Joint Meeting Dutch-Italian Pharmacological Societies 2003

Wednesday February 12

13:00-14:00	Lunch
14:00-15:30	Business Meeting of the Dutch Pharmacological Society
15:35	Opening of the Joint Meeting	V. Cuomo, P. Saxena
15:45-17:35	I. Pulmonary pharmacology	(P. Geppetti, Firenze; J. Zaagsma, Groningen)
	Plenary symposium in remembrance of S. Nicosia
	H. Meurs, Groningen	NO in allergic asthma: excess or shortness?
	G.E. Rovati, Milano	Leukotrienes in asthma pathophysiology
	Oral abstract presentations
	A.R. Kranenburg et al., Rotterdam	Enhanced bronchial expression of vascular endothelial growth factor and receptors (FLK-1 and FLT-1) in patients with chronic obstructive pulmonary disease
	S. Marzocco et al., Salerno	Anti-inflammatory activity of methylguanidine on carrageenan induced rat pleurisy
	M. Kool et al., Utrecht	Role for the neurokinin-1 receptor in the early phase of non-IgE mediated pulmonary hypersensitivity reactions
	H. Maarsingh et al., Groningen	Role of arginase in neuronal nitric oxide production and airway smooth muscle relaxation induced by inhibitory nonadrenergic noncholinergic (iNANC) nerve stimulation
17:35-17:50	Break
17:50-19:40	II. Pharmacology of migraine	(L.A. Pini, Modena; P. Saxena, Rotterdam
	H. Doods, Biberach	CGRP and migraine
	G. Geppetti, Firenze	Trigeminal neurons and migraine
	Oral abstract presentations
	U. Arulmani et al., Rotterdam	Effects of BIBN4096BS on capsaicin-induced haemodynamic changes in a porcine experimental model for migraine
	L.A. Pini et al., Modena	Serotonergic and opiatergic modifications induced by paracetamol as a model for daily chronic headache with analgesic overuse
	S. Gupta et al., Rotterdam	Differential potency of BIBN4096BS in blocking CGRP relaxations in human distal and proximal coronary arteries
	A. Ottani et al., Modena	Different effect of sumatriptan in models of thermal, chemical or cephalalgic pain in rats
17:50-19:40	III. CNS effects of steroids	(G. Biggio, Cagliari; A. Rijnders, Oss)
	A. Ederveen, Oss	The use of in vivo models in drug development to elucidate tissue selectivity of partial estrogen receptor agonists
	M.L. Barbaccia, Roma	Neurosteroids and the mechanism of action of antipsychotic drugs
	Oral abstract presentations
	F. di Michele et al., Roma	Neuroactive steroids in Parkinson's disease
	M. Serra, Cagliari	Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol
19:40-20:30	Reception/posters
20.30	Dinner

Thursday February 13

07:45-09:00	Breakfast
09:00-12:00	IV. Neuropeptides	(A. Bertolini, Modena; B. Olivier, Utrecht)
	G. van Dijk, Groningen	Involvement of the brain melanocortin system in regulation of energy balance
	A. Bertolini, Modena	Melanocortins in shock and in other conditions of tissue hypoxia
	B. Olivier, Utrecht	The CRH-overexpressing mouse: model for depression?
	F. Drago, Catania	Neurotransmitter interactions in the amnesic effects induced by beta-amyloid related peptides
10:40-11:00	Break
	Oral abstract presentations
	J. Hillebrand, Utrecht	The melanocortin system and eating disorders
	A.V. Vergoni et al., Modena	Chronic intracerebroventricular infusion either of a melanocortin agonist and of a melanocortin antagonist at low doses profoundly modifies energy balance without any other behavioral effect in rats
	K. de Vries et al., Groningen	The central melanocortin system and metabolism
	M. Massi et al., Camerino	Inhibition of CRF-induced anorexia by NOP receptor activation
09:00-12:00	V. Immunopharmacology	(C. Riccardi, Perugia; F. Nijkamp, Utrecht
	F. Redegeld/A. Kraneveld, Utrecht	Free light chain elicits immediate hypersensitivity-like responses: possible implication for asthma
	C. Riccardi, Perugia	Glucocorticoid hormones and regulation of T lymphocytes activation and death
	M. Smit, Amsterdam	Virally encoded G Protein-coupled receptors: new targets for drug therapy
	S. Cuzzocrea, Messina	Ligands of the peroxisome proliferator-activated receptor-g (PPAR-g) reduce acute and chronic inflammation
10:40-11:00	Break
	Oral abstract presentations
	M.W. Zuurman et al., Groningen	L-CCR: a novel functional C-C chemokine receptor expressed in murine glial cells
	R. d'Emmanuele di Villa Bianca et al., Napoli	Role of endothelium derived hyperpolarizing factor (EDHF) in glucocorticoids induced hypertension
	A. Rijnerse et al., Utrecht	Validation of a murine model for colonic hypersensitivity
	S. Ronchetti et al., Perugia	Signals through the TNFR superfamily (TNFRSF) member GITR are costimulatory to T lymphocytes
12:00-14:00	Lunch/posters
14:00-15:00	Plenary lectures	(J. Smits, Maastricht; A. Mugelli, Firenze)
	E. Cattaneo, Milano	Huntington: a "model" disease
	R. Leurs, Amsterdam	Do receptors need ligands?
15:00-15:30	Break
15:30-16:30	Plenary lectures	(J. Smits, Maastricht; F. Drago, Catania)
	F. Nicoletti, Roma	Cell cycle activation and neuronal death
	R. Masereeuw, Nijmegen	Endothelin-regulated drug transport in the kidney
16:30-17:00	Break
17:00-18:00	Ariëns lecture (P. Saxena)
	Ariëns lecturer:	H. Timmerman, Amsterdam
19:00	Banquet

Friday February 14

07:45-08:30	Breakfast
08:30-11:30	VI. Cardiovascular Pharmacology: Heart Failure	(L. Berrino , Napoli; P. van Zwieten, Amsterdam)
	W. van Gilst, Groningen	New concepts on the treatment of heart failure with RAS inhibitors
	E. Cerbai, Firenze	Electrophysiologic remodeling in heart failure
	M. Blankesteijn, Maastricht	The myofibroblast as a therapeutic target to prevent heart failure development after myocardial infarction
	M. Ziche, Siena	Coronary dysfunction and angiogenesis
10:10-10:30	Break
	Oral abstract presentations
	A. Nap et al., Amsterdam	Different AT1-receptor subtypes at prejunctional and postjunctional sites: AT1A versus AT1B-receptors
	G. Lonardo et al., Firenze	ANP increases the pacemaker current (IF): A potentially new link between stretch and arrhythmogenesis?
	B. Tom et al., Rotterdam	No role for oxygen-derived free radicals in angiotensin-II-mediated vasoconstriction of human coronary arteries
	L. Raimondi et al., Firenze	Chronic treatment with w-3 PUFA decreases plasma concentration of asymmetric dimethylarginine (ADMA) in aging SHR rats
08:30-11:3	VII. Pharmacology of Drug Abuse	(W. Fratta, Cagliari; J. van Ree, Utrecht
	T. Schoffelmeer, Amsterdam	Towards a pharmacotherapy of relapse behavior
	L. Fattore, Cagliari	Opioid-cannabinoid interactions in release mechanisms to drug-seeking
	A. Cools, Nijmegen	Individual differences in vulnerability to drugs of abuse: role of genetic background, early postnatal factors, and stress
	P. Nencini, Roma	What makes heroin different: the case of morphine glucoronidation
10:10-10:30	Break
	Oral abstract presentations
	J.R. Homberg, Amsterdam	Neuropharmacological assessment of enhanced motivation of rats to self-administer cocaine
	P. Fadda et al., Cagliari	Antagonism by baclofen of nicotine rewarding effects: behavioral and neurochemical studies
	E.D. Schmidt, Amsterdam	Drug-specific hot spots in rat brain associated with relapse to heroin-seeking behavior
	M.R. Carratù et al., Bari	An experimental model simulating gestational carbon monoxide exposure in human cigarette smokers: subtle myelin alterations in rat offspring
11:30-13:00	Lunch
13:00-16:00	VIII. Endocrine Pharmacology: Diabetes	(M. Carruba, Milan; P. Smits, Nijmegen
	P. Smits, Nijmegen	Oral blood glucose lowering drugs: new aspects
	L. Berrino, Napoli	Hyperglycemia and cardiovascular damage
	E. Blaak, Maastricht	Disturbances in fatty acid metabolism in type 2 diabetes mellitus
	E. Nisoli, Milano	Role of nitric oxide in adipose cell biology
14:40-15:00	Break
	Oral abstract presentations
	G.A. Rongen, Nijmegen	Tc-99m-HYNIC-Annexin V scintigraphy: detection of ischemic preconditioning in humans in vivo
	L. Raimondi et al., Firenze	Glucose disposition and electrophysiological features in diabetic cardiomyocytes: the effect of angiotensin II blockade
	P. Pickkers et al., Nijmegen	Activation of the ATP-dependent potassium channel attenuates noradrenalin-induced vasoconstriction in the human forearm
	S. Grande et al., Milan (pres. Visioli)	Mediterranean wild plant extracts ameliorate endothelial function: an in vitro study
13:00-16:00	IX. Receptor Pharmacology	(P.A. Borea, Ferrara; R. Leurs, Amsterdam)
	A. IJzerman, Leiden	Allosteric modulation of G protein-coupled receptors
	P. Borea, Ferrara	Adenosine receptors and cancer: new pharmacological targets?
	C. van Koppen, Oss	Molecular pharmacology of low molecular weight agonists for the lutropin receptor
	M.A. Riva, Milano	Dopaminergic system and modulation of neurotrophic factor expression in the rat brain
14:40-15:00	Break
	Oral abstract presentations
	M.C. Hendriks-Balk et al., Weesp	The role of RGS4 in ligand-directed signaling of the dopamine D2-receptor
	E. Giannini et al, Roma	Roma Prokineticins and their receptors participate in the peripheral transmission of inflammatory pain
	M.C. Wittendorp et al., Groningen	CL-IB-MECA induced release of CCL2 by astrocytes: possible role for the adenosine A3 receptor?
	G. De Sarro et al., Catanzaro (pres. Gallelli)	Tetrahydroisoquinoline derivatives: a new class of non-competitive AMPA receptor antagonists with potential anticonvulsant activity.
16:00	Adjournment

V.K.T. Allagappan et al.	Insulin-like growth factors stimulate proliferation of cultured human airwya epithelial but not smooth muscle cells
R.A. Bakker et al	Inverse agonists reveal conditional synergy between Gai- and Gaq-coupledreceptors
W.W. Batenburg et al.	AT2 receptor-mediated vasodilation in human and rat coronary arteries. Role of nitric oxide
F. Borelli et al.	Green tea and gastrointestinal cancer risk
M. Bruysters et al.	A mutagenic and in silico approach to characterise the histamine H1-receptor binding-pocket
M. Bucci et al.	Involvement of heat shock protein 90 (Hsp-90) in testosterone-induced vasorelaxation in vitro
W.M. Blankesteijn et al.	Time course of gene expression in infarcted and non-infarcted areas of the left ventricle after MI, analyzed by microarray
P. Casarosa et al.	Differential constitutive signaling properties of the human and rat cytomegalovirus- encoded receptors UL33 and R33
S. Casini et al.	Functional characterization of a novel Brugada syndrome mutation in the cardiac Na+ channel
W.X. Chai et al.	Role of calcitonin gene-related peptide in ischaemic preconditioning in rat isolated heart
S. Cuzzocrea et al.	Role of the inducible nitric oxide synthase in experimental model of acute pancreatitis
A.A. de Groot et al.	Involvement of the beta(3) adrenoceptor in nebivolol-induced vasorelaxation in the rat aorta
I.M. Dijkstra et al	Expression and functional activity of the chemokine receptor CXCR3 in microglia and its role in neurodegenation
M. Festa et al.	Petrosaspongiolide M reduces morphine withdrawal in vitro
M. Fornai et al.	Gastrin/CCK-2 receptors mediate relaxant effects of gastrin and cck-8s on the motility of the distal colon
M.N. Ghayur et al.	Pharmacological basis for the cardiodepressant and sialogogue effects of betel nut
R. Gosens et al.	Role of PKC and p42/p44 MAP kinase in synergism of airway smooth muscle proliferation induced by G-protein coupled receptor agonists and growth factors
R. Gosens et al.	Cholinergic synergism of mitogenesis in airway smooth muscle is mediated by muscarinic M3-, not M2-receptors
E. Lipsic et al.	Erythropoietin activates MAP kinase in isolated rat hearts
S. Marzocco et al.	Inhibition of nitric oxide synthase expression by yuccaol c isolated from Yucca schidigera roezl
M. Massi et al.	Effect of nociceptin-orphanin FQ on ethanol self-administration and ethanol seeking behaviour in rats
S. Notenboom et al.	Short-term gentamicin exposure to renal proximal tubule has long-term intracellular signaling consequences
P. Ochodnický et al.	Variability in renal damaging effects of doxorubicin explained by variability in prevailing renal blood flow
J. Oostendorp et al.	Localization and regulation of expression of the orphan chemokine receptor L-CCR in the lung in a murine model of ovalbumin-induced airway inflammation
J.B.G. Paquay et al.	Contractile properties of myocardial scar tissue
A. Popolo et al.	Role of calcium flux on vascular hyporeactivity induced by endothelial mechanical injury in rat carotid arteries
C. Sand et al.	The contribution of endogenously produced reactive oxygen species to the inotropic and chronotropic effects of adrenoceptor- and et-receptor stimulation
M.W. Sanders et al.	Effects of prenatal stress on renal function and blood pressure in adult rats
M. Sandovici et al.	Differential regulation of glomerular and interstitial endothelial nitric oxide synthase expression in the kidney of the hibernating ground squirrel
J.J. Saris et al.	(Pro)renin receptor-dependent responses in cardiomyocytes: do they occur?
M.P.Schuijt et al.	Superoxide: a direct or an indirect vasoconstrictor?
I. Serraino et al.	Pyrrolidine dithiocarbamate modulates the severity of cerulein induced murine acute pancreatitis
P.H.E. Smeets et al	ATP-dependent transport of para-aminohippurate and fluorescein by multidrug resistance proteins 2 and 4 (MRP2/ABCC2 and MRP4/ABCC4)
J.O. Streefkerk et al.	Facilitating effect of vasopressin on sympathetic nervous system in the human plethysmography model
D.L. Valstar et al.	Depletion on lung function and airway inflammation in a rat model for tma-induced occupational asthma
H.P.M. van der Kleij et al.	Functional expression of neurokinin-1 receptors on mast cells induced by IL-4 and SCF
E.C.A.M. van Esch et al.	Role for IL-10 in allergen immunotherapy in a mouse model of allergic asthma
T.J.A. van Eijl et al.	Use of ex-vivo perfusion to assess lung function changes in a murine model of elastase-induced emphysema
J. van Golde et al.	Mechanisms of sympathetic hyperinnervation in chick embryo exposed to chronic moderate hypoxia
A.H. van Houwelingen et al.	F991, a new therapeutical compound for contact dermatitis
C.E. van Meijeren et al.	Use of different pharmacological tools in search for an alternative in vitro method for the histamine sensitization test in mice
J.L.M. Vissers et al.	Stimulation of IL-10 production by allergen-loaded macrophages enhances the immunosuppressive effects in a mouse model of allergic asthma
J.P.M. Wesselman et al.	Role of the rho/rho kinase pathway in flow-related remodeling of rat resistance arteries in vivo