Post-Doctoral Fellow

University of Poitiers, France

Department of Physiology

 

A 2 year postdoctoral appointment, EEC-funded, has become available to join a group studying the modulation of cell-to-cell communication in cardiac cells. The project is focussed on the identification of enzymatic cascades involved in the phosphorylation/dephosphorylation balance which governs the gating of gap junctional channels. Methods employed involve measurements of junctional conductance in double patch clamp conditions and cell-to-cell diffusion of fluorescent dyes. The investigations are performed on dispersed cells (rat ventricular myocytes) and cell lines (transfected HeLa cells). Dysfunction of gap junctions is critically involved in several diseases (e.g. cardiovascular, diabetic cataract, deafness, cancer).

 

Applicants should have a background in the regulation of membrane channels (not necessarily gap junctional channels), with expertise in electrophysiology.

 

Applications will be accepted until the position is filled. For informal inquiries and for applications, please contact :

 

 

Dr. Jean-Claude Hervé

Physiologie Cellulaire, UMR CNRS 6558

40, avenue du R. Pineau

86022 POITIERS Cédex, France

 

Tel. : (+33)(0)549 45 37 51

Fax  : (+33)(0)549 45 40 14

E-mail : Jean.Claude.Herve@univ-poitiers.fr