SIF - Società Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

AUTONOMIC PHARMACOLOGY

 

RESEARCH GROUP MEMBERS:

  1. Breschi Maria Cristina, P.A.
  2. Nieri Paola, R.U.
  3. Lazzeri Nicola, B.

AFFILIATION:

Sezione di Farmacologia

Istituto Policattedra di Discipline Biologiche

Facoltà di Farmacia

Università di Pisa

ADDRESS: Via Bonanno, 6

CITY: Pisa

POSTAL CODE: 56126

TELEPHONE: 050-24092

FAX: 050-40517

E-MAIL: breschi@farm.unipi.it

PUBLICATIONS:

  1. MACCHIA B., BALSAMO A., BRESCHI M.C., CHIELLINI G., LAPUCCI A., MACCHIA M., MANERA C., MARTINELLI A., MARTINI C., SCATIZZI R. AND UCCELLO BARRETTA G. Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis and adrenergic activity of isochroman derivatives. J. Med. Chem. 36: 3077-3086, 1993.
  2. BRESCHI M.C., PELLEGRINI A., SOLDANI P., MARTINOTTI E., SCATIZZI R. AND PAPARELLI A. Morphofunctional changes in the noradrenergic innervation of rat cardiovascular system after various duration of noise stress. Int. J. Neurosci. 75: 73-81, 1994.
  3. PELLEGRINI A., SOLDANI P., BRESCHI M.C., SCATIZZI R., NIERI P., CAMPAGNI A., DEL BIANCHI S. AND PAPARELLI A. Noradrenergic innervation and receptor responses of cardiovascular tissues from young and aged rats after acute microwave exposure. Int. J. Neurosci. 76: 165-175, 1994.
  4. BRESCHI M.C., NIERI P., LAZZERI N. AND MARTINOTTI E. Adenosine enhances the bronchocontractile response to histamine in anaesthetized and curarized guinea-pigs through a mechanism partly blocked by hexamethonium. Pharmacology 49: 42-51, 1994.
  5. BRESCHI M.C., SCATIZZI R., CAMPAGNI A., SOLDANI P., PELLEGRINI A., GESI M., PAPARELLI A. AND DEL BIANCHI S. Age-related changes in the noradrenergic pattern and receptor responses of the rat cardiovascular system after repeated microwave exposure. Int. J. of Neurosci. 82: 61-69, 1995.
  6. BRESCHI M.C., MARTINI C., SCATIZZI R., CRISTOFANI R., GIANNACCINI G., MARTINOTTI E. AND LUCACCHINI A. Benzodiazepine agonists reverse the effects of noise exposure on central benzodiazepine receptors and cardiac responsiveness. Life Sci. 57: 1131-1140, 1995.
  7. BALSAMO A., BRESCHI M.C., CHIELLINI G., FAVERO L., MACCHIA M., MARTINELLI A., MARTINI C., ROSSELLO A. AND SCATIZZI R. Synthesis and ß-adrenergic properties of (E)-N-[3-(alkylamino)-2-hydroxypropilidene](methyloxy)amines substituted with an aromatic group on their [(methyloxy)imino]methyl moiety (MOIMM): an investigation into the biopharmacological effects of an aryl substitution in the class of MOIM ß-blocking drugs. Eur. J. Med. Chem. 30: 743-755, 1995.
  8. NIERI P., LAZZERI N., MARTINOTTI E., SCATIZZI R. AND BRESCHI M.C. Acetylcholine-induced -bronchoconstriction modified by noise exposure in normal but not in sensitized guinea-pigs. J. Auton. Pharmacol. 16: 55-62, 1996.
  9. NIERI P., MARTINOTTI E., LAZZERI N. AND BRESCHI M.C. Effects of adenosine on NANC bronchoconstriction in anaesthetised guinea- pigs. J. Pharm. Pharmacol. 48: 422-428, 1996.
  10. BRESCHI M.C., MACCHIA M., MANERA C., MICALI E., NARDINI C., NENCETTI S., ROSSELLO A. AND SCATIZZI R. Conformationally restrained b-blocking oxime ethers. 3. Synthesis and b-adrenergic antagonistic activity diastereomeric anti and syn 2-(5'-(3'-methyl)isoxazolidinyl)-N-alkylethanolamines. Eur. J. Med. Chem. 31: 159-163, 1996.

RESEARCH GROUP MEMBERS:

  1. Crema Antonio, P.O.
  2. De Ponti Fabrizio, R.U.
  3. Crema Francesca, R.U.

AFFILIATION:

Dipartimento di Medicina Interna e Terapia Medica

Facoltà di Medicina e Chirurgia

Università degli Studi di Pavia

ADDRESS: Piazza Botta, 10

CITY: Pavia

POSTAL CODE: 27100

TELEPHONE: 0382-506357

FAX: 0382-22741

E-MAIL: deponti@ipv36.unipv.it

PUBLICATIONS:

  1. DE PONTI F., EINAUDI A., COSENTINO M., D'ANGELO L., LECCHINI S., FRIGO G.M. AND CREMA A. Differential effects of antimuscarinic agents on intestinal motility in the conscious dog. J. Pharmacol. Exp. Ther.. 264: 789-794, 1993.
  2. DE PONTI F., GIARONI C., COSENTINO M., LECCHINI S. AND FRIGO G.M. Calcium channel blockers and gastrointestinal motility: basic and clinical aspects. Pharmacol. Therapeut. 60: 121-148, 1993.
  3. SPADA M., DE PONTI F., ALESSIANI M., COSTA A., GIRANI M., DIONIGI P., VISCHI S., PELONI G., REYES J., TODO S. AND CREMA A. Monitoring of intestinal myoelectrical activity after isolated small bowel transplantation in FK506-immunosuppressed pigs. Transplantation Proceedings. 26: 1537-1539, 1994.
  4. DE PONTI F., COSENTINO M., COSTA A., GIRANI M., GIBELLI G., D'ANGELO L., FRIGO G.M. AND CREMA A. Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of 3-adrenoceptors. British J. Pharmacol.. 114: 1447-1453, 1995.
  5. DE PONTI F., CREMA F., D'ANGELO L., CARAVAGGI M., BROCCALI G., BIANCO L. AND LECCHINI S. Repeated administration of SL 84.0418, a new oral antihyperglycaemic agent. A phase I study. Clinical Drug Investigation. 9: 191-196, 1995.
  6. DE PONTI F., GIBELLI G., CREMA F. AND LECCHINI S. Functional evidence for the presence of 3-adrenoceptors in the guinea-pig common bile duct and colon. Pharmacology. 51: 288-297, 1995.
  7. DE PONTI F., GIBELLI G., CROCI T., ARCIDIACO M., CREMA F. AND MANARA L. Functional evidence of atypical 3-adrenoceptors in the human colon using the 3-selective adrenoceptor antagonist SR 59230A. British J. Pharmacol.. 117: 1374-1376, 1996.
  8. DE PONTI F., GIARONI C., COSENTINO M., LECCHINI S. AND FRIGO G.M. Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications. Pharmacol. Therapeut.. 69: 59-78, 1996.
  9. COSTA A., DE PONTI F., SPADA M., ALESSIANI M., BARBERA D., FERRARI P., ZANOLA S., MORBINI P., ARBUSTINI E. AND CREMA A. Reduced intestinal myoelectrical activity during rejection of small bowel allografts in pigs. Transplantation Proceedings. In press, 1996.
  10. COSTA A., ALESSIANI M., DE PONTI F., SPADA M., MERLI M., ZANOLA S., BARBERA D., RADEMACHER J., DRIVAS E. AND CREMA A. Stimulatory effect of FK506 and erythromycin on pig intestinal motility. Transplantation Proceedings. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Martinotti Enrica, P.A.
  2. Scatizzi Roberta, D.DR.
  3. Calderone Vincenzo, B.

AFFILIATION:

Sezione di Farmacologia

Istituto Policattedra di Discipline Biologiche

Facoltà di Farmacia

Università di Pisa

ADDRESS: Via Bonanno, 6

CITY: Pisa

POSTAL CODE: 56126

TELEPHONE: 050-24092

FAX: 050-40517

E-MAIL: emartin@farm.inupi.it

PUBLICATIONS:

  1. BRESCHI, M.C., MARTINOTTI, E., CATALANO, S., FLAMINI, G., MORELLI, I. AND PAGNI, A.M. Vasoconstrictor activity of 8-o-acetylharpagide from Ajuga Reptans. Journal of Natural Products, 8: 1145-1148, 1993
  2. MACCHIA, B., BRESCHI, M.C., GENTILI, D., LAPUCCI, A., MACCHIA, M., MANERA, C., MARTINELLI, A., MARTINOTTI, E., NENCETTI, S. AND NIERI, P. Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis and adrenergic activity of tetrahydrobenzocycloheptene derivatives. Eur. J. Med. Chem. 29: 753-760, 1994.
  3. MACCHIA, B., MACCHIA, M., MANERA, C., MARTINOTTI, E., NENCETTI, S., ORLANDINI, E., ROSSELLO, A. AND SCATIZZI, R. Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting -adrenergic activity. Synthesis and 1- and 2-adrenergic activity of 3-phenyl-3-piperidinols and their desoxy analogs Eur. J. Med. Chem. 30: 869-880, 1995.
  4. DELLA PIETà, F., BRESCHI, M.C., SCATIZZI, R. AND CINELLI, F. Relaxing activity of two linear diterpenes from Cystoseira Brachycarpa var. balearica on intestinal preparations. Planta Medica 61 (6): 493-496, 1995.
  5. CALDERONE, V., MARTINOTTI, E., SCATIZZI, R., PELLEGRINI, A. AND BRESCHI, M.C. A modified aortic multiple-ring preparation for functional studies J. Pharmacologic and Toxicologic Methods, 35: 131-138, 1996.

RESEARCH GROUP MEMBERS:

  1. Mitolo-Chieppa Delia, P.O.
  2. Serio Miralma, B.PDR.
  3. Potenza Maria Assunta, D.DR.
  4. Macchiarulo Carmela, B.
  5. Montagnani Monica, B.
  6. Mansi Gianfranco, B.
  7. Rinaldi Rosanna, D.DR:
  8. Genualdo Marisa, D.DR:

AFFILIATION:

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università di Bari

ADDRESS: Piazza Giulio Cesare

CITY: Bari

POSTAL CODE: 70124

TELEPHONE: 080/5478449

FAX: 080/5478444

E-MAIL: cuomo@cimedoc.uniba.it

PUBLICATIONS:

  1. SERIO, M., MITOLO-CHIEPPA, D., POTENZA, M.A. Presynaptic cholinergic receptors modulating neurotransmitters release in the guinea-pig urinary bladder. Functional Neurology. 9 (3): 101-105, 1994.
  2. SERIO, M., POTENZA, M.A., VULPIS, V., PIRRELLI, A., MITOLO-CHIEPPA, D., JIRILLO, E. Decrease of phagocytic functions in hypertensive rats. Immunopharmacol. Immunotoxicol. 16 (2): 261-280, 1994.
  3. POTENZA, M.A., DE SALVATORE, G., MONTAGNANI, M., SERIO, M., MITOLO-CHIEPPA, D. Vasodilatation induced by capsaicin in rat mesenteric vessels is probably independend of nitric oxide synthesis. Pharmacol. Res. 30 (3): 253-261, 1994.
  4. POTENZA, M.A., DE SALVATORE, G., MONTAGNANI, M., SERIO, M., MITOLO-CHIEPPA, D. Vasodilatation induced by capsaicin in rat mesenteric resistance vessels: role of nitric oxide. Polish J. Pharmacol. 46 (4): 326-327, 1994.
  5. SERIO, M., MONTAGNANI, M., POTENZA, M.A., MANSI, G., DE SALVATORE, G., MITOLO-CHIEPPA, D. Posnatal developmental changes of receptor responsiveness in rat mesenteric vascular bed. J. Auton. Pharmacol. 16: 63-68, 1996.
  6. MITOLO-CHIEPPA, D., SERIO, M., POTENZA, M.A., MONTAGNANI, M., MANSI, G., PECE, S., JIRILLO, E., STOCLET, J.C. Hyporeactivity of mesenteric vascular bed in endotoxin-treated rats. Eur. J. Pharmacol. 309 (2): 175-182, 1996.
  7. SERIO, M., POTENZA, M.A., MONTAGNANI, M., MANSI, G., MITOLO-CHIEPPA, D., JIRILLO, E. Beta adrenoceptor responsiveness of splenic macrophages in normotensive and hypertensive rats. Immunopharmacol. Immunotoxicol. 18 (2): 249-265, 1996.
  8. MANSI, G., SERIO, M., POTENZA, M.A., MONTAGNANI, M., MITOLO-CHIEPPA, D. Involvement of nitric oxide in hyporeactivity of rat mesenteric vascular bed during endotoxin shock: effect of dexamethasone and endothelin-I. J. Biol. Res. 72: 155-162, 1996.
  9. SERIO, M., POTENZA, M.A., MONTAGNANI, M., MANSI, G., RINALDI, R., PECE, S., FUMAROLA, D., JIRILLO, E., MITOLO-CHIEPPA, D. Bacterial lipopolysaccharide-induced hyporeactivity in rat perfused resistance vessels. Modulating effect of dexamethasone. J. Endotoxin Res. 1996, in press.
  10. MONTAGNANI, M., SERIO, M., POTENZA, M.A., MANSI, G., DE SALVIA, M.A., CAGIANO, R., CUOMO, V., AND MITOLO-CHIEPPA, D. Prenatal exposure to carbon monoxide and vascular responsiveness of rat resistance vessels. Life Sci. 59 (18): 1553-1561, 1996.

RESEARCH GROUP MEMBERS:

  1. Testa Rodolfo, C.L.
  2. Poggesi Elena, C.L.
  3. Taddei Carlo, R.I.
  4. Guarnieri Luciano, C.L.
  5. Angelico Patrizia, R.I.
  6. Ibba Marina, R.I.
  7. Sironi Giorgio, C.L.
  8. Colombo Davide, R.I.
  9. Leonardi Amedeo, Dir. R.

AFFILIATION:

RECORDATI Industria Chimica e Farmaceutica S.P.A.

ADDRESS: Via M. Civitali 1

CITY: Milano

POSTAL CODE: 20148

TELEPHONE: (02) 48787.1

FAX: (02) 40073747

PUBLICATIONS:

  1. TADDEI C., POGGESI E., LEONARDI A., AND TESTA R. Affinity if different alpha1-antagonists for the alpha1-adrenoceptors of rabbit and rat liver membranes. Life Sci. 53: 177-181, 1993.
  2. TESTA R., GUARNIERI L., IBBA M., STRADA G., POGGESI E., TADDEI C., SIMONAZZI I., AND LEONARDI A. Characterization of alpha1-adrenoceptor subtypes in prostate and prostatic urethra of rat, rabbit, dog, and man. Eur. J. Pharmacol. 249: 307-315, 1993.
  3. TESTA R., GUARNIERI L., POGGESI E., SIMONAZZI I., TADDEI C., AND LEONARDI A. Mediation of noradrenaline-induced contractions of rat aorta by the alpha1b-adrenoceptor subtype. Brit. J. Pharmacol. 114: 745-750, 1995.
  4. TESTA R., TADDEI C. POGGESI E., DESTEFANI C., COTECCHIA S., HIEBLE J.P., SULPIZIO A.C. NASELSKY D., BERGSMA D., ELLIS C., SWIFT A., GANGULY S., RUFFOLO R.R. JR., AND LEONARDI A. Rec 15/2739 (SB 216469): a novel prostate selective alpha 1-adrenoceptor antagonist. Pharmacol. Comm. 6: 1-3, 79-86, 1995.
  5. TESTA R., DESTEFANI C., GUARNIERI L., POGGESI E., SIMONAZZI I., TADDEI C., AND LEONARDI A. The alpha1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of the rat aorta. Life Sci. 57: PL159-PL163, 1995.
  6. GUARNIERI L., ANGELICO P., IBBA M., POGGESI E., TADDEI C., LEONARDI A., AND TESTA R. Pharmacological in vitro studies of the new 1,4-dihydropyridine calcium antagonist lercanidipine. Arzneim.-Forsch. Drug Res. 46: 15-24, 1996.
  7. SIRONI G., MONTAGNA E., GRETO L., BIANCHI G., LEONARDI A., AND TESTA R. Antihypertensive effects of lercanidipine in experimental hypertensive rats and dogs. Arzneim.-Forsch. Drug Res. 46 : 145-152, 1996.
  8. SIRONI G., MONTAGNA E., GRETO L., LEONARDI A., AND TESTA R. Haemodynamic effects of lercanidipine in anaesthetized open-chest dogs. Arzneim.-Forsch. Drug Res. 46: 256-261, 1996.
  9. TESTA R., GUARNIERI L., TADDEI C., POGGSI E., ANGELICO P., SARTANI A., LEONARDI A., GOFRIT O.N., MERETYK S., AND CAINE M. Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenalilne-induced contraction of human prostate and mesenteric artery. J. Pharmacol. Exp. Ther. 277: 1237-1246, 1996.

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