SIF - Società Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

CARDIOVASCULAR PHARMACOLOGY

 

RESEARCH GROUP MEMBERS:

  1. Anania Vittorio Domenico, P.O.
  2. Madeddu Paolo, R.U.
  3. Demontis Maria Piera, R.U.
  4. Varoni Maria Vittoria, T.L.
  5. Fresi Angela, D.DR.

AFFILIATION:

Sezione di Farmacologia

Dipartimento di Biologia Animale

Facoltà di Medicina Veterinaria

Università di Sassari

ADDRESS: Via Vienna, 2

CITY: Sassari

POSTAL CODE: 07100

TELEPHONE: 079-22-8518, 9519

FAX: 079-229432

PUBLICATIONS:

  1. MADEDDU P., ANANIA V., PINNA, PARPAGLIA P., DEMONTIS M.P., VARONI M.V., FATTACCIO M.C., GLORIOSO N. Chronic kinin receptor blockade induces hypertension in deoxycorticosterone-treated rats. Brit. J. Pharmacol. 108: 651-657, 1993.
  2. MADEDDU, P., DEMONTIS, M.P., VARONI, M.V., FATTACCIO, M.C., PALMIERI, A., ANANIA, V. Verapamil prevents the acute hypertensive response to intracerebroventricular cadmium in conscious normotensive rats. Amer. J. Hypertension 6: 193-197, 1993.
  3. MADEDDU, P., GLORIOSO, N., VARONI, M.V., DEMONTIS, M.P., FATTACCIO, M.C., ANANIA, V. Cardiovascular effects of brain kinin receptor blockade in spontaneously hypertensive rats. Hypertension 23 (suppl. I): I189-I192, 1994.
  4. MADEDDU, P., PINNA, PARPAGLIA, P., VARONI, M.V., DEMONTIS, M.P., FATTACCIO, M.C., ANANIA, V., GLORIOSO, N. Chronic inhibition of bradykinin receptors alters cardiovascular function in rats with an excess of circulating vasoconstrictors. Brazilian J. Med. Biol. Res. 27: 1985-1993, 1994.
  5. DE RIU, P.L., DEMONTIS, M.P., ANANIA, V., CARIA, M.A., MAMELI, O., BECCIU, A., TOLU, E. Brain electrobiogenesis protection induced by nimodipine and MK-801 during acute hypoxia in hypertensive rats. Pharm. Res. 31:169-173, 1995.
  6. MADEDDU, P., PINNA, PARPAGLIA, P., DEMONTIS, M.P., VARONI, M.V., FATTACCIO, M.C., ANANIA, V., GLORIOSO, N. Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats. Hypertension 25: 453-459, 1995.
  7. MADEDDU, P., PINNA, PARPAGLIA, P., DEMONTIS, M.P., VARONI, M.V., FATTACCIO, M.C., ANANIA, V., GLORIOSO, N. Effects of kinin blockade on the blood pressure of salt-loaded pregnant rats. Hypertension 25: 823-827, 1995.
  8. MADEDDU, P., ANANIA, V., VARONI, M.V., PINNA, PARPAGLIA, P., DEMONTIS, M.P., FATTACCIO, M.C., PALOMBA, D., POLLOCK ,D., GLORIOSO, N. Prevention by blockade angiotensin subtype1-receptors of the development of genetic hypertension but not its heritability. British J. Pharmacol. 115: 557-562, 1995.
  9. MADEDDU, P., VARONI, M.V., DEMONTIS, M.P., PINNA, PARPAGLIA, P., GLORIOSO, N., ANANIA, V. Urinary kallikrein: A marker of blood pressure sensitivity to salt. Kidney International 49: 1422-1427, 1996.
  10. MADEDDU, P., VARONI, M.V., DEMONTIS, M.P., PINNA, PARPAGLIA, P., GLORIOSO, N., ANANIA, V. Blood pressure sensitivity to salt in rats with low urinary kallikrein excretion. Immunopharmacol. 33: 301-304, 1996.

RESEARCH GROUP MEMBERS:

  1. Berti Ferruccio, P.O.
  2. Rossoni Giuseppe, T.L.
  3. Bernareggi Micaela, D.DR.

AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica "Emilio Trabucchi"

Facoltà di Medicina e Chirurgia

Università degli Studi di Milano.

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02/74.90.243 - 70146.312.

FAX: 02/70146.371

E-MAIL: berti@imiucca.csi.unimi.it.

PUBLICATIONS:

  1. BERTI F., ROSSONI G., DELLA BELLA D., VILLA L.M., BUSCHI A., TRENTO F., BERTI M., AND TONDO C. Nitric oxide and prostacyclin influence coronary vasomotor tone in perfused rabbit heart and modulate endothelin-1 activity. J. Cardiovasc. Pharmacol. 22: 321-326, 1993.
  2. SALA A., ROSSONI G., BUCCELLATI C., BERTI F., FOLCO G., AND MACLOUF J. Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated cell-perfused heart of rabbit. British J. Pharmacol.. 110:1206-1212, 1993;
  3. SALA A., RONA P., POMPILIO G., PAROLARI A., ANTONA C., BIGLIOLI P., ROSSONI G., VILLA L.M., AND BERTI F. Prostacyclin production by different human grafts employed in coronary operations. Ann. Thorac. Surg. 57: 1147-1150, 1994.
  4. BERTI F., ROSSONI G., FERRO L,. TRENTO F., VILLA L.M., POMPILIO G., AND SALA A. Defibrotide, via prostacyclin release, antagonizes endothelin-1 induced vasospasm in rabbit and human coronary artery. Internal Medicine. 2: 49-56, 1994.
  5. ROSSONI G., BERTI F., BERTI M., BERNAREGGI M., TRENTO F., PORTA R., PESCADOR R., AND FERRO L. Oligotide, a new single-stranded oligodeoxyribonucleotide, preserves postsynaptic b-adrenergic and cholinergic receptor functions in rabbit hearts after acute infarction. Thromb. Res. 78: 429-440, 1995.
  6. ROSSONI G., BERTI F., BERNAREGGI M., VILLA L.M., AGOZZINO S., CEREDA R., GIULIANI P., AND MIZRAHI J. Protective effects of ITF 296 in the isolated rabbit heart subjected to global ischemia. J. Cardiovasc. Pharmacol. 26: S44-S52, 1995.
  7. ROSSONI G., SALA A., BERTI F., TESTA T., BUCCELLATI C., MOLTA C., MÜLLER-PEDDINGHAUS R., MACLOUF J., AND FOLCO G.C. Myocardial protection by the leukotriene synthesis inhibitor BAY X 1005. Importance of transcellular biosynthesis of cysteinyl­leukotrienes. J. Pharmacol. Exp. Ther.. 276: 335-341, 1996.
  8. GJUMRAKCH M.A., SALA A., ROSSONI G., BERTI F., BUCCELLATI C., BURNSTOCK G., FOLCO GC., AND MACLOUF, J. Morphological and functional changes of coronary vasculature caused by transcellular biosynthesis of sulfidopeptide leukotrienes in isolated heart of rabbit. Blood. 87: 1824-1832, 1996.
  9. DE GENNARO COLONNA V., ROSSONI G., BONACCI D., CICERI S., CATTANEO L., MÜLLER E.E., AND BERTI F. Worsening of ischemic damage in hearts from rats with selective growth hormone deficiency. Eur. J. Pharmacol. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Bongrani Stefano, Dir. R.
  2. Civelli Maurizio, C. L.
  3. Giossi Massimo, R. I.
  4. Galbiati Elisabetta , R.I.
  5. Razzetti Roberta, C. L.
  6. Bergamaschi Marco, R.I.
  7. Fornasier Massenzio, R.I.
  8. Pastore Fiorella, R.I.
  9. Cadel Sandro, C.L.
  10. Villetti Gino, R.I.

AFFILIATION:

Chiesi Farmaceutici S.p.A.

ADDRESS: Via Palermo 26/A

CITY: Parma

POSTAL CODE: 43100

TELEPHONE: 0521-2791

FAX: 0521-774468

E-MAIL: chiesi@mbox.vol.it

PUBLICATIONS:

  1. BONGRANI, S., FORNASIER, M., PAPOTTI, M., RAZZETTI, R., AND ROBERTSON, B. Lung gas volumes and expiratory time constant in immature newborn rabbits treated with natural or synthetic surfactant or detergents. Biol. Neonate. 65: 406-415, 1994.
  2. RAZZETTI, R., FORNASIER, M., PAPOTTI, M., AND BONGRANI, S. Antihypertensive and diuretic effects of Delapril, Indapamide and their combination in spontaneously hypertensive rats. High Blood Pressure. 3 : 8-16, 1994.
  3. CIVELLI, M., CARUSO, P., GIOSSI, M., BERGAMASCHI, M., RAZZETTI, R., BONGRANI, S., AND GASCO, A. CHF 2206, a new potent vasodilating and antiaggregating drug as potential nitric oxide donor. Eur. J. Pharmacol. 225: 17-24, 1994.
  4. ZENG, Y.C., BONGRANI, S., BRONZETTI, E., CADEL, S., RICCI, A., VALSECCHI, B., AND AMENTA, F. Influence of long-term treatment with L-deprenyl on the age-dependent changes in rat brain microanatomy. Mech. Age. Dev.. 73: 113-126, 1994.
  5. RAZZETTI, R., AND ACERBI, D. Pharmacokinetic and pharmacologic properties of Delapril, a lipophilic nonsulfhydryl angiotensin-converting enzyme inhibitor. Amer. J. Cardiol.. 75 : 7-12, 1995.
  6. GIOSSI, M., CARUSO, P., CIVELLI, M., AND BONGRANI, S. Inhibition of parathyroid hormone-stimulated resorption in cultured fetal rat long bones by the main metabolites of ipriflavone. Calcified Tissue Int. 58: 419-422, 1996.
  7. CIVELLI, M., GIOSSI, M., CARUSO, P., RAZZETTI, R., BERGAMASCHI, M., BONGRANI, S. AND GASCO, A. The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363. Brit. J. Pharmacol. 118: 923-928, 1996.

RESEARCH GROUP MEMBERS:

  1. Caparrotta Laura, P.A.
  2. Ragazzi Eugenio, P.A.
  3. Froldi Guglielmina, R.U.
  4. Chinellato Alessandro, B.PDR.

AFFILIATION:

Dipartimento di Farmacologia "E. Meneghetti"

Facoltà di Farmacia

Università degli Studi di Padova

ADDRESS: Largo E. Meneghetti, 2

CITY: Padova

POSTAL CODE: 35131

TELEPHONE: 049-827-5090 / 5092

FAX: 049-827-5093

E-MAIL: caparrot@ipdunidx.unipd.it  mina@dfem.unipd.it  ragazzi@dfem.unipd.it

PUBLICATIONS:

  1. CHINELLATO A., RAGAZZI E., PANDOLFO L., FROLDI G., CAPARROTTA L., FASSINA G. Unimpaired adenosine 5'-triphosphate-induced relaxation in in vitro Watanabe heritable hyperlipidemic rabbit aorta. Nutr. Metab. Cardiovasc. Dis. 3:5-9, 1993.
  2. FROLDI G., PANDOLFO L., DE BIASI M., CHINELLATO A., RAGAZZI E., CAPARROTTA L., FASSINA G. Species-dependent effects of increasing hypoxia on functions and energy balance in isolated atria. Comp. Biochem. Physiol. 105A:21-27, 1993
  3. RAGAZZI E., CHINELLATO A., PANDOLFO L., FROLDI G., CAPARROTTA L., PROSDOCIMI M., ALIEV G., FASSINA G. Atherosclerosis-related remodeling of aortic relaxation to purines in Watanabe heritable hyperlipidemic (WHHL) rabbit. J. Pharmacol. Exp. Ther. 266:1091-1096, 1993.
  4. FROLDI G., PANDOLFO L., CHINELLATO A., RAGAZZI E., CAPARROTTA L., FASSINA G. Dual effect of ATP and UTP on rat atria: which types of receptors are involved? Naunyn-Schmied. Arch. Pharmacol., 349: 381-386, 1994.
  5. CHINELLATO A., RAGAZZI E., PANDOLFO L., FROLDI G., CAPARROTTA L., FASSINA G. Purine- and nucleotide-mediated relaxation of thoracic aorta: common and different sites of action. J. Pharm. Pharmacol. 46:337-341, 1994.
  6. CHINELLATO A., RAGAZZI E., PANDOLFO L., PALERMO ALVANO A., FROLDI G., DE BIASI M., CAPARROTTA L., ALIEV G., FASSINA G. Functional and morphologic characterization of thoracic aorta in heritable hyperlipidemic Yoshida rats of different ages. J. Cardiov. Pharmacol. 24: 216-228, 1994.
  7. FROLDI G., GUERRA L., PANDOLFO L., CHINELLATO A., RAGAZZI E., CAPARROTTA L., BOREA P.A., FASSINA G. Phentolamine and hypoxia: modulation of contractility and a1-adrenoceptors in isolated rat atria. Naunyn-Schmied. Arch. Pharmacol., 350: 563-568, 1994.
  8. CALABRO A., RAGAZZI EUGENIO, REALDON N., RAGAZZI ENRICO, PAGANO F. New topical formulation of isosorbide dinitrate in the treatment of male impotence. Pharmaceut. Sci. 1 :499-500, 1995.
  9. RAGAZZI E., CHINELLATO A., PANDOLFO L., FROLDI G., CAPARROTTA L., FASSINA G. Endothelial nucleotide-mediated aorta relaxation in aged Watanabe hertable hyperlipidemic rabbits. J. Cardiovasc. Pharmacol. 26: 119-126, 1995.

RESEARCH GROUP MEMBERS:

  1. Caputi Achille, P.O.
  2. Squadrito Francesco, P.A.
  3. Spina Edoardo, P.C. (prof. a contratto)
  4. Calapai Gioacchino, T.L.
  5. Altavilla Domenica, T.L.
  6. Zingarelli Basilia, D.DR.
  7. Campo Giuseppe, D.DR.
  8. Avenoso Angela, D.DR.
  9. Ferlito Marcella, D.DR.
  10. Minutoli Letteria, D.DR.
  11. Cuzzocrea Salvatore, D.DR.
  12. Mazzaglia Giampiero, B.
  13. Marciano Concetta, B

 

AFFILIATION:

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università di Messina

ADDRESS: Piazza XX Settembre, 4

CITY: Messina

POSTAL CODE: 98122

TELEPHONE: 090-712533

FAX: 090-661029

PUBLICATIONS:

  1. CALAPAI G., MAZZAGLIA G., CILIA M., ZINGARELLI B., SQUADRITO F., CAPUTI A.P. Mediation by nitric oxide formation in the preoptic area of endotoxin and tumour necrosis factor-induced inhibition of water intake in the rat. Brit. J. Pharmacol. 111: 1328-1332, 1994.
  2. CAMPO G.M., SQUADRITO F., IOCULANO M., ALTAVILLA D., CALAPAI G., ZINGARELLI B., SCURI R., CAPUTI A.P. Reduction of myocardial infarct size in rat by IRFI-048, a selective analogue of vitamin E. Free Rad. Bio. Med. 16: 427-435, 1994.
  3. SPINA E., ANCIONE M, DI ROSA A,E., ARTEMISIA A., NATOLI C., CAPUTI A.P. Iron status in schizophrenic patients with acute neuroleptic-induced dystonic reactions. Progr. Neuro-Psychopharmacol. Biol. Psychiat. 18: 891-898, 1994.
  4. SQUADRITO F., ALTAVILLA D., CANALE P., IOCULANO M., CAMPO G.M., AMMENDOLIA L., SQUADRITO G., SAITTA A., CALAPAI G., CAPUTI A. P. Contribution of intercellular adhesion molecule 1 (ICAM-1) to the pathogenesis of splanchnic artery occlusion shock in the rat. Brit. J. Pharmacol. 113: 912-916, 1994
  5. SQUADRITO F., ALTAVILLA D., CANALE P., IOCULANO M., CAMPO G.M., AMMENDOLIA L., FERLITO M., ZINGARELLI B., SQUADRITO G., SAITTA A., CAPUTI A. P. Partecipation of tumour necrosis factor and nitric oxide in the mediation of vascular dysfunction in splanchnic artery occlusion shock. Brit. J. Pharmacol. 113: 1153-1158, 1994.
  6. SPINA E., AVENOSO A., CAMPO G.M., CAPUTI A.P., PERUCCA E. The effect of carbamazepine on the 2-hydroxylation of desipramine. Psychopharmacol. 117: 413-416, 1995
  7. SQUADRITO F., ALTAVILLA D., AMMENDOLIA L., SQUADRITO G., CAMPO M.G., SPERANDEO A., CANALE P., IOCULANO M., SAITTA A., CAPUTI A.P. Improved survival and reversal of endothelial dysfunction by the 21- aminosteroid, U-74389G in splanchnic ischemia-reperfusion injury in the rat. Brit. J. Pharmacol. 115: 395-400, 1995.
  8. ZINGARELLI B., O'CONNOR M., WONG H., SALZMAN A.L. SZABO' C. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J. Immunol. 156: 350-358, 1996.
  9. CAMPO G.M., SQUADRITO F., ALTAVILLA D., SQUADRITO G., AVENOSO A., CANALE P., IOCULANO M., SPERANDEO A., CAPUTI A.P. Protection of ischemic and reperfused rat myocardium by the nonglucocoticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation. J. Pharmacol. Exp. Ther. 277: 1-8, 1996.
  10. CALAPAI G., MAZZAGLIA G., SAUTEBIN L., COSTANTINO G., MARCIANO M.C., CUZZOCREA S., DI ROSA M., CAPUTI A.P. Inhibition of nitric oxide formation reduces voluntary ethanol consumption in the rat. Psychopharmacol. 125: 398-401, 1996.

RESEARCH GROUP MEMBERS:

  1. Carmignani Marco, P.O.
  2. Volpe Anna Rita, R.CNR
  3. Poma Anna, R.U.

AFFILIATION:

Sezione di Farmacologia

Dipartimento di Biologia di Base ed Applicata

Facoltà di Scienze Matematiche, Fisiche e Naturali

Università degli Studi di L'Aquila

ADDRESS: Via Vetoio

CITY: Coppito (L'Aquila)

POSTAL CODE: 67010

TELEPHONE: 0862-43-3262, 3265

FAX: 0862-433273

E-MAIL: a.volpe@uniserv.ccr.rm.cnr.it

PUBLICATIONS:

  1. M. MIRANDA, F. AMICARELLI, A.R. VOLPE, A. POMA, L. MASCIOCCO, M. CARMIGNANI. Specific increase of L-DOPA levels in plasma upon infusion of tyrosinase containing liposomes. Gen. Pharmacol. 24: 1319-1322, 1993
  2. C. DELLE MONACHE, B. BOTTA, R. ESPINAL, M. BOTTA, M. CARMIGNANI. Novel hypotensive agents from "Verbesina Caracasana". 2. Synthesis and pharmacology of Caracasanamide. J. Med. Chem. 36: 2956-2963, 1993
  3. P. BOSCOLO, M. CARMIGNANI, A.R. VOLPE, M. FELACO, G. DEL ROSSO, G. PORCELLI, G. GIULIANO. Renal toxicity and arterial hypertension in rats chronically exposed to metavanadate. Occup. Environ. Med. 51: 500-503, 1994
  4. M. MIRANDA, F. AMICARELLI, A. POMA, A.M. RAGNELLI, O. ZARIVI. Cyto-genotoxic species leakage within human melanoma melanosomes. Molecular-morphological correlations. Biochem. Mol. Biol. 32: 913-922, 1994
  5. N. MORES, M. MARTIRE, G. PISTRITTO, A.R. VOLPE, E. MENINI, G. FOLLI, C. CARDILLO. Platelet alpha2-adrenoceptors and diurnal changes of platelet aggregability in hypertensive patients. J. Hypertension 12: 939-945, 1994
  6. M. CARMIGNANI, A.R. VOLPE, O. MASCI, P. BOSCOLO, F. DI GIACOMO, A. GRILLI, G. DEL ROSSO, M. FELACO. Vanadate as factor of cardiovascular regulation by interactions with the catecholamine and nitric oxide systems. Biol. Trace Elem. Res. 51: 1-12, 1996
  7. D. CURRO', A.R. VOLPE, P. PREZIOSI. Nitric oxide synthase activity and non-adrenergic non-cholinergic relaxation in the rat gastric fundus. Brit. J. Pharmacol. 117: 717-723, 1996
  8. F. CORELLI, D. DEI, G. DELLE MONACHE, B. BOTTA, C. DE LUCA, M. CARMIGNANI, A.R. VOLPE, M. BOTTA. Synthesis and preliminary pharmacological evaluation of analogues of caracasamide, a hypotensive natural product. Bioorg. Med. Chem. Lett. 6: 653-658, 1996
  9. A.R. VOLPE, B. GIARDINA, P. PREZIOSI, M. CARMIGNANI. Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor. Immunopharmacology 33: 287-290 1996
  10. M. CARMIGNANI, A.R. VOLPE. Nitric oxide and -opioid receptors in the tissue interactions among enkephalins, angiotensins and kinins. Immunopharmacology 32: 172-175, 1996

RESEARCH GROUP MEMBERS:

  1. Ciabattoni Giovanni
  2. Currò Diego
  3. Montuschi Paolo

AFFILIATION:

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università Cattolica S. Cuore

ADDRESS: Largo Francesco Vito, 1

CITY: Roma

POSTAL CODE: 00168

TELEPHONE: 06-3015 4253

FAX: 06-3050159, 3051343

PUBLICATIONS:

  1. KOUDSTAAL P.J., CIABATTONI G., VAN GIJN J., NIEUWENHUIS H.K., DE GROOT P., SIXMA J., PATRONO C. Increased thromboxane biosynthesis in patients with acute cerebral ischemia. Stroke 24:219-223, 1993.
  2. CIABATTONI G., UJANG S., SRITARA P., ANDREOTTI F., DAVIES G., SIMONETTI B.M., PATRONO C., MASERI A. Aspirin, but not heparin, suppresses the transient increase in thromboxane biosynthesis associated with cardiac catheterisation or coronary angioplasty. J. Amer. Coll. Cardiol. 21:1377-1381, 1993.
  3. RANGEMARK C., CIABATTONI G., WENNMALM A. Excretion of thromboxane metabolites in healthy women after cessation of smoking. Arterioscler. Thromb. 13:777-782, 1993.
  4. DI MINNO G., DAVI' G., MARGAGLIONE M., CIRILLO F., GRANDONE E., CIABATTONI G., CATALANO I., STRISCIUGLIO P., ANDRIA G., PATRONO C., MANCINI M. Abnormally high thromboxane biosynthesis in homozigous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism. J. Clin. Invest. 92:1400-1406, 1993.
  5. VAN KOOTEN F., CIABATTONI G., PATRONO C., SCHMITZ P., VAN GIJN J., KOUDSTAAL P. Evidence for episodic platelet activation in acute ischemic stroke. Stroke 25:1400-1406, 1994.
  6. LANDOLFI R., DE CANDIA E., ROCCA B., CIABATTONI G., ANTINORI A., MASETTI R., PATRONO C. Effects of unfractionated and low molecular weight heparins on platelet thromboxane biosynthesis "in vivo". Thromb. Haemostas. 72:942-946, 1994.
  7. WANG Z., CIABATTONI G., CREMINON C., LAWSON J., FITZGERALD G.A., PATRONO C., MACLOUF J. Immunological characterization of urinary 8-epi-prostaglandin F2a excretion in man. J. Pharmacol. Exp. Ther. 275:94-100, 1995.
  8. ROCCA B., CIABATTONI G., TARTAGLIONE R., CORTELAZZO S., BARBUI T., PATRONO C., LANDOLFI R. Increased thromboxane biosynthesis in essential thrombocythemia. Thromb. Haemostas. 74:1225-1230, 1995.
  9. LAFFI G., CINOTTI S., FILIMBERTI E., CIABATTONI G., CAPORALE R., MARRA F., MELANI L., GROSSI A., Gentilini P. Defective aggregation in cirrhosis is independent of in vivo platelet aggregation. J. Hepatol. 24:436-443, 1996.
  10. PATRIGNANI P., SANTINI G., PANARA M.R., SCIULLI M.G., GRECO A., ROTONDO M.T. DI GIAMBERARDINO M., MACLOUF J., CIABATTONI G., PATRONO C. Induction of prostaglandin endoperoxide synthase-2 in human monocytes associated with cyclo-oxygenase-dependent F2-isoprostane formation. Brit. J. Pharmacol. 118:1285-1293, 1996.

RESEARCH GROUP MEMBERS:

  1. Dorigo Paola, P.O.
  2. Maragno Ildebrando, Dir. M
  3. Gaion Rosa Maria, P.O.
  4. Dalla Volta Sergio, P.O.
  5. Fraccarollo Daniela, D. Dr.
  6. Santostasi Giovanni, R.U.

AFFILIATION:

Dipartimento di Farmacologia "E. Meneghetti"

Facoltà di Farmacia

Università di Padova

ADDRESS: Largo E. Meneghetti, 2

CITY: Padova

POSTAL CODE: 35131

TELEPHONE: 049-8275101

FAX: 049-8275093

PUBLICATIONS:

  1. DORIGO, P., GAION, R.M., BELLUCO, P., FRACCAROLLO, D., MARAGNO, I., BOMBIERI, G., BENETOLLO, F. A pharmacological, crystallographic and quantum chemical study of new inotrpic agents. J. Med. Chem. 36: 2475-2484, 1993.
  2. MOSTI, L., SCHENONE, P., IESTER, M., DORIGO, P., GAION, R.M., FRACCAROLLO, D. Synthesis and cardiotonic activity of esters of 2-substituted 5-acetyl-1,6-dihydro-6-oxo-3 pyridine-carboxylix acids. Eur. J. Med. Chem. 28: 853-858, 1993.
  3. DORIGO, P., SANTOSTASI, G., FRACCAROLLO, D., MARAGNO, I. Inotropic agents in development . Exp. Invest. Drugs 3: 457-468, 1994.
  4. DORIGO, P., BELLUCO, P., FRACCAROLLO, D., GAION, R.M., SANTOSTASI, G. AND MARAGNO, I. Vasodilating action of etozoline in aorta from hypercholesterolemic and spontaneously hypertensive rats. Pharmacol. (Life Sci. Adv.) 13: 101-105, 1994.
  5. VEROTTA, L., ABURJAI, T., ROGERS, C.B., DORIGO, P., MARAGNO, I., FRACCAROLLO, D., SANTOSTASI, G., GAION, R.M., FLOREANI, M., CARPENEDO, F. Chemical and Pharmacological Characterization of Erythrophleum Lasiantum Alkaloids. Planta Medica. 61: 271-274, 1995.

RESEARCH GROUP MEMBERS:

  1. Ferrari Patrizia, Dir. R.
  2. Torielli Lucia, C.L.
  3. Conti Fabio, R.I.
  4. Padoani Gloria, R.I.
  5. Tripodi M. Grazia, C.L.
  6. Florio Monica, R.I.
  7. Reina Cristina, R.I.
  8. Modica Rossana, R.I.
  9. Salardi Sergio, C.L.
  10. Molinari Isabella, R.I.
  11. Pastore Sabrina, R.I.
  12. Ferrandi Mara, C.L.
  13. Duzzi Liliana, R.I.
  14. Minotti Elena, R.I.
  15. Barber Barry R., C.L.

AFFILIATION:

Sezione di Farmacologia Cellulare

Prassis - Istituto di Ricerca Sigma Tau

ADDRESS: via Forlanini 1/3

CITY: Settimo Milanese - Milano

POSTAL CODE: 20019

TELEPHONE: 02-33500401, 33501107

FAX: 02-33500408

E-MAIL: mc3405@mclink.it

PUBLICATIONS:

  1. FERRANDI M, MINOTTI E, SALARDI S, FLORIO M, BIANCHI G, FERRARI P. Characteristics of a ouabain-like factor from Milan hypertensive rats. J. Cardiovasc. Pharmacol. 22: S75-S78, 1993.
  2. SALARDI S., FALCHETTO R., TROFFA C., PARENTI P., BARBER B.R., PASTORE S., GLORIOSO N., BIANCHI G. Relationships among alterations in renal membrane sodium transport, renin and aminopeptidase M activities in genetic hypertension. Biochim. Biophys. Acta 1182: 22-29, 1993.
  3. FERRARI P., FERRANDI M., MINOTTI E., DUZZI L., BIANCHI G. Effect of canrenone and hydrochlorothiazide on the development of hypertension in rat models of genetic hypertension. J. Hypertens. 11 : S330-S331, 1993.
  4. BIANCHI G., TRIPODI G., CASARI G., SALARDI S., BARBER B.R., GARCIA R., LEONI P., TORIELLI L., CUSI D., FERRANDI M., PINNA L.A., BARALLE F.E., FERRARI P. Two point mutations within the adducin genes are involved in blood pressure variation. Proc. Natl. Acad. Sci USA 91: 3999-4003, 1994.
  5. SOLDATI L.P., BARBER B.R. SALARDI S., MOLINARI I., BIANCHI G. A new rat model for studying the calpain-calpastatin system. Lab. Anim. 29 : 420-426, 1995.
  6. TORIELLI L., CONTI F., CINATO E., CEPPI E., ANVERSA P., BIANCHI G., FERRARI P. Alterations in energy metabolism of hypertrophied rat cardiomyocytes: influence of Propionyl-L-Carnitine. J. Cardiovasc. Pharmacol. 26: 372-380, 1995.
  7. FERRANDI M., MINOTTI E., FLORIO M., BIANCHI G., FERRARI P., Age-dependency and dietary influence on the hypothalamic ouabain-like factor in Milan hypertensive rats. J. Hypertension 13:1571-1574, 1995.
  8. TRIPODI G., CASARI G., TISMINETZKY S., BIANCHI G., DEVESCOVI G., MURO A., TUTEJA R., BARALLR F.E. Characterization and chromosomal localization of the rat alpha- and beta adducin encoding genes. Gene 166 : 307-311, 1995.
  9. TRIPODI G., VALTORTA F., TORIELLI L., CHIEREGATTI E., SALARDI S., TRUSOLINO L., MENEGON A. FERRARI P., MARCHISIO P.C., BIANCHIO G. Hypertension-associated point mutations in the adducin alpha- and beta subunits affect actin cytoskeleton and ion transport. J. Clin. Invest. 97: 2815-2822, 1996.
  10. FERRANDI M., TRIPODI G., SALARDI S., FLORIO M;, MODICA R., BARASSI P., PARENTI P., SHAINSKAYA A., KARLISH S., BIANCHI G., FERRARI P. Renal Na-K-ATPase in genetic hypertension. Hypertension In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Floreani Maura, P.A.

AFFILIATION:

Dipartimento di Farmacologia "E.Meneghetti"

Facoltà di Scienze MM.FF.NN.

Università degli Studi di Padova

ADDRESS: Largo Meneghetti , 2

CITY: Padova

POSTAL CODE: 35131

TELEPHONE: 049-827-5088, 5083

FAX : 049-827-5093

E-MAIL: floreani@dfem.unipd.it

PUBLICATIONS:

  1. CARPENEDO F. AND FLOREANI M. Stimulation of rat liver microsomal cGMP-inhibited cAMP phosphodiesterase (PDE III) by phospholipase C and D. Biochem. Biophys. Res. Commun.190: 609-615, 1993.
  2. PALU' G., BIASOLO M.A., SARTOR G., MASOTTI L , PAPINI E., FLOREANI M. AND PALATINI P. Effects of Herpes Simplex type 1 virus infection on plasma membrane and related functions of HeLa S3 cells. J. Gen.Virol. 75: 3337-3344, 1994.
  3. FLOREANI M. AND CARPENEDO F. Metabolism of simple quinones in guinea pig and rat cardiac tissue. Gen.Pharmacol.26:1757-1764,1995.
  4. FLOREANI M., FORLIN A., BELLIN S. AND CARPENEDO F. Structure- activity relationship for the inhibition of cardiac sarcoplasmic reticulum Ca2+ ATPase activity b naphthoquinones. Biochem. Mol. Biol.Int. 37: 757-763,1995.
  5. GIUSTI, P., LIPARTITI, M., FRANCESCHINI, D., SCHIAVON, N., FLOREANI, M., AND MANEV H. Neuroprotection by melatonin from kainate-induced excititoxicity in rats. FASEB J.10: 891-896, 1996.
  6. FLOREANI M., FORLIN A., BELLIN S. AND CARPENEDO F. Cardiac sarcoplasmic reticulum Ca2+ pump as a target for benzoquinones. Gen. Pharmacol. 27: 873-878,1996.
  7. FLOREANI,M., FORLIN, A., PANDOLFO,L., PETRONE,M., AND BELLIN S. Mechanisms of plumbagin action on guinea pig isolated atria. J.Pharmac.Exp.Ther. 278: 763-770, 1996.

RESEARCH GROUP MEMBERS:

  1. Franconi Flavia, P.O.
  2. Bennardini Federico, R.U.
  3. Alberti Luisa, B.

AFFILIATION:

Dipartimento Scienze del Farmaco

Facoltà di Farmacia

Università di Sassari

ADDRESS: Via Muroni , 23 A

CITY: Sassari

POSTAL CODE: O7100

TELEPHONE: 079- 228717

PUBLICATIONS:

  1. NARO F., FAZZINI A., GRAPPONE C., CITRO G., DINI G.,GIOTTI, A., MALATESTA F., FRANCONI F., BRUNORI M.,: Release of cytochromes from hypoxic and reoxygenated guinea pig heart. Cardioscience 4:177-184, 1993.
  2. SEGHIERI, G., MARTINOLI, L., MICELI, M., CIUTI, M.,D'ALESSANDRI, G.,GIRONI, A., PALMIERI, L., ANICHINI, R.,BARTOLOMEI, G., FRANCONI F.: Renal excretion of ascorbic acid in insulin dependent diabetes mellitus. Internat. J. Vit. Nutr. Res. 64: 119-124, 1993.
  3. MATTANA A., BENNARDINI F., JULIANO C., PICCI V., MARCEDDU S., SCIOLA L., PIPPIA P., FRANCONI F.: Cytotoxicity of lazaroid U-75412E in human epithelial cell line (WISH). Biochem. Pharmacol. 48: 259-265, 1994.
  4. BENNARDINI F., JULIANO C., BENETTI D., MIAN M., CHIESI M., MATTANA A., FRANCONI F.: aB crystallin is constitutively expressed in cultures of bovine articular chondrocytes. Biochem. Biophys. Res. Commun. 208: 742-747, 1995.
  5. FRANCONI F., BENNARDINI F., MATTANA A., MICELI M., CIUTI M., MIAN M., GIRONI, A. BARTOLOMEI G., ANICHINI R., SEGHIERI G.: Taurine deficiency in plasma and platelets of diabetic insulin-dependent patients: effects of taurine supplementation. Amer. J. Clin. Nutr. 61: 1115-1119, 1995.
  6. TADOLINI B., PINTUS G., PINNA G.G., BENNARDINI F., FRANCONI F.: Effects of taurine and hypotaurine on lipid peroxidation. Biochem. Biophys. Res. Commun. 213: 820-826, 1995.
  7. BENNARDINI F., MATTANA A., PINNA NOSSAI E., MIGNANO M., FRANCONI F., JULIANO C., SCIOLA L., PIPPIA P., CHIESI M.: Kinetic changes of -crystallin expression in neoplastic cells and syngeneic rat fibroblasts at various subculture stages. Mol. Cell. Biochem. 152: 23-30, 1995.
  8. DISIMPLICIO P., DEGIORGIO L.A., CARDAIOLI E., LECIS R., MICELI M., ROSSI R., ANICHINI R., MIAN M., SEGHIERI G., FRANCONI F.: Glutathione, glutathione utilizing enzymes, and thioltransferase in platelets of insulin-dependent diabetic patients: relation with platelet aggregation and with microangiopatic complications. Eur. J. Clin. Invest. 25: 665-669, 1995.
  9. FRANCONI F., MICELI M., DE MONTIS M.G., LUPIS CRISAFI E., BENNARDINI F., TAGLIAMONTE A.: NMDA receptors play an anti-aggregating role in human platelets. Thromb. Haemostatsis,76 : 84-87,1996
  10. MATUCCI R., BIANCHI B., OTTAVIANI M.F., CAMPANA S., BENNARDINI F., FRANCONI F.: Carbon centered radicals reduce the density of L-type calcium channels in rat cardiac membranes. Biochem. Biophys. Res. Commun. 223 :85-90,1996.

RESEARCH GROUP MEMBERS:

  1. Giorgi Giorgio, P.A.
  2. Bruni Giancarlo, P.A.
  3. Runci Francesco Michele, P.A.
  4. Cerretani Daniela, T.L.
  5. Fiaschi Anna Ida, T.L.
  6. Micheli Lucia, T.L.
  7. Romeo Maria Raffaella, B.

AFFILIATION:

Istituto di Farmacologia

Facoltà di Medicina e Chirurgia

Università degli Studi di Siena

ADDRESS: Strada delle Scotte, 6

CITY: Siena

POSTAL CODE: 53100

TELEPHONE: 0577/ 263280, 263279, 263251, 263228

FAX: 0577-280896

E-MAIL: giorgig@unisi.it

PUBLICATIONS:

  1. CECCHETTI V., FRAVOLINI A., SCHIAFFELLA F., TABARRINI O., BRUNI G., AND SEGRE G. o-chlorobenzenesulfonamidic derivatives of (Aryloxy) propanolamines as beta-blocking/diuretic agents. J. Med. Chem. 36: 157-161, 1993.
  2. CAMPIANI F., GAROFALO A., FIORINI I., NACCI V., BOTTA M., TAFI A., CHIARINI A., BUDRIESI R., BRUNI G., AND ROMEO M.R.. Synthesis and in vitro cardiovascular activity of 4-aryl-2,3, 3a,4-tetrahydro-1H-pyrrolo2,1-c benzothiazin-1-ones and 7-acetoxy-6-phenyl-7A,8,9,10-tetrahydro-pyrrolo 2,1-D 1,5benzothiazepin-10-one. Bioorg. Med. Chem. Lett. 4: 1235-1240, 1994.
  3. SETTIMI G., DEL GIUDICE M.R., FERRETTI R., COTOCHINI V., BRUNI G., AND ROMEO M.R. -carbolines as inverseagonistic benzodiazepine receptor ligands. 2. synthesis and in vitro and in vivo binding of some new 6-amino and 6-fluoro--carboline-3-carboxylates. Eur. J. Med. Chem. 30: 245-251, 1995.
  4. CAMPIANI F., GAROFALO A., FIORINI I., BOTTA M., NACCI V., TAFI A., CHIARINI A., BUDRIESI R., BRUNI G., AND ROMEO M.R. Pyrrolo2,1-cbenzothiazines: synthesis, structure-activity relationships, molecular modelling studies, and cardiovascular activity. J. Med. Chem. 38: 4393-4410, 1995.
  5. CAMPIANI G., FIORINI I., DE FILIPPIS M.P., CIANI S.M., GAROFALO A., NACCI V., GIORGI G., SEGA A., BOTTA M., CHIARINI A., BUDRIESI R., BRUNI G., ROMEO M.R., MANZONI C., AND MENNINI T. Cardiovascular characterization of pyrrolo2,1-d 1,5-benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity andcalcium antagonist activity to novel and selective calcium entry blockers. J. Med. Chem. 39: 2922-2938, 1996.
  6. BATTISTON L., MORETTI M., TALUSSI P., MICHELI L., MARCHI P., MAZZORAN L., LUNAZZI G., AND POZZATO G. Hepatic glutathione determination after ethanol administration in rat: evidence of the first-pass metabolism of ethanol. Life Sci. 56: 241-258, 1995.
  7. CERRETANI D., MICHELI L., FIASCHI A.I., AND GIORGI G. Rapid and sensitive determination of piroxicam in rat plama, muscle and skin by high-performance liquid chromatographic. J. Chromatogr. 614: 103-108, 1993.
  8. MICHELI L., FIASCHI A.I., CERRETANI D., AND GIORGI G. Effect of acetaminophen on glutathione levels in several regions of the rat brain. Curr. Ther. Res. 53: 730-736, 1993.
  9. CERRETANI D., MICHELI L., FIASCHI A.I., ROMEO M.R., TADDEI I., AND GIORGI G.MK-801 potentiates the glutathione depletion induced by acetaminophen in rat brain. Curr. Ther. Res. 55: 707-711, 1994.
  10. CERRETANI D., MICHELI L., FIASCHI A.I., AND GIORGI G. High-performance liquid chromatography of flufenamic acid in rat plasma. J. Chromatogr. 678: 365-368, 1996.

RESEARCH GROUP MEMBERS:

  1. Giotti Alberto , P.O. Fuori Ruolo
  2. Failli Paola, R.U.
  3. Ruocco Carlo, D.DR
  4. Cecchi Enrica, B.
  5. Fazzini Alessandro, D.DR

AFFILIATION:

Dipartimento di Farmacologia Preclinica e Clinica "Mario Aiazzi Mancini"

Facoltà di Medicina e Chirurgia

Università degli Studi di Firenze

ADDRESS: Viale Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-418663

FAX: 055-4361613

E-MAIL: Failli@stat.ds.unifi.it

PUBLICATIONS:

  1. FAILLI P., CECCHI E., RUOCCO C., FAZZINI A. & GIOTTI A. - Effects of L- and D-arginine and some related esters on the cytosolic mechanisms of a-thrombin-induced human platelet activation. Brit. J. Pharmacol. 110 : 213-218, 1993.
  2. TANINI A., FAILLI P., MAGGI M., FRANCESCHELLI F., FREDIANI U., BECHERINI L., GIOTTI A., RUOCCO C. and BRANDI M.L. - Effects of endothelin-1 on bovine parathyroid cells. Biochem. Biophy. Res. Comm. 193 : 59-66, 1993 .
  3. NARO F., FAZZINI A., GRAPPONE C., CITRO G., DINI G., GIOTTI A., MALATESTA F., FRANCONI F., BRUNORI M. Release of cytochromes from hypoxic and reoxygenated guinea pig heart. Cardioscience 4 : 177-184, 1993.
  4. LAFFI G., MARRA F., FAILLI P., RUGGIERO M., CECCHI E., CARLONI V., GIOTTI A. and GENTILINI P. - Defective signal transduction in platelets from cirrhotics is associated with increased cyclic nucleotides. Gastroenterology 105 : 148-156, 1993.
  5. FALSETTI C., BALDI E., KRAUSZ C., CASANO R., FAILLI P., FORTI G. Decreased Responsiveness to progesterone of spermatozoa in oligozoospermic patients. J. Androl., 14 : 17-22, 1993.
  6. MALMBERG AIELLO P., LAMBERTI C., GHELARDINI C., GIOTTI A. and BARTOLINI A. - Role of histamine in rodent antinociception. Brit. J. Pharmacol. 111 : 1269-1279, 1994.
  7. CECCHI E., CAPONE L., RUOCCO C., FAZZINI A., MUGELLI A., GIOTTI A., FAILLI P.- Iloprost antagonises the increase in internal calcium concentration induced by a-thrombin in human platelets: A study of desensitization. Cardiovasc. Drugs & Ther. 9 : 773-777, 1995.
  8. FAIILI P., RUOCCO C., DE FRANCO R., CALIGIURI A., GENTILINI A., GIOTTI A., GENTILINI P., PINZANI M. - The mitogenic effect of platelet--derived growth factor in human hepatic stellate cells requires calcium influx. Amer. J. Physiol. Cell Physiol., 269 : C1133-C1139, 1995.
  9. PINZANI M., MILANI S., DE FRANCO R., GRAPPONE C., CALIGIURI A., TOSTI-GUERRA C., MAGGI M., GENTILINI A., FAILLI P., RUOCCO C., GENTILINI P. - Endothelin-1 is overexpressed in cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology, 110 : 534-548, 1996.
  10. FAILLI P., TESCO G., RUOCCO C., GINESTRONI A., SORBI S., GIOTTI A., AMADUCCI L. - The effect of tetraethylammonium on intracellular calcium concentration in Alzheimer's disease fibroblasts with APP, S182 and E5-1 missense mutations. Neurosci Lett., 208 : 1-3, 1996.

RESEARCH GROUP MEMBERS:

  1. Guarini Salvatore, R.U.
  2. Bazzani Carla, R.U.
  3. Cainazzo Maria Michela, B.

AFFILIATION:

Sezione di Farmacologia, Dipartimento di Scienze Biomediche

Facoltà di Medicina e Chirurgia

Università di Modena

ADDRESS: Via Campi, 287

CITY: Modena

POSTAL CODE: 41100

TELEPHONE: 059-428-440, 415

FAX: 059-372653

E-MAIL: farmacol@unimo.it

PUBLICATIONS:

  1. BAZZANI, C., BALUGANI, A., BERTOLINI, A., AND GUARINI S. Comparison of the effects of ACTH-(1-24), methylprednisolone, aprotinin, and norepinephrine in a model of hemorrhagic shock in rats. Resuscitation 25: 219-226, 1993.
  2. GUARINI, S., BAZZANI, C., AND BERTOLINI, A. Role of neuronal and vascular Ca2+- channels in the ACTH-induced reversal of haemorrhagic shock. British J. Pharmacol. 109: 645-650, 1993.
  3. BAZZANI, C., NARDI, M.G., FERRANTE, F., BERTOLINI, A., AND GUARINI, S. Dopamine D1 receptors are involved in the ACTH-induced reversal of hemorrhagic shock. Eur. J. Pharmacol. 253: 303-306, 1994.
  4. BAZZANI, C., BERTOLINI, A., CASALGRANDI, L., BERTOLINI, E., BALUGANI, A., FIORE, L., AND GUARINI, S. Adrenocorticotropin release is not involved in the nicotine-induced reversal of hemorrhagic shock in anesthetized rats. Pharmacology 50: 34-39, 1995.
  5. GUARINI, S., MARTINI, M.C., AND BERTOLINI, A. Reperfusion-induced arrhythmias and lethality are reduced by a 2KDa heparin fragment. Life Sci. 57: 967-972, 1995.
  6. BAZZANI, C., BERTOLINI, A., MATTERA RICIGLIANO, G., CAINAZZO, M.M., BALUGANI, A., AND GUARINI, S. The reversal of experimental hemorrhagic shock induced by nicotine and dimethylphenylpiperazinium is adrenal-dependent. Resuscitation 31: 145-150, 1996.
  7. GUARINI, S. A highly reproducible model of arterial thrombosis in rats. J. Pharmacol. Toxicol. Met. 35: 101-105, 1996.
  8. GUARINI, S., BAZZANI, C., BOTTICELLI, A., BALUGANI, A., AND BERTOLINI, A. Antithrombotic activity of a 2-kDa heparin fragment in an experimental model of carotid artery thrombosis in rats. J. Pharm. Pharmacol. 48: 407-410, 1996.
  9. BAZZANI, C., FIORE, L., FERRANTE, F., BERTOLINI, A., AND GUARINI, S. Serotonin is involved in the ACTH-induced reversal of hemorrhagic shock in anesthetized rats. Pharmacology 52: 207-215, 1996.
  10. GUARINI, S., BAZZANI, C., MATTERA RICIGLIANO, G., BINI, A., TOMASI, A., AND BERTOLINI, A. Influence of ACTH-(1-24) on free radical levels in the blood of haemorrhage-shocked rats: direct ex vivo detection by electron spin resonance spectrometry. British J. Pharmacol. 119: 29-34, 1996.

RESEARCH GROUP MEMBERS:

  1. Ledda Fabrizio, P.O.
  2. Ziche Marina, R.U.
  3. Amerina Sandra, B.
  4. Morbidelli Lucia, B.
  5. Parenti Astrid, D.DR.
  6. Brogelli Laura, S.S.
  7. Filippi Sandra, S.S.
  8. Donnini Sandra, B.

AFFILIATION:

Dipartimento di Farmacologia Preclinica e Clinica

Laboratorio di Farmacologia Cardiovascolare e del Microcircolo

Università di Firenze

ADDRESS: Viale Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237-405, 411(centralino)

055-4237-450, 451 (laboratori)

FAX: 055-4361613

E-MAIL: Ledda@Stat.Ds.UNIFI.IT  Ziche@Stat.Ds.UNIFI.IT.

PUBLICATIONS:

  1. ZICHE M., MORBIDELLI L., MASINI E., GRANGER H.J., GEPPETTI P. AND LEDDA F. Nitric oxide promotes DNAsynthesis and cyclic GMP formation in endothelial cells from postcapillary venules. Biochem. Biophys. Res. Comm. 192: 1198-1203, 1993.
  2. MANTELL L., AMERINI S., FILIPPI S. AND LEDDA F. Blockade of adenosine receptors unmasks a stimulatory effect of ATP on cardiac contractility. British J. Pharmacol. 109: 1268-1271, 1993.
  3. AMERINI S., MANTELLI L., FILIPPI S. AND LEDDA F. Effects of aging and hypertension on the vasorelaxant activity of calcitonin gene-related peptide: a comparison with other vasodilator agents. J. Cardiovasc. Pharmacol. 23: 432-437, 1994.
  4. ZICHE M., MORBIDELLI L., MASINI E., AMERINI S., GRANGER H.J., MAGGI C.A, GEPPETTI P. AND LEDDA. F. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J. Clin. Invest. 94: 2036-2044, 1994.
  5. MANTELLI L., AMERINI S. AND LEDDA. F. Roles of nitric oxide and endothelium-derived hyperpolarizing factor in the vasorelaxant effect of acetylcholine as influenced by aging and hypertension. J. Cardiovasc. Pharmacol. 25: 595-602, 1995.
  6. MANTELLI L., AMERINI S., LEDDA F., FORTI G. AND MAGGI M. The potent relaxant effect of adenosine in rabbit corpora cavernosa is nitric oxide independent and mediated by A2 receptors. J. Androl. 16: 312-317, 1995.
  7. MORBIDELLI L., ORLANDO C., MAGGI C.A., LEDDA F. AND ZICHE M. Proliferation and migration of endothelial cells is promoted by endothelins via activation of ETB receptors.Amer. J. Physiol. 269: H686-H695, 1995.
  8. PARENTI A., AMERINI S., LEDDA F. , MAGGI C.A. AND ZICHE M. The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture. Naunyn-Schmied. Arch. Pharmacol. 353: 475-481, 1996.
  9. MORBIDELLI L.,CHANG C-H., DOUGLAS J.G.,GRANGER H.J., LEDDA F. AND ZICHE M. Nitric oxide mediates the mito-genic effect of VEGF on coronary venular endothelium.Amer. J. Physiol. 270: H411-H415, 1996.
  10. AMERINI S., FILIPPI S., PARENTI A., ZICHE M. AND LEDDA F. Thapsigargin inhibits the vasorelaxant response to acetylcholine and substance P but does not interfere with the responses to endothelium independent agents. J. Cardiovasc. Pharmacol. 28: 82-88, 1996.

RESEARCH GROUP MEMBERS:

  1. Luciani Sisto, P.O.
  2. Cargnelli Gabriella, P.A.
  3. Debetto Patrizia, R.U.
  4. Bova Sergio, R.U.
  5. Trevisi Lucia, B.PDR.
  6. Varotto Roberto, T.

AFFILIATION:

Dipartimento di Farmacologia

Università degli Studi di Padova

ADDRESS: Largo E. Meneghetti, 2

CITY: Padova

POSTAL CODE: 35131

TELEPHONE: 049-827-5076, 5097, 5098, 5094

FAX: 049-827-5093

E-MAIL: luciani@ipdunivx.unipd.it

PUBLICATIONS:

  1. LUCIANI, S., BOVA, S., CARGNELLI, G., AND DEBETTO, P. Effects of amiloride on the cardiovascular system: role of Na+/Ca2+ exchange.Pharmacol. Res.. 25: 303-310, 1992.
  2. BOVA, S., PADRINI, R., GOLDMAN, W.G., BERMAN, D.M., AND CARGNELLI, G. On the mechanism of vasodilating action of berberine: possible role of inositol lipid signalling system. J. Pharmacol. Exp. Ther. 261: 318-323, 1992.
  3. ANTOLINI, M., TREVISI, L., DEBETTO, P., AND LUCIANI, S. Effect of amiloride on sodium-calcium exchange activity in rat cardiac myocytes. Pharmacol. Res. 27: 227-231, 1993.
  4. ROSSI, G.P., ZANIN, L., PAULETTO, P., TONELLO, M., BOVA, S., CARGNELLI, G., AND PESSINA, A.C. Age-related changes of endothelin-1 binding sites in aortic smooth muscle cells of normotensive and hypertensive rats. High Blood Pressure. 2: 313-318, 1993.
  5. BOVA, S., ROSSI, G.P., LUCIANI, S., DEBETTO, P., PESSINA, A.C., AND CARGNELLI, G. Effect of subthreshold ouabain on the tone of guinea-pig aortic strips following repeated noradrenaline stimulation. British J. Pharmacol.. 111: 1067-1072, 1994.
  6. CARGNELLI, G., BOVA, S., CANNAS, S., DEBETTO, P, AND LUCIANI, S. Effect of amiloride on inotropic and toxic actions of ouabain in guinea-pig left atria. Eur. J. Pharmacol.. 292: 103-110, 1994.
  7. LUCIANI, S., DEBETTO, P., TREVISI, L., BOVA, S., AND CARGNELLI, G. Pharmacological modulation of Na/Ca exchange in cardiac and vascular smooth muscle. Pharmacology (Life Sciences Advances). 13: 141-147, 1994.
  8. YANG, C., PADRINI, R., BOVA, S., PIOVAN, D., AND MAGNOLFI, G. Electrophysiological interactions between pinacidil, a potasium channel opener, and class 1 antiarrhythmic agents in guinea-pig isolated perfused heart. British J. Pharmacol.. 114: 1745-1749, 1995.
  9. LUCIANI, S., ANTOLINI, M., BOVA, S., CARGNELLI,G., CUSINATO, F., DEBETTO, P., TREVISI, L., AND VAROTTO, R. Inhibition of cardiac sarcolemmal sodium-calcium exchanger by gycerophopshoinositol 4-phosphate and glycerophosphoinositol 4,5 bisphosphate. Biochim. Biophys. Res. Comm. 206: 674-680, 1995.
  10. BOVA, S., TREVISI, L., DEBETTO, P., CIMA, L., FURNARI, M., LUCIANI, S., PADRINI, R., AND CARGNELLI, G. Vasorelaxant properties of norbormide, a selective vasoconstrictor agent for the rat microvasculature. British J. Pharmacol.. 117: 1041-1046, 1996.

RESEARCH GROUP MEMBERS:

  1. Mugelli Alessandro, P.O
  2. Cerbai Elisabetta, R.U.
  3. Matucci Rosanna, T.L.
  4. Stendardi Isabella,.T.L.
  5. Porciatti Francesco, B.PDR.
  6. Pino Roberto, D.DR
  7. Crucitti Antonio, Specializzando (B.)

AFFILIATION:

Dipartimento di Farmacologia Preclinica e Clinica "Mario Aiazzi Mancini"

Facoltà di Medicina e Chirurgia

Università degli Studi di Firenze

ADDRESS: viale Morgagni, 65

CITY: Firenze

POSTAL CODE: 50134

TELEPHONE: 055-4237405,411

FAX: 055-4361613

E-MAIL: mugelli@stat.ds.unif.it

PUBLICATIONS:

  1. CERBAI E., BARBIERI M., LI Q., MUGELLI A. Ionic basis of action potential prolongation of hypertrophied myocytes isolated from the heart of hypertensive rats of different ages. Cardiovasc Res, 28:1180-1187, 1994.
  2. GAMBASSI G., CERBAI E., PAHOR M., CAPOGROSSI MC., CARBONIN PU., MUGELLI A. Temperature modulates Ca2+ homeostasis and ventricular arrhythmia.s in myocardial preparations. Cardiovasc. Res. 28 :391-399, 1994.
  3. BARBIERI M., VARANI K., CERBAI E., GUERRA L., LI Q., BOREA PA., MUGELLI A. Electrophysiological basis for the enhanced cardiac arrhythmogenic effect of isoprenaline in aged spontaneously hypertensive rats. J. Mol. Cell. Cardiol. 26 : 849-860, 1994 .
  4. CERBAI E., BARBIERI M. AND MUGELLI A. Characterization of the hyperpolarization-activated current, If, in ventricular myocytes isolated from hypertensive rats. J. Physiol. 481 :585-592, 1994.
  5. PAHOR M., CECCHI E., FUMAGALLI S., MANTO A., PEDONE C., CAROSELLA L., COCCHI A., BERNABEI R., MARCHIONNI N., MUGELLI A., CARBONIN P. Association of serum creatinine and age with headache caused by nitrates. Clinical Pharmacol. Ther. 58 : 470-481, 1995.
  6. CERBAI E., GUERRA L., VARANI K., BARBIERI M., BOREA P.A., MUGELLI A. b-adrenoceptor subtypes in young and old rat ventricular myocytes: A combined patch-clamp and binding study. Brit. J. Pharmacol. 116 : 1835-1842, 1995.
  7. GUERRA L., CERBAI E., GESSI S., BOREA P.A., MUGELLI A. The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricula myocytes. Brit. J. Pharmacol. 118 : 1278-1284, 1996.
  8. MATUCCI R., BIANCHI B., OTTAVIANI M.F., CAMPANA S., BENNARDINI F. FRANCONI F. Carbon centered radicals reduce the density of L-type calcium channel in rat cardiac membranes. Biochem. Biophys. Res. Commun. 223 : 85-90, 1996.
  9. CERBAI E., BARBIERI M., MUGELLI A. Occurrence and properties of the hyperpolarization-activated current, if, in ventricular myocytes from normotensive and hypertensive rats during aging. Circulation 94 : 1674-1681, 1996.
  10. CERBAI E., BARBIERI M., MUGELLI A. Electrophysiological study on lercanidipine and its enantiomers. J Cardiovasc Pharmacol. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Rossi Francesco, P.O.
  2. Berrino Liberato, R.U.
  3. Calderaro Vincenzo, R.U.
  4. Filippelli Amelia, R.U.
  5. Filippelli Walter, T.L.
  6. Maione Sabatino, B.
  7. D'Amico Michele, D.DR.
  8. De Novellis Vito, B.
  9. Stella Luigi, B.PDR.
  10. Falciani Maddalena, D.DR.
  11. Pizzirusso Anna, D.DR.

AFFILIATION:

Istituto di Farmacologia e Tossicologia

Facoltà di Medicina e Chirurgia

Seconda Università degli Studi di Napoli

ADDRESS: Via Costantinopoli, 16

CITY: Napoli

POSTAL CODE: 80138

TELEPHONE: 081-566-5878, 5877, 459802

FAX: 081-566-5877, 5878

PUBLICATIONS:

  1. MAIONE S., D'AMICO M., BERRINO L., FILIPPELLI A., LEYVA J., ROSSI F.: Involvement of periaqueductal gray area NMDA receptors in endothelin-induced behavioural effects. Eur. J. Pharm. 250: 209-212, 1993.
  2. STELLA L., BERRINO L., MAIONE S., DE NOVELLIS V., ROSSI F.: Cardiovascular effects of adenosine and its analogs in anaesthetized rats. Life Sci. 53: 755-763, 1993.
  3. CALDERARO V., PARRILLO C., BALESTRIERI M.L., GIOVANE A., FILIPPELLI A., ROSSI F.: Docosahexaenoic acid and signaling pathways in rabbit colon. Mol. Pharmacol. 45: 737-746, 1994.
  4. D'AMICO M., BERRINO L., MAIONE S., FILIPPELLI A., PIZZIRUSSO A., VITAGLIANO S., ROSSI F.: Endothelin-1 in rat periaqueductal gray area induces hypertension via glutammergic receptors. Hypertension 25: 507-510, 1995.
  5. MAIONE S., LEYVA J., PALLOTTA M., BERRINO L., DE NOVELLIS V., ROSSI F.: Involvement of opioid receptors in N-methyl-D-aspartate induced arterial hypertension in periaqueductal gray matter. Naunyn-Schmied. Arch. Pharmacol. 351: 87-92, 1995.
  6. D'AMICO M., WARNER T.D.: Involvement of endothelin in the pressor response following injection of NMDA to the periaqueductal gray area of rats. Brit. J. Pharmacol. 116: 2787-2789, 1995.
  7. MAIONE S., BIGGS C.S., ROSSI F., FOWLER L.J., WHITTON P.S.: -amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors modulate dopamine release in rat hippocampus and striatum. Neurosci. Lett. 193: 1-4, 1995.
  8. D'AMICO M., DASHWOOD M.R., WARNER T.D.:Endothelin-1 and the periaqueductal gray area of the rat: an autoradiographic and functional pharmacological study. Brit. J. Pharmacol. 118: 21-26, 1996.
  9. D'AMICO M., BERRINO L., MAIONE S., FILIPPELLI A., DE NOVELLIS V., ROSSI F.: Endothelin-1 in periaqueductal gray area of mice induces analgesia via glutamatergic receptors. Elsevier Scientific Publishers Ireland LTD. Pain 65: 205-209, 1996.
  10. NOREL X., WALCH L., COSTANTINO M., LABAT C., GORENNE I., DULMET E., ROSSI F. AND BRINK C.: M1 and M3 muscarinic receptors in human pulmonary arteries. Brit. J. Pharmacol. 119: 149-157, 1996.

RESEARCH GROUP MEMBERS:

  1. Rossini Luigi, P.O.
  2. Bernardi Marina, B.PDR.
  3. Lamura Elena, D.DR.
  4. Concettoni Carolina, T.L.
  5. Tonnini Cecilia, T.L., DR.
  6. Moretti Vincenzo, P.C., A.O. (°)
  7. Pigini Paola, P.C., A.O. (°)

AFFILIATION:

Istituto di Medicina Sperimentale e Clinica

Università degli Studi di Ancona

Servizio di Farmacologia clinica e Tossicologia

Azienda Sanitaria n. 7, Regione Marche

ADDRESS: Via Tronto

CITY: Ancona

POSTAL CODE: 60100

TELEPHONE: 071/2206037

FAX: 071/2206037

E-MAIL: animo@anvax2.cineca.it

PUBLICATIONS:

  1. OLSEN, J.I., ROSSINI, P., SCHWEIZER, M.P., BERNARDI, M., MORETTI, V., RE, L., ROSSINI, L. A 31-P NMR spectroscopy study of Xenopus laevis heart perfused in vitro by phosphocreatine, adenosine-triphosphate, fructose-diphosphate and ouabain. Pharmacol. Res. 28: 1-17, 1993.
  2. RE, L., COLA, V., FULGENZI, G., MARINELLI, F., CONCETTONI, C., ROSSINI, L. Post-synaptic effects of methoctramine at the mouse neuromuscular junction. Neuroscience 57: 451-457, 1993.
  3. RE, L., COLA, V., FULGENZI, G., MARINELLI, F., CONCETTONI, C., ROSSINI, L. Muscarinic receptors in mouse neuromuscular junction: on the effects of some agonists and antagonists. Gen. Pharmacol. 24: 1447-1453, 1993.
  4. ROSSINI, L., BERNARDI, M., CONCETTONI, C., DE FLORIO, L., DESLAURIERS, R., MORETTI, V., PIANTELLI, F., PIGINI, P., RE, L., ROSSINI, P., TONNINI, C. Some approaches to the pharmacology of multisubstrate enzyme systems. Pharmacol. Res. 29: 313-335, 1994.
  5. BERNARDI, M., DESLAURIERS, R., DOCHERTY, J., ROSSI, C., ROSSINI, L., ROSSINI, P., TONNINI, C. Spectral analysis of intercycle heart fluctuations in Xenopus laevis, conscious or spinalized, treated with calcium channel blockers. Part I. Gen. Pharmacol. In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Semeraro Claudio, Dir. R.
  2. Marchini Francesco, Dir. R.
  3. Pocchiari Felice, Dir. R.
  4. Santangelo Francesco, Dir. R.
  5. Ferlenga Pier Paolo, C.L.
  6. Pradella Lorenzo, C.L.
  7. Morazzoni Gabriele, C.L.
  8. Masotto Claudio, C.L.
  9. Brambilla Nadia, R.I.
  10. Zanzottera Daniele, R.I.
  11. Buschi Alberto, R.I.
  12. Palazzolo Laura, R.I.
  13. Allievi Leopoldo R.I.
  14. Bisiani Chiara, R.I.
  15. Da Ros Bruna, R.I.
  16. Fantoni Maurizio, R.I.
  17. Moriggi Ermanno, R.I.
  18. Scatturin Melania, R.I.

AFFILIATION :

Direzione Ricerca Cardiovascolare

Direzione Ricerche e Sviluppo Internazionali

Zambon Group S.p.A.

ADDRESS: Via Lillo del Duca, 10

CITY: Bresso (Milano)

POSTAL CODE: 20091

TELEPHONE: 02-665241

FAX : 02-66524524

PUBLICATIONS :

  1. NORCINI, L. ALLIEVI, G. BERTOLINI, C. CASAGRANDE, G. MIRAGOLI, F. SANTANGELO,C. SEMERARO Synthesis and pharmacological evaluation of tyramine congeners containing fused heterocyclic rings. Eur. J. Med. Chem. 28 : 505-511, 1993.
  2. BERTOLINI, C. CASAGRANDE, G. NORCINI, F. SANTANGELO Synthesis and reactivity of mevinolin-like lactone precursors. Synthetic Comm. 24 : 1833-1845, 1994.
  3. SANTANGELO, C. CASAGRANDE, G. MIRAGOLI, V. VECCHIETTI Synthesis and positive inotropic effect of 1-alkyl-and 1-acyl-6,7-dimethoxy-3-dimethylamino-1,2,3,4-tetrahydroquinolines. Eur. J. Med. Chem. 29 : 877-882, 1994.
  4. NAPOLETANO, D. DELLA BELLA, C. FRAIRE, G. GRANCINI, C. MASOTTO, S. RICCIARDI, C. ZAMBON Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective -opioid analgesic. Bioorg. Med. Chem. Lett. 5 : 589-592, 1995.
  5. F. SANTANGELO, C. CASAGRANDE, G. NORCINI, F. GERLI A convenient synthesis of 9-hydroxy-3,4,5,6-tetrahydro-1H-azepino [5,4,3-cd] indole from 7-methoxyindole. Synthetic Comm. 23 : 2717-2725, 1995.
  6. K.H. BANNER, F. MARCHINI, A. BUSCHI, E. MORIGGI, C. SEMERARO, C.P. PAGE The effect of selective phosphodiesterase inhibitors in comparison with other anti-asthma drugs on allergen-induced eosinophilia in guinea-pig airways. Pulm. Pharmacol. 8 :37-42, 1995.
  7. S. IANELLI, M. NARDELLI, F. DOGGI, G. NORCINI, F. SANTANGELO Structure and conformation of three stereoisomers of a novel and selective opioid analgesic. Acta Crystallographica C51 : 1338-1341, 1995.
  8. M. FANTONI, E. MORIGGI, C. BISIANI, C. MASOTTO, F. POCCHIARI, C. SEMERARO Z1046 : Biochemical characterization of its dopaminergic activity. Acta Physiol. Hungarica, In press, 1996.
  9. P. FERLANGA, D. ZANZOTTERA, I. BIASINI, F. MARCHINI, C. SEMERARO Z1046, a new specific peripheral dopaminergic compound. Acta Physiol. Hungarica, In press, 1996.


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