Francolini Maura, B.
  6. Di Mauro Debora, B.PDR.

AFFILIATION:

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università di Verona

ADDRESS: Ospedale di Borgo Roma

CITY: Verona

POSTAL CODE: 37134

TELEPHONE: 045-8098605

FAX: 045-581111

E-MAIL: fumagalli@farma.univr.it

PUBLICATIONS :

  1. ANDREOSE J.S., XU R., LØMO T., SALPETER M.M. AND FUMAGALLI G.: Degradation of two AChR population at rat neuromuscular junctions: regulation in vivo by electrical stimulation. J. Neurosci 13: 3433-3438, 1993
  2. ANDREOSE J.S., FUMAGALLI G. AND CLEMENTI F.: On the effect of aging on the distribution of Vaso-Intestinal Polypeptide and Calcitonin Gene-Related Polypeptide in the rat brain. Neurosci. Lett. 171: 167-171, 1994
  3. ANDREOSE J.S., SALA C. AND FUMAGALLI G.: Immunolocalisation of chromogranin B, secretogranin II, calcitonin gene-related peptide and substance P at developing and adult neuromuscular synapses. Neurosci. Lett. 174: 177-180, 1994
  4. VERDERIO C, COCO S, FUMAGALLI G AND MATTEOLI M: Spatial changes in calcium signaling during the establishment of neuronal polarity and synaptogenesis. J. Cell Biol. 126: 1527-1536, 1994
  5. SALA C, ANDREOSE JS, FUMAGALLI G AND LØMO T: Calcitonin gene-related peptide: possible role in formation and maintenance of neuromuscular junctions. J. Neurosci. 15: 520-528, 1995
  6. ANDREOSE JS, FUMAGALLI G AND LØMO T: Number of junctional acetylcholine receptors: control by neural and muscular influences in the rat. J. Physiol. 483.2: 397-406, 1995
  7. VERDERIO C, COCO S, FUMAGALLI G AND MATTEOLI M: calcium-dependent glutamate release during neuronal development and synaptogenesis: Different involvement of w-Aga-IVA- and -CTx-GVIA-sensitive channels. Proc. Nat. Acad. Sci. USA 92: 6449-6453,1995
  8. LORENZON P, ZACCHETTI D, CODAZZI F, FUMAGALLI G, MELDOLESI J AND GROHOVAZ F: Ca2+ waves in PC12 neurites: a bidirectionl, receptor-oriented form of Ca2+ signaling. J. Cell Biol. 129: 797-804, 1995
  9. MATTEOLI M., VERDERIO C., KRAWZESKI K., MUNDIGL O., COCO S., FUMAGALLI G. AND DE CAMILLI P.: Mechanisms of synaptogenesis in hippocampal neurons in primary culture. J. Physiol. 89: 51-55, 1995
  10. ANDREOSE J. S., FUMAGALLI G., SIGWORTH F. J. AND CAPLAN M. J.: Real-time detection of the surface delivery of newly synthesized membrane proteins. Proc. Nat. Acad Sci. USA, 93: 7661-7666, 1996.

RESEARCH GROUP MEMBERS:

  1. Galli Alessandro, P.A.
  2. Mori Francesca, D.DR.

AFFILIATION:

Dipartimento di Farmacologia Preclinica e Clinica

Facoltà di Farmacia

Università di Firenze

ADDRESS: Viale G.B. Morgagni 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237416

FAX: 055-4361613

E-MAIL: gallia@stat.ds.unifi.it

PUBLICATIONS :

  1. GALLI, A., MORI, F., BARGELLINI, M., AND COPPINI, L. Sodium-dependent release of exogenous glycine from preloaded rat hippocampal synaptosomes. J. Neur. Transm., 93: 167-179, 1993.
  2. COLOTTA, V., CECCHI, L., CATARZI, D., FILACCHIONI, G., GALLI A., AND MORI, F. Synthesis and structure-activity relationships of 1-aminophthalazinium salts as GABAA receptor antagonists. Eur. J. Med. Chem. 29: 95-105, 1994.
  3. GALLI, A., MORI, F., BENINI, L., AND CACCIARELLI, N. Acetylcholinesterase protection and the anti-diisopropylfluorophosphate efficacy of E2020. Eur. J. Pharmacol., 270: 189-193, 1994.
  4. MORONI, F., GALLI, A., MANNAIONI, G., CARLà, V., COZZI, A., MORI, F., MARINOZZI, M., AND PELLICCIARI, R. NMDA receptor heterogeneity in mammalian tissues: focus on two agonists, (2S,3R,4S)cyclopropylglutamate and the sulfate ester of 4-hydroxy-(S)-pipecolic acid. Naunyn-Schmied. Arch. Pharmacol. 351: 371-376, 1995.
  5. PELLICCIARI, R., ARENARE, L., DE CAPRARIIS, P., NATALINI, B., MARINOZZI, M., AND GALLI, A. Synthesis of all four diasteroisomers of 4-(carboxymethyl)proline, a conformationally constrained analogue of 2-aminoadipic acid. J. Chem. Soc. Perkin Trans., 1,1251-1257, 1995.
  6. GALLI, A., AND MORI, F. Acetylcholinesterase inhibition and protection by dizocilpine (MK-801) enantiomers. J. Pharm. Pharmacol. 48: 71-76, 1996.
  7. COLOTTA, V., CATARZI, D., VARANO, F., MELANI, F., FILACCHIONI, G., CECCHI, L., GALLI, A., AND COSTAGLI, C. Benzodiazepine binding activity of some tricyclic heteroaromatic systems to define the hydrogen bonding strength of the proton donors of the receptor site. Farmaco. 51: 223-229, 1996.
  8. COLOTTA, V., CATARZI, D., VARANO, F., CECCHI, L., FILACCHIONI, G., COSTAGLI, C., AND GALLI, A. Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to define an optional binding site of a benzodiazepine receptor ligand. J. Med. Chem., In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Gandolfi Ottavio, P.A.
  2. Dall'Olio Rossella, R.U.
  3. Rimondini Roberto, B.

AFFILIATION:

Dipartimento di Farmacologia

Facoltà di Medicina e Chirurgia

Università degli Studi di Bologna

ADDRESS: Via Irnerio, 48

CITY: Bologna

POSTAL CODE: 40126

TELEPHONE: 051-242025, 243101, 249561

E-MAIL: Gandolfi@biocfarm.unibo.it

PUBLICATIONS:

  1. DALL'OLIO R., AND GANDOLFI O. The NMDA positive modulator D-cycloserine potentiates the neuroleptic activity of D1 and D2 dopamine receptor blockers in the rats. Psychopharmacology. 110: 165-168, 1993.
  2. GANDOLFI O., AND DALL'OLIO R. Chronic treatment with MK-801 decreases D2 dopamine receptor function in rat striatum. Pharmacol. Biochem. Behav. 44: 683-687, 1993.
  3. DALL'OLIO R., RIMONDINI R., AND GANDOLFI O. The NMDA sensitive modulator D-cycloserine inhibits dopamine-mediated behaviors in the rat. Neuropharmacology. 33: 55-59, 1994.
  4. GANDOLFI O., DALL'OLIO R., RIMONDINI R., BONGRANI S., AND VALSECCHI B. Repeated administrations of (-)-deprenyl increase [3H]-MK 801 binding in rat brain and antagonize the impairment of passive avoidance conditioning induced by N-methyl-D-aspartate receptor antagonists. Neurosci. Lett. 165: 113-116, 1994.
  5. FACCHINETTI F., DALL'OLIO R., CIANI E., SPARAPANI M., VIRGILI M., AND CONTESTABILE A. Long lasting effects of chronic neonatal blockade of NMDA receptor through the competitive antagonist CGP 39551 in rats. Neuroscience. 60: 343-353, 1994.
  6. GANDOLFI O., RIMONDINI R., AND DALL'OLIO R. D-cycloserine decreases both D1 and D2 dopamine receptors number and their function in rat brain. Pharmacol. Biochem. Behav. 48: 351-356, 1994.
  7. DALL'OLIO R., FACCHINETTI R., CONTESTABILE A., AND GANDOLFI O. Chronic neonatal blockade of N-methyl-D-aspartate receptor by CGP 39551 increases dopaminergic function in adult rat. Neuroscience. 63: 451-455, 1994.
  8. DALL'OLIO R., RIMONDINI R., AND GANDOLFI O. The competitive NMDA antagonists CGP 43487 and APV potentiate dopaminergic function. Psychopharmacology. 118: 310-315, 1995.
  9. DALL'OLIO R., RIMONDINI R., AND GANDOLFI O. Effect of NMDA receptor antagonists on D1, D2, D1/D2 mediated behaviors in intact rats. Psychopharmacology. 123 : 187-190, 1996.
  10. GANDOLFI O., AND DALL'OLIO R. Modulatory role of dopamine on excitatory aminoacid receptors. Prog. Neuro-Psychopharmacol. Biol. Psychiat. 20: 659-671, 1996.

RESEARCH GROUP MEMBERS:

  1. Gessa Gian Luigi, P.O.
  2. Collu Maria, R.U
  3. Imperato Assunta, T.L.
  4. Devoto Paola, T.L.
  5. Colombo Giancarlo, R.CNR
  6. Obinu Maria Carmen, D.DR.
  7. Fà Mauro, D.DR.
  8. Lobina Carla, D.DR
  9. Reali Roberta, D.DR.
  10. Casu Maria Antonietta, D.DR.
  11. Mascia Maria Stefania, D.DR.
  12. Agabio Roberta, B.
  13. Muntoni Annalisa, B.
  14. Melis Miriam ,.
  15. Pistis Marco, B.
  16. Marchese Giorgio, B.

AFFILIATION:

Dipartimento di Neuroscienze "B.B. Brodie"

Facoltà di Medicina e Chirurgia

Università di Cagliari

ADDRESS: Via Porcell, 4

CITY: Cagliari

POSTAL CODE: 09124

TELEPHONE: 070-6758318

FAX: 070-657237

E-MAIL: LGessa@unica.it

PUBLICATIONS:

  1. IMPERATO, A., OBINU, M.C., CASU M.A., MASCIA, M.S., DAZZI, L., AND GESSA, G.L., Evidance That Neuroleptics Increase Striatal Acetylcholine Release through Stimulation of Dopamine D1 Receptors. J. Pharmacol. Exp. Ther.. 266:557-562, 1993.
  2. IMPERATO, A., OBINU, M.C., AND GESSA, G.L., Stimulation of both dopamine D1 and D2 receptors facilitates in vivo acetylcholine release in the hippocampus. Brain Res. 618:341-345,1993.
  3. IMPERATO, A., OBINU, M.C., AND GESSA, G.L., Effects of cocaine and amphetamine on acetylcholine release in the hippocampus and caudate nucleus. Eur. J. Pharmacol. 238:377-381, 1993.
  4. IMPERATO, A., OBINU, M.C., DAZZI, L., AND GESSA, G.L., Does dopamine exert a tonic inhibitory control on the release of striatal acetylcholine in vivo? Eur. J. Pharmacol. 251:271-279, 1994.
  5. COLOMBO, G., AGABIO, R., LOBINA, C., REALI, R., FADDA, F., AND GESSA., G.L., Blockade of ethanol discrimination by isradipine. Eur. J. Pharmacol. 265: 167-170, 1994.
  6. COLOMBO, G., AGABIO, R., LOBINA, C., REALI, R., FADDA, F., AND GESSA., G.L., Symmetrical generalization between the discriminative stimulus effects of gamma- hydroxybutyric acid and ethanol: Occurrence within narrow dose ranges. Physiol. Behav. 57: 105-111,1995.
  7. COLOMBO, G., AGABIO, R., LOBINA, C., REALI, R., FADDA, F., AND GESSA., G.L.,Cross-tolerance to ethanol and y-hydroxybutyric acid. Eur. J. Pharmacol. 273: 235-238, 1995.
  8. D'AQUILA, P.S., COLLU, M., PANI, L., GESSA, G.L., AND SERRA, G., Antidepressant-like effect of selective D1 receptor agonists in the behavioural despair animal model of depression. Eur. J. Pharmacol. 262: 107-111, 1995.
  9. DEVOTO, P., COLLU, M., MUNTONI, A.M., PISTIS, M., SERRA, G., GESSA, G.L., AND DIANA, M., Biochemical and electrophysiological effects of 7-OH-DPAT on the mesolimbic dopaminergic system. Synapse 20:153-155, 1995.
  10. COLLU, M., POGGIU, A.S., PANI, L., AND SERRA, G., Fluoxetine -induced conditioned place preference: a preliminary study. Synapse, In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Gorio Alfredo, P.O.
  2. Di Giulio Anna Maria, P.A.
  3. Vergani Letizia, D.DR.
  4. De Tollis Angela, Specializzanda
  5. Finco Cristina, B.
  6. Lesma Elena, D.DR.
  7. Germani Elena, D.DR.

AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Facoltà di Medicina e Chirurgia

Università degli Studi di Milano

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-70146-360, 364

FAX: 02-70146-368

E-MAIL: AMDG@imiucca.csi.unimi.it  ALGORIO@imiucca.csi.unimi.it

PUBLICATIONS:

  1. GORIO A., DONADONI M.L., DI GIULIO A.M., Nitric oxide sensitive protein ADP-ribosylation is altered in diabetic neuropathy. J. Neurosci. Res., 40 : 420-426, 1995
  2. DONADONI M.L., GAVEZZOTTI R., BORELLA F., DI GIULIO A.M., GORIO A., Experimental diabetic neuropathy. Inhibition of protein mono-ADP-ribosylation prevents reduction of substance P axonal transport. J. Pharm. Exp. Ther., 274 : 570-576, 1995
  3. DI GIULIO A.M., LESMA E., GORIO A., Diabetic neuropathy in the rat. I. Alcar augments the reduced levels and axoplasmatic transport of substance P. J. Neurosci. Res., 40 : 414-419, 1995
  4. DI GIULIO A.M., TENCONI B., MALOSIO M.L., VERGANI L., BERTELLI A., GORIO A., Perinatal morphine. I: Effects on synapsin and neurotransmitter system in the brain. J. Neurosci. Res., 42 : 479-485, 1995
  5. GERMANI E., LESMA E., DE BIASI S., DI GIULIO A.M., BERTELLI A., GORIO A., Perinatal morphine. II: Changes in cortical plasticity, J. Neurosci. Res., 42 : 829-834, 1995
  6. CONTI A.M., SCARPINI E., MALOSIO M.L., DI GIULIO A.M., BARON P., SCARLATO G., MANTEGAZZA P., GORIO A., In situ hybridization of Po and MBP myelin protein mRNA in experimental diabetic neuropathy. Neurosci. Lett., 206 : 1-5, 1996
  7. TENCONI B., LESMA E., DI GIULIO A.M., GORIO A., High opioid doses inhibit whereas low doses enhance neuritogenesis in PC12 cells. Develop. Brain Res., 94 : 175-181, 1996
  8. GORIO A., VERGANI L., MALOSIO M.L., LESMA E., DI GIULIO A.M., Perinatal exposure to morphine: reactive changes in the brain after 6-hydroxidopamine, Eur. J. Pharmacol., 303 : 21-26, 1996
  9. GORIO A., MALOSIO M.L., VERGANI L., DI GIULIO A.M., Exposure to morphine promotes developmental changes in the rat striatum. Int. J. Develop. Neurosci., 14 : 471-479, 1996

RESEARCH GROUP MEMBERS:

  1. Govoni Stefano, P.O. *
  2. Racchi Marco,D.DR. # ^
  3. Ianna Paola ,B. #
  4. Gasparini Laura, B. ^
  5. Benussi Luisa, B ^

AFFILIATION :

* Istituto di Farmacologia, Facoltà di Farmacia Università di Pavia

# Istituto di Scienze Farmacologiche, Facoltà di Farmacia, Università di Milano

^ Lab. di Neurobiologia Cellulare e Molecolare, Istituto Sacro Cuore FBF, Brescia

ADDRESS: Viale Taramelli 14

CITY: Pavia

POSTAL CODE: 27100

TELEPHONE: 0382/507397

FAX: 0382/507405

E-MAIL: Govoni@isfunix.farma.unimi.it

PUBLICATIONS:

  1. GOVONI S., BERGAMASCHI S., RACCHI M., BATTAINI F., BINETTI G., BIANCHETTI A. AND TRABUCCHI M.: Cytosol protein kinase C downregulation in fibroblasts from Alzheimer' disease patients, Neurology 43 : 2581-2586, 1993.
  2. RACCHI M., BERGAMASCHI S., GOVONI S., WETSEL W.C., BIANCHETTI A., BINETTI G., BATTAINI F. AND TRABUCCHI M.: Characterization of presence and distribution of protein kinase C isoforms in human skin fibroblasts. Arch. Biochem. Biophys. 314: 107-111, 1994.
  3. FRISONI G.B., GOVONI S., GEROLDI C., BIANCHETTI A., CALABRESI L., FRANCESCHINI G., TRABUCCHI M.: Gene dose of the e4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease. Ann. Neurol. 37 : 110-118, 1995.
  4. BERGAMASCHI S., BINETTI G.,GOVONI S.,WETSEL W.C.,BATTAINI F.,TRABUCCHI M.,BIANCHETTI A. AND RACCHI M.: Defective phorbol ester stimulated secretion of b-amyloid precursor protein from Alzheimer's disease fibroblasts. Neurosci. Lett.,201 : 1-4 1995.
  5. PERRONE R., BERARDI F., COLABUFO N.A., LEOPOLDO M., TORTORELLA V., FIORENTINI F., OLGIATI V., GHIGLIERI A., GOVONI S., High affinity and selectivity on 5HT1A receptor of 1-aryl-4-((1-tetralin)alkyl)piperazines. 2., J. Med. Chem. 38 : 942-949, 1995.
  6. HIRASHIMA N. ,ETCHEBERRIGARAY R. ,BERGAMASCHI S. ,RACCHI M., BATTAINI F., BINETTI G. ,GOVONI S., AND ALKON D.: Intracellular release and influx of calcium: diagnostic molecular profile for Alzheimer's disease fibroblasts. Neurobiol. Aging, 17:549-555, 1996.
  7. GOVONI S., GASPARINI L., RACCHI M., AND TRABUCCHI M.: Peripheral cells as an investigational tool for Alzheimer's disease. Life Sci. 59: 461-468, 1996
  8. GOVONI S., BERGAMASCHI S., GASPARINI L., QUAGLIA C., RACCHI M., CATTANEO E., BINETTI G., BIANCHETTI A., GIOVETTI F., BATTAINI F., AND TRABUCCHI M. : Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation. Neurology,47:1069-1075, 1996
  9. BERARDI F., COLABUFO N.A., GIUDICE G., PERRONE R., TORTORELLA V., GOVONI S., LUCCHI L., New sigma and 5HT1A receptor ligands w-(tetralin-1-yl)-n-alkylamine derivatives. J. Med.Chem. 39 : 176-182, 1996.
  10. RACCHI M., BAETTA R., SALVIETTI N., IANNA., FRANCESCHINI G., PAOLETTI R., FUMAGALLI R., GOVONI S., TRABUCCHI M., AND SOMA M. : Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content. Biochem J., In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Matteoli Michela, R.CNR
  2. Verderio Claudia, D.DR.
  3. Coco Silvia, B.
  4. Bacci Alberto, D.DR.

AFFILIATION :

Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Università di Milano

ADDRESS: via Vanvitelli 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-70146-391, 254

FAX: 02-7490574

E-MAIL: MichelaM@Farma.csfic.cnr.mi.it

PUBLICATIONS :

  1. MUNDIGL, O., MATTEOLI, M., DANIELL, L., THOMAS REETZ, A., MATCALF, A., JAHN, R. AND DE CAMILLI, P. Synaptic vesicle proteins in cultured hippocampal neurons: differential effects of brefeldin A in axon and dendrites. J. Cell Biol., 122: 1207-1221, 1993.
  2. CAPORASO, G.L., TAKEI, K., GANDY, S.E., MATTEOLI, M., MUNDIGL, O., GREENGARD, P. AND DE CAMILLI, P. Microscopic and biochemical examination of the intracellular traffic of the Alzheimer b/A4 Amyloid Precursor Protein. J. Neurosci.,14: 3122-3138, 1994.
  3. VERDERIO, C., COCO, S., FUMAGALLI, G. AND MATTEOLI, M. Activity independent spatial changes in calcium signaling during the establishment of neuronal polarity. J. Cell Biol., 126: 1527-1536, 1994.
  4. MUNDIGL, O., VERDERIO, C., KRASZEWSKI, K., DE CAMILLI, P. AND MATTEOLI, M. A radioimmunoassay to monitor synaptic activity in hippocampal neurons in vitro. Eur. J. of Cell Biol., 66: 246-256, 1995.
  5. KRASZEWSKI, K., MUNDIGL, O., DANIELL, L., VERDERIO, C., MATTEOLI, M. AND DE CAMILLI, P. Synaptic vesicle dynamics in living cultured hippocampal neurons visualized with CY3-conjugated antibodies directed against the lumenal domain of synaptotagmin. J. Neurosci, 15: 4328-4342, 1995.
  6. VERDERIO, C., COCO, S., FUMAGALLI ,G. AND MATTEOLI, M. Calcium-dependent glutamate release during neuronal development and synaptogenesis: different involvement of w-aga-iva and w-ctx-gvia sensitive channels. Proc. Nat. Acad. Sci. USA 92: 6449-6453, 1995.
  7. MATTEOLI, M., VERDERIO, C., KRAWZESKI, K., MUNDIGL, O., COCO, S., FUMAGALLI, G. AND DE CAMILLI, P. Mechanisms of synaptogenesis in hippocampal neurons in primary culture. J. Physiol., 89: 51-55, 1995.
  8. MATTEOLI,M., VERDERIO, C., ROSSETTO, O., IEZZI,N., COCO, S., SCHIAVO, G. AND MONTECUCCO, C. Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neurons. Proc Nat. Acad. Sci. USA In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Melchiorri Pietro, P.O.
  2. ImprotaGiovanna,P.A.
  3. Negri Lucia, P.A.
  4. Sopranzi Nello, P.A.
  5. Broccardo Maria, R.U.
  6. Noviello Vittoria, R.U.
  7. Noviello Lia, R.U.
  8. Lattanzi Roberta, D.DR.
  9. LuchettiFabio, D.DR.
  10. Narzi Lorena, D.DR.
  11. Tabacco Alessandra, D.DR.
  12. Tabacco Fabio, D.DR.

AFFILIATION:

Istituto di Farmacologia Medica

Facoltà di Medicina e Chirurgia

Università "La Sapienza" di Roma

ADDRESS: Piazzale A. Moro,5

CITY: Roma

POSTAL CODE: 00185

TELEPHONE: 06-49912488

FAX : 06-4450307

E-MAIL: melchiorri@uniromal.it

PUBLICATIONS:

  1. RENDA,T., NEGRI, L., TOOYAMA, I., CASU, C., AND MELCHIORRI, P. Autoradiographic study on [3H] [D-Ala2 ]deltorphin-I binding sites in the rat brain. NeuroReport. 4: 1143- 1146, 1993.
  2. BROCCARDO, M., AND IMPROTA, G. Sauvagine-induced hypothermia: evidence for an interaction with the dopaminergic system. Eur. J. Pharmacol. 258: 179-184, 1994.
  3. IMPROTA, G., AND BROCCARDO, M. Effect of selective m1, m2 and d2 opioid receptor agonists on gastric functions in the rat. Neuropharmacology. 33: 977-981, 1994.
  4. NEGRI L., LATTANZI R., AND MELCHIORRI P. Lys7 dermorphin, a naturally occuring peptide with high affinity for opioid receptors, produces antinociception by peripheral administration. Brit. J. Pharmacol. 114 : 57-66, 1995.
  5. NEGRI, L., IMPROTA, G., LATTANZI, R., POTENZA, R. L., LUCHETTI, F., AND MELCHIORRI, P. Interaction between the mu agonist dermorphin and the delta agonist [D-Ala2, Glu4]deltorphin in supraspinal antinociception and_d opioid receptor binding. Brit. J. Pharmacol. 116: 2931-2938, 1995.
  6. KITCHEN, I., LESLIE, F.M., KELLY, M., BARNES, R., CROOK, T.J., HILL, R.J., BORSODI, A., TOTH, G., MELCHIORRI, P., AND NEGRI, L. Development of d-opioid receptor subtypes and the regulatory role of weaning: radioligand binding, autoradiography and in situ hybridization studies. J. Pharmacol. Exp. Ther. 275: 1597-1607, 1995.
  7. BROCCARDO, M., IMPROTA, G., AND SEVERINI C. Parallel bioassay of PG-SPI, an amphibian acidiclike peptide, mammalian basic substance P and neurokinins A and B, on in vitro and in vivo test systems. Peptides, 16: 609-614, 1995.
  8. BROCCARDO, M., IMPROTA, G., BRANDONI, A., AND TABACCO A. Effect of PG-SPI and PG-KII, two novel and natural tachykinins, on salivary secretion in the rat. Peptides, 17: 729-732, 1996.
  9. NEGRI, L., NOVIELLO, L., AND NOVIELLO, V. Antinociceptive and behavioral effects of synthetic deltorphin analogs. Eur. J. Pharmacol. 296: 9-16, 1996.

RESEARCH GROUP MEMBERS:

  1. Meldolesi Jacopo, P.O.
  2. Gatti Giuliana, T.L.
  3. Malosio M.Luisa, B. PDR.
  4. Lievremont J. Philippe, B.PDR.
  5. Podini Paola, R.
  6. Borgonovo Barbara, D. DR.
  7. Racchetti Gabriella, T.

AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Facoltà di Medicina e Chirurgia

Università di Milano e DIBIT, Istituto Scientifico San Raffaele

ADDRESS: Via Olgettina, 58

CITY: Milano

POSTAL CODE: 20090

TELEPHONE: 02-2643 2770

FAX: 02-2643 4813

E-MAIL: meldolj@dibit.hsr.it

PUBLICATIONS:

  1. POZZAN, T., RIZZUTO, R., VOLPE, P. AND MELDOLESI J. Molecular and cellular physiology of intracellular Ca2+ stores. Physiol. Rev. 74: 595-637, 1994.
  2. FISCHER, G.A., CLEMENTI, E., RAICHMAN, M., SUDHOF, T., ULLRICH, A. AND MELDOLESI J. Stable expression of truncated inositol 1,4,5-trisphosphate receptor subunits in 3T3 fibroblasts: coordinate signalling changes and differential suppression of cell growth and transformation. J. Biol. Chem. 269: 19216-19224, 1994.
  3. RAICHMANN, M., PANZERI, M.C., CLEMENTI, E., PAPAZAFIRI, P., ECKLEY, M., CLEGG, D.O., VILLA, A. AND MELDOLESI J. Differential localization and functional role of calsequestrin in growing and differentiated myoblasts. J. Cell Biol. 128: 341-354, 1995.
  4. GRIERSON, J.P. AND MELDOLESI J. Shear stress-induced [Ca2+]i transients and oscillations in mouse fibroblasts are mediated by endogenously released ATP. J. Biol. Chem. 270: 4451-4456, 1995.
  5. LORENZON, P., ZACCHETTI, D., CODAZZI, F., FUMAGALLI, G., MELDOLESI, J. AND GROHOVAZ F. Ca2+ waves in PC12 neurites a bidirectional, receptor oriented form of Ca2+ signalling. J. Cell Biol. 129: 797-804, 1995.
  6. BASTIANUTTO, C., CLEMENTI, E., CODAZZI, F., PODINI, P., DE GIORGI, F., RIZZUTO, R., MELDOLESI, J. AND POZZAN T. Overexpression of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of their lumenal microenvironment and function. J. Cell Biol. 130: 847-855, 1995.
  7. LORENZON, P., ZACCHETTI, D., CODAZZI, F., FUMAGALLI, G., MELDOLESI, J. AND GROHOVAZ F. Ca2+ waves in PC12 neurites a bidirectional, receptor oriented form of Ca2+ signalling. J. Cell Biol. 129: 797-804, 1995.
  8. BASTIANUTTO, C., CLEMENTI, E., CODAZZI, F., PODINI, P., DE GIORGI, F., RIZZUTO, R., MELDOLESI, J. AND POZZAN T. Overexpression of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of their lumenal microenvironment and function. J. Cell Biol. 130: 847-855, 1995.
  9. MELDOLESI, J., KRAUSE, H. AND MICHALAK M. Calreticulin: how many functions in how many cellular compartments? Cell Calcium 20: 83-86, 1996.
  10. CORRADI, N., BORGONOVO, B., CLEMENTI, E., BASSETTI, M., RACCHETTI, G., CONSALEZ, G.G., HUTTNER, W.B., MELDOLESI, J. AND ROSA P. Overall lack of regulated secretion in a PC12 variant cell clone. J. Biol. Chem. In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Miele Egidio, P.O.
  2. De Natale Guglielmo, P.O.
  3. Miele Maddalena, R.U.
  4. Enrico Paolo, R.U.

AFFILIATION:

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università di Sassari

ADDRESS: Viale S.Pietro 43B

CITY: Sassari

POSTAL CODE: 07100

TELEPHONE: 079-2285-15,16,17,26,27,56,57 

079-218024

FAX: 079-228525

E-MAIL : pharmaco@ssmain.uniss.it

PUBLICATIONS :

  1. MIELE M., BOUTELLE M.G. AND FILLENZ M. The physiologically-induced release of ascorbate in rat brain is dependent on impulse traffic, calcium influx and glutamate uptake. Neuroscience 62: 87-91, 1994.
  2. MIELE M., ESPOSITO G., SIRCANA S.,ZANGANI D., MIGHELI R.,FRESU L. AND DESOLE M.S. Effects of allopurinol on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurochemical changes in the striatum and in the brainstem of the rat. Neurosci. Lett. 183: 155-159, 1995.
  3. MIELE M., ENRICO P., ESPOSITO G., FRESU L., MIGHELI R., DE NATALE G. AND DESOLE M.S. Cortical ablation and drug-induced changes in striatal ascorbic acid oxidation and behavior in the rat. Pharmacol. Biochem. Behav. 50: 1-7,1995.
  4. DESOLE M.S., MIELE M., ESPOSITO G., MIGHELI R., FRESU L. G., MIGHELI R., ZANGANI D., SIRCANA S., GRELLA G. AND MIELE E. Neuronal antioxidant system and MPTP-induced oxidative stress in the striatum and brainstem of the rat. Pharmacol. Biochem. Behav. 51: 581-592,1995.
  5. DESOLE M.S., ESPOSITO G., MIGHELI R., FRESU L., SIRCANA S., MIELE M., DE NATALE G. AND MIELE E. Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat. Neurosci. Lett.192:73-76, 1995.
  6. MIELE M., BERNERS M., BOUTELLE M. G., KUSAKABE H. AND FILLENZ M. The determination of true extracellular concentrations of glutamate using quantitative microdialysis. Brain Res. 707: 131-133, 1996.
  7. DESOLE M.S., ESPOSITO G., FRESU L., MIGHELI R., ENRICO P., MURA M. A., DE NATALE G., MIELE E. AND MIELE M. Effects of morphine treatment and withdrawal on striatal and limbic monoaminergic activity and ascorbic acid oxidation in the rat. Brain Res. 723:154-161,1996.
  8. MIELE M. AND FILLENZ M. In vivo determination of extracellular brain ascorbate. J. Neurosci. Meth. 69: 23-28, 1996.

RESEARCH GROUP MEMBERS :

  1. Molinengo Costa Luigi, P.O.
  2. Orsetti Marco, R.U.
  3. Ghi Piera, R.U.
  4. Di Carlo Giovanni, D.DR.

AFFILIATION:

Sezione di Farmacologia

Dipartimento di Anatomia, Farmacologia e Medicina Legale

Università di Torino

ADDRESS: Via P. Giuria, 9

CITY: Torino

POSTAL CODE: 10125

TELEPHONE: 011-6707688, 7691

FAX: 011-6707688

PUBLICATIONS:

  1. MOLINENGO L., ORSETTI M., GHI P., AND PASTORELLO B. Action of chronic choline administration on behavior and on cholinergic and noradrenergic systems. Pharmacol. Biochem. Behav. 44: 587-594, 1993.
  2. MOLINENGO L., SCORDO I., AND PASTORELLO B. Action of caffeine, L-PIA and their combination on memory retention in the rat. Life Sci. 54: 1247-1250, 1994.
  3. MOLINENGO L., ORSETTI M., PASTORELLO B., SCORDO I., AND GHI P. The action of arecoline on retrieval and memory storage evaluated in the staircase maze. Neurobiol. Learn. Mem. 63: 167-173, 1995.
  4. MOLINENGO L., ORSETTI M., PASTORELLO B., SCORDO I., AND GHI P. Habituation of exploratory activity in rats: action of N6-Phenylisopropyladenosine, caffeine and their combination. Prog. Neuro-Psychopharmacol. Biol. Psychiat. 1189-1200, 1995.
  5. GHI P., FERRETTI C., BLENGIO M., AND PORTALEONE P. Stress induces changes in histaminergic system: effects of diazepam and amitriptyline. Pharmacol. Biochem. Behav. 51: 65-68, 1995.
  6. GHI P., BLENGIO M., FERRETTI C., AND PORTALEONE P. Stress and brain H3-histamine receptors. Inflamm. Res. 44: 62-63, 1995.
  7. GHI P., FERRETTI C., BLENGIO M. Effects of different types of stress on histamine-H3 receptors in the rat cortex. Brain Res. 690: 104-107, 1995.
  8. ORSETTI M., CASAMENTI F., PEPEU G. Enhanced acetylcholine release in the hippocampus and cortex during acquisition of an operant behavior. Brain Res. 724: 89-96, 1996.
  9. MOLINENGO L., SCORDO I., PASTORELLO B., ORSETTI M., AND GHI P. Behavioral and neurochemical effects induced by chronic L-DOPA administration. Pharmacol. Biochem. Behav. 54: 779-785, 1996.

RESEARCH GROUP MEMBERS :

  1. Morelli Micaela, P.O.
  2. Fenu Sandro, T.L.
  3. Pinna Annalisa, B.
  4. Carta Anna, B.

AFFILIATION :

Dipartimento di Tossicologia

Facoltà di Farmacia

Università di Cagliari

ADDRESS: Viale A. Diaz 182

CITY: Cagliari

POSTAL CODE: 09100

TELEPHONE: 070-300437, 300463

FAX: 070-300740

E-MAIL: mmorelli@mbox.vol.it

PUBLICATIONS:

  1. MORELLI M., FENU S., COZZOLINO A., PINNA A., CARTA A. AND DI CHIARA G. Blockade of muscarinic receptors potentiated D-1 dependent turning behavior and c-fos expression in 6-hydroxydopamine lesioned rats while does not influence D-2 mediated responses. Neurosci. 53: 673-678, 1993
  2. MORELLI M., COZZOLINO A., PINNA A., FENU S., CARTA A. AND DI CHIARA G. L-DOPA stimulates c-fos expression in dopamine denervated striatum by combined activation of D-1 and D-2 receptors. Brain Res. 623: 334-336, 1993.
  3. MORELLI M., FENU S., PINNA A., COZZOLINO A., CARTA A. AND DI CHIARA G. "Priming" to dopamine agonist-induced contralateral turning as a model of non associative sensitization to the expression of the post-synaptic dopamine message. Behav. Pharmacol. 4: 389-397, 1993
  4. MORELLI. M., PONTIERI F., LINFANTE I., ORZI F. AND DI CHIARA G. Local cerebral glucose utilization after D1 receptor stimulation in 6-OHDA lesioned rats: effect of sensitization (priming) with a dopaminergic agonist. Synapse, 13: 264-269, 1993.
  5. MORELLI M., FENU S., PINNA A. AND DI CHIARA G. Adenosine A-2 receptors interact negatively with dopamine D-1 and D-2 receptors in unilaterally 6-hydroxydopamine lesioned rats. Eur. J. Pharmacol. 251: 21-25, 1994.
  6. MORELLI M., PINNA A., FENU S., CARTA A., COZZOLINO A. AND DI CHIARA G. Differential effect of MK 801 and scopolamine on c-fos expression induced by l-dopa in the striatum of 6-hydroxydopamine lesioned rats. Synapse, 18: 288-293, 1994.
  7. FENU S., CARTA A. AND MORELLI M. Modulation of dopamine D1-mediated turning behavior and striatal c-fos expression by the substantia nigra. Synapse, 19: 233-240, 1995.
  8. FENU S, CARTA A. AND MORELLI M. Intranigral injections of glutamate antagonists modulate dopamine D-1-mediated turning behavior and striatal c-fos expression. J. Neural. Transm., 45: 75-81, 1995
  9. MORELLI M., PINNA A., WARDAS J. AND DI CHIARA G. Adenosine A2 receptors stimulate c-fos expression in striatal neurons of 6-hydroxydopamine-lesioned rats. Neurosci. 67: 49-55, 1995.
  10. PINNA A., DI CHIARA G., WARDAS J. AND MORELLI M. Blockade of A2a adenosine receptors positively modulates turning behavior and c-fos expression induced by D1 agonists in dopamine denervated rats. Eur. Jour. Neurosci 8: 1176-1181, 1996.

RESEARCH GROUP MEMBERS:

  1. Moroni Flavio, P.O.
  2. Pellegrini-Giampietro Domenico E., R.U.
  3. Carlà Vincenzo, R.U.
  4. Cozzi Andrea, T.
  5. Leonardi Patrizia, B.
  6. Mannaioni Guido, B.
  7. Chiarugi Alberto, B.
  8. Carpenedo Raffaella, B.
  9. Albani Torregrossa Serenella, D.DR.
  10. Attucci Sabina, D.DR.
  11. Peruginelli Fiamma, B.

AFFILIATION:

Dipartimento di Farmacologia Preclinica e Clinica "Mario Aiazzi Mancini"

Università degli Studi di Firenze

ADDRESS: Viale G.B. Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237-411, 419, 433, 428, 459

FAX: 055-4361-613

E-MAIL: moronif@stat.ds.unifi.it,  dompel@stat.ds.unifi.it

PUBLICATIONS:

  1. LOMBARDI, G., ALESIANI, M., LEONARDI, P., CHERICI, G., PELLICCIARI, R. AND MORONI, F. Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-3H-aspartate output in rat striatum, Brit. J. Pharmacol. 110 : 1407-1412, 1993.
  2. CARPENEDO, R., CHIARUGI, A., RUSSI, P., LOMBARDI, G., CARLà, V., PELLICCIARI, R., MATTOLI, L. AND MORONI, F. Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenic acid and have sedative and anticonvulsant activities, Neuroscience, 61 :237-244, 1994.
  3. FRIEDMAN, L.K., PELLEGRINI-GIAMPIETRO, D.E., SPERBER, E.F., BENNETT, M.V.L., MOSHÉ, S.L. AND ZUKIN, R.S. Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study, J. Neurosci. 14 :2697-2707, 1994.
  4. LOMBARDI, G., MORONI, F.J. AND MORONI, F. Glutamate receptor antagonists protect against ischemia-induced retinal damage, Eur. J. Pharmacol. 271 :489-495, 1994.
  5. PELLEGRINI-GIAMPIETRO, D.E., PULSINELLI, W.A. AND ZUKIN, R.S. NMDA and non-NMDA receptor gene expression following global ischemia in rats: effect of NMDA and non-NMDA receptor antagonists, J. Neurochem. 62 :1067-1073, 1994.
  6. PELLEGRINI-GIAMPIETRO, D.E., COZZI, A. AND MORONI, F. The glycine antagonist and free radical scavenger 7-Cl-thio-kynurenate reduces CA1 ischemic damage in the gerbil, Neuroscience, 63 :701-709, 1994.
  7. CHIARUGI, A., CARPENEDO, R., MOLINA, M.T., MATTOLI, L., PELLICCIARI, R. AND MORONI, F. Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase. J. Neurochem. 65 :1176-1183, 1995.
  8. LOMBARDI, G., LEONARDI, P. AND MORONI, F. Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices, Brit. J. Pharmacol. 117 :189-195, 1996.
  9. MANNAIONI, G., CARLà, V. AND MORONI, F. Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations, Brit. J. Pharmacol. 118 :1530-1536, 1996.
  10. PELLEGRINI-GIAMPIETRO, D.E., ALBANI TORREGROSSA, S. AND MORONI, F. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus, Brit. J. Pharmacol. 118 :1035-1043, 1996.

RESEARCH GROUP MEMBERS:

  1. Navarra Pierluigi, P.A.
  2. Pozzoli Giacomo, R.U.
  3. Tringali Giuseppe, B.
  4. Pistritto Giuseppa, T.L.
  5. Mancuso Cesare, D.D.R.

AFFILIATION :

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università Cattolica del Sacro Cuore

ADDRESS: Largo Francesco Vito, 1

CITY: Roma

POSTAL CODE: 00168

TELEPHONE: 06-3015-4367, 4531

FAX: 06-3050159

PUBLICATIONS:

  1. NAVARRA, P., POZZOLI, G., BECHERUCCI, C., PREZIOSI, P., GROSSMAN, A. AND PARENTE, L. Prostaglandin E2 and bacterial lipopolysaccharide specifically stimulate interleukin-1 release by rat hypothalamic explants. Neuroendocrinol. 57: 257-261, 1993.
  2. POZZOLI, G., COSTA, A., GRIMALDI, M., SCHETTINI, G., PREZIOSI, P., GROSSMAN A. AND NAVARRA, P. Bacterial lipopolysaccharide modulation of eicosanoid and corticotrophin releasing hormone release from rat hypothalamic explants and astrocyte cultures in vitro: evidence for the involvement of prostaglandin E2 but not F2, and lack of effect of NGF. J. Endocrinol. 140: 103-109, 1994.
  3. YASIN, S., COSTA, A., POZZOLI, G., NAVARRA, P., FORSLING, M. AND GROSSMAN, A. Endothelin-1 stimulates the in vitro release of neurohypophyseal hormones, but not corticotrophin-releasing hormone, via ETa receptors. Neuroendocrinol. 60: 553-558, 1994.
  4. POZZOLI, G., MANCUSO, C., MIRTELLA, A., PREZIOSI, P., GROSSMAN, A.B. AND NAVARRA, P. Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated CRH release from acute rat hypothalamic explants. Endocrinology 135: 2314-2317, 1994.
  5. MIRTELLA, A., TRINGALI, G., GUERRIERO, G., GHIARA, P., PARENTE, L., PREZIOSI, P. AND NAVARRA, P. Evidence that interleukin-1-induced prostaglandin E2 release from rat hypothalamus is mediated by both type I and type II receptors. J. Neuroimmunol. 61: 171-177, 1995.
  6. AMBROSETTI, D.-C., PALLA, E., MIRTELLA, A., GALEOTTI, C., SOLITO, E., NAVARRA, P., PARENTE, L. AND MELLI, M. Synthetic alleles at position 121 define a functional domain of human interleukin-1. Eur. J. Biochem. 238: 308-316, 1996.
  7. COSTA, A., POMA, A., NAVARRA, P., FORSLING, M.L., GROSSMAN, A. Gaseous transmitters as new agents in neuroendocrine regulation. J. Endocrinol. 149: 199-207, 1996.
  8. KOSTOGLOU-ATHANASSIOU, I., FORSLING, M.L., NAVARRA, P. AND GROSSMAN, A.B. Oxytocin release is inhibited by the generation of carbon monoxide from the rat hypothalamus - further evidence for carbon monoxide as a neuromodulator. Mol. Brain Res. In press, 1996.
  9. MANCUSO, C., PISTRITTO, G., TRINGALI, G., GROSSMAN, A., PREZIOSI, P. AND NAVARRA, P. Evidence that carbon monoxide stimulates prostaglandin endoperoxide synthase activity in rat hypothalamic explants and in primary cultures of rat hypothalamic astrocytes. Mol. Brain Res. In press, 1996.
  10. TRINGALI, G., MANCUSO, C., MIRTELLA, A., POZZOLI, G., PARENTE, L., PREZIOSI, P. AND NAVARRA, P. Evidence for the neuronal origin of immunoreactive interleukin-1 released by hypothalamic explants. Neurosci. Lett. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Navone Francesca, R. CNR
  2. Vignali Giovanna, B.
  3. Sprocati Maria Teresa, T.

AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Università di Milano

Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare

ADDRESS: Via Vanvitelli 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 01-70146-254, 258

FAX: 02-7490574

E-MAIL: segreteria@farma5.csfic.mi.cnr.it  France@farma7.csfic.mi.cnr.it

PUBLICATIONS:

  1. NICLAS, J., NAVONE, F., HOM-BOOHER, N., AND VALE, R.D. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. Neuron 12: 1059-1072, 1994.
  2. VIGNALI, J., NICLAS, J., SPROCATI, M. T., VALE, R., D., SIRTORI, C., AND NAVONE, F. Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells. Eur. J. Neurosci. 8: 536-544, 1996.

RESEARCH GROUP MEMBERS:

  1. Nencini Paolo, P.O.
  2. Fraioli Sabina, D.DR.
  3. Cioli I., B.
  4. Nucerito V., B.

AFFILIATION:

Istituto di Farmacologia Medica

Facoltà di Medicina e Chirurgia

Università di Roma "La Sapienza"

ADDRESS: P.le A. Moro 5

CITY: Roma

POSTAL CODE: 00185

TELEPHONE: 06-49912497

FAX: 06-49910348

PUBLICATIONS:

  1. NENCINI, P. AND FRAIOLI, S.:Environment specific reinstatement of amphetamine-mediated hyperdipsia by morphine and (-)-norpseudoephedrine. Pharmacol. Biochem. Behav. 47 : 339-343, 1994.
  2. NENCINI, P. AND VALERI, P.: The role of opioid mechanisms in the anorectic effects of stimulants: U-50,488H enhances amphetamine inhibition of free feeding in rats. Pharmacol. Biochem. Behav. 48 : 63-68, 1994.
  3. CAMANNI, S. AND NENCINI, P., Physiological and environmental aspects of drinking stimulated by chronic exposure to amphetamine in rats. Gen. Pharmacol. 24 : 7-13, 1994.
  4. NENCINI, P., FRAIOLI, S. AND PERRELLA, D., Tolerance does not develop to the suppressant effects of (-)-norpseudoephedrine on ingestive behavior in the rat. Pharmacol. Biochem. Behav. 53 : 297-301, 1996.

RESEARCH GROUP MEMBERS:

  1. Nisticò Giuseppe, P.O.
  2. Mollace Vincenzo, R.U.
  3. Libri Vincenzo, R.U.
  4. Politi Giovanni, C.T.
  5. Del Duca Claudio, C.T.
  6. Berliocchi Laura, B.
  7. Piccirilli Silvia, B.
  8. Melchiorri Daniela, D.DR.

AFFILIATION:

Dipartimento di Biologia - Cattedra di Farmacologia

Facoltà di Scienze Matematiche, Fisiche e Naturali

Università di Roma "Tor Vergata"

ADDRESS: Via della Ricerca Scientifica

CITY: Roma

POSTAL CODE: 00133

TELEPHONE: 06-72594875

FAX: 06-2022720

PUBLICATIONS:

  1. CONSTANTI A., BAGETTA G., AND LIBRI V. Electrophysiological characterization of a slow post-stimulus afterdepolarization induced by muscarinic receptor activation in guinea-pig olfactory cortex neurones in vitro. Neuroscience. 56: 887-904, 1993.
  2. BAGETTA G., IANNONE M., DEL DUCA C., AND NISTICO' G. Inhibition by Nw-nitro-L-arginine methyl ester of the electrocortical arousal response in rats. Brit. J. Pharmacol. 108: 858-860. 1993.
  3. LIBRI V., CONSTANTI A., CALAMINICI M., AND NISTICO' G. A comparison of the muscarinic response and morphological properties of identified cells in the guinea-pig olfactory cortex in vitro. Neuroscience. 59: 331-347, 1994.
  4. MOLLACE V., COLASANTI M., RODINO' P., LAURO G.M., AND NISTICO' G. HIV coating gp120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation. Biochem. Biophys. Res. Commun. 203: 87-92, 1994.
  5. MOLLACE V., ROMEO F., MARTUSCELLI E., ROSANO G., FEDERICI G., NISTICO' G., AND MARINO B. Law formation of nitric oxide in polymorphonuclear cells in unstable angina pectoris. Amer. J. Cardiol. 74: 65-68, 1994.
  6. BAGETTA G., AND NISTICO' G. Tetanus toxin as a neurobiological tool to study the mechanisms of neuronal cell death in the mammalian brain. Pharmacol. Ther. 62: 29-39, 1994.
  7. BAGETTA G., CORASANITI M.T., FINAZZI-AGRO' A., AND NISTICO' G. Does the HIV-1 coat protein gp120 produce brain damage? TIPS. 15: 363, 1994.
  8. BAGETTA G., RODINO' P., PAOLETTI A.M., ARABIA A., MASSOUD R., AND NISTICO' G. Systemic administration of lithium chloride and tacrine but not kainic acid augments citrulline content of rat brain. Eur. J. Pharmacol. 294: 341-344, 1995.
  9. BAGETTA G., CORASANITI M.T., ALOE L., BERLIOCCHI L., COSTA N., FINAZZI-AGRO' A., AND NISTICO' G. Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat. Proc. Nat. Acad. Sci. USA. 93: 928-933, 1996
  10. BAGETTA G., IANNONE M., PALMA E., NISTICO' G., AND DOLLY O.J. N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors mediate seizures and CA1 hippocampal damage induced by dendrotoxin-K in rats. Neuroscience. 71: 613-624, 1996.

RESEARCH GROUP MEMBERS:

  1. Oliverio Alberto, P.O.
  2. Castellano Claudio, Dir.R.
  3. Sansone Mario, Dir.R.
  4. Ammassari Teule Martine, R.
  5. D'Amato Francesca Romana, R.
  6. Pavone Flaminia, R.
  7. Cabib Simona, R.

AFFILIATION:

Consiglio Nazionale delle Ricerche

Istituto di Psicobiologia e Psicofarmacologia

ADDRESS: Via Reno n. 1

CITY: Roma

POSTAL CODE: 00198

TELEPHONE: 06-8554898, 85353772

FAX: 06-8553561

PUBLICATIONS:

  1. CASTELLANO C., CESTARI V., CABIB S. AND PUGLISI ALLEGRA S. The effects of morphine on memory consolidation in mice involve both D1 and D2 dopamine receptors. Behav. Neural Biol. 61: 156-161, 1994.
  2. D'AMATO F.R. Physiological evidence for genetically mediated sibling recognition in mice. Behav. Genet.. 24: 493-496, 1994.
  3. INTROINI-COLLISON I.B., CASTELLANO C. AND MCGAUGH J..L. Interaction of GABAergic and Beta-noradrenergic drugs in the regulation of memory storage. J. Pharm. Pharmacol.. 46: 205-213, 1994.
  4. ROSSI-ARNAUD C. AND AMMASSARI-TEULE M. Radial maze performance in inbred mice: evidence for distint neural nets subserving strain-dependent learning abilities. Psychobiology. 22: 320-327, 1994.
  5. SANSONE M, BATTAGLIA M AND CASTELLANO C. Effects of caffeine and nicotine on avoidance lerning in mice: lack of interaction. J. Pharm. Pharmacol.. 46: 765-767, 1994.
  6. AMMASSARI-TEULE M., TOZZI A., ROSSI-ARNAUD C., SAVE E. AND THINUS-BLANC C. Reactions to spatial and non spatial change in two inbred strains of mice: further evidence supporting the ippocampal disfunction in the DBA strain. Psychobiology. 23 : 284-289, 1995.
  7. CABIB S., D'AMATO F.R., NEVEU P., DELEPLANQUE B., LE MOAL M. AND PUGLISI ALLEGRA S. Paw preference and brain dopamine asymmetries. .Neuroscience. 64: 427-432, 1995.
  8. MELE A., CABIB S. AND OLIVERIO A.Effects of the NMDA-antagonist, MK-801, on stress-induced alterations of dopamine dependent behavior. Psychopharmacology. 117: 313-317, 1995.
  9. MELE A., CASTELLANO C. AND OLIVERIO A. Chronic treatment with MK-801 affects the behavioral response to both D1 and D2 dopamine agonist in one-trial inhibitory avoidance. Psychopharmacology. 121: 401-405, 1995.
  10. SANSONE M., PAVONE F., BATTAGLIA M. AND VETULANI J. Locomotor activity pattern induced by diazepam in control and caffeine-treated mice. Polish J. Pharmacol.,. 47: 387-392, 1995.

RESEARCH GROUP MEMBERS:

  1. Ongini Ennio, Dir. R.
  2. Bertorelli Rosalia, C.L.
  3. Dionisotti Silvio, C.L.
  4. Mattavelli Amanda, B.
  5. Monopoli Angela, C.L.
  6. Adami Marina, R.I.
  7. Basudev Harsha, R.I.
  8. Casati Carlo, R.I.
  9. Ferri Nives, T.
  10. Forlani Angelo, T.
  11. Lozza Gianluca, T.L.
  12. Molta Cristina, B.
  13. Veronese Eliana, B.
  14. Bianchi Daniele, T.
  15. Rabuffetti Moonica, B.
  16. Viganò Giulia, B.
  17. Corradini Laura, B.
  18. Barbieri Ilaria, B.

AFFILIATION:

Schering Plough Research Institute

San Raffaele Science Park

ADDRESS: Via Olgettina 58

CITY: Milano

POSTAL CODE: 20132

TELEPHONE: 02 - 21219202

FAX: 02 - 21219253

E-MAIL: schering-plough@science-park.spr.it

PUBLICATIONS:

  1. ONGINI E., E. BONIZZONI, N. FERRI, S. MILANI AND M. TRAMPUS Differential effects of dopamine D1 and D2 receptor antagonist antipsychotics on sleep­wake patterns in the rat. J. Pharmacol. Exp. Ther. 266 : 726­731, 1993.
  2. CASATI C., A. MONOPOLI, S. DIONISOTTI, C. ZOCCHI, E. BONIZZONI AND E. ONGINI Repeated administration of selective adenosine A1 and A2 receptor agonists in the spontaneously hypertensive rat: tolerance develops to A1 -mediated hemodynamic effects. J. Pharmacol. Exp. Ther. 268 : 1506-1511, 1994.
  3. DIONISOTTI S., A. CONTI, D. SANDOLI, C. ZOCCHI, F. GATTA AND E. ONGINI Effects of the new A2 adenosine receptor antagonist 8FB-PTP, an 8-substituted pyrazolo-triazolo-pyrimidine, on in vitro functional models. Brit. J. Pharmacol. 112 : 659-665, 1994.
  4. BONIZZONI E., S. MILANI, E. ONGINI, C. CASATI AND A. MONOPOLI Modeling hemodynamic profiles by telemetry in the rat. A study using A1 and A2A adenosine agonists. Hypertension, 25 : 564-569, 1995.
  5. CASATI C., A. MONOPOLI, A. FORLANI, E. BONIZZONI AND E. ONGINI Telemetry monitoring of hemodynamic changes induced over time by adenosine agonists in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 275 : 914-919, 1995.
  6. ADAMI M., R. BERTORELLI, N. FERRI, M.C. FODDI AND E. ONGINI Effects of repeated administration of selective adenosine A1 and A2A receptor agonists on pentylenetetrazole-induced convulsions in the rat. Eur. J. Pharmacol. 294 : 383-389, 1995.
  7. ZOCCHI C., E. ONGINI, A. CONTI , A. MONOPOLI, A. NEGRETTI, P.G. BARALDI AND S. DIONISOTTI The non-xanthine heterocyclic compound, SCH 58261, is a new potent and selective A2Aadenosine receptor antagonist. J. Pharmacol. Exp. Ther. 276 : 398-404, 1996.
  8. ZOCCHI C., E. ONGINI, S. FERRARA, P.G. BARALDI AND S. DIONISOTTI Binding of the radioligand [3H]SCH 58261, a non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes. Brit. J. Pharmacol. 117 : 1381-1386, 1996.
  9. DIONISOTTI S., S. FERRARA, C. MOLTA, C. ZOCCHI AND E. ONGINI Labeling of the A2A adenosine receptors in human platelets using the non-xanthine antagonist radioligand [3H]-SCH 58261. J. Pharmacol. Exp. Ther. 278 : 1209-1214., 1996
  10. ONGINI E. AND B.B. FREDHOLM Pharmacology of adenosine A2A receptors. Trends Pharmacol. Sci. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Panerai Alberto E. P.O.
  2. Bianchi Mauro R.U.
  3. Sacerdote Paola T.L.
  4. Manfredi Barbara B.PDR.

AFFILIATION:

Dipartimento di Farmacologia Chemioterapia e Tossicologia Medica

Facoltà di Scienze MM.FF.NN.

Università di Milano

ADDRESS: Via Vanvitelli 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-719750; 70146-286; -288; -289

FAX: 02-730470

E-MAIL: panerai@imiucca.csi.unimi.it;  sacerdot@imiucca.csi.unimi.it

PUBLICATIONS:

  1. MANFREDI, B, SACERDOTE, P., BIANCHI, M., LOCATELLI, L., VELIC-RADULOVIC, J.,.AND.PANERAI, A.E. Evidence for an opioid inhibitory effect on T cell proliferation. J. Neuroimmunol. 44: 43-48, 1993.
  2. SACERDOTE, P., DENIS-DONINI, S., PAGLIA, P., GRANUCCI, F., PANERAI, A.E., AND RICCIARDI-CASTAGNOLI, P. Cloned microglial cells, but not macrophages synthesize ß-endorphin in response to CRH activation. Glia 9: 305-310, 1993.
  3. PANERAI, A.E., RADULOVIC, J., MONASTRA, G., MANFREDI, B., LOCATELLI, L., AND SACERDOTE, P. ß-endorphin concentrations in brain areas and peritoneal macrophages in rats susceptible and resistant to experimental allergic encephalomyelitis: a possible relationship between tumor necrosis factor and opioids in the disease. J. Neuroimmunol. 51: 169-177, 1994.
  4. BIANCHI, M., SACERDOTE, P., AND PANERAI, A.E. Chlomipramine differently affects inflammatory edema and pain in the rat. Pharmacol. Biochem. Behav. 48:1037-1047, 1994
  5. BIANCHI, M., SACERDOTE, P., AND PANERAI, A. E. Fluoxetine reduces inflammatory edema in the rat: involvement of the pituitary-adrenal axis. Eur.J.Pharmacol. 263: 81-84, 1994.
  6. SACERDOTE, P., BIANCHI, M., MANFREDI, B. AND PANERAI, A.E. Intracerebroventricular interleukin-1 increases immunocyte ß-endorphin concentrations in the rat: involvement corticotrophin-releasing hormone, catecholamines, and serotonin. Endocrinology, 135: 1346-1352, 1994.
  7. PANERAI, A.E., MANFREDI, B., GRANUCCI, F., AND SACERDOTE, P. The ß-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid. J. Neuroimmunol. 58: 71-76, 1995
  8. MANFREDI, B., CLEMENTI, E., SACERDOTE, P., BASSETTI, M. AND PANERAI, A.E. Age-related changes in mitogen-induced ß-endorphin release from human peripheral blood mononuclear cells. Peptides, 16: 699-706, 1995
  9. BIANCHI, M., AND PANERAI, A.E. The dose-related effect of paracetamol on hyperalgesia and nociception in the rat. Brit. J. Pharmacol. 117:130-132, 1996
  10. BIANCHI, M., SACERDOTE, P., AND PANERAI, A.E. Peripherally administered GM-CSF interferes with scopolamine-induced amnesia in mice: involvement of interleukin-1. Brain Res. 728: 285-289, 1996

RESEARCH GROUP MEMBERS:

  1. Parenti Marco, R.U.
  2. Galbiati Ferruccio, D.DR.
  3. Guzzi Francesca, B.

AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Facoltà di Medicina e Chirurgia

Università degli Studi di Milano

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02 - 70146 282

FAX: 02 - 70146 371

E-MAIL: parenti@imiucca.csi.unimi.it

PUBLICATIONS:

  1. PARENTI M., VIGANO' M.A., NEWMAN C.M.H., MILLIGAN G., AND MAGEE A.I. A novel N-terminal motif for palmitoylation of G-protein a subunits. Biochem. J. 291: 349-353, 1993.
  2. PAROLARO D., RUBINO T., GORI E., MASSI P., BENDOTTI C., PATRINI G., MARCOZZI C., AND PARENTI M. In situ hybridization reveals specific increases in Gas and Gao mRNA in discrete brain regions of morphine-tolerant rats. Eur. J. Pharmacol. (Mol. Pharm. Sec.) 244: 211-222, 1993.
  3. GRASSIE M. A., MCCALLUM J. F., GUZZI F., MAGEE A. I., MILLIGAN G., AND PARENTI M. The palmitoylation status of the G-protein Go1a regulates its avidity of interaction with the plasma membrane. Biochem. J. 302: 913-920, 1994.
  4. GALBIATI F., GUZZI F., MAGEE A.I., MILLIGAN G., AND PARENTI M. N-Terminal fatty acylation of the a subunit of the G-protein Gi1: only the myristoylated protein is a substrate for palmitoylation. Biochem. J. 303: 697-700, 1994.
  5. MILLIGAN G., PARENTI M., AND MAGEE A.I. The dynamic role of palmitoylation in signal transduction. Trends Biochem. Sci. 20: 181-186, 1995.
  6. SALA M., BRAIDA D., COLOMBO M., GROPPETTI A., SACCO S., GORI E., AND PARENTI M. Behavioral and biochemical evidence of opioidergic involvement in cocaine sensitization. J. Pharmacol. Exp. Ther. 274: 450-457, 1995.
  7. RUBINO T., PARENTI M., PATRINI G., MASSI P., AND PAROLARO D. Morphine withdrawal syndrome and G protein expression: a study of the time course in the rat Central Nervous System. Eur. J. Neurosci. 7: 2334-2340, 1995.
  8. MCCALLUM J.F., WISE A., GRASSIE M.A., MAGEE A.I., GUZZI F., PARENTI M., AND MILLIGAN G. The role of palmitoylation of the guanine nucleotide binding protein G11a in defining interaction with the plasma membrane. Biochem. J. 310: 1021-1027, 1995.
  9. GALBIATI F., GUZZI F., MAGEE A.I., MILLIGAN G., AND PARENTI M. Chemical inhibition of myristoylation of the G-protein Gi1a by 2-hydroxymyristate does not interfere with its palmitoylation or membrane association. Biochem. J. 313: 717-720, 1996.

RESEARCH GROUP MEMBERS :

  1. Parolaro Daniela, P.A.
  2. Giagnoni Gabriella, P.A.
  3. Massi Paola, R.U.
  4. Rubino Tiziana, B.
  5. Patrini Gabriela, B.
  6. Fuzio Domenica, B.

AFFILIATION:

Istituto di Farmacologia,

Facoltà di Scienze MMFFNN

Università degli Studi di Milano

ADDRESS: Via Vanvitelli, 32/A

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-7385568

FAX: 02-70002270

E-MAIL: gori@imiucca.csi.unimi.it

PUBLICATIONS :

  1. PAROLARO, D., RUBINO, T., GORI, E., MASSI, P., BENDOTTI, C., PATRINI, G., MARCOZZI, C., AND PARENTI, M. In situ hybridization reveals specific increases in G s and Go mRNA in discrete brain regions of morphine-tolerant rats. Eur. J. Pharmacol. - Mol. Pharmacol. Section. 244: 211-222, 1993.
  2. MASSI, P., RUBINO, T., PARENTI, M., GIAGNONI, G., GROPPETTI, A., AND PAROLARO, D. Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism. Eur. J. Pharmacol. 243: 65-71, 1993.
  3. RUBINO, T., MASSI, P., PATRINI, G., VENIER, I., GIAGNONI, G., AND PAROLARO, D. Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system. Mol. Brain Res.. 23: 333-337, 1994.
  4. PACIFICI, R., PATRINI, G., VENIER, I., PAROLARO, D., ZUCCARO, P., AND GORI, E. Effect of morphine and methadone acute treatment on immunological activity in mice: pharmacokinetic and pharmacodynamic correlates. J. Pharmacol. Exp. Ther. 269: 1112-1116, 1994.
  5. RUBINO, T., MASSI, P., PATRINI, G., VENIER, I., GIAGNONI, G.,AND PAROLARO, D. Chronic CP-55,940 alters cannabinoid receptor mRNA in the rat brain: an in situ hybridization study. Neuroreport. 5: 2493-2496, 1994.
  6. RUBINO, T., PARENTI, M., PATRINI, G., MASSI, P.,AND PAROLARO, D. Morphine withdrawal syndrome and G protein expression: a study of the time course in the rat central nervous system. Eur. J. Neurosci. 7: 2334-2340, 1995.
  7. PATRINI, G., MASSI, P., RICEVUTI, G., MAZZONE, A., FOSSATI, G., MAZZUCCHELLI, I., GORI, E., AND PAROLARO. D. Changes in opioid receptor density on murine splenocytes induced by in vivo treatment with morphine and methadone. J. Pharmacol. Exp. Ther. 279: 172-176, 1996.
  8. COSTA, B., PAROLARO, D., AND COLLEONI, M.P. Chronic cannabinoid, CP-55940, administration alters biotransformation in the rat. Eur. J. Pharmacol. 313: 17-24, 1996.
  9. RUBINO, T., PATRINI, G., PARENTI, M., MASSI, P., AND PAROLARO, D. Chronic treatment with a synthetic cannabinoid CP-55,940 alters G protein expression in the rat central nervous system. Mol. Brain Res. In press, 1996.
  10. MASSI, P., PATRINI, G., RUBINO, T., FUZIO, D., AND PAROLARO, D. Changes in rat spleen cannabinoid receptors after chronic CP-55940: an autoradiographic study. Pharmacol. Biochem. Behav. In press, 1996.

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