SIF - Società Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

PHARMACOLOGY OF THE
CENTRAL NERVOUS SYSTEM IV

 


RESEARCH GROUP MEMBERS:

  1. Pepeu Giancarlo, P.O.
  2. Marconcini Pepeu Ileana, P.A.
  3. Pedata Felicita, P.A.
  4. Casamenti Fiorella, R.U.
  5. Giovannelli Lisa, R.U.
  6. Giovannini Maria Grazia, T.L.
  7. Corsi Claudia, D.D.R
  8. Latini Serena, D.D.R.
  9. Prosperi Costanza, D.D.R.
  10. Pazzagli Marta, B.
  11. Scali Carla, B.

AFFILIATION :

Dipartimento di Farmacologia Preclinica e Clinica

Università di Firenze

Unità Operativa Neurofarmacologia

ADDRESS: Viale Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237.411 (centralino),

418, 441, 442, 443, 446.

FAX : 055-4361613

E-MAIL : pepeu@stat.ds.unifi.it  unit12@stat.ds.unifi.it  

PUBLICATIONS:

  1. CASAMENTI, F., SCALI, C., VANNUCCHI, M. G., BARTOLINI, L., AND PEPEU, G. Long-term ethanol consumption by rats: effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior. Neuroscience 56 : 465-471, 1993.
  2. PAZZAGLI, M., CORSI, C., LATINI, S. PEDATA, F. AND PEPEU, G. In vivoregulation of extracellular adenosine levels in the cerebral cortex by NMDAand muscarinic receptors. Eur. J. Pharmacol. 254: 277-282, 1994.
  3. GIOVANNINI, M.G., MUTOLO, D., BIANCHI, L., MICHELASSI, A. AND PEPEU, G.NMDA receptor antagonists decrease GABA outflow from the septum andincrease acetylcholine outflow from the hippocampus: a microdialysis study. Neuroscience 4: 1358-1365, 1994.
  4. GIOVANNINI, M.G., CAMILLI, F., MUNDULA, A., BIANCHI, L., COLIVICCHI, M.A. AND PEPEU, G. Differential regulation by N-methyl-d-aspartate andnon-N-methylaspartate receptors of acetylcholine release from the ratstriatum in vivo Neuroscience 65: 409-415, 1995.
  5. VANNUCCHI, M.G. AND PEPEU, G. Muscarinic receptor modulation ofacetylcholine release from rat cerebral cortex and hippocampus. Neurosci. Lett. 190: 53-56, 1995.
  6. GIOVANNELLI, L., CASAMENTI, F., SCALI, C., BARTOLINI, L. AND PEPEU, G. Differential effects of amyloid peptides ß-(1-40) and ß-(25-35) injectionsinto the rat nucleus basalis. Neuroscience 66: 781-792, 1995.
  7. PAZZAGLI, M., CORSI, C., FRATTI, S., PEDATA, F. AND PEPEU, G. Regulationof extracellular adenosine levels in the striatum of aging rats. Brain Res. 103-106, 1995.
  8. BARTOLINI, L., CASAMENTI, F. AND PEPEU, G. Aniracetam restores objectrecognition impaired by age, scopolamine, and nucleus basalis lesions. Pharmacol. Biochem. Behav. 53: 277-283, 1996.
  9. ORSETTI, M., CASAMENTI, F., PEPEU, G. Enhanced acetylcholine release inthe hippocampus and cortex during acquisition of an operant behavior. Brain Res. 724: 89-96, 1996

RESEARCH GROUP MEMBERS:

  1. Pietra Claudio, R.I.
  2. Arban Roberto, R.I.
  3. Valerio Enzo, T.
  4. Tarter Giorgio, T
  5. Costa Silvano, T

AFFILIATION:

Direzione Farmacologia

Chiesi Farmaceutici S.p.A.

ADDRESS: Via Palermo 26/A

CITY: Parma

POSTAL CODE: 43100

TELEPHONE: 0521-279248

FAX: 0521-774468

PUBLICATIONS:

  1. M. CORSI, G. DAL FORNO, B. OLIOSI, C. PIETRA, F.TH.M. VAN AMSTERDAM AND D. TRIST Combined Dose-Ratio Analysis for the CCK-B Antagonist Virginyamicin in Guinea pig ileum. Ann. New York Acad. Sci. 713 : 353-354, 1994.
  2. J.C. MARTINOU, M. DUBOIS-DAUPHIN, J.K.STAPLE, I. RODRIGUEZ,H. FRANKOWSKI, M. MISSOTTEN, P.ALBERTINI, D. TALABOT, S. CATSICAS, C. PIETRA AND J. HUARTE. Overexpression of BCL-2 in Transgenic mice protects neurones from naturally occurring cell death and experimental ischemia. Neuron. 13: 1017-1030, 1994.
  3. S. PALEA, C. PIETRA, D.G. TRIST, W. ARTIBANI, A. CALPISTA AND M.CORSI Evidence for the presence of both pre-and postjunctional P2-purinoceptor subtypes in human isolated urinary bladder. Brit. J. Pharmacol.. 114. 35-40, 1995.
  4. R. DI FABIO, C. PIETRA, R.J. THOMAS AND L. ZIVIANI. The asymmetric synthesis of both enantiomers of eliprodil. Bioorg. Med. Chem. . 5: 551-554, 1995.
  5. Z.C. PENG, C. PIETRA, A. SBARBATI, L. ZIVIANI, X.B. YAN, F. OSCULATI AND M. BENTIVIGLIO. Induction of NADPH-diaphorase activity in the rat forebrain after middle cerebral artery occlusion. Exp. Neurol. 138: 105-120, 1996.
  6. S. PALEA, M. CORSI, W. ARTIBANI, E. OSTARDO AND C. PIETRA. Pharmacological characterization of tachykinin NK-2 receptor on isolated human urinary bladder, prostatic urethra and prostate. J. Pharmacol. Exp. Ther. 277: 700-705, 1996.
  7. A. SBARBATI, C. PIETRA, A.M. BALDASSARRI, U. GUERRINI, L. ZIVIANI, A. REGGIANI, A. BOICELLI, F. OSCULATI. The microvascular system in ischemic cortical lesions. Acta Neuropathol.. 92: 56-63, 1996.

RESEARCH GROUP MEMBERS:

  1. Polenzani Lorenzo, C.L.
  2. Durando Lucia, C.L.
  3. Magnani Maurizio, C.L.
  4. Picollo Rossella, C.L.
  5. Basta Francesco, R.I.
  6. Del Vecchio Alessandra, R.I.
  7. Garrone Beatrice, R.I.
  8. Luparini Maria Rita, R.I.
  9. Tolu Liliana, R.I.

AFFILIATION:

Angelini Ricerche S.p.A.

ADDRESS: P.le della Stazione snc

CITY: S. Palomba - Pomezia (Rm)

POSTAL CODE: 00040

TELEPHONE: 06 - 910451

FAX: 06 - 91984597

PUBLICATIONS:

  1. LEONE MG., SASO L., DEL VECCHIO A., MO M.Y., SILVESTRINI B., CHENG C.Y. Micropurification of two human cerebrospinal fluid proteins by high performance electrophoresis chromatography. J. Neurochem. 61: 533-540, 1993
  2. GRASSI F., POLENZANI L., MILEO A.M., CARATSCH C.G., EUSEBI F. AND MILEDI R. Blockage of nicotinic acetylcholine receptors by 5-hydroxytryptamine. J. Neurosci. Res. 34: 562-570, 1993.
  3. WOODWARD R.M., POLENZANI L. AND MILEDI R. Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric acidB receptor agonist and antagonists. Mol. Pharmacol. 43: 609-625, 1993.
  4. WOODWARD, R.M., POLENZANI, L. AND MILEDI, R. Effects of fenamates and other non-steroidal anti-inflammatory drugs on rat brain GABA A receptors expressed in Xenopous oocytes. J. Pharmacol. Exp. Ther. 268: 806-817, 1994.
  5. MILEO A.M., PALMA E., POLENZANI L., LIMATOLA C., GRASSI F. AND EUSEBI F. Protein kinases C modulates exogenous acetylcholine receptors currents in Xenopus oocytes J. Neurosci. Res. 41 : 443-451 1995
  6. DELPINO A., MILEO A.M., LAPENTA V., PISELLI P., VERDINA A. AND POLENZANI L. Characterization of a new high temperature-induced mammalian heat shock protein (HSP 66), antigenically related to heat shock protein 72. J. Cell. Biochem. 63 : 51-60 1996

RESEARCH GROUP MEMBERS :

  1. Racagni Giorgio, P.O.
  2. Ambrosini Anna, B.PDR.
  3. Blom Joan, B.
  4. Garbini Sara, B.
  5. Lovati Emanuela, B.
  6. Molteni Raffaella, B.
  7. Mori Silvia, D.DR.
  8. Perez Jorge, R.
  9. Popoli Maurizio, T.L.
  10. Riva Marco, R.
  11. Iuliano Emilio, T.

AFFILIATION :

Centro di Neurofarmacologia

Istituto di Scienze Farmacologiche

Università di Milano

ADDRESS: Via Balzaretti 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-20488331

FAX: 02-29403673

E-MAIL: racagni@isfunix.farma.unimi.it

PUBLICATIONS:

  1. VOLTERRA A., TROTTI D., TROMBA C., FLORIDI S. AND RACAGNI G. Glutamate Uptake Inhibition by Oxygen Free Radicals in Rat Cortical Astrocytes. J. Neurosci. 14: 2924-2932, 1994.
  2. AMBROSINI A., BRESCIANI L., FRACCHIA S., BRUNELLO N., RACAGNI G. Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit NMDA receptor activity and prevent neurotoxicity in mesencephalic neuron in vitro. Mol. Pharmacol. 47: 1057-1064, 1995.
  3. PEREZ J., ZANARDI R., MORI S., GASPERINI M., SMERALDI E., RACAGNI G. Abnormalities of cAMP dependent endogenous phosphorylation in platelets from bipolar patients. Amer. J. Psych. 152: 1204-1206, 1995.
  4. TROTTI D., VOLTERRA A., LEHRE K.P., ROSSI D., GJESDAL O., RACAGNI G., DANBOLT N.C. Arachidonic acid inhibits a purified and reconstituted glutamate transporter directly from the water phase and not by via the phospholipid membrane. J. Biol. Chem. 270: 9890-9895, 1995.
  5. POPOLI M., VOCATURO C., PEREZ J., RACAGNI G. Presynaptic Ca2+/Calmodulin-dependent protein kinase II: autophosphorylation and activity increase in the hippocampus after long-term blockade of serotonin reuptake. Mol. Pharmacol. 48:623-629, 1995.
  6. RIVA M.A., FUMAGALLI F., BLOM J.C.M., DONATI E., RACAGNI G. Adrenalectomy reduces FGF-1 and FGF-2 gene expression in specific rat brain regions and differently affects their induction by seizures. Mol. Brain Res., 34: 190-196, 1996.
  7. GIACCONE G., VERGA L., PEREZ J., RACAGNI G., PEDROTTI B., DE GIOIA L., SELVAGGINI C., SALMONA M., GHISO J., FRANGIONE B., ISLAM K., BUGIANI O., AND TAGLIAVINI F. ßPP and Tau nteraction: a possible link between amyloid and neurofibrillary tangles in Alzheimer's disease. Amer. J. Pathol. 148: 79-87 1996.
  8. RIVA M.A., MOLTENI R., LOVATI E., FUMAGALLI F., RUSNATI M. AND RACAGNI G. Cyclic AMP-dependent regulation of Fibroblast Growth Factor-2 messenger RNA levels in rat cortical astrocytes: comparison with Fibroblast Growth Factor-1 and Ciliary Neurotrophic Factor. Mol. Pharmacol. 49: 699-706, 1996.
  9. TROTTI D., ROSSI D., GJESDAL O., LEVY L.M., RACAGNI G., DANBOLT N.C. AND VOLTERRA A. Peroxynitrite inhibits glutamate transporter subtypes. J. Biol. Chem., 271 :pp. 5976-5979, 1996.
  10. VOLTERRA A., BEZZI P., LODI RIZZINI B., TROTTI D., ULLENSVANG K., DANBOLT N.C. AND RACAGNI G. The competitive transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxycate triggers excitotoxicity in rat cortical neuron-astrocyte cocultures via glutamate release rather than uptake inhibition. Eur. J. Neurosci. 8: 2019-2028, 1996.

RESEARCH GROUP MEMBERS:

  1. Raiteri Maurizio, P.O.
  2. Marchi Mario, P.O.
  3. Maura Guido, P.A.
  4. Bonanno Giambattista, P.A.
  5. Gemignani Anita, R.U.
  6. Marcoli Manuela, R.U.
  7. Pittaluga Anna, R.U.
  8. Fedele Ernesto, R.U.
  9. Fassio Anna, D.DR.
  10. Schmid Giovanna, D.DR.
  11. Paudice Paolo, T.L.
  12. Fontana Giovanni, T.

AFFILIATION:

Istituto di Farmacologia e Farmacognosia

Facoltà di Farmacia

Università di Genova

ADDRESS: Viale Cembrano 4

CITY: Genova

POSTAL CODE: 16148

TELEPHONE: 010-3532651

FAX: 010-3993360

E-MAIL: M.Raiteri@pharmatox.unige.it

PUBLICATIONS:

  1. BONANNO, G., AND RAITERI M. Multiple GABAB receptors. Trends Pharmacol. Sci. 14: 259-261, 1993.
  2. RUSSO, C., MARCHI, M., ANDRIOLI, G.C., CAVAZZANI, P., AND RAITERI, M. Enhancement of glycine release from human brain cortex by acetylcholine acting at M4 muscarinic receptors. J. Pharmacol. Exp. Ther. 266: 142-146, 1993.
  3. LEVI, G., AND RAITERI, M. Carrier-mediated release of neurotransmitters. Trends Neurosci. 16: 415-419, 1993.
  4. GEMIGNANI, A., PAUDICE, P., BONANNO, G., AND RAITERI, M. Pharmacological discrimination between GABAB receptors regulating cholecystokinin and somatostatin release from rat neocortex synaptosomes. Mol. Pharmacol. 46: 558-562, 1994.
  5. MAURA, G., GUADAGNIN, A., AND RAITERI, M. Low nanomolar serotonin inhibits the glutamate receptor/nitric oxide/cyclic GMP pathway in slices from adult rat cerebellum. Neuroscience 68: 455-463, 1995.
  6. MAURA, G., AND RAITERI, M. Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro. J. Neurochem. 66: 203-209, 1996.
  7. FEDELE, E., AND RAITERI, M. Desensitization of AMPA receptors and AMPA-NMDA receptor interaction: an in vivo cGMP microdialysis study in rat cerebellum. Brit. J. Pharmacol. 117: 1133-1138, 1996.
  8. FASSIO, A., BONANNO, G., FONTANA, G., USAI, C., MARCHI, M., AND RAITERI, M. Role of external and internal calcium on heterocarrier-mediated transmitter release. J. Neurochem. 66: 1468-1474, 1996.
  9. PITTALUGA, A., PATTARINI, R., SEVERI, P., AND RAITERI, M. Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120. AIDS 10: 463-468, 1996.
  10. BONANNO, G., GEMIGNANI, A., SCHMID, G., SEVERI, P., CAVAZZANI, P., AND RAITERI, M. Human brain somatostatin: release from isolated cortical nerve endings and its modulation through GABAB receptors. Brit. J. Pharmacol. 118: 1441-1446, 1996.

RESEARCH GROUP MEMBERS :

  1. Ricci Gamalero, P.A.
  2. Eva Carola, R.U.
  3. Brusa Rossella, B.PDR.
  4. Oberto Alessandra, D.DR.
  5. Musso Rita, B.

AFFILIATION :

Sezione di Farmacologia

Dipartimento di Anatomia, Farmacologia e Medicina Legale

Università di Torino

ADDRESS: Via Pietro Giuria, 13

CITY: Torino

POSTAL CODE: 10125

TELEPHONE: 011-6707717/8

FAX: 011-658606

E-MAIL: eva@medfarm.unito.it

PUBLICATIONS:

  1. EVA, C. AND SPRENGEL, R. A novel putative G protein-coupled receptor highly expressed in lung and testes. DNA Cell Biol. 12: 393-399, 1993.
  2. GALLO, M.P., ALLOATTI, G., EVA, C., OBERTO, A. AND LEVI, R.C. m1 muscarinic receptors increase calcium current and phosphoinositide turnover in guinea-pig ventricular cardiocytes. J. Physiol. 471:41-60, 1993.
  3. EVA, C. AND SPRENGEL, R.: Cloning of G-protein coupled receptors. Met. Neurosci. 12:24-40, 1993.
  4. EVA, C., FUSCO, M., BRUSA, R., SCHIAVO, N., RICCI GAMALERO, S., VANTINI, G. AND GENAZZANI, E. Intracerebroventricular administration of nerve growth factor affects muscarinic cholinergic receptors in the cerebral cortex of neonatal rats. Neurochem. Int. 24:57-65, 1994.
  5. OBERTO, A., LONGONE, P., AND KRUEGER, K.E. Identification of three transcriptional regulatory elements in the rat mitochondrial benzodiazepine receptor encoding gene. Gene, 167:255-260, 1995.
  6. BRUSA, R., RICCI GAMALERO, S., GENAZZANI, E. AND EVA, C. In primary neuronal cultures muscarinic m1 and m3 receptor mRNA levels are regulated by agonists, partial agonists and antagonists. Eur. J. Pharmacol., Molec. Pharmacol. Sect., 289:9-16, 1995.
  7. BRUSA, R., ZIMMERMANN, F., DUK-SU, K., FELDMEYER, D., GASS, P., SEEBURG, P.H., SPRENGEL, R. Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-Ballele in mice. Science 270:1677-1680, 1995.
  8. OBERTO, A., MARKS N., EVANS, H.L. AND GUIDOTTI, A. Lead (Pb2+) promotes apoptosis in newborn rat cerebellar neurons: pathological implications. J. Pharmacol. Exp. Ther., In press, 1996.
  9. MUSSO, R., GRILLI, M.G., OBERTO, A., RICCI GAMALERO, S. AND EVA, C. Regulation of mouse NPY-Y1 receptor gene transcription: a potential role for NF-kB/Rel proteins. Mol. Pharmacol., In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Rotiroti Domenicantonio, P.O.
  2. Rispoli Vincenzo, R.U.
  3. Palma Ernesto, R.U.
  4. Pelaia Girolamo, R.U.
  5. Russo Diego, R.U.
  6. Clementi Emilio, R.U.
  7. Corasaniti M.Tiziana, R.U.
  8. Navarra Michele, R.U.
  9. Trozzi Alessandra, R.U.

AFFILIATION:

Facoltà di Farmacia

Università degli Studi di Reggio Calabria

ADDRESS: Complesso "Ninì Barbieri"

CITY: Roccelletta di Borgia (CZ)

POSTAL CODE: 88021

TELEPHONE: 0961-391157

FAX: 0961-391490

E-MAIL: rotiroti@area.cs.cnr.it

PUBLICATIONS :

  1. ZORZATO F., SCUTARI E., TEGAZZIN V., CLEMENTI E., TREVES S. Chlorocresol : an activator of ryanodine receptor-mediated Ca2+ release. Mol. Pharmacol. 44 : 1192-1201, 1993.
  2. BAGETTA G., CORASANTI MT., MELINO G., PAOLETTI AM., FINAZZI-AGRO A., NISTICO' G. Lithium and tacrine increase the expression of netric oxide synthase mRNA in the hippocampus of rat. Biochem. Biophys. Res.Com. 197 :1132-1139, 1993.
  3. DE SARRO G.B., ROTIROTI D., AUDINO M.G., GRATTERI S., NISTICO' G.: Effects of interleukin-2 on various models of experimental epilepsy in DBA/2 mice. Neuroimmunomodulation 1 : 161-369, 1994.
  4. BAGETTA G., IANNONE M., VECCHIO I., RISPOLI., ROTIROTI D., NISTICO' G. Neurodegeneration produced by intrahippocampal injection of paraquat is reduced by systemic administration of the 21-aminosteroid U7489F in rats. Free Rad. Res. 21 : 85-93, 1994.
  5. MOLLACE V., COLASANTI M., RODINO' P., LAURO G.M., ROTIROTI D., NISTICO' G: NMDA-dependent prostaglandin E2 release by human cultured astroglial cells is driven by nitric oxide. Biochem. Biophys. Res. Comm. 215 : 793-799, 1995.
  6. CLEMENTI, E., VECCHIO, I., CORASANITI, M.T. AND NISTICO', G. Nitric oxide modulates agonist-evoked Ca2+ release and influx responses in PC12 cells. Eur. J. Pharmacol. 289: 113-123. 1995
  7. CLEMENTI E., SCIORATI C., RICCIO M., MILOSO M., MELDOLESI J., NISTICO' G., Nitric oxide action on growth factor-elicited signals. J. Biol. Chem. 270 : 22277-22282, 1995.
  8. CAROLEO, M.C., RISPOLI, V., ARBITRIO, M., STRONGOLI, C., RAINALDI, G., ROTIROTI, D. AND NISTICO', G. Chronic administration of Praquat produces immunosuppression of T lymphocytes and astrocytosis in rats. Toxic Subst. Mech. 15: 183-194. 1996
  9. DE SARRO G., AMMENDOLA D., DE SARRO A., NACCARI F., NAVA F., GARERI P., ROTIROTI D. Behavioural and ECoG effects of IL-4, IL-6, IL-8 and IL-10 after intraventricular injection in rat. Fund. Clin. Pharmacol. 10 : 184-190. 1996.
  10. BAGETTA G., IANNONE M., PALMA E., NISTICO G., DOLLY J.O. N-Methyl-D-Aspartate and non N-Methyl-D-Aspartate receptors mediate seizures and CA1 hippocampal damage induced by dendrotoxin-k in rats. Neuroscience 71 : 613-624, 1996.

RESEARCH GROUP MEMBERS :

  1. Sala Mariaelvina, R.U.
  2. Braida Daniela, B
  3. Leone Maria Primula, B.PDR.
  4. Paladini Emma B.

AFFILIATION :

Laboratorio di Farmacologia Comportamentale

Istituto di Farmacologia

Facoltà di Scienze MM FF NN

Università degli Studi di Milano

ADDRESS: Via Vanvitelli 32/A

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02/7385568

FAX: 02/70002270

E-MAIL: gori@i.miucca.csi.unimi.it

PUBLICATIONS :

  1. SALA M., BRAIDA D., CALCATERRA P, LEONE M.P. AND GORI E. Possibility of a spontaneous drugs abuse tested in rat. Pharmacol. Res. 27: 1-14, 1993.
  2. SALA M., BRAIDA D., COLOMBO M., TERZI F., LEONE M.P. AND GORI E. Behavioral sensitization to cocaine and its antagonism with naltrexone. Behav. Pharmacol. 4: 456, 1993.
  3. SALA M., LEONE M.P., BRAIDA D., LAMPUGNANI P. AND GORI E. Quantitative EEG and behavioral modifications during tolerance and withdrawal after prolonged administration of chlordiazepoxide in rats. Behav. Pharmacol.
  4. SALA M., BRAIDA D., COLOMBO M., TERZI F., LEONE M.P. AND GORI E. Influence of opioid system on behavioral sensitization induced by cocaine in the rat. Regul. Peptides. 50:S199-200,1994.
  5. SALA M., BRAIDA D., LEONE M.P., CALCATERRA P., FRATTOLA D. AND E. GORI. Chronic morphine affects working memory during treatment and withdrawal in rats: possible residual long-term impairment. Behav. Pharmacol.
  6. SALA M., LEONE M.P.,LAMPUGNANI P., BRAIDA D., AND GORI E. Different kinetics of tolerance to behavioral and electroencephalographic effects of chlordiazepoxide in the rat. Eur. J. Pharmacol. 273: 35-45, 1995.
  7. SALA M., BRAIDA D., COLOMBO M., GROPPETTI A., SACCO S., GORI E. AND M.PARENTI, Behavioral and biochemical evidence of opioidergic involvement in cocaine sensitization. J. Pharmacol. Exp. Ther.. 274: 450-457, 1995.
  8. SALA M., LEONE M.P., LAMPUGNANI P., BRAIDA D., FRATTOLA D. AND GORI E. EEG power spectra and behavioural correlates in rats given chronic morphine. Lack of residual long-term EEG and neuronal changes. Pharmacol. Res. 32: 95-103, 1995.
  9. BRAIDA D., PALADINI E., GRIFFINI P., LAMPERTI M., MAGGI A. AND M.SALA. An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors. Eur. J. Pharmacol. 302: 13-20, 1996.

RESEARCH GROUP MEMBERS:

  1. Sandrini Maurizio, P.A.
  2. Ottani Alessandra, B.

AFFILIATION :

Sezione di Farmacologia

Dipartimento di Scienze Biomediche

Facoltà di Medicina e Chirurgia

Università degli Studi di Modena

ADDRESS: Via G. Campi, 287

CITY: Modena

POSTAL CODE: 41100

TELEPHONE: 059­428­440, 451

FAX: 059­372653

E-MAIL: farmacol@.unimo.it 

PUBLICATIONS:

  1. SANDRINI, M., VERGONI A.V. AND BERTOLINI A. No modifications of GABAA and benzodiazepine receptors following experimental dysthyroidism in rats. Pharmacol. Res. 28: 47­51, 1993.
  2. SANDRINI, M., VERGONI A.V. AND BERTOLINI A. Lack of influence of aromatase and 5Ó­reductase inhibition on [3H]imipramine binding in the male rat brain. J. Endocrinol. Inv. 16: 179­181, 1993.
  3. PINI, L., VITALE, G. AND SANDRINI, M. The role of serotonin brain receptors in the anlagesic effect of phenazone. Drugs Exptl. Clin. Res. 19: 13­17, 1993.
  4. SANDRINI, M, VITALE, G., PINI L.A., STERNIERI, E. AND BERTOLINI, A. Effects of chronic treatment with phenazone on the hot­plate test and [3H]serotonin binding sites in pons and cortex membranes of the rat. Pharmacol. 47: 84­90, 1993
  5. PINI, L.A., TRENTI, T., VITALE G., AND SANDRINI, M. Action of analgesic drugs on brain 5­HT receptors as a model to study chronic drug­sustained headaches. New Adv. Head. Res. 4: 159­166, 1994.
  6. VITALE, G., SANDRINI, M, AND PINI L.A. Lack of activity of ketorolac in hot­plate test and serotonin binding capacity of brain membranes in rats. Agents Actions 41: 184­187, 1994.
  7. PINI L.A., SANDRINI, M, AND VITALE, G. Involvement of brain serotonergic system in the antinociceptive action of acetylsalicilic acid in the rat. Inflamm. Res. 44: 30-35, 1995.
  8. SANDRINI, M, VITALE, G., DONDI, M., AND PINI L.A. Effects of acetylsalicilic acid on serotonin brain receptor subtypes. Gen. Pharmacol. 26: 737­741, 1995.
  9. SANDRINI, M, VITALE, G., VERGONI, A.V., OTTANI, A., AND BERTOLINI, A. Effect of acute and chronic treatment with triiodothyronine on serotonin levels and serotonergic receptor subtypes in the rat brain. Life Sci. 58: 1551­1559, 1996.
  10. PINI L.A., SANDRINI, M, AND VITALE, G. The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. Europ. J. Pharmacol. 308: 31­40, 1996.

RESEARCH GROUP MEMBERS:

  1. Schettini Gennaro, P.O.
  2. Florio Tullio, PC (B.PDR.)
  3. Carlo Pia, P.A.
  4. Maura Annalisa, P.A.
  5. Albiano Pina, R.U.
  6. Meucci Olimpia, B.
  7. Scorziello Antonella, D.DR.
  8. Bajetto Adriana, B.
  9. Thellung Stefano, D.DR.
  10. Angelini Giovanna, R.

AFFILIATION:

°Istituto di Farmacologia

Facoltà di Medicina e Chirurgia, Università di Genova

*Servizio di Farmacologia Clinica e Sperimentale,

Istituto Nazionale per la Ricerca sul Cancro (IST)

Unità di Neuroscienze, Centro Biotecnologie Avanzate (CBA)

ADDRESS: °Viale Benedetto XV 2

*Largo Rosanna Benzi 10

CITY: Genova

POSTAL CODE: 16132

TELEPHONE: °010-353-8806 *010-573-7256 /54

FAX: °010-353-8849 *010-573-7257

E-MAIL: schettini@sirio.cba.unige.it

PUBLICATIONS:

  1. MEUCCI O., SCORZIELLO A., AVALLONE A., VENTRA C., GRIMALDI M., BERLINGIERI M.T., AND SCHETTINI G., Alpha 1A and alpha 1B-adrenergic receptors mediate the effect of norepinephrine on cytosolic calcium levels in rat PC CL3 thyroid cells. Thyrotropin modulation of alpha 1B-linked response via a cAMP/protein kinase A-dependent pathway. Endocrinology 134:424-431, 1994.
  2. GRIMALDI M., POZZOLI G., NAVARRA P., PREZIOSI P. AND SCHETTINI G. Vasoactive Intestinal peptide and forskolin stumulate interleukin 6 production by rat cortical astrocytes in culture via a cAMP-dependent prostaglandins-independent mechanism. J. Neurochem. 63:344-350, 1994.
  3. FLORIO T., RIM C., HERSHBERGER R.E., LODA M., STORK P.J.S. The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells. Mol. Endocrinol. 8: 1289-1297, 1994.
  4. MEUCCI O., SCORZIELLO A., AVALLONE A., FLORIO T., SCHETTINI G. A1A, but not 1B, adrenoreceptors activates calcium influx through the stimulation of a tyrosine kinase/phosphotyrosine phosphatase pathway, following noradrenaline-induced emptying of IP3 sensitive calcium stores, in PC Cl3 thyroid cell line. Biochem. Biophys. Res. Comm. 209: 630-638, 1995.
  5. GALLI C., MEUCCI O., SCORZIELLO A., CALISSANO P., SCHETTINI G. Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, IGF-I through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J. Neurosci. 15: 1172-1179, 1995.
  6. GRIMALDI M., ARCONE R., CILIBERTO G., AND SCHETTINI G. Synergistic stimulation of IL-6 release and gene expression by phorbol esters and IL-1 beta in rat cortical astrocytes: role of protein kinase C blockade and activation. J. Neurochem. 64: 1945-1953, 1995.
  7. VENTRA C., PORCELLINI A., FELICIELLO A., GALLO A., PAOLILLO M., MELE E., AVVEDIMENTO V., AND SCHETTINI G. The differential response of protein kinase A to cyclic AMP in discrete brain areas correlates with the abundance of regulatory subunit II. J. Neurochem. 66 :1752-1761, 1996.
  8. FLORIO T., SCORZIELLO A., FATTORE M., D'ALTO V., SALZANO S., ROSSI G., BERLINGIERI M.T., FUSCO A., SCHETTINI G., Somatostatin inhibits PC Cl3 thyroid clonal cell line proliferation through the modulation of phosphotyrosine phosphatase activity: impairment of the somatostatinergic effects by stable expression of E1A viral oncogene. J. Biol. Chem. 271: 6129-6136, 1996.
  9. SCORZIELLO A., MEUCCI O., FLORIO T., FATTORE M., FORLONI G., SALMONA M., SCHETTINI G. 25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells. J. Neurochem. 66: 1995-2003, 1996.
  10. MEUCCI O., MILLER R.J. gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-1 J. Neurosci. 16:4080-4088, 1996.

RESEARCH GROUP MEMBERS:

  1. Sgaragli Giampietro, P.O.
  2. Mantovani Piero, P.A.
  3. Palmi Mitri, R.U.
  4. Valoti Massimo, R.U.
  5. Giséle Youmby Tchuisseu, D.DR.
  6. Frosini Maria, B.PDR.
  7. Fusi Fabio, B.

AFFILIATION:

Istituto di Scienze Farmacologiche

Facoltà di Farmacia

Università degli Studi di Siena

ADDRESS: Via Enea Silvio Piccolomini, 170

CITY: Siena

POSTAL CODE: 53100

TELEPHONE: 0577-221255, 48724

FAX: 0577-281928

E-MAIL: farmacologia@unisi.it

PUBLICATIONS:

  1. SGARAGLI, G.P., VALOTI, M., FUSI, F., PALMI, M., MANTOVANI, P., DE SANTI, M.M., LORENZINI, L., AND TOSI, P. Toxic injury to the gut musculature by 2-t-butyl-4-methoxyphenol. Eur. J. Pharmacol. 248: 121-129, 1993.
  2. DELLA CORTE, L., VALOTI, M., PALMI, M., GIOVANNINI, M.G., AND SGARAGLI, G.P. Pharmacokinetics of chlorimipramine, chlorpromazine and their N-dealkilated metabolites in plasma of healty volunteers after a single oral dose of the parent compounds. J. Pharm. Pharmac. 45: 825-829, 1993.
  3. SGARAGLI, G.P., VALOTI, M., GORELLI, B., FUSI, F., PALMI, M., AND MANTOVANI, P. Calcium antagonist and antiperoxidant properties of some hindered phenols. Brit. J. Pharmacol. 110: 369-377, 1993.
  4. FROSINI, M., GORELLI, B., MATTEINI, M., PALMI, M., VALOTI, M., AND SGARAGLI, G.P. HPLC determination of inorganic cation levels in CSF and plasma of conscious rabbits. J. Pharmacol. Toxicol. Met. 29: 99-104, 1993.
  5. VALOTI, M., COSTANZO, M., SGARAGLI, G.P., PEREZ, V., FERNANDEZ-ALVAREZ, E., AND UNZETA M. Interactions of monoamine oxidase inhibitors, N-acetylenic analogues of tryptamine, with rat liver microsomal cytochrome P450. J. Pharm. Pharmacol. 46:360-365, 1994.
  6. PALMI, M., FROSINI, M., BECHERUCCI, C., SGARAGLI, G.P., AND PARENTE, L. Increase of extracellular brain calcium involved in interleukin-1ß-induced pyresis in the rabbit: antagonism by dexamethasone. Brit. J. Pharmacol. 112: 449-452, 1994.
  7. SGARAGLI, G.P., VALOTI, M., PALMI, M., FROSINI, M., GIOVANNINI, M.G., BIANCHI, L., AND DELLA CORTE, L. Rat tissue concentrations of chlorimipramine, chlorpromazine and their N-demethylated metabolites after a single oral dose of the parent compounds. J. Pharm. Pharmacol. 47: 782-790, 1995.
  8. MORI, F., LAI, C.C., FUSI, F., GIACOBINI, E. Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. NeuroReport. 6: 633-636, 1995
  9. PALMI, M., FROSINI, M., AND SGARAGLI, G.P. Interleukin-1 of 45Ca2+ release from rat striatal slices. Brit. J. Pharmacol. 118: 1705-1710, 1996.

RESEARCH GROUP MEMBERS :

  1. Sher Emanuele, R.CNR
  2. Passafaro Maria, R.CNR
  3. Codignola Agnese, B.
  4. Francolini Maura, B.
  5. Giovannini Federica, B.
  6. Gasperi Cristina, B.
  7. Brioschi Angelica, B.

AFFILIATION :

Consiglio Nazionale delle Ricerche

Centro per lo studio della Farmacologia Cellulare e Molecolare

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-70146-320, 253

FAX: 02-7490574

E-MAIL: Sher@farma6.csfic.mi.cnr.it

PUBLICATIONS:

  1. PELUCCHI, A., CICERI, E., CLEMENTI, F., MARAZZINI, L., FORESI, A. AND SHER, E. Calcium channel autoantibodies in myasthenic syndrome and small-cell lung cancer. Amer. Rev. Resp. Dis. 147: 1229-1232, 1993.
  2. CATTANEO, M.G., CODIGNOLA, A., VICENTINI, L.M., CLEMENTI, F. AND SHER, E. Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma. Cancer Res. 53: 5566-5568, 1993.
  3. CODIGNOLA, A., TARRONI, P., CLEMENTI, F., POLLO, A., LOVALLO, M., CARBONE, E. AND SHER, E. Calcium channel subtypes controlling serotonin release from human small cell lung carcinoma cell lines. J. Biol. Chem. 268: 26240-26247, 1993.
  4. PASSAFARO, M., CLEMENTI, F., POLLO, A., CARBONE, E., AND SHER, E. w-conotoxin and Cd++ stimulate the recruitment to the plasmamembrane of an intracellular pool of voltage-operated calcium channels. Neuron. 12: 317-326, 1994.
  5. TARRONI, P., PASSAFARO, M., POLLO, A., CARBONE, E., POPOLI, M., CLEMENTI, F. AND SHER, E. Anti-b2 subunit antisense oligonucleotides modulate surface expression of the a1 subunit of N-type w-conotoxin sensitive Ca++ channel in IMR32 human neuroblastoma cells. Biochem. Biophys. Res. Comm. 201: 180-185, 1994.
  6. MAGNELLI, V., POLLO, A., SHER, E. AND CARBONE, E. Block of non-L, non-N-type Ca++ channels in rat insulinoma RINm5F cells by w-agatoxin IVA and w-conotoxin MVIIC. Eur. J. Physiol. 429: 762-771, 1995.
  7. CODIGNOLA, A., MCINTOSH, M., CATTANEO, M.G., VICENTINI, L.M., CLEMENTI, F. AND SHER, E. a-conotoxin ImI inhibits nicotine-evoked hormone release and cell proliferation in human neuroendocrine carcinoma cells. Neurosci. Lett. 206: 53-56, 1996.
  8. RICHMOND, J.E., CODIGNOLA, A., COOKE, I.M. AND SHER, E. Calcium- and barium-dependent exocytosis from the rat insulinoma cell line RINm5F assayed using membrane capacitance measurements and serotonin release. Eur. J. Physiol. 432: 258-269, 1996.
  9. SHER, E., CESARE, P., CODIGNOLA, A., CLEMENTI, F., POLLO, A., MAGNELLI, V. AND CARBONE, E. Activation of d-opioid receptors inhibits neuronal-like Ca++-channels and distal steps of Ca++-dependent secretion in human small-cell lung carcinoma. J. Neuroscience. 16: 3672-3684, 1996.
  10. SHER, E., CODIGNOLA, A., ROGERS, M. AND RICHMOND, J. Noradrenaline inhibition of Ca++ channels and secretion in single patch clamped insulinoma cells. FEBS Lett. 385: 176-180, 1996.

RESEARCH GROUP MEMBERS:

  1. Spampinato Santi, P.A.
  2. Canossa Marco, R.U.
  3. Cacciaguerra Silvia D.DR.
  4. Campana Gabriele D.DR.

AFFILIATION:

Dipartimento di Farmacologia

Università degli Studi di Bologna

ADDRESS: Via Irnerio, 48

CITY: Bologna

POSTAL CODE: 40126

TELEPHONE: 051-243597, 242025

FAX: 051-248862

E-MAIL: spampi@biocfarm.unibo.itgabri@biocfarm.unibo.it  silvia@biocfarm.unibo.it

marco@biocfarm.unibo.it

PUBLICATIONS:

  1. SPAMPINATO, S., PARADISI, R., CANOSSA, M., CAMPANA, G., FRANK, G., FLAMIGNI, C., AND FERRI, S. Immunoreactive dynorphin A-like material in extracted human hypothalamic-hypophysial plasma. Life Sci. 52: 223-230, 1993.
  2. CANOSSA, M., VENTURA, C., VAONA, I., CARBONI, L., GUARNIERI, C., AND SPAMPINATO, S. Prodynorphin mRNA expression in adult cultured rat ventricular cardiac myocytes. Biochim. Biophys. Acta. 1172: 247-250, 1993.
  3. SPAMPINATO, S., BACHETTI, T., CARBONI, L., RATTI, E., Van AMSTERDAM, F.T.M., AND FERRI, S. Ca2+ channel blocking activity of lacidipine and amlodipine in A7r5 vascular smooth muscle cells. Eur. J. Pharmacol. Molecular Pharmacology Section. 244: 139-144, 1993.
  4. ROVELLI, G., HELLER, R.A., CANOSSA, M., AND SHOOTER, E.M. Chimeric tumor necrosis factor-TrkA receptors reveal that ligand-dependent activation of the TrkA tyrosine kinase is sufficient for differentation and survival of PC12 cells. Proc. Nat. Acad. Sci. USA 90: 8717-8721, 1993.
  5. MELCHIORRE, C., BOLOGNESI, M.L., CHIARINI, A., MINARINI, A., AND SPAMPINATO, S. Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-Acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. J. Med. Chem. 36: 3734-3737, 1993.
  6. VENTURA, C., GUARNIERI, C., VAONA, I., CAMPANA, G., PINTUS, G., AND SPAMPINATO, S.Dynorphin gene expression and release in the myocardial cell. J. Biol. Chem. 269: 5384-5386, 1994.
  7. FLAMIGNI, F., CAMPANA, G., CARBONI, L., GUARNIERI, C., AND SPAMPINATO, S. Zinc is required for the expression of ornithine decarboxylase in a difluoromethylornithine-resistant cell line. Biochem. J. 299: 515-519, 1994.
  8. SPAMPINATO, S., CANOSSA, M., CARBONI, L., CAMPANA, G., LEANZA, G., and FERRI, S. Inhibition ofproopiomelanocortin expression by an oligodeoxynucleotide complementary in beta-endorphin mRNA. Proc. Nat. Acad. Sci. USA. 91: 8072-8076, 1994.
  9. SPAMPINATO, S., CANOSSA, S., CAMPANA, G., CARBONI, L., AND BACHETTI , T. Estrogen regulation of prodynorphin gene expression in the rat adenohypophisis:effect of the anti-estrogen tamoxifen. Endocrinology. 136: 1589-1594, 1995.
  10. CANOSSA, M., TWISS, J., VERITY, N., AND SHOOTER, E.M. p75NGFR and TrkA receptors cooperate to rapidly activate a p75NGFR associated protein kinase. EMBO J. 15: 3369-3376, 1996.

RESEARCH GROUP MEMBERS :

  1. Tagliamonte Alessandro, P.O.
  2. De Montis M. Graziella, R.U.
  3. Bianchi Enrica, R.U.
  4. Gambarana Carla, B.PDR.
  5. Ghiglieri Ombretta, D.DR.
  6. Meloni Domenico, D.DR.

AFFILIATION :

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università di Siena

ADDRESS: Via Delle Scotte, 6

CITY: Siena

POSTAL CODE: 53100

TELEPHONE: 0577-263-285, 226

FAX: 0577-280896

E-MAIL: tagliamonte@unisi.it

PUBLICATIONS:

  1. DE MONTIS M.G., C. GAMBARANA, D. MELONI, I. TADDEI, AND A. TAGLIAMONTE. "Long-term imipramine effects are prevented by NMDA receptor blockade". Brain Res., 606: 63-67, 1993.
  2. MELONI D., C. GAMBARANA, M.G. DE MONTIS, P. DAL PRà, I. TADDEI, AND A. TAGLIAMONTE. "Dizocilpine antagonizes the effect of chronic imipramine on learned helplessness in rats". Pharmacol. Biochem. Behav., 46: 423-426, 1993.
  3. DE MONTIS M.G., C. GAMBARANA, AND D. MELONI. "a-Methyl-para-tyrosine antagonizes the effect of chronic imipramine on learned helplessness in rats". Eur. J. Pharmacol., 249: 179-183, 1993.
  4. BIANCHI E., C. ALESSANDRINI, M. GUARNA, AND A. TAGLIAMONTE. "Endogenous codeine and morphine are stored in specific brain neurons". Brain Res. 627: 210-215, 1993.
  5. BIANCHI E., M. GUARNA, AND A, TAGLIAMONTE. "Immunocytochemical localization of endogenous codeine and morphine". Adv. Neuroimm. 4: 83-92,1994.5.
  6. GAMBARANA C., O. GHIGLIERI, A. TAGLIAMONTE, N. D'ALESSANDRO, AND M.G. DE MONTIS. "Crucial role of D1 dopamine receptors in mediating the antidepressant effect of imipramine". Pharmacol. Biochem. Behav., 50: 147-151, 1995.
  7. GAMBARANA C., O. GHIGLIERI, I. TADDEI, A. TAGLIAMONTE, AND M.G. DE MONTIS. "Imipramine and fluoxetine prevent the stress-induced escape deficits in rats through a distinct mechanism of action". Behav. Pharmacol., 6: 66-73, 1995.
  8. GAMBARANA C., O. GHIGLIERI, AND M.G. DE MONTIS. "Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine". Prog. Neuro-Psych. Biol. Psych., 19: 741-755, 1995.
  9. DWORKIN S.I., S. GLEESON, D. MELONI, T.R KOVES, T.J. MARTIN. "Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats". Psychopharmacology 117: 257-261, 1995
  10. DE MONTIS M.G., C. GAMBARANA, O. GHIGLIERI, AND A. TAGLIAMONTE. "Reversal of stable behavioural modifications through NMDA receptor inhibition in rats". Behav. Pharmacol., 6: 562-567, 1995.

RESEARCH GROUP MEMBERS:

  1. Vertua Rodolfo, P.O.
  2. Florio Chiara, R.U.
  3. Frausin Fabiana, D.DR.

AFFILIATION:

Sezione di Farmacologia

Dipartimento di Scienze Biomediche

Università di Trieste

ADDRESS: via L.Giorgieri, 7/9

CITY: Trieste

POSTAL CODE: 34127

TELEPHONE: 040-676-3529, 3532, 3534

FAX: 040-577435

PUBLICATIONS:

  1. ROSATI, A.M., TRAVERSA, U., FLORIO C., AND VERTUA, R. Circadian rhythm of cortical and striatal adenosine receptors. Life Sci. 52: 1677-1684; 1993
  2. FLORIO, C., MARTIN, J. G., STHYLER, A., AND HEISLER, S. Antiproliferative effect of prostaglandin E2 in guinea pig tracheal smooth muscle cells. Amer. J. Physiol. 266: L131-L137, 1994.
  3. FLORIO, C., ROSATI, A.M., TRAVERSA, U., AND VERTUA, R. Strain-related differences in adenosine receptor density and in behavioral sensitivity to adenosine analogs in mice. Pharmacol. Biochem. Behav. 49: 271- 276, 1994.
  4. TRAVERSA, U., ROSATI, A.M., FLORIO, C., AND VERTUA, R. Effects of divalent cations on adenosine agonist binding to A1 and non A1/A2 sites in rat cerebral cortex. Pharmacol. Toxicol. 75: 28-35, 1994.
  5. TRAVERSA, U., ROSATI, A.M., FLORIO, C., AND VERTUA, R. Effects of chronic administration of adenosine antagonists on adenosine A1 and A2 receptos in mouse brain. In Vivo. 8: 1073-1078, 1994.
  6. NAURCCKAS, E.T., HERSHENSON, M. B., ABE, M.K., KELLEHER, M.D., FLORIO, C., HEISLER, S., ABSHER, M., EVANS, J.N., SAMSEL, R.W., AND SOLWAY, J. Bronchoalveolar lavage fluid from immature rats with hyperoxia-induced airway remodelling is mitogenic for airway smooth muscle. Amer. J. Res. Cell. Mol. Biol. 12: 268-274, 1995.
  7. TUBARO, A., FLORIO, C., LUXICH, E., SOSA, S., DELLA LOGGIA, R., AND YASUMOTO, T. A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels. Toxicon. 34: 743-752, 1996.
  8. TUBARO, A., FLORIO, C., LUXICH, E., VERTUA, R., DELLA LOGGIA, R., AND YASUMOTO, T. Suitability of the MTT-based cytotoxicity assay to detect okadaic acid contamination of mussels. Toxicon. 34: 965-974, 1996.

RESEARCH GROUP MEMBERS:

  1. Vicentini Lucia, P.A.
  2. Cattaneo M. Grazia, T.L.

AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Facoltà di Medicina e Chirurgia

Università degli Studi di Milano

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02 - 70146240

FAX: 02 - 70146371

E-MAIL: luciav@imiucca.csi.unimi.it

PUBLICATIONS:

  1. SKOLNICK E.Y., LEE C.H., BATZER A., VICENTINI L.M., ZHOU M., DALY R., MYERS M.J., BACKER J.M., ULLRICH A., WHITE M.F. E SCHLESSINGER J. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implication for insulin control of ras signalling. EMBO J., 12: 1929-1936, 1993.
  2. CATTANEO M.G., GULLO M. E VICENTINI L.M. Ca2+ and Ca2+ channel antagonists in the control of human small cell lung carcinoma cell proliferation. Eur. J. Pharmacol., 247: 325-331, 1993.
  3. CATTANEO M.G., CODIGNOLA A., VICENTINI L.M., CLEMENTI F. E SHER E. Nicotine stimulates a serotoninergic autocrine loop in human small cell lung carcinoma. Cancer Res., 53: 5566-5568, 1993.
  4. CODIGNOLA A., TARRONI P., CATTANEO M.G., VICENTINI L.M., CLEMENTI F. E SHER E. Serotonin release and cell proliferation are under the control of -bungarotoxin-sensitive nicotinic receptors in small-cell lung carcinoma cell lines. FEBS Lett., 342: 286-290, 1994.
  5. CATTANEO M.G., PALAZZI E., BONDIOLOTTI G.P. E VICENTINI L.M. 5-HT1D receptor type is involved in stimulation of cell proliferation in human small cell lung carcinoma. Eur. J. Pharmacol., 268: 425-430, 1994.
  6. CATTANEO M.G., FESCE R. E VICENTINI L.M. Mitogenic effect of serotonin in human small cell lung carcinoma cells via both 5-HT1A and 5-HT1D receptors. Eur. J. Pharmacol., 291: 209-211, 1995.
  7. CODIGNOLA A., MCINTOSH J.M., CATTANEO M.G., VICENTINI L.M., CLEMENTI F. E SHER E. -conotoxin Imperialis I inhibits nicotine-evoked hormone release and cell proliferation in human neuroendocrine carcinoma cells. Neurosci. Lett., 206: 53-56, 1996.
  8. VICENTINI L.M., CATTANEO M.G. E FESCE R. Evidence for receptor subtype cross-talk in the mitogenic action of serotonin on human small-cell lung carcinoma cells. Eur. J. Pharmacol., In press, 1996.
  9. CATTANEO M.G., AMOROSO D., GUSSONI G., SANGUINI A.M. E VICENTINI L.M. A somatostatin analogue inhibits MAP kinase activation and cell proliferation in human neuroendocrine cells, FEBS Lett., In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Volterra Andrea, R.U.
  2. Trotti Davide, D.DR.
  3. Bezzi Paola, D.DR.
  4. Lodi Rizzini Barbara, B.
  5. Rossi Daniela, B.

AFFILIATION:

Centro di Neurofarmacologia, Istituto di Scienze Farmacologiche

Facoltà di Farmacia

Università di Milano

ADDRESS: Via Balzaretti, 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-20488206

FAX: 02-29404961

E-MAIL: volterra@isfunix.farma.unimi.it

PUBLICATIONS:

  1. VOLTERRA A., TROTTI D., TROMBA C., FLORIDI S. AND RACAGNI G. Oxygen free radicals inhibit glutamate uptake in rat cortical astrocytes. J. Neurosci. 14: 2924-2932, 1994.
  2. TROMBA C., SALVAGGIO A., RACAGNI G. AND VOLTERRA A. Hippocampal hypoglycemia-activated K+ channels: single-channel analysis of glucose- and voltage-dependence. Pflügers Arch. Eur. J. Physiol. 429: 58-63, 1994.
  3. VOLTERRA A., TROTTI D. AND RACAGNI G. Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms. Mol. Pharmacol. 46: 986-992, 1994.
  4. VOLTERRA A., TROTTI D., BEZZI P., CIVENNI G. AND RACAGNI G. [Ca++] modulates the ratio between cycloxygenase and lipoxygenase metabolism of arachidonic acid in homogenates of hippocampal astroglial cultures. Neurosci. Lett. 183: 160-163, 1995.
  5. TROTTI D., VOLTERRA A., LEHRE K.P., ROSSI D., GJESDAL O., RACAGNI G. AND DANBOLT NC. Arachidonic acid inhibits a purified and reconstituted glutamate transporter directly from the water phase and not by via the phospholipid membrane. J. Biol. Chem. 270: 9890-9895, 1995.
  6. TROTTI D., ROSSI D., GJESDAL O., LEVY L.M., RACAGNI G., DANBOLT N.C. AND VOLTERRA A. Peroxynitrite inhibits glutamate transporter subtypes. J. Biol. Chem. 271: 5976-5979, 1996.
  7. VOLTERRA A., BEZZI P., LODI RIZZINI B., TROTTI D., ULLENSVANG K., DANBOLT N.C. AND RACAGNI G. The competitive transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition. Eur. J. Neurosci. 8: 2019-2028, 1996.

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