SIF - Società Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

PHARMACOLOGY OF THE
RESPIRATORY SYSTEM

 

RESEARCH GROUP MEMBERS:

  1. Folco Giancarlo, P.O.
  2. Sala Angelo, R.U.
  3. Rossoni Giuseppe, T.L.
  4. Bolla Manlio, D.Dr.
  5. Armetti Laura, D.Dr.
  6. Buccellati Carola, B.
  7. Hernandez Alicia, B.
  8. Bonazzi Albino, B.
  9. Zarini Simona, B.

AFFILIATION:

Istituto di Scienze Farmacologiche

Centro di Studio e Ricerca di Farmacologia Cardiopolmonare Sperimentale

Facoltà di Farmacia

Università di Milano

ADDRESS: Via Balzaretti 9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-20488312

FAX: 02-29404961

E-MAIL: folco@isfunix.farma.unimi.it

PUBLICATIONS:

  1. SALA A., ROSSONI G., BUCCELLATI C., BERTI F., FOLCO G.C., MACLOUF J. Formation of sulphidopeptide-leukotrienes by cell cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. Brit. J. Pharmacol. 110: 1206-1212, 1993.
  2. LETARI O., MIOZZO A., FOLCO G.C., BELLONI P.A., SALA A., ROVATI G.E., NICOSIA S. Effects of Loratadine on cytosolic calcium levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity. Eur. J. Pharmacol. 266: 219-227, 1994.
  3. WHEELAN P., SALA A., FOLCO G.C., NICOSIA S., FALCK J.R., BHATT R.K., MURPHY R.C. Stereochemical analysis of the 3-hydroxy-leukotriene B4 metabolite from ethanol treated rat hepatocytes and biological activity of 3(S)-hydroxy- and 3(R)-hydroxy-leukotriene B4. J. Pharmacol. Exp. Ther. 271: 1514-1519, 1994.
  4. VIGANO' T., HERNANDEZ A., CORSINI A., GRANATA A., BELLONI P., FUMAGALLI R., PAOLETTI R., FOLCO G.C. Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation. Eur. J. Pharmacol.-Mol. Pharmacol. Section 291: 201-203, 1995.
  5. FERIOLI R., FOLCO G.C., FERRETTI C., GASCO A.M., MEDANA C., FRUTTERO R., CIVELLI M., GASCO A. A new class of furoxan derivatives as NO donors: mechanism of action and biological activity. Brit. J. Pharmacol. 114:816-820, 1995.
  6. ROSSONI G., SALA A., BERTI F., TESTA T., BUCCELLATI C., MOLTA C., MÜLLER-PEDDINGHAUS R., MACLOUF J., FOLCO G.C. Myocardial protection by the leukotriene synthesis inhibitor BAY X1005: importance of transcellular biosynthesis of cysteinyl-leukotrienes. J. Pharmacol. Exp. Ther. 276: 335-341, 1996.
  7. SESTINI P., ARMETTI L., GAMBARO G., PIERONI M.G., REFINI R.M., SALA A., VAGHI A., FOLCO G.C., BIANCO S., ROBUSCHI M. Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma. Amer. J. Respir. Crit. Care Med. 153:572-575, 1996.
  8. SALA A., ALIEV G.M., ROSSONI G., BERTI F., BUCCELLATI C., BURNSTOCK G., FOLCO G.C., MACLOUF J. Morphological and functional changes of coronary vasculature caused by transcellular biosynthesis of sulfidopeptide leukotrienes in isolated heart of rabbit. Blood 87 : 1824-1832, 1996.
  9. ROSSONI G., SALA A., BUCCELLATI C., MACLOUF J., FOLCO G.C., BERTI F. Vasoconstriction to polymorphonuclear leukocytes in the isolated, perfused rabbit heart: inhibition by prostacyclin mimetics. J. Cardiovasc. Pharmacol. 27: 680-685, 1996.
  10. SALA A., BOLLA M., ZARINI S., MULLER-PEDDINGHAUS R., FOLCO G.C. Release of Leukotriene A4 versus Leukotriene B4 from human polymorphonuclear leukocytes. J. Biol. Chem. 271 : 17944-17948, 1996.

RESEARCH GROUP MEMBERS:

  1. Lampa Enrico, P.O.
  2. Vacca Ciro, P.A.
  3. Matera Maria Gabriella, T.L.
  4. Cazzola Mario, professore a contratto
  5. Marabese Ida, D.DR.
  6. D'Agostino Bruno, B.
  7. Mangrella Mario, B.

AFFILIATION:

Istituto di Farmacologia e Tossicologia

Facoltà di Medicina e Chirurgia

Seconda Università degli Studi di Napoli

ADDRESS: Via Costantinopoli, 16

CITY: Napoli

POSTAL CODE: 80138

TELEPHONE: 081-566-5878, 5877, 459802

FAX: 081-566-5877, 5878

PUBLICATIONS:

  1. CAZZOLA M., MATERA M.G., LICCARDI G., SACERDOTI G., D'AMATO G., ROSSI F.: Effect of telenzepine, an M1-selective muscarinic receptor antagonist, in patients with nocturnal asthma. Pulm. Pharmacol. 7: 91-97, 1994.
  2. MATERA M.G., D'AGOSTINO B., COSTANTINO M., MANGRELLA M., CALDERARO V., ROSSI F.: K+ channels and guinea pig trachea: a possible functional modulation by GABAB receptors. Pulm. Pharmacol. 7: 259-263, 1994.
  3. MAROTTA T., FERRARA L.A., DI MARINO L., MANCINO M., ANNUZZI G., RUSSO O., D'ORTA G., LUCARELLI C., ROSSI F.: Factors affecting lipoprotein lipase in hypertensive patients. Metabolism 44: 712-718, 1995.
  4. MATERA M.G., DE SANTIS D., D'AGOSTINO B., PALLOTTA M., VACCA C., CAZZOLA M., ROSSI F.:Role of 5-hydroxytryptamine in mediating adenosine-induced airway contraction. Immunopharmacology 29: 73-78, 1995.
  5. MATERA M.G., CAZZOLA M., VINCIGUERRA A., DI PERNA F., CALDERARO F., CAPUTI M., ROSSI F.: A comparison of the bronchodilating effects of salmeterol, salbutamol and ipratropium bromide in patients with chronic obstructive pulmonary disease. Pulm. Pharmacol. 8: 267-271, 1995.
  6. CAZZOLA M., MATERA M.G., D'AMATO G., ROSSI F.: Effects of serotonin on airways: recent developments. Allergy 50: 1-10, 1995.
  7. CAZZOLA M., MATERA M.G., SANTANGELO G., VINCIGUERRA A., ROSSI F., D'AMATO G.: Salmeterol and formeterol in partially reversible severe chronic obstructive pulmunary disease: a dose-response study. Respir. Med. 89: 357-362, 1995.
  8. D'AGOSTINO B., MATERA M.G., CAZZOLA M., MANGRELLA M., ROSSI F.: Effects of in vitro 5-HT1 receptor activation in guinea pig trachea. Life Sci. 7: 153-160, 1996.
  9. EL-HASHIM A., D'AGOSTINO B., MATERA M.G., PAGE C.: Characterization of adenosine receptors involved in adenosine-induced bronchoconstriction in allergic rabbits. Brit. J. Pharmacol. 119: 1262-1268, 1996.
  10. MATERA M.G., CAPUTI M., CAZZOLA M.: A combination with clinical recommended dosages of salmeterol and ipratropium is not more effective than salmeterol alone in patients with chronic obstructive pulmunary disease. Respir. Med. 90: 497-99, 1996.

RESEARCH GROUP MEMBERS:

  1. Nicosia Simonetta, P.O.
  2. Rovati Gian Enrico, R.U
  3. Capra Valèrie, D.DR.
  4. Accomazzo Maria Rosa, T.L.
  5. Ciceri Paola, B.

AFFILIATION:

Istituto di Scienze Farmacologiche

Facoltà di Farmacia

Università di Milano

ADDRESS: Via Balzaretti,9

CITY: Milano

POSTAL CODE: 20133

TELEPHONE: 02-20488312

FAX: 02-20488385

E-MAIL: nicosia@isfunix.farma.unimi.it

PUBLICATIONS:

  1. OLIVA D, ACCOMAZZO MR, GIOVANAZZI S, NICOSIA S. Correlation between LTD4-induced contraction and cytosolic calcium elevation: a quantitative and simultaneous evaluation in smooth muscle. J. Pharmacol. Exp. Ther. 268: 159-166, 1994.
  2. LETARI O, MIOZZO A, FOLCO GC, BELLONI PA, SALA A, ROVATI GE, NICOSIA S. Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity. Eur. J. Pharmacol.-Mol. Pharmacol. Section 266: 219-227, 1994.
  3. ROVATI GE, NICOSIA S. Lower efficacy: interaction with an inhibitoty receptor or partial agonism? Trends Pharmacol. Sci. 15: 140-144, 1994.
  4. WHEELAN P, SALA A, FOLCO GC, NICOSIA S, FALCK JR, BHATT RK, MURPHY RC. Stereochemical analysis of the 3-hydroxy-leukotriene B4 metabolite from ethanol treated rat hepatocytes and biological activity of 3(S)-hydroxy- and 3(R)-hydroxy-leukotriene B4. J. Pharmacol. Exp. Ther. 271: 1514-1519, 1994;.
  5. RIGHI M, LETARI O, SACERDOTE P, MARANGONI F, MIOZZO A, NICOSIA S. Myc-immortalized microglial cells express a functional PAF receptor. J. Neurochem. 64: 121-129, 1995.
  6. ROVATI GE, SHRAGER R, NICOSIA S, MUNSON PJ. KINFIT II: a nonlinear least-squares program for analysis of kinetic binding data. Mol. Pharmacol. 50: 86-95, 1996.
  7. CORSINI A, BONFATTI M, QUARATO P, ACCOMAZZO MR, RAITERI M, SARTANI A, TESTA R, NICOSIA S, PAOLETTI R, FUMAGALLI R. Effect of the new calcium antagonist lercanidipine and its enantiomers on the migration and proliferation of arterial myocytes. J. Cardiovasc. Pharmacol. In press, 1996.
  8. LEONARDI A, POGGESI E, TADDEI C, GUARNERI L, ANGELICO P, ACCOMAZZO MR, NICOSIA S, TESTA R. In vitro calcium-antagonist activity of lercanidipine and its enantiomers. J. Cardiovasc. Pharmacol. In press, 1996.

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