SIF - Societā Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

ENDOCRINE AND NEUROENDOCRINE PHARMACOLOGY

 


RESEARCH GROUP MEMBERS:

  1. Arletti Rossana, P.A.
  2. Poggioli Rosanna, P.A.
  3. Vergoni Anna Valeria, R.U.
  4. Calzā Laura, P.A.
  5. Luppi Patrizia, B.

AFFILIATION:

Sezione di Farmacologia

Dipartimento di Scienze Biomediche

Facoltā di Medicina e Chirurgia

Universitā degli Studi di Modena

ADDRESS: Via G. Campi 287

CITY: Modena

POSTAL CODE: 41100

TELEPHONE: 059-428440

FAX: 059-372653

E-MAIL: farmacol@unimo.it

PUBLICATIONS:

  1. LUPPI P., LEVI-MONTALCINI R., BRACCI-LAUDIERO L., BERTOLINI A., ARLETTI R., TAVERNARI D., VIGNETI E. AND ALOE L. NGF is released into plasma during human pregnancy:an oxytocin-mediated response? NeuroReport 4: 1063­1065, 1993.
  2. ARLETTI R., BENELLI A. AND BERTOLINI A. Influence of oxytocin on nociception and morphine antinocipetion. Neuropeptides 24: 125-129, 1993.
  3. ARLETTI A., BENELLI A., MAZZAFERRO M., CALZā L., GIARDINO L. AND BERTOLINI A. The effect of oxytocin on feeding, drinking and male copulatory behavior is not diminished by neonatal monosodium glutamate. Horm. Behav. 27: 499­510, 1993.
  4. BENELLI A., ARLETTI R., BERTOLINI A., MENOZZI B., BASAGLIA R. AND POGGIOLI R. Galantide stimulates sexual behavior in male rats. Eur. J. Pharmacol. 260: 279-282, 1994.
  5. BENELLI A., POGGIOLI R., LUPPI P., RUINI L., BERTOLINI A. AND ARLETTI R. Oxytocin enhances and oxytocin antagonism decreases, sexual receptivity in intact female rats. Neuropeptides 27: 245-250, 1994.
  6. POGGIOLI R., BENELLI A., ARLETTI R., MENOZZI B. AND BERTOLINI A. Benextramine, an NPY antagonist, improves sexual behavior in male rats. Neuropeptides 26: 355-358, 1994.
  7. BENELLI A., BERTOLINI A., POGGIOLI R., MENOZZI B., BASAGLIA R. AND ARLETTI R. Polymodal dose-response curve for Oxytocin in the social recognition test. Neuropeptides 28: 251-255, 1995.
  8. ARLETTI R., BENELLI A., POGGIOLI R., LUPPI P., MENOZZI B. AND BERTOLINI A. Aged rats are still responsive to the antidepressant and memory-improving effects of oxytocin. Neuropeptides 29: 177-182, 1995.
  9. LUPPI P., ROSSIELLO M.R., FAAS S. AND TRUCCO M. Genetic background and environment contribute synergistically to the onset of autoimmune diseases. J. Mol. Med. 73: 381-393, 1995.
  10. VERGONI A.V., FORGIONE A. AND BERTOLINI A. Chronic administration of l-sulpiride at non-neuroleptic doses reduces the duration of immobility in experimental models of "depression-like" behavior. Psycopharmacology 121: 279­281, 1995.

RESEARCH GROUP MEMBERS:

  1. Canonico Pier Luigi, P.O.
  2. Sortino Maria Angela, R.U. Universitā di Catania
  3. Cavallaro Sebastiano, B.
  4. Favit Antonella, B.
  5. Aleppo Grazia, B.
  6. Condorelli Fabrizio, B.
  7. Musco Simone, B.

 

AFFILIATION:

Sezione di Farmacologia

Dipartimento di Medicina Interna e Terapia Medica

Universitā di Pavia

ADDRESS: Piazza Botta, 10

CITY: Pavia

POSTAL CODE: 27100

TELEPHONE: 0382-506398; 095-580545

FAX: 0382-28246; 095-580545

E-MAIL: msortino@ictuniv.unict.it

PUBLICATIONS:

  1. FAVIT A., WETZEL W.C., AND NEGRO-VILAR A. Differential expression of g-aminobutyric acid receptors in immortalized luteinizing hormone-releasing hormone neurons. Endocrinology 133: 1983-1989, 1993.
  2. SORTINO M.A., ALEPPO G., SCAPAGNINI. U., AND CANONICO P.L. Involvement of nitric oxide in the regulation of GnRH release from the GT1-1 neuronal cell line. Endocrinology 134: 1782-1787, 1994.
  3. FAVIT A., SCAPAGNINI U., AND CANONICO P.L. Pituitary adenylate cyclase-activating polypeptide activates different signal transducing mechanisms in cultured cerebellar granule cells. Neuroendocrinology 61: 377-382, 1995.
  4. CAVALLARO S., D'AGATA V., GUARDABASSO V. TRAVALI S., STIVALA F., AND CANONICO P.L. Differentiation induces pituitary adenylate cyclase activating polypeptide receptor expression in PC-12 cells. Mol. Pharmacol. 48: 56-62, 1995.
  5. D'AGATA V., CAVALLARO S., STIVALA F., TRAVALI. S., AND CANONICO P.L. Tissue and developmental expression of pituitary adenylate cyclase activating polypeptide (PACAP) receptors in rat brain. Eur. J. Neurosci. 8: 310-318, 1996.
  6. SORTINO M.A., AND CANONICO P.L. Neuroprotective effects of insulin-like growth factor I (IGF-I) in immortalized hypothalamic cells: Endocrinology 137: 1418-1422, 1996.
  7. SORTINO M.A., ALEPPO G., SCAPAGNINI U., AND CANONICO P.L. Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging. Brain Res. Bull. 41: In press, 1996.
  8. CAVALLARO S., COPANI A., D'AGATA V., MUSCO S., PETRALIA S., VENTRA C., STIVALA F., TRAVALI S., AND CANONICO P.L. Pituitary adenylate cyclase activating polypeptide prevents apoptosis in cultured cerebellar granule neurons. Mol. Pharmacol.50: 60-66, 1996.
  9. SORTINO M.A., ALEPPO G., COPANI A., CASABONA G., NICOLETTI F., KUHN R., KNOEPFEL T., MALITSCHEK B., AND CANONICO P.L. Immortalized hypothalamic neurons express metabotropic glutamate receptors positively coupled to cyclic AMP formation. Eur. J. Neurosci. 8: 2407-2415, 1996

RESEARCH GROUP MEMBERS:

  1. Cocchi Daniela, P.O.
  2. De Gennaro Vito, R.U.
  3. Cattaneo Lorena, D.DR.

AFFILIATION:

Dipartimento Scienze Biomediche e Biotecnologie

Facoltā di Medicina e Chirurgia

Universitā di Brescia

ADDRESS: Via Valsabbina, 19

CITY: Brescia

POSTAL CODE: 25124

TELEPHONE: 030-3715290

FAX: 030 - 3701157

PUBLICATIONS:

  1. PARENTI M., COCCHI D., CERESOLI G., MARCOZZI C., MÜLLER E.E.: Age-related changes of growth hormone secretory mechanisms in the rat pituitary gland. J. Endocrinol. 131: 251-257, 1991.
  2. COCILOVO L., DE GENNARO COLONNA V., ZOLI M., BIAGINI G., SETTEMBRINI B., MÜLLER E.E., COCCHI D: Central mechanisms subserving the impaired growth hormone secretion induced by persistent blockade of NMDA receptors in immature rats. Neuroendocrinology 55: 416-421, 1992.
  3. LAMPERTI E., COCCHI D., PARATI E.A., CARACENI T., MÜLLER E.E.: Growth hormone responses to cholinergically active drugs in patients with dementia of the Alzheimer type. Alzheimer Disease and Associated Disorders 6: 44-50, 1992.
  4. MÜLLER E.E., COCCHI D., GHIGO E., ARVAT E., LOCATELLI V., CAMANNI F.: Growth hormone response to GHRH during lifespan. J. Ped. Endocrinol. 6: 5-13, 1993.
  5. QUING Y., PARENTI M., GUZZI F., CERESOLI G., MÜLLER E.E., COCCHI D.: Alterations of adenylyl cyclase-coupled growth hormone-releasing hormone (GHRH) pituitary receptors in different conditions of GHRH deprivation. Brain Res. 13-18, 1994.
  6. DE LUCA A., PIERNO S., COCCHI D., CONTE CAMERINO D. Growth hormone administration to aged rats improves membrane electrical properties of skeletal muscle fibers. J. Pharmacol. Exp. Ther. 269: 948-953, 1994.
  7. VALENTI G., COCCHI D., MÜLLER E.E., CAMANNI F.: Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects. J. Endocrinol. Invest. 17: 113-117, 1994.
  8. COCCHI D., CATTANEO L., LANE M.A., INGRAM D.K., CUTLER R.G., ROTH G.S.: Effect of a long-term dietary restriction on the somatotrophic axis in adult and aged monkeys. Neuroendocrinol. Lett. 17: 181-186, 1995.
  9. CATTANEO L., MÜLLER E.E., COCCHI D.: "In vivo" microdialysis of the hypothalamus: a suitable method to study the function of hypophysiotropic neurons in the rat. J. Neuroendocrinol. 8: 31-33, 1996.
  10. CATTANEO L., DE GENNARO COLONNA V., ZOLI M., MÜLLER E.E., COCCHI D. Characterization of the hypothalamo-pituitary-IGF-1 axis in rats made obese by overfeeding. J. Endocrinol. 148: 347-353, 1996.

RESEARCH GROUP MEMBERS:

  1. Di Carlo Raffaele, P.O.
  2. Meli Rosaria, R.U.
  3. Gualillo Oreste, D.DR.
  4. Mattace Raso Giuseppina, D.DR.
  5. Pacilio Maria, D.DR.

 

AFFILIATION:

Dipartimento di Farmacologia Sperimentale

Universitā degli Studi di Napoli "Federico II"

ADDRESS: Via D. Montesano, 49

CITY: Napoli

POSTAL CODE: 80131

TELEPHONE: 081-7466401

FAX: 081-7486403

PUBLICATIONS:

  1. MELI R., GUALILLO O., MATTACE RASO G., DI CARLO R. Further evidence for the involvement of prolactin in the inflammatory response. Life Sci. 53: pp PL 105-110, 1993
  2. CAPPELLO B., GRECO G., NOVELLINO E., PERISSUTTI E., SANTAGADA V., SILIPO C., VITTORIA A., MELI R, DI CARLO R., MUCCIOLI G. Synthesis and muscarinic receptor binding profiles of antagonist benzotriazole derivatives. Farmaco. 48: 907-918, 1993.
  3. CALIENDO G., DI CARLO R., MELI R., PERISSUTTI E., SANTAGADA V., SILIPO C., VITTORIA A.Synthesis and trazodone-like pharmacological profiles of 1- and 2-[3-[4-(x)-1-piperazinyl]-propyl]- benzotriazoles.Eur. J. Med. Chem. 28: 969-974, 1993.
  4. DI CARLO R., FAGGIUOLO R., MUCCIOLI G., ORTEGA C., DI CARLO F., COSTANTINI M., DOGLIOTTI L. Prognostic significance of prolactin receptor on overall survival of patients with early breast cancer: a long term retrospective analysis.The Breast. 3: 147-150, 1994.
  5. MUCCIOLI G., DI CARLO R. Modulation of prolactin receptors in the rat hypothalamus in response to changes in serum concentration of endogenous prolactin or to ovine prolactin administration.. Brain Res., 663: 244-250, 1994.
  6. DI CARLO R., BOLE FEYSOT C., GUALILLO O., MELI R., NAGANO M AND KELLY P.A. Regulation of prolactin receptor mRNA expression in peripheral lymphocytes in rats in response to changes in serum concentration of prolactin. Endocrinology. 136: N°10, 4713-4716,1995.
  7. CALIENDO G., DI CARLO R., GRECO C., MELI R., NOVELLINO E., PERISSUTTI E., SANTAGADA V. Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone. Eur. J. Med. Chem., 30: 77-84, 1995
  8. BENEDETTO N., FOLGORE A., GALDIERO M., MELI R., DI CARLO R. Effect of prolactin, rIFN-g or rTNF-a in murine toxoplasmosis. Pathologie Biologie. 43 :, 395-400, 1995.
  9. CALIENDO G., DI CARLO R., GRECO G., GRIECO P., MELI R., NOVELLINO E., PERISSUTTI E., SANTAGADA V. Synthesis, local anesthetic activity and QSAR studies for a set of N-[2-(alkylamino)ethyl]benzotriazol-x-yl acetamides.Eur. J. Med. Chem. 30: 603-608, 1995.
  10. BERLANGA J.J., GUALILLO O., BUTEAU H., APPLANAT M., KELLY P.A., EDERY M. Prolactin activates tyrosyl phosphorylation of insulin receptor substrate1 and phosphatidylinositol -3-OH kinase. J. Biol. Chem., In press, 1996.

RESEARCH GROUP MEMBERS :

  1. Girardi Carlo, P.O.Girardi Carlo
  2. Re Giovanni, R.U.
  3. Badino Paola, T.L.
  4. Novelli Antonella, D.DR.
  5. Odore Rosangela, B.

 

AFFILIATION :

Settore di Farmacologia, Dipartimento di Patologia Animale,

Facoltā di Medicina Veterinaria

Universitā degli Studi di Torino

ADDRESS: Via Nizza, 52

FAX: 011-6502687

PUBLICATIONS:

  1. RE, G., BADINO, P., DACASTO, M., NEBBIA, C., BIOLATTI, B., DI CARLO, F., AND GIRARDI, C. Effects of long-term administration of clenbuterol in mature female rats. Amer. J. Vet. Res. 54:438-442, 1993.
  2. RE, G., BADINO, P., DACASTO, M., DI CARLO, F., AND GIRARDI C. Regulation of uterine estrogen receptors (ER) by beta-adrenergic stimulation in immature rats. J. Vet. Pharmacol. Ther. 16:328-334, 1993.
  3. RE, G., BADINO, P., NOVELLI, A., VALLISNERI, A., AND GIRARDI C. Specific binding of dl-cloprostenol and d-cloprostenol to PGF2_ receptors in bovine corpus luteum and myometrial cell membranes. J. Vet. Pharmacol. Ther. 17:455-458, 1994.
  4. RE, G., BADINO, P., NOVELLI, A., CANESE, M.G., AND GIRARDI, C. Identification of ß-adrenoceptor subtypes in bovine ovarian and myometrial cell membranes. Brit. Vet. J. 151:567-578, 1995.
  5. RE, G., BADINO, P., NOVELLI, A., DI RENZO, G.F., SEVERINO, L., DE LIGUORO, M., AND FERONE M.R. Distribution of cytosolic oestrogen and progesterone receptors in the genital tract of the mare. Res. Vet. Sci. 59:214-218, 1995.
  6. RE, G., BADINO, P., NOVELLI, A., AND GIRARDI, C. Down-regulation of ß-adrenergic receptors and up-regulation of estrogen and progesterone receptors induced in thereproductive system of female veal calves by dietary clenbuterol. Amer. J. Vet. Res. 56:1493-1498, 1995.
  7. CERRUTI SOLA, S., BERGERO, D., BADINO, P., CORNAGLIA, E., NOVELLI, A., AND RE, G. Effects of dietary clenbuterol in female broiler chickens: pathological lesions and endocrine modifications. Eur. J. Vet. Pathol. 2:87-92,1996.

    RE, G., BADINO, P., NOVELLI, A., GIRARDI, C. AND DI CARLO, F. Evidence for functional ß-adrenoceptor subtypes in CG-5 breast cancer cells. Pharmacol. Res. In press, 1996.

    RE, G., BADINO, P., NOVELLI, A., AND GIRARDI, C. Effects of clenbuterol as a repartitioning agent on ß-adrenoceptor concentrations in heart, bronchi and brain of veal calves. Brit. Vet. J. In press, 1996.

  8. RE, G., BELLOLI, C., BADINO, P., ARIOLI, F., NOVELLI, A., GIRARDI, C., AND BERETTA, C. Identification of ß-adrenoceptor subtypes mediating relaxation in horse ileum. Amer. J. Vet. Res. In press, 1996.


RESEARCH GROUP MEMBERS:

  1. Maggi Adriana, P.A.
  2. Agrati Paola, D.DR.
  3. Bennici Simona, B.
  4. Garnier Martine, B.
  5. Patrone Cesare, D.DR.
  6. Pollio Giuseppe, B.
  7. Rebecchi Monica B.
  8. Santagati Sabrina B.
  9. Vegeto Elisabetta, B.PDR.

AFFILIATION :

Centro MPL, Istituto di Scienze Farmacologiche

Facoltā di Farmacia

Universitā degli Studi di Milano

ADDRESS: Via Balzaretti, 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-20488375

FAX: 02-29404961

E-MAIL: maggia@isfunix.farma.unimi.it

PUBLICATIONS :

  1. MA Z. Q., SPREAFICO E., POLLIO G., SANTAGATI S., CATTANEO E. AND MAGGI A. Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line. Proc. Nat. Acad. Sci. USA 90: 3740-3744, 1993
  2. POLLIO G., XUE P., ZANISI M., NICOLIN A. AND MAGGI A. Antisense oligonucleotide blocks progesterone-induced lordosis behavior in ovariectomized rats. Mol. Brain Res., 19: 135-139, 1993
  3. MA Z.Q., BONDIOLOTTI G.P., OLASMAA M., VIOLANI E., PATRONE,C., PICOTTI G.B. AND MAGGI A. Estrogen modulation of catecholamine synthesis and monoamine oxidase A activity in the human neuroblastoma cell line SK-ER3. J. Steroid Biochem. Mol. Biol., 47: 207-211, 1993
  4. MA Z.Q., SANTAGATI S., PATRONE C., POLLIO G., VEGETO E. AND MAGGI A. Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3. Mol. Endocrinology, 8: 910-918, 1994
  5. SANTAGATI S., MELCANGI R.C., CELOTTI F., MARTINI L. AND MAGGI A Estrogen receptor is expressed in different types of glial cells in cultures. J. Neurochemistry, 63: 2058-2064, 1994
  6. MAGALINI A., FERRARI F., SAVOLDI G., INGRASSIA R., ALBERTINI A., POLLIO G., MAGGI A. AND DI LORENZO D. Specificity of action of a herpes virus VP16/tetracycline-dependent trans-activator in mammalian cell culture. DNA and Cell Biology, 14: 665-671, 1995
  7. MA Z.Q., VIOLANI E., VILLA F., PICOTTI G.B. AND MAGGI A. Estrogenic control of monoamine oxidase A activity in human neuroblastoma cells expressing physiological concentrations of estrogen receptor. Eur. J. Pharmacol. 284: 171-176, 1995
  8. SANTAGATI S., MA Z.Q., FERRARINI C., POLLIO G. AND MAGGI A. Expression of early genes in estrogen induced phenotypic conversion of neuroblastoma cells. J. Neuroendocrinol. 7:875-879, 1995
  9. PATRONE C., MA Z.Q., POLLIO G., ANTONUCCI A., AGRATI P., PARKER M.G. AND MAGGI A. Cross-coupling between insulin and estrogen receptor in human neuroblastoma cells. Mol. Endocrinol. 10:499-507, 1996
  10. CARLO P., VIOLANI E., DEL RIO M., OLASMAA M., SANTAGATI S., MAGGI A. AND PICOTTI G. Monoamine oxidase B expression is selectively regulated by dexamethasone in cultured rat astrocytes. Brain Res., 711: 175-183, 1996

RESEARCH GROUP MEMBERS

  1. Marchetti Bianca, R.U.
  2. Morale Maria C. B.
  3. Gallo Francesco, B.
  4. Pellitteri Rosalia, B.PDR.
  5. Nunzio Batticane, B.
  6. Brouwer Jantien, B.PDR.

AFFILIATION :

Istituto di Farmacologia

Facoltā di Medicina e Chirurgia

Universitā di Catania

ADDRESS: Viale Andrea Doria 6

CITY: Catania

POSTAL CODE: 95125

TELEPHONE: (095)330-533, int. 255

FAX: (095)333-219

E-MAIL : marc@ictuniv.unict.it

PUBLICATIONS :

  1. GALLO, F., MORALE, M.C., SAMBATARO, D., FARINELLA, Z., SCAPAGNINI, U. AND MARCHETTI, B The immune system response during development and progression of carcinogen-induced rat mammary tumors. Breast Cancer Res. Treat., 27:221-237, 1993.
  2. PEIFFER, A., MORALE, M.C., BARDEN, N. AND MARCHETTI, B Modulation of glucocorticoid receptor gene expression in the thymus by the sex steroid hormone milieu and correlation with sexual dimorphism of immune response. Endocrine J. 2:181-192, 1994
  3. MARCHETTI, B., MORALE, M.C., PARADIS, P. AND BOUVIER, M Characterization, expression and hormonal control of a thymic ß2-adrenergic receptor. Amer. J. Physiol. 267 (Endocrinol. Metab. 30): E718-E731, 1994.
  4. B. MARCHETTI, MORALE, M.C., GALLO, F., BATTICANE, N., FARINELLA, Z., CIONI, M. Invited Review: "Neuroendocrinimmunology at the turn of the century: towards a molecular understanding of basic mechanisms and clinical implications for reproductive physiology". Endocrine, 3: 845-871, 1995
  5. MORALE MC, BATTICANE, N., GALLO F., BARDEN, N., AND MARCHETTI, B Disruption of hypothalamic-pituitary adrenocortical system in transgenic animals expressing type II glucocorticoid receptor antisense ribonucleic acid permanently impairs T cell function: effects on T-cell trafficking and T cell responsiveness during postnatal development. Endocrinology 136: 3949-3960, 1995
  6. TROIANO, L., MONTI, D., COSSARIZZA, A. LOVATO, E:, TROPEA, F., BARBIERI D., MORALE, M.C., GALLO, F., MARCHETTI, B., and Franceschi, C Involvement of CD45 in dexamethasone and heat-shok induced apoptosis of rat thymocytes. Biochem. Biophys. Res. Comm. 214: 941-948, 1995
  7. GALLO, F., MORALE M.C., AVOLA, R., AND MARCHETTI, B Cross-talk between luteinizing hormone-releasing hormone (LHRH) neurons and astroglial cells: developing glia release factors that accelerate neuronal differentiation and stimulate LHRH release from GT1 neuronal cell lines and LHRH neurons stimulate astroglia proliferation. Endocrine, 3: 863-874, 1995
  8. MARCHETTI, B. (1996). Invited Review: The LHRH-Astroglia Network of signals as a Model to study Neuroimmune Interactions: Assessment of Messenger Systems, Transduction Mechanisms at Cellular and Molecular Levels, Neuroimmunomodulation 3: 1-27, 1996
  9. MARCHETTI B. (1996) Invited Review: Cross-talk signals between pathways in the CNS: Role of neurotrophic and hormonal factors, adhesion molecules and intercellular signaling agents in luteinizing hormone-releasing hormone (LHRH) neuron-astroglial interactions. Trends in Biosci. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Motta Marcella, P.O.
  2. Limonta Patrizia, R.U.
  3. Negri-Cesi Paola, R.U.
  4. Poletti Angelo, R.U.
  5. Magni Paolo, R.U.
  6. Montagnani Marelli Marina, D. D.R.
  7. Brevini Tiziana , T.L.
  8. Dondi Donatella, T.L.

AFFILIATION:

Istituto di Endocrinologia

Facoltā di Farmacia

Universitā degli Studi di Milano

ADDRESS: Via Balzaretti, 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-29406576

FAX: 02-29404927

E-MAIL: motta@isfunix.farma.unimi.it

PUBLICATIONS:

  1. LIMONTA P., DONDI D., MORETTI R.M., MAGGI R., MOTTA M. Antiproliferative effects of luteinizing hormone-releasing hormone agonists on the human prostatic cancer cell line LNCaP. J. Clin. Endocrinol. Met. 75: 207-212, 1992.
  2. LIMONTA P., DONDI D., MORETTI R.M., FERMO D., GARATTINI E., MOTTA M. Expression of luteinizing hormone-releasing hormone mRNA in the human prostatic cancer cell line LNCaP. J. Clin. Endocr. Met. 76: 797-800, 1993.
  3. BREVINI T.A.L., BIANCHI R., MOTTA M. Direct inhibitory effect of somatostatin on the growth of the human prostatic cancer cell line LNPOSTAL CODE: possible mechanisms of action. J. Clin. Endocrinol. Met. 77: 626-631, 1993.
  4. LIMONTA P., MORETTI R.M., DONDI D., MONTAGNANI MARELLI M., MOTTA M. Androgen-dependent prostatic tumors: biosynthesis and possible actions of LHRH. J. Steroid Biochem. Mol. Biol. 49: 347-350,1994.
  5. DONDI D., LIMONTA P., MORETTI R.M., MONTAGNANI MARELLI M., GARATTINI E., MOTTA M. Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54: 4091- 4095, 1994.
  6. LIMONTA P., MORETTI R.M., DONDI D., MONTAGNANI MARELLI M., MOTTA M. The EGF/TGFa system as an autocrine growth stimulatory loop in LNCaP cells. Endocr. Rel. Cancer 1: 5-13,1994.
  7. NEGRI-CESI P., MOTTA M. Androgen metabolism in the human prostatic cancer cell line LNCaP. J. Steroid Biochem. Mol. Biol. 51: 89-96, 1994.
  8. MELCANGI R.C., GALBIATI R., MESSI E., PIVA F., MARTINI L., MOTTA M. Type 1 astrocytes influence luteinizing hormone-releasing hormone release from the hypothalamic cell line GT-1: is transforming growth factor-b the principle involved? Endocrinology 136: 679-686,1995.
  9. LIMONTA P., DONDI D., MONTAGNANI MARELLI M., MORETTI M.R., NEGRI-CESI P., MOTTA M. Growth of the androgen - dependent tumor of the prostate: role of androgens and of locally expressed growth modulatory factors. J. Steroid Biochem. Molec. Biol. 53: 401-405,1995.
  10. POLETTI A., CELOTTI F., MOTTA M., MARTINI L. Characterization of rat 5a-reductases type 1 and type 2 expressed in Saccharomyces cerevisiae. Biochem. J. 314: 1047-1052, 1996.

RESEARCH GROUP MEMBERS :

  1. Muccioli Giampiero, P.A.
  2. Ghigo Mariacristina, B.PDR.
  3. Scordamaglia Antonella, B.
  4. Ghč Corrado, T.L.

AFFILIATION :

Sezione di Farmacologia, Dipartimento di Anatomia, Farmacologia e Medicina Legale,

Facoltā di Medicina e Chirurgia

Universitā di Torino

ADDRESS: Via P. Giuria 13

CITY: Torino

POSTAL CODE: 10125

TELEPHONE: 011-670-7789-7715

FAX: 011-658606

E-MAIL: muccioli@medfarm.unito.it

PUBLICATIONS :

  1. CAPPELLO B., GRECO G., NOVELLINO E., PERISSUTTI E., SANTAGADA V., SILIPO C., VITTORIA A., DI CARLO R., MELI R., AND MUCCIOLI G. Synthesis and muscarinic receptor binding profiles of antagonist benzotriazole derivatives. Farmaco. 48: 907-918, 1993.
  2. GUARDABASSI A., MUCCIOLI G., ANDREOLETTI G.E., PATTONO P., AND USAI P. Prolactin and interrenal hormone balance in adult specimens of Xenopus Laevis exposed to hyperhosmotic stress for up to one week. J. Exp. Zool. 265: 515-521, 1993.
  3. DI CARLO R., FAGGIUOLO R., MUCCIOLI G., DI CARLO F., COSTANTINI M., AND DOGLIOTTI L. Prognostic significance of prolactin receptor on overall survival of patients with early breast cancer: a long-term retrospective analysis. The Breast. 3:144-150, 1994.
  4. MUCCIOLI G., AND DI CARLO R. Modulation of prolactin receptors in the rat hypothalamus in response to changes in serum concentration of endogenous prolactin or to ovine prolactin administration. Brain Res. 663: 244-250, 1994.
  5. CICCARELLI E., FACCANI G., LONGO A., DALLE ORE G., PAPOTTI M., GROTTOLI S., RAZZORE P., GHE' C., AND MUCCIOLI G. Prolactin receptors in human pituitary adenomas. Clin. Endocrinol. 42: 487-491, 1995.
  6. MUCCIOLI G., MATTACE RASO G., GHE' C., AND DI CARLO R. Age-dependent changes of muscarinic receptor subtypes and membrane microviscosity in the rat brain: effect of L-alpha-glycerylphosphorylcholine. Progr. Neuro-Psychopharmacol Biol. Psychiat. 20: 323-339, 1996.
  7. GHIGO E., ARVAT E., MUCCIOLI G., AND CAMANNI F. Growth hormone (GH)-releasing peptides. Eur. J. Endocrinol. In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Müller Eugenio E., P.O.
  2. Locatelli Vittorio, P.A.
  3. De Gennaro Colonna Vito, R.U.
  4. Cella Silvano G., T.L.
  5. Torsello Antonio, T.L.
  6. Grilli Roberta, D.DR.
  7. Guidi Margherita, D.DR.
  8. Luoni Marina, B.
  9. Rigamonti Antonello, B.

AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Facoltā di Medicina e Chirurgia

Universitā di Milano

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-70146-212, 214, 215, 208,

209, 210, 217, 237

FAX: 02-70106838

E-MAIL: muller@imiucca.csi.unimi.it

PUBLICATIONS:

  1. LOCATELLI, V., GRILLI, R., TORSELLO, A., CELLA, S.G., WEHRENBERG, W.B., AND MÜLLER, E.E. Growth hormone releasing hexapeptides is a potent stimulator of growth hormone gene expression and release in the growth hormone-releasing hormone-deprived infant rat. Pediat. Res. 36: 169-174, 1994.
  2. CELLA, S.G., LOCATELLI, V., BROCCIA, M.L., MENEGOLA, E., GIAVINI, E., DE GENNARO COLONNA, V., TORSELLO, A., WEHRENBERG, W.B., AND MÜLLER, E.E. Long-term changes of somatotrophic function induced by deprivation of growth hormone-releasing hormone during the fetal life of the rat. J. Endocrinol. 140: 111-117, 1994.
  3. CELLA, S.G., DE GENNARO COLONNA, V., LOCATELLI, V., BESTETTI, G., ROSSI, G.L., TORSELLO, A., WEHRENBERG, W.B., AND MÜLLER, E.E. Somatotropic dysfunction in growth hormone-releasing hormone-deprived neonatal rats: effect of growth hormone replacement therapy. Pediat. Res. 36: 315-322, 1994.
  4. DEGHENGHI, R., CANANZI, M., TORSELLO, A., BATTISTI, C., MÜLLER, E.E., AND LOCATELLI, V. GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats. Life Sci. 54: 1321-1328, 1994.
  5. CONLEY, L.K., TEIK, J.A., DEGHENGHI, R., IMBIMBO, B.P., GIUSTINA, A., LOCATELLI, V., AND WEHRENBERG, W.B. Mechanism of action of Hexarelin and GHRP-6: analysisof the involvement of GHRH and somatostatin in the rat. Neuroendocrinology 6: 44-50, 1995.
  6. BOUJON, C.E., BESTETTI, G.E., ABRAMO, F., LOCATELLI, V., AND ROSSI, G.L. The reduction of circulating growth hormone and prolactin in streptozocin-induced diabetic male rats is possibly caused by hypothalamic rather than pituitary changes. J. Endocrinol. 145: 19-26, 1995.
  7. MÜLLER, E.E., ROLLA, M., GHIGO, E., BELLITI, D., ARVAT, E., ANDREONI, A., TORSELLO, A., LOCATELLI, V., AND CAMANNI, F. Involvement of brain catecholamines and acetylcholine in growth hormone hypersecretory states. Pathophysiological, diagnostic and therapeutic implications. Drugs 50: 805-837, 1995.
  8. CELLA, S.G., LUCERI, M., CATTANEO, L., TORSELLO, A., AND MÜLLER, E.E. Somatostatin withdrawal as generator of pulsatile GH release in the dog: a possible tool to evaluate the endogenous GHRH tone? Neuroendocrinology 63: 481-488, 1996.
  9. VRONTAKIS, M., TORSELLO, A., LEITE, V., VUILLE, J.C., AND ZHANG, H. Regulation of galanin by dexamethasone in the rat anterior pituitary and the uterus. Neuroendocrinology 64: 20-24, 1996.
  10. HORIKAWA, R., HELLMANN, P., CELLA, S.G., TORSELLO, A., DAY, R.N., MÜLLER, E.E., AND THORNER, M.O. Growth hormone-releasing factor (GRF) regulates expression of its own receptor. Endocrinology 137: 2642-2645, 1996.

RESEARCH GROUP MEMBERS :

  1. Pecile Antonio, P.O.
  2. Guidobono-Cavalchini Francesca, P.A.
  3. Netti Carmela, P.A.
  4. Pagani Francesca, T.L.
  5. Sibilia Valeria, T.L.
  6. Ticozzi Chiara, B.

AFFILIATION:

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Facoltā di Medicina e Chirurgia

Universitā degli Studi di Milano

ADDRESS: Via Vanvitelli, 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-70146-243, 247, 277, 246, 245

FAX: 02-70146-369

E-MAIL: pecile@imiucca.csi.unimi.it

PUBLICATIONS:

  1. SIBILIA, V., GUIDOBONO, F., PECILE, A., PAGANI, F., VILLA, I., AND NETTI, C. Involvement of the catecholaminergic system in the inhibitory effect of brain histamine on growth hormone secretion. Agents Actions. 38: 272-274, 1993.
  2. MICHALSKY, M., NORRIS-SUAREZ, K., BETTICA, P., PECILE, A., AND MORO, L. Rat cortical and trabecular bone collagen glycosylation are differently influenced by ovariectomy. Biochem. Biophys. Res. Comm. 192: 1281-1288, 1993.
  3. NETTI, C., SIBILIA, V., GUIDOBONO, F., AND PECILE, A. Influence of brain histamine on growth hormone secretion induced by 2-receptor activation. Neuroendocrinology. 57: 1066-1070, 1993.
  4. NETTI, C., SIBILIA, V., GUIDOBONO, F., VILLANI, P., PECILE, A., AND BRAGA, P.C. Evidence for an ihnibitory role of central histamine on carrageenin-induced hyperalgesia. Neuropharmacology. 33: 205-210, 1994.
  5. GUIDOBONO, F., COLUZZI, M., PAGANI, F., PECILE, A., AND NETTI, C. Amylin given by central and peripheral routes inhibits acid gastric secretion. Peptides. 15: 699-702, 1994.
  6. VILLA, I., COLANGELO, A.M., VESCOVI, A.L., GRITTI, A., SCHINELLI, S., PAGANI, F., AND GUIDOBONO, F. Differential effects of CGRP on adenylyl-cyclase in adult and embryonic rat brain. Neuroreport. 5: 2489-2492, 1994.
  7. NETTI, C., SIBILIA, V., PAGANI, F., LATTUADA, N., COLUZZI, M., PECILE, A., AND GUIDOBONO, F. Inhibitory effect of amylin on growth hormone responsiveness to growth hormone-releasing hormone in the rat. Neuroendocrinology. 62: 313-318, 1995.
  8. REINA, G., RUBINACCI, A., MORO, L., MORO, G.L., AND PECILE, A. Time relationship between bone growth and the increment of bone mineral content in growing rats. Minerva Endocrinol. 20: 211-216, 1995.
  9. BRAGA, P.C., SOLDAVINI, E., PECILE, A., SIBILIA, V., AND NETTI, C. Involvement of H1 receptors in the central antinociceptive effect of histamine: pharmacological dissection by electrophysiological analysis. Experientia. 52: 60-65, 1996.
  10. PECILE, A., NETTI, C., SIBILIA, V., VILLA, I., TENNI, R., COLUZZI, M., MORO G.L., AND RUBINACCI A. Comparison between urinary pyridinium cross-links and hydroxylysine glycosides in monitoring the effects of ovariectomy and 17-estradiol replacement in aged rats. J. Endocrinol. 150: 383-390, 1996.

RESEARCH GROUP MEMBERS:

  1. Piva Flavio, P.A.
  2. Maggi Roberto, R.U.
  3. Melcangi Roberto, R.U.
  4. Pimpinelli Federica, D.DR.
  5. Magnaghi Valerio, D.DR.
  6. Cavarretta Ilaria, B.

AFFILIATION :

Istituto di Endocrinologia

Facoltā di Farmacia

Universitā degli Studi di Milano

ADDRESS: Via Balzaretti, 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02/29406576

FAX: 02/29404927

E-MAIL: endo@isfunix.farma.unimi.it

PUBLICATIONS :

  1. PIVA F., CELOTTI F., DONDI D., LIMONTA P., MAGGI R., MESSI E., NEGRI-CESI P., ZANISI M., MOTTA M., MARTINI L. Ageing of the neuroendocrine system in the brain of male rats: receptor mechanisms and steroid metabolism. J. Reprod. Fert. Suppl. 46: 47-59, 1993
  2. MAGGI R., DONDI D., ROVATI G.E., MARTINI L., PIVA F., LIMONTA P. Binding characteristics of hypothalamic mu opioid receptors throughout the estrous cycle in the rat. Neuroendocrinology 58: 366-372, 1993
  3. PIVA F., LIMONTA P., MAGGI R., DONDI D., MESSI E., ZANISI M., MARTINI L. Effect of aging on opioid and LHRH receptors in the brain, pituitary, and testis of the male rat. Neurobiol. Aging 15: 553-557,1994
  4. MAGGI R., MARTINI L., PIVA F. Effect of ovariectomy on the binding characteristics of hypotalamic mu opioid receptors in the rat. Endocr. Regul. 28: 171-178, 1994
  5. MAGGI R., PIMPINELLI F., MARTINI L. , PIVA F. Characterization of funtional opioid delta receptors in a luteinizing hormone-releasing hormone producing neuronal cell line. Endocrinology 136: 289-295, 1995
  6. MELCANGI R.C., GALBIATI R., MESSI E., PIVA F., MARTINI L., MOTTA M. Type 1 astocytes influence luteinizing hormone-releasing hormone release from the hypothalamic cell line GT-1: is trasforming growth factor-beta the principle involved? Endocrinology 136 : 679-686, 1995.
  7. PIVA F., LIMONTA P., DONDI D., PIMPINELLI F., MARTINI L., MAGGI R. Effects of steroids on the brain opiod system. J. Steroid Biochem. Molec. Biol. 53: 343-348,1995
  8. MAGGI R.,PIMPINELLI F.,MARTINI L., PIVA F.Inhibition of luteinizing hormone-releasing hormone secretion by d-opioid agonists in GT1-neuronal cells. Endocrinology 136:5177-5181,1995
  9. MELCANGI R.C., FROELICHSTHAL P., MARTINI L., VESCOVI A.L. Steroid metabolizing enzymes in pluripotential progenitor central nervous system cells: effect of differentiation and maturation. Neuroscience 72: 467-475, 1996
  10. MAGGI R., PIMPINELLI F.,CASULARI L.A., PIVA F. , MARTINI L. Antiprogestins inhibit the binding of opioids to m-opioid receptors in nervous membrane preparations. Eur. J. Pharmacol. 301: 169-177,1996

RESEARCH GROUP MEMBERS:

  1. Rosa Patrizia, C.L.
  2. Corradi Nicoletta, B.
  3. Bassetti Monique, T.

AFFILIATION:

Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare

Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica

Universitā di Milano

ADDRESS: Via Vanvitelli 32

CITY: Milano

POSTAL CODE: 20129

TELEPHONE: 02-70146-254, 262, 266, 256

FAX: 02-7490574

E-MAIL: RosaP@farma2.csfic.mi.cnr.it

PUBLICATIONS:

  1. ROSA P. AND GERDES H.H. The granin protein family: markers for neuroendocrine cells and tools for the diagnosis of neuroendocrine tumors. J. Endocrinol. Invest. 17: 207-225, 1994
  2. SHER E., ROSA P., BASSETTI M., ZANINI A. Immunolocalization of secreogranin II and insulin in a nerve growth factor-differentiaties insulinoma cell line. Eur. J. Cell Biol. 67: 15-22, 1995
  3. BASSETTI M., LODI PASINI D. AND ROSA P. Degradation of gonadotropin ß-subunits retained in the endoplasmic reticulum of the gonadotropes of castrated rats. Endocrinology 136: 1168-1176, 1995
  4. CORRADI N., BORGONOVO B., CLEMENTI E., BASSETTI M., RACCHETTI G., CONSALEZ G.G., HUTTNER W.B., MELDOLESI J. AND ROSA P. Overall lack of regulated section in a PC12 variant cell clone. J. Biol. Chem. 271: 27116-27124, 1996
  5. PASSAFARO M., ROSA P., SALA C., CLEMENTI E. AND SHER E. N-type Ca2+ channels are present in secretory granules and are transiently translocated to the plasma membrane during regulated exocytosis. J. Biol. Chem., In press, 1996.

RESEARCH GROUP MEMBERS:

  1. Scaccianoce Sergio, R.U.
  2. Angelucci Luciano, P.O.
  3. Affricano Daniela, B.
  4. Lombardo Katia, B.
  5. Antonelli Maria Antonietta, B.

AFFILIATION:

Istituto di Farmacologia Medica

Facoltā di Medicina e Chirurgia

Universitā "La Sapienza"

ADDRESS: Piazzale Aldo Moro, 5

CITY: Roma

POSTAL CODE: 00185

TELEPHONE: 06-4992-2511, 665

FAX: 06-4940588

E-MAIL: scaccianoce@uniroma1.it

PUBLICATIONS:

  1. CATALANI A., MARINELLI M., SCACCIANOCE S. AND ANGELUCCI L. Long term behavioural and andocrine effects of maternal hypercorticosteronemia during lactation. Behav. Pharmacol. 4: 457-458, 1993.
  2. CATALANI A., MARINELLI M., SCACCIANOCE S., NICOLAI R., MUSCOLO L.A.A., PORCU A., KORāNYI L., PIAZZA P.V. AND ANGELUCCI L. Progeny of mothers drinking corticosterone during lactation has lower stress-induced corticosterone secretion and better cognitive performance. Brain Res. 624: 209-215, 1993.
  3. SCACCIANOCE S., CIGLIANA G., NICOLAI R., MUSCOLO L.A.A., PORCU A., NAVARRA D., PEREZ-POLO J.R. AND ANGELUCCI L. Hypothalamic involvement in the activation of the pituitary-adrenocortical axis by nerve growth factor. Neuroendocrinology 58: 202-209, 1993.
  4. SCACCIANOCE S. Regolazione della risposta di stress nell' invecchiamento. Gior. Geront. 42 :667-671, 1994.
  5. MARDENTE S., SCACCIANOCE S., MISASI R., CATALANI A., LENTI L., MARINELLI M., ANGELUCCI L. AND PONTIERI G.M. Phenotypic modifications in mouse thymocytes during tumor growth: role of corticosterone. Medecine Biologie Environnement 22: 485-497, 1994.
  6. SCACCIANOCE S., NICOLAI R., CIGLIANA G. AND ANGELUCCI L. Reduced glucocorticoid response to corticotropin secretagogues in the aged Sprague-Dawley rat. Neuroendocrinology 62: 32-38, 1995.
  7. BRUNO G., SCACCIANOCE S., BONAMINI M., PATACCHIOLI F.R., CESARINO F., GRASSINI P., SORRENTINO E., ANGELUCCI L, AND LENZI G.L. Acetyl-l-carnitine in Alzheimer's disease: a short-term study on CSF neurotransmitter and neuropeptides. Alzheimer's disease and associated disorders 9: 128-131, 1995.
  8. CALOGERO, S. SCACCIANOCE, N. BURRELLO, R. NICOLAI, L.A.A. MUSCOLO, M. A. KLING, L. ANGELUCCI AND R. D'AGATA. The kappa-opioid agonist MR-2034 stimulates the rat hypothalamic-pituitary-adrenal axis: studies in vivo and in vitro. J. Neuroendocrinol. 8: 579-585, 1996.

RESEARCH GROUP MEMBERS:

  1. Vacca Michele, P.O.
  2. Brunetti Luigi, R.U.
  3. Cannizzaro Carla, R.U.
  4. Amitrano Maria, T.L.
  5. Del Cecato Paolo, T.

AFFILIATION:

Cattedra di Farmacologia e Farmacognosia

Istituto di Scienza del Farmaco

Facoltā di Farmacia

Universitā G. D'Annunzio

ADDRESS: via dei Vestini

CITY: Chieti

POSTAL CODE: 66013

TELEPHONE: 0871-355384, -89, -90

FAX: 0871-355391

PUBLICATIONS:

  1. BRUNETTI, L., PREZIOSI, P., RAGAZZONI, E., AND VACCA, M. Involvement of nitric oxide in basal and interleukin-1ß-induced CRH and ACTH release in vitro. Life Sci. 53: PL219-222, 1993.
  2. CANNIZZARO, G., FLUGY, A., CANNIZZARO, C., GAGLIANO, M., AND SABATINO, M. Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol. Eur. Neuropsychopharmacol. 3: 477-484, 1993.
  3. BRUNETTI, L., PREZIOSI, P., RAGAZZONI, E., AND VACCA, M. Effects of lipopolysaccharide on hypothalamic-pituitary-adrenal axis in vitro. Life Sci. 54: PL165-171, 1994.
  4. SABATINO, M., CANNIZZARO, C., FLUGY, A., GAGLIANO, G., AND CANNIZZARO, G. NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms. Eur. Neuropsychopharmacol. 4: 103-109, 1994
  5. BRUNETTI, L., PREZIOSI, P., RAGAZZONI, E., AND VACCA M. Effects of vindesine on hypothalamic-pituitary-adrenal axis. Toxicol. Lett. 75: 69-73, 1995.
  6. BRUNETTI, L., RAGAZZONI, E., PREZIOSI, P., AND VACCA M. A possible role for nitric oxide but not for prostaglandin E2 in basal and interleukin-1-ß-induced PRL release in vitro. Life Sci. 56: PL277- 283, 1995.
  7. CANNIZZARO, C., CANNIZZARO, E., GAGLIANO, M., MINEO, A., SABATINO, M., AND CANNIZZARO, G. Effects of desipramine and alprazolam in forced swimming behaviour of adult rats exposed to prenatal diazepam. Eur. J. Pharmacol.. 273: 239-245, 1995
  8. BRUNETTI, L., VOLPE, A.R., RAGAZZONI, E., PREZIOSI, P., AND VACCA M. Interleukin-1ß specifically stimulates nitric oxide production in the hypothalamus. Life Sci. 58: PL373-377, 1996.

 

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