SIF - Societą Italiana di Farmacologia                                               "SIF - La Ricerca Farmacologica in Italia"

GASTROINTESTINAL PHARMACOLOGY

  

RESEARCH GROUP MEMBERS:

  1. Bertaccini Giulio, P.O.
  2. Coruzzi Gabriella, P.A.
  3. Scarpignato Carmelo, P.A.
  4. Poli Enzo, P.A.
  5. Morini Giuseppina, R.U.
  6. Adami Maristella, R.U.
  7. Pozzoli Cristina, R.U.
  8. Gambarelli Enrica, D.DR.
  9. Coppelli Gabriella, B.

AFFILIATION:

Istituto di Farmacologia

Facoltą di Medicina e Chirurgia

Universitą degli Studi di Parma

ADDRESS: Via Gramsci, 14, Ospedale Maggiore

CITY: Parma

POSTAL CODE: 43100

TELEPHONE: 0521-290-383, 384, 381

FAX: 0521-294-089

PUBLICATIONS:

  1. CORUZZI G., TIMMERMAN H., ADAMI M. AND BERTACCINI G. The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion. Naunyn-Schmied. Arch. Pharmacol. 348: 77-81,1993.
  2. POLI E., POZZOLI C., CORUZZI G. AND BERTACCINI G. Histamine H3-receptor-induced inhibition of duodenal cholinergic transmission is independent of intracellular cyclic AMP and GMP. General Pharmacol. 24: 1273-1278, 1993.
  3. SOLDANI G., MENGOZZI G., INTORRE L., DE GIORGI G., CORUZZI G. AND BERTACCINI G. Histamine H3 receptor-mediated inhibition of gastric acid secretion in conscious dogs. Naunyn-Schmied. Arch. Pharmacol. 347: 61-65, 1993.
  4. POLI E., TODOROV S., POZZOLI C. AND BERTACCINI G. Presynaptic histamine H2 receptors modulate the sympathetic nerve transmission in the isolated rat vas deferens; no role for H3-receptors. Agents Actions. 42: 95-100, 1994.
  5. POLI E., POZZOLI C., CORUZZI G. AND BERTACCINI G. Signal transducing mechanisms coupled to histamine H3 receptors and alpha-2 adrenoceptors in the guinea pig duodenum: possible involvement of N-type Ca++ channels. J. Pharmacol. Exp. Ther.. 270: 788-794, 1994.
  6. CORUZZI G., GAMBARELLI E., BERTACCINI G. AND TIMMERMAN H. Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat. Naunyn-Schmied. Arch. Pharmacol. 351: 569-575, 1995.
  7. MORINI G., GRANDI D. AND BERTACCINI G. (R)-alpha-methylhistamine inhibits ethanol-induced gastric lesions in the rat: involvement of histamine H3 receptors?. Digestion 56: 145-152, 1995.
  8. BERTACCINI G. AND CORUZZI G. An update on histamine H3 receptors and gastrointestinal functions. Digestive Diseases and Sciences 40: 2052-2063, 1995.
  9. MORINI G., GRANDI D., ARCARI M.L. AND BERTACCINI G. Indomethacin-induced morpholigical changes in the rat gastric mucosa, with or without prior treatment with two proton pump inhibitors. Alimen. Pharmacol. Therap. 9: 615-623, 1995.
  10. CORUZZI G., ADAMI M., POZZOLI C., GIORGI F. AND BERTACCINI G. Cardiac and gastric effects of histamine H2 receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinity. Brit. J. Pharmacol.. 118: 1813-1821, 1996.

RESEARCH GROUP MEMBERS:

  1. Capasso Francesco, P.O.
  2. Mascolo Nicola, R.U.
  3. Di Carlo Giulia, B.PDR
  4. Izzo Angelo A., B.PDR
  5. Borrelli Francesca, B.

AFFILIATION:

Dipartimento di Farmacologia Sperimentale

Facoltą di Farmacia

Universitą di Napoli Federico II

ADDRESS: Via D. Montesano 49

CITY: Napoli

POSTAL CODE: 80131

TELEPHONE: 081-7486415-432-436-439

FAX: 081-7486403

PUBLICATIONS:

  1. MASCOLO N., IZZO A.A., BARBATO F., CAPASSO F. Inhibitors of nitric oxide synthase prevent castor-oil induced diarrhoea in rats. Brit. J. Pharmacol. 108 : 861-864, 1993.
  2. MASCOLO N., IZZO A.A., AUTORE G., BARBATO F., CAPASSO F. Nitric oxide and castor oil induced diarrhoea. J. Pharmacol. Exp. Ther. 268 : 291-295, 1994.
  3. IZZO A.A., GAGINELLA T.S., MASCOLO N., CAPASSO F. Nitric oxide is a mediator of the laxative action of magnesium sulphate. Brit. J. Pharmacol. 113 : 228-232, 1994.
  4. GAGINELLA T.S., MASCOLO N., IZZO A.A., AUTORE G., CAPASSO F. Nitric oxide is a mediator of bisacodyl and phenolphtalein laxative action: induction of nitric oxide synthase. J. Pharmacol. Exp. Ther. 270 : 1239-1245, 1994.
  5. MASCOLO N., GAGINELLA T.S., IZZO A.A., DI CARLO G., CAPASSO F. Nitric oxide involvement in sodium choleate -induced fluid secretion and diarrhoea in rats. Eur. J. Pharmacol. 264 : 21-26, 1994.
  6. CAPASSO F., MASCOLO N., IZZO A.A., GAGINELLA T.S. Dissociation of castor- oil-induced diarrhoea and intestinal mucosal injury in rat:effect of NG-nitro-L-arginine methyl ester Brit. J. Pharmacol. 113 :1127-1130, 1994
  7. IZZO A.A., GAGINELLA T.S., MASCOLO N., CAPASSO F. L-NAME modulates intestinal secretion and motility produced by carbachol. Eur. J. Pharmacol. 271 : 31-35,1994
  8. MASCOLO N., IZZO A.A., AUTORE G., MAIELLO F.M., DI CARLO G., CAPASSO F. Acetic acid-induced colitis in normal and EFAD rats. J. Pharmacol. Exp. Ther. 272 : 469-475,1995
  9. IZZO A.A., GAGINELLA T.S., MASCOLO N., BORRELLI F., CAPASSO F. NG-nitro-L-arginine methyl ester reduces senna-and cascara-induced diarrhoea and fluid secretion in the rat. Eur. J. Pharmacol. 301 : 137-142, 1996.
  10. MASCOLO N., IZZO A.A., GAGINELLA T.S., CAPASSO F. Relationship between platelet-activating factor and nitric oxide in castor oil-induced damage in the rat duodenum. Naunyn-Schied. Arch. Pharmacol. 353 : 680-684, 1996

RESEARCH GROUP MEMBERS:

  1. Carganico Germano, Dir. Ricerca & Sviluppo
  2. Maggi Carlo Alberto, Dir. Discovery
  3. Giachetti Antonio, Dir. Sviluppo
  4. Evangelista Stefano, Sviluppo Preclinico
  5. Subissi Alessandro, Progetti esterni
  6. Furio Martino, Pianificazione
  7. Criscuoli Marco, Resp. Dip. Farmacol. Firenze
  8. Giuliani Sandro, C. L.
  9. Renzetti Anna Rita, C. L.
  10. Santicioli Paolo, C. L.
  11. Catalioto Rose-Marie, R. I.
  12. Cucchi Paola, R. I.
  13. Lecci Alessandro, R. I.
  14. Lippi Annalisa, R. I.
  15. Meini Stefania, R. I.
  16. Patacchini Riccardo, R. I.
  17. Tramontana Manuela, R. I.
  18. Manzini Stefano, Resp. Dip. Farmacol. Pomezia
  19. Cirillo Rocco, C.L
  20. Iafrate Elisabetta, C.L.
  21. Palma Carla, C.L.
  22. Astolfi Mara, R.I.
  23. Bellarosa Daniela, R.I.
  24. Bigioni Mario, R.I.
  25. Ciucci Alessandra, R.I.
  26. Conte Bruno, RI.
  27. Cutrufo Corrado, R.I.
  28. Parlani Massimo, R.I.
  29. Sacco Giuseppe, R.I.
  30. Salvatore Carmela, R.I.
  31. Crea Attilio, Resp. Dip. Farmacocinetica & Metabolismo
  32. Urso Renato, Resp. Dip. Farmacocinetica
  33. Agostara Giuseppina, R. I.

AFFILIATION:

Menarini Ricerche S.p.A.

ADDRESS: Via Tito Speri 10, 00040 Pomezia (Roma)

Research and Development: Via Sette Santi 1, 50131 Firenze,

TEL: 055/56801

FAX: 055/5680510

Labs. Florence: Via Rismondo SNC, 50131 Firenze,

Mailing Address:Via sette Santi 3, 50131 Firenze

TEL: 055/56801 FAX: 055/5680419

Labs. Pomezia: Via Tito Speri 10, 00040 Pomezia (Roma),

TEL: 06/911841

FAX: 06/9100220

PUBLICATIONS:

  1. GIULIANI, S., LECCI, A., GIACHETTI, A., AND MAGGI, C.A. Tachykinins and reflexly evoked atropine-resistant motility in the guinea-pig colon in vivo. J. Pharmacol. Exp. Ther. 265: 1224-1231, 1993.
  2. MAGGI C.A., PATACCHINI R., MEINI S., QUARTARA L., SISTO A., POTIER E., GIULIANI S., AND GIACHETTI A. Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon. Brit. J. Pharmacol. 112:150-160, 1994.
  3. SANTICIOLI, P., AND MAGGI ,C.A. Inhibitory transmitter action of calcitonin gene-related peptide in guinea-pig ureter via activation of glibenclamide-sensitive K channels. Brit. J. Pharmacol. 113: 588-592, 1994.
  4. TRAMONTANA, M., RENZI, D., CALABRO', A., PANERAI, C., MILANI, S., SURRENTI, C., EVANGELISTA, S. Influence of capsaicin-sensitive afferent fibers on acetic acid-induced chronic gastric ulcers in rats. Sc. J. Gastroenterol. 29: 406-413, 1994.
  5. CIRILLO, R., RENZETTI, A.R., CUCCHI, P., GUELFI, M., SALIMBENI, A., CALIARI, S., CASTELLUCCI, A., EVANGELISTA, S., SUBISSI, A. AND GIACHETTI A. Pharmacology of LR-B/081, a new highly potent, selective and orally active nonpeptide angiotensin II AT1 receptor antagonist. Brit. J. Pharmacol. 114: 1117-1124, 1995.
  6. GOSO C., ASTOLFI M., PARLANI M. AND MANZINI S. [3 H] [bAla8] neurokin¦n A-(4-10): a novel, selective radioligand for the tachykinin NK2 receptor. Eur. J. Pharmacol. 294:239-245, 1995.
  7. PALMA, C., URBANI, F., AND MANZINI, S. Interleukin-6 production by U373 MG, a human astrocytoma cell line: different pathways involved in substance P and lipopolysaccharide activation. J. Neuroimmunol. 59: 155-163, 1995.
  8. CATALIOTO, R-M., RENZETTI, A.R., CRISCUOLI, M., MORBIDELLI, L., AND SUBISSI, A. Role of calcium in angiotensin II-induced prostaglandin release and DNA synthesis in rat vascular smooth muscle cells. J. Cardiovasc. Pharmacol. 27: 195-200, 1996.
  9. CIUCCI, A., MANZINI, S., LOMBARDI, P., AND ARCAMONE F. Backbone and benzoyl mustard carrying moiety modifies DNA interaction of distamycin analogues. Nucl. Acid Res. 24 : 311-315, 1996.
  10. CONTE, B., CUTRUFO, C., AND MANZIR¦I, S. Electrocorticographic desynchronization after application of visceral and somatic noxious stimuli in urethane anesthetized rats: effect of intratechal administration of tachykinin (NK1 or NK2) receptor antagonists. J. Pharmacol. Exp. Ther. 276: 212-218, 1996.

RESEARCH GROUP MEMBERS:

  1. Del Tacca Mario, P.O.
  2. Danesi Romano, R.U.
  3. Blandizzi Corrado, R.U.
  4. Di Paolo Antonello, D.DR.
  5. Colucci Rocchina, D.DR.
  6. Carignani Diego, B.
  7. Innocenti Federico, B.
  8. Bocci Guido, B.
  9. Natale Gianfranco, B.
  10. Lazzeri Gloria, B.
  11. Nardini Denise, B.

AFFILIATION:

Istituto di Farmacologia

FacoltÆ di Medicina e Chirurgia

Universitą di Pisa

ADDRESS: Via Roma, 55

CITY: Pisa

POSTAL CODE: 56126

TELEPHONE: 050-560109/560509

FAX: 050-551434

E-MAIL: mbxdanesi@mail.cnuce.cnr.it

PUBLICATIONS:

  1. DANESI R., DEL BIANCHI S., SOLDANI P., CAMPAGNI A., LA ROCCA R.V., MYERS C.E., PAPARELLI A., DEL TACCA M.: Suramin inhibits bFGF-induced proliferation of bovine aortic endothelial cells and angiogenesis in the chick chorioallantoic membrane. Brit. J. Cancer 68: 932-938, 1993.
  2. BLANDIZZI C., TARKOVACS G., NATALE G., DEL TACCA M., VIZI E.S.: Functional evidence that [3H]acetylcholine and [3H]noradrenaline release from guinea-pig ileal myenteric plexus and noradrenergic terminals is modulated by different presynaptic a2-adrenoceptor subtypes. J. Pharmacol. Exp. Ther. 267: 1054-1060, 1993.
  3. COSTA M., DANESI R., AGEN C., DI PAOLO A., BASOLO F., DEL BIANCHI S., DEL TACCA M.: MCF-10A cells infected with the int-2 oncogene induce angiogenesis in the chick chorioallantoic membrane and in the rat mesentery. Cancer Res. 54: 9-11, 1994.
  4. BLANDIZZI C., GHERARDI G., NATALE G., MARVEGGIO C., DEL TACCA M.: Protective action of omeprazole against gastric mucosal injury induced by haemorrhagic shock in rats. Digest. Dis. Sci. 39: 2109-2117, 1994.
  5. INNOCENTI F., DANESI R., DI PAOLO A., AGEN C., NARDINI D., BOCCI G., DEL TACCA M.: Plasma and tissue disposition of taxol in mice. Drug Metab. Disposition 23: 713-717, 1995.
  6. BLANDIZZI C., NATALE G., CARIGNANI D., COLUCCI R., LAZZERI G., DEL TACCA M.: Central administration of cholecystokinin stimulates gastric pepsinogen secretion from anaesthetized rats. Neurosci. Lett. 193: 13-16, 1995.
  7. BLANDIZZI C., COLUCCI R., CARIGNANI D., NATALE G., LAZZERI G., CREMA F., DEL TACCA M.: Role of peripheral GABA-B receptors in the regulation of pepsinogen secretion in anaesthetized rats. Eur. J. Pharmacol. 294: 191-200, 1995.
  8. DANESI R., LA ROCCA R.V., COOPER M.R., RICCIARDI M.P., PELLEGRINI A., KRAGEL P.J., PAPARELLI A., DEL TACCA M., MYERS C.E.: Clinical and experimental evidence of inhibition of testosterone production by suramin. J. Clin. Endocrinol. Metab. 81: 2221-2230, 1996.
  9. DANESI R., NARDINI D., BASOLO F., DEL TACCA M., SAMID D., MYERS C.E.: Phenylacetate inhibits protein isoprenylation and androgen-independent growth of LNCaP prostate cancer cells transfected with the T24 Ha-ras oncogene. Mol. Pharmacol. 49: 1329-1337, 1996.
  10. COLUCCI R., BLANDIZZI C., CARIGNANI D., LAZZERI G., NATALE G., CREMA F., DEL TACCA M.: Determination on functional basis of presynaptic a2-adrenoceptors subtypes in guinea-pig duodenum. Neurosci. Lett. 210: 29-32, 1996.

RESEARCH GROUP MEMBERS:

  1. Franco Luigina, R.U.
  2. Doria Denise, B.

AFFILIATION:

Istituto di Farmacologia

Facoltą di Medicina e Chirurgia

Universitą di Verona

ADDRESS: Policlinico di Borgo Roma

CITY: Verona

POSTAL CODE: 37134

TELEPHONE: 045-8098611, 8098604, 8074244

FAX: 045-581111

E-MAIL: luigina@farma.univr.it

PUBLICATIONS:

  1. FRANCO, L., ERBETTI, I. AND VELO, G.P. Synthesis of prostaglandin E2 in rat liver. Pharmacol. Res. 28:367-374, 1993
  2. FRANCO, L., MANARA, P., ERBETTI, I. AND VELO, G.P. Anti-ulcer activity of carbenoxolone and ISF-3401 on PGE2, release in rat gastric mucosa. Pharmacol. Res. 27:141-150, 1993.
  3. CAVALLINI, G., BOVO, P., MARCORI, M., MALTINTI, G., MARCHI, S., COSTA, I.F., BELLINI, M., FRANCO, L. AND ANGELINI, G. Effect of sulglycotide on the release of PGI2 into gastric juice in healthy volunteers. Advances in Therapy 11: 58-61, 1994
  4. FRANCO, L. Role of nitric oxide in prevention of ethanol-induced damages by CuNSN a copper-chelating compound. Inflamm. Res.: 44:27-29, 1995
  5. FRANCO, L., CAVALLINI, G., BOVO, P., MARCORI, M., ORLANDI, P.G., MOLTRER, G., VETTURI, B. AND VELO G.P. Gastric eicosanoid synthesis in normal subjects and alcoholics after ethanol stimulation. Ital. J. Gastroenterol. 27: 244-247, 1995
  6. FRANCO, L. AND VELO, G.P. Eicosanoid and gastroprotectrion by copper derivatives and NDGA. Inflamm. Res. 44: 139-142, 1995
  7. FRANCO, L. AND VELO G.P. A copper-complex reduced gastric damage caused by acetylsalicylic acid and ethanol. Prostaglandins 51:331-338 1996.

RESEARCH GROUP MEMBERS:

  1. Impicciatore Mariannina, P.O.
  2. Rescigno Aldo, P.O.
  3. Bernini Franco, P.A.
  4. Caretta Antonio, P.A.
  5. Molina Enzo, P.A.
  6. Barocelli Elisabetta, R.U.
  7. Chiavarini Milena, R.U.
  8. Ballabeni Vigilio, D.DR.
  9. Castelli Cristina, D.DR.

AFFILIATION:

Istituto di Farmacologia e Farmacognosia

Facoltą di Farmacia

Universitą degli Studi di Parma

ADDRESS: Viale delle Scienze - Campus Universitario

CITY: Parma

POSTAL CODE: 43100

TELEPHONE: 0521-905090

FAX: 0521-905091

E-MAIL: marimp@IPRUNIV.CCE.UNIPR.IT

PUBLICATIONS:

  1. BAROCELLI, E., BALLABENI, V., CARETTA, A., BORDI, F., SILVA, C., MORINI, G. AND M. IMPICCIATORE Pharmacological profile of new thioperamide derivatives at histamine peripheral H1-, H2, H3-receptors in guinea-pig. Agents Actions 38:158-164, 1993.
  2. BERNINI, F., DIDONI, G., BELLOSTA, S. AND FUMAGALLI, R. Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages. Atherosclerosis 104: 19-26, 1993
  3. BAROCELLI, E., BALLABENI, V., CHIAVARINI, M., MOLINA, E., LAVEZZO, A. AND IMPICCIATORE, M. Muscarinic M1 and M3 receptor antagonist effects of a new pirenzepine-analog in isolated guinea-pig ileal longitudinal muscle-myenteric plexus. Eur. J. Pharmacol. 254:151-157, 1994.
  4. BAROCELLI, E., BALLABENI, V., CHIAVARINI, M. AND AND IMPICCIATORE, M. R-a-methylhistamine-induced inhibition of gastric acid secretion in pylorus-ligated rats via central histamine H3 receptors. Brit. J. Pharmacol. 115: 1326-1330, 1995.
  5. PLAZZI, P.V., BORDI, F., MOR, M., SILVA, C., MORINI, G., CARETTA, A., BAROCELLI, E. AND VITALI, T. Heteroarylamines and heteroarylthioethtl imidazoles. Synthesis and H3-receptor affinity. Eur. J. Med. Chem. 30: 881-889, 1995.
  6. BERNINI, F., SCURATI, N., BONFADINI, G. AND FUMAGALLI, G. HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages. Arteriosclerosis, Thromb. Vasc. Biol. 15: 1352-1358, 1995.
  7. CARELLI, A., LIBERATORE, F., SCIPIONE, L., IMPICCIATORE, M., BAROCELLI, E., CARDELLINI, M. AND GIORGIONI, G.F. New System for the specific delivery and sustained release of dopamine to the brain. J. Control Release 42: 209-216, 1996
  8. BERNINI, F., CALABRESI, L., BONFADINI, G. AND FRANCESCHINI, G. The molecular structure of apolipoprotein A-II modulates the capacity of HDL to promote cell cholesterol efflux. Biochim. Biophys. Acta 1299: 103-109, 1996
  9. RESCIGNO, A. On absorption rate and fraction absorbed. J. Pharmacokin. Biopharm. 22: 255-257, 1994

RESEARCH GROUP MEMBERS:

  1. Manara Luciano, Dir. R.
  2. Aureggi Giulio, C.L.
  3. Badone Domenico, C.L.
  4. Baroni Marco, C.L.
  5. Barzaghi Laura, R.I.
  6. Bertario Andrea, R.I.
  7. Boccardi Giovanni, Capo Sezione
  8. Cardamone Rosanna, R.I.
  9. Cecchi Roberto, C.L.
  10. Cefalą Antonio, Capo Sezione
  11. Croci Tiziano, Capo Sezione
  12. Guzzi Umberto, Capo Sezione
  13. Ielmini Alessandra, R.I.
  14. Landi Marco, C.L.
  15. Manzoni Laurenzia, C.L.
  16. Marini Pietro, R.I.
  17. Miranda Giovanna, Capo Sezione
  18. Ottolina Elisabetta, R.I.

AFFILIATION:

Centro Ricerche Sanofi Midy

Sanofi Winthrop S.p.A.

ADDRESS: Via G.B. Piranesi, 38

CITY: Milano

POSTAL CODE: 20137

TELEPHONE: 02 - 7394-1

FAX: 02 - 7394-453

PUBLICATIONS:

  1. EMONDS-ALT X., ADVENIER C., CROCI T., MANARA L., NELIAT G., PONCELET M., PROIETTO V., SANTUCCI V., SOUBRIE' P., VAN BROECK D., VILAIN P., LE FUR G., AND BRELIERE J.C. SR 48968, a neurokinin A (NK2) receptor antagonist. Regul. Peptides. 46: 31-36, 1993.
  2. LANDI M., CROCI T., AND MANARA L. Similar atypical ß-adrenergic receptors mediate in vitro rat adipocyte lipolysis and colonic motility inhibition. Life Sci. 53: PL 297-302, 1993.
  3. FOURNIER J., STEINBERG R., GAUTHIER T., KEANE P.E., GUZZI U., COUDE' F.X., BOUGAULT I., MAFFRAND J.P., SOUBRIE' P., AND LE FUR G. Protective effects of SR 57746 in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience. 55: 629-641, 1993.
  4. CROCI T., BASILISCO G., BASSANI A., AND MANARA L. Manometric patterns of rat colonic motor activity and defecation - Effect of selective 5HT1A agonist 8-OH-DPAT. Digestive Diseases and Sciences. 39: 1968-1973, 1994.
  5. CROCI T., EMONDS-ALT X., LE FUR G., AND MANARA L. In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR 140333 and SR 48968 in different rat and guinea-pig intestinal segments. Life Sci. 56: 267-275, 1995.
  6. CROCI T., LANDI M., BIANCHETTI A., AND MANARA L. Drug-induced defaecation in rats: role of central 5-HT1A receptors. Brit. J. Pharmacol. 115: 203-209, 1995.
  7. CROCI T., GIUDICE A., MANARA L., GULLY D., AND LE FUR, G. Promotion by SR 48692 of gastric emptying and defaecation in rats suggesting a role of endogenous neurotensin. Brit. J. Pharmacol. 115: 383-384, 1995.
  8. CROCI T., LANDI M., EMONDS-ALT X., LE FUR G., AND MANARA L. Neuronal NK3-receptors in guinea-pig ileum and taenia caeci: in vitro characterization by their first non-peptide antagonist, SR 142801. Life Sci. 57: PL 361-366, 1995.
  9. MANARA L., BADONE D., BARONI M., BOCCARDI G., CECCHI R., CROCI T., GIUDICE A., GUZZI U., LANDI M., AND LE FUR G. Functional identification of rat atypical ß-adrenoceptors by the first ß3-selective antagonists, aryloxypropanolaminotetralins. Brit. J. Pharmacol. 117: 435-442, 1996.
  10. DE PONTI F., GIBELLI G., CROCI T., ARCIDIACO M., CREMA F., AND MANARA L. Functional evidence of atypical ß3-adrenoceptors in the human colon using the ß3-selective adrenoceptor antagonist, SR 59230A. Brit. J. Pharmacol. 117: 1374-1376, 1996.

RESEARCH GROUP MEMBERS:

  1. Maselli Maria Antonietta, R..O.
  2. Piepoli Anna Lodadea, B.
  3. Montanaro Simone, T.

AFFILIATION:

Laboratorio di Fisiopatologia Sperimentale

IRCCS. "Saverio de Bellis"

ADDRESS: Via Francesco Valente 4

CITY: Castellana Grotte (Bari)

POSTAL CODE: 70013

TELEPHONE: 080-4960231

FAX: 080-4960231/4961394

PUBLICATIONS:

  1. RIEZZO G., PEZZOLLA F., MASELLI M.A., GIORGIO I. Electrical activity recorded from the abdominal surface before and after right hemicolectomy in man. Digestion 55: 185-190, 1994.
  2. MASELLI M.A., CAROPPO R., DEBELLIS L., CURCI S., GIORGIO I. Effect of trimipramina and fluoxetine on H+ secretion and transephitelial electrical parameters of gastric mucosa. Med. Sci. Res. 22 : 263-266, 1994.
  3. CHILOIRO M., PEZZOLLA F., RIEZZO G., MASELLI M.A., LORUSSO D. Gallbladder motility before and after Billroth II gastric resection. Neurogastroenterology and Motility 7: 145-149, 1995.
  4. MASELLI M.A., PEZZOLLA F. PIEPOLI A.L., CARUSO M.L., LORUSSO D. Gallbladder motility in vitro in man with gallstones following Billroth II gastric resection. Neurogastroenterology and Motility 8: 29-33, 1996.

RESEARCH GROUP MEMBERS:

  1. Soldani Giulio, P.O.
  2. Mengozzi Grazia, R.U.
  3. Intorre Luigi, R.U.
  4. Bertini Simone, D.DR.
  5. Della Croce Clara Maria, D.DR.
  6. Luchetti Elena, D.DR.
  7. Demi Sergio, T.L.

AFFILIATION:

Laboratorio di Farmacologia e Tossicologia

Istituto di Clinica Medica Veterinaria

Facoltą di Medicina Veterinaria

Universitą di Pisa

ADDRESS: Via Piagge, 2

CITY: Pisa

POSTAL CODE: 56124

TELEPHONE: 050 - 570583 - 570582 - 570525

FAX: 050 - 570771

PUBLICATIONS:

  1. SOLDANI G., MENGOZZI G., INTORRE L., DE GIORGI G., CORUZZI G. AND BERTACCINI G. Histamine H3 receptor- mediated inhibition of gastric acid secretion in conscious dogs. Naunyn-Schmied. Arch. Pharmacol. 347: 61-65, 1993.
  2. INTORRE L., MENGOZZI G., VANNI E., GRASSI F. AND SOLDANI G. The role of peripheral opioid receptor subtypes in the modulation of gastric acid secretion and plasma gastrin in dogs. Eur. J. Pharmacol. 243: 265-272, 1993.
  3. MAUGERI S., FERRE' J.P., INTORRE L. AND SOLDANI G. Effects of medetomidine on intestinal and colonic motility in the dog. J. vet. Pharmacol. Therap. 17: 148-154, 1994.
  4. SOLDANI G., INTORRE L., BERTINI S., LUCHETTI E., CORUZZI G. AND BERTACCINI G. Regulation of gastric acid secretion by histamine H3 receptors in the dog: an investigation into the site of action. Naunyn-Schmied- Arch. Pharmacol. 350: 218-223, 1994.
  5. INTORRE L., BLANDIZZI C., NATALE G., INTORRE D., MENGOZZI G. AND SOLDANI G. Regulation of gastrin release in the dog by alfa2-adrenergic receptors. J. Auton. Pharmacol. 14: 345-353, 1994.
  6. INTORRE L., FORNAI F., ALESSANDRI' M.G., LENZI L., CORSINI G.U. AND SOLDANI G. Behavioural and biochemical effects of the tremorgenic mycotoxin verruculogen. Toxicol. Environ. Chem. 46: 119-125, 1994.
  7. INTORRE L., MENGOZZI G., MACCHERONI M., BERTINI S. AND SOLDANI G. Enrofloxacin-theophylline interaction: influence of enrofloxacin on theophylline steady-state pharmacokinetics in the beagle dog. J. Vet. Pharmacol. Therap. 18: 352-356, 1995.
  8. MENGOZZI G., INTORRE L., BERTINI S. AND SOLDANI G. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and intramuscular administration in sheep. Amer. J. Vet. Res. 57: 1040-1043, 1996.
  9. INTORRE L., BERTINI S., LUCHETTI E., MENGOZZI G., CREMA F. AND SOLDANI G. The effect of ethanol, beer and wine on histamine release from the dog stomach. Alcohol. 13: 321- 326, 1996.
  10. SOLDANI G., GARBARG M., INTORRE L., BERTINI S., ROULEAU A. AND SCHWARTZ J-C. Modulation of entagastrin-induced histamine release by histamine H3 receptors in the dog. Scand. J. Gastroenterol. 31: 631-638, 1996.

RESEARCH GROUP MEMBERS:

  1. Tonini Marcello, P.A.
  2. DíAgostino Gianluigi, R.U.
  3. Di Nucci Amalia, R.U.
  4. Ricotti Paola, B.
  5. Tagliani Monica, B.

AFFILIATION :

Sezione di Farmacologia e Tossicologia,

Dipartimento di Medicina Interna e Terapia Medica

Facoltą di Medicina e Chirurgia

Universitą di Pavia

ADDRESS: Piazza Botta, 10

CITY: Pavia

POSTAL CODE: 27100

TELEPHONE: 0382-506363

FAX: 0382-22741

E-MAIL: tonini@ipv36.unipv.it

PUBLICATIONS :

  1. COCCINI T., CANDURA S.M., MANZO L., COSTA L.G., TONINI M. Interaction of the neurotoxic pesticides ivermectin and lindane with the enteric GABAA receptor-ionophore complex in the guinea-pig. Eur. J. Pharmacol. (Environ. Pharmacol. Toxicol. Section), 248 : 1-6, 1993.
  2. WATERMAN S.A., COSTA M., TONINI M. Accommodation mediated by enteric inhibitory reflexes in the isolated guinea-pig small intestine. J. Physiol., 474 : 539-546, 1994.
  3. TONINI M., MESSORI E., FRANCESCHETTI G.P., RIZZI C.A., CASTOLDI A.F., COCCINI T., CANDURA S.M. Characterization of the 5-hydroxytryptamine receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle. Brit. J. Pharmacol., 113 : 1-2, 1994.
  4. CICCOCIOPPO R., ONORI L., MESSORI E., CANDURA S.M., COCCINI T., TONINI M. Role of nitric oxide-dependent and -independent mechanisms in peristalsis and accommodation in the rabbit distal colon. J. Pharmacol. Exp. Ther., 270 : 929-937, 1994.
  5. WATERMAN S.A., TONINI M., COSTA M. The role of ascending excitatory and descending inhibitory pathways in peristalsis in the isolated guinea-pig small intestine. J. Physiol., 481 : 223-232, 1994.
  6. LUCCHELLI A., SANTAGOSTINO-BARBONE M.G., BARBIERI A., CANDURA S.M., TONINI M. The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors. Brit. J. Pharmacol., 114 : 1017-1025 1995.
  7. MESSORI E., CANDURA S.M., COCCINI T., BALESTRA B., TONINI M. 5-HT3 receptor involvement in descending reflex relaxation in the rabbit isolated distal colon. Eur. J. Pharmacol., 286 : 205-208, 1995.
  8. TONINI M., BROOKES S.J.H, HUMPHREYS C.M.S., COSTA M. Dissociation of the ascending excitatory reflex from peristalsis in the guinea-pig small intestine. Neuroscience , 73 : 287-297, 1996.
  9. CANDURA S.M., MESSORI E., FRANCESCHETTI G.P., D'AGOSTINO G., VICINI D., TONINI M. Neural 5-HT4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists. Brit. J. Pharmacol., 118 : 1965-1970, 1996.

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