21. ROLE OF NO/Ca2+/CaM/MAPK SIGNALLING PATHWAY IN THE MITOGENIC EFFECT OF IL-1B IN C6 GLIOMA CELLS
Sticozzi Claudia, Meini Antonella and Palmi Mitri
Dipartimento di Scienze Biomediche, Università degli Studi di Siena, via Aldo Moro, 2 Siena

22. NEUROGENIC RESPONSE INDUCED BY FLUOXETINE CHRONIC TREATMENT IN NEURAL PROGENITOR CELLS ISOLATED FROM RAT POSTNATAL CEREBELLUM
Morena Zusso, Patrizia Debetto, Massimo Barbierato, Diego Guidolin*, and Pietro Giusti
Department of Pharmacology and Anestesiology, University of Padova, Italy
*Department of Anatomy and Physiology, University of Padova, Italy

23. INVOLVEMENT OF CANNABINOID SYSTEM IN PROLIFERATION OF CEREBELLAR NEURAL PROGENITOR CELLS
Silvia Soffia, Marco Corso, Massimo Barbierato, Pietro Giusti, Patrizia Debetto, and Morena Zusso
Department of Pharmacology and Anesthesiology “E. Meneghetti”, University of Padova, Italy

24. EFFECT OF OXYSTEROLS ON CELL SURVIVAL AND PROLIFERATION PATHWAYS IN HUMAN ENDOTHELIAL CELLS
Laura Agnoletto, Chiara Poggiani, Federico Cusinato, Lucia Trevisi and Sisto Luciani
Department of Pharmacology and Anaesthesiology, University of Padova

25. EXPRESSION OF CXCR4 AND SDF1/CXCL12 IN HUMAN NORMAL PITUITARY AND PITUITARY ADENOMA TISSUES: ROLE IN CELL PROLIFERATION
Federica Barbieri, Adriana Bajetto, Carola Porcile, Alessandra Pattarozzi, Monica Gatti, Alessandro Corsaro, Stefano Thellung, Valentina Villa, Gennaro Schettini and Tullio Florio
Section of Pharmacology, Department of Oncology, Biology and Genetics, University of Genova, Italy

26. DOPAMINE AND L-DOPA INCREASE IN VITRO PROLIFERATION OF STEM CELLS FROM THE MOUSE SUBVENTRICULAR ZONE
Pier Andrea Serra a, Rossana Migheli, Gaia Rocchitt a, Giammario Calia, Sonia Dedola, Antonio Manca a, Francesca L‘Episcopo c, Stefano Pluchino b, Bianca Marchetti a,c, Maria S. Desole a
aDepartment of Pharmacology, University of Sassari, 07100 Sassari, Italy
bDepartment of Neuroscience, S. Raffaele Scientific Institute, Milano, Italy
cOASI Institute for Research and Care on Mental Retardation and Brain Aging (IRCCS), Neuropharmacology Section, Troina, Italy

27. ANTIPROLIFERATIVE EFFECTS OF PYRAZOLO-PYRIMIDINE -TYPE INHIBITORS OF SRC FAMILY TYROSINE KINASES DERIVATES ON HUMAN NEUROBLASTOMA CELLS
Navarra Michele1, Celano Marilena2, Schenone Silvia3, Botta Maurizio4, Bramanti Placido5, Russo Diego2
1 Pharmaco-Biological Department, University of Messina, 2Department of Pharmacobiological Sciences, University "Magna Græcia" of Catanzaro, 2Department of Pharmaceutical Sciences, University of Genova, 4Department of Pure and Applied Medicinal Chemistry, University of Siena, 5IRCCS centro neurolesi “Bonino-Pulejo”

28. NEURON-LIKE CELLS DERIVED FROM BONE MARROW STROMAL CELLS: EXPRESSION AND FUNCTIONING OF GABAB RECEPTORS
Cervetto Chiara1, Paluzzi Paola1, Guarnieri Stefania1, Marcoli Manuela1, Castagnola Patrizio2, Tonachini Laura2, Mastrogiacomo Maddalena2, Monticone Massimiliano2, Pestarino Mario3, Candiani Simona3, Maura Guido1*
1Dep. Experimental Medicine, 3Dep. Biology, *Centre of Excellence for Biomedical Research, University of Genova and 2Ist Naz Ricerca sul Cancro, Genova, Italy

29. INFLUENCE OF LEPTIN ON THE EARLY PHASES OF BONE FORMATION DURING MOUSE SKELETON ORGANOGENESIS
1Rivasi Marianna, 1Benelli Augusta, 2Ferretti Marzia, 2Benincasa Marta, 2Bertoni Laura, 2Cavani Francesco, 2Palumbo Carla.
1Dept. of Biomedical Sciences, Section of Pharmacology; 2Dept. of Anatomy and Istology, Section of Human Anatomy; University of Modena and Reggio Emilia, Modena, Italy

30. PROLIFERATION AND INVASIVENESS OF HUMAN SMOOTH MUSCLE TSC2-/- CELLS. EFFECT OF ANTI-EGFR AND RAPAMYCIN
Di Giulio Anna Maria, Isaia Eleonora, Grande Vera, Lesma Elena, Gorio Alfredo
Pharmacological Laboratories, Dept. of Medicine, Surgery and Dentistry, Università degli Studi di Milano

31. REVERSION OF THE PHENOTYPE OF HUMAN TSC2-/- SMOOTH MUSCLE CELLS. NOVEL INSIGHTS FOR TSC AND LAM THERAPY

Lesma Elena, Grande Vera, Isaia Eleonora, Di Giulio Anna Maria, Gorio Alfredo
Pharmacological Laboratories, Dept. of Medicine, Surgery and Dentistry, Università degli Studi di Milano

32. EXPRESSION OF ANNEXIN A1 IN MOUSE MYOBLAST DIFFERENTIATION CELL LINE
Valentina Bizzarro, Michela Festa, Simona F. Ercolino, Silvia Franceschelli, Egle Solito*, Luca Parente and Antonello Putrella
Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy
*Department of Cellular and Molecular Neuroscience, Faculty of Medicine, Imperial College, London, UK

33. THE GLUCOCORTICOID-INDUCED LEUCINE ZIPPER (GILZ) INHIBITS SKELETAL MYOGENESIS BY COUNTERACTING MYOD ACTIVITY
Donato Valerio1, Velardi Enrico1, Bruscoli Stefano1, Bastianelli Alessandra1, Donato Rosario2 and Riccardi Carlo1
1Dept. Clinical and Experimental Medicine, Sect. Pharmacology, and 2Dept. Experimental Medicine and Biochemical Sciences, Sect. Anatomy, Perugia University Medical School, 06122, Perugia, Italy

34. CALIXARENE GLYCOCONJUGATES INHIBIT C6 GLIOMA CELL PROLIFERATION AND MIGRATION: INTERACTION WITH GROWTH FACTORS
Viola Santa1, Consoli Grazia M.L.2, Merlo Sara1, Geraci Corrada2, Sortino Maria Angela1
1Department of Experimental and Clinical Pharmacology, University of Catania and 2Institute of Biomolecular Chemistry, CNR, Valverde, Catania

35. CANNABINOIDS INHIBIT HUMAN COLON CANCER CELL PROLIFERATION THROUGH CB2-RECEPTOR AND CERAMIDE PATHWAY ACTIVATION
Mastroianni Rosanna a, Cianchi Fabio b, Magnelli Lucia c, Nicola Schiavone c, Perna Ferderico b, Capaccioli Sergio c, Manera Clementina d, Mannaioni Pier Francesco a and Masini Emanuela a
aDepartment of Preclinical and Clinical Pharmacology, bDepartment of Critical Care Medicine and cDepartment Pathology and Experimental Oncology, University of Florence, Florence, Italy; dDepartment of Pharmaceutical Sciences, University of Pisa, Pisa, Italy

36. ROLE OF LOX PATHWAY AND ENDOCANNABINOID SYSTEM IN ANTITUMOR ACTIVITY OF CANNABIDIOL, A NON-PSYCHOACTIVE CANNABINOID
Massi Paola1, Valenti M. 2, Gasperi M.3, Meli S. 2, Maccarrone M.3 and Parolaro D.2
1 Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via Vanvitelli 32, Milan, Italy
2 Department of Structural and Functional Biology, Pharmacology Section, Center of Neuroscience, University of Insubria, Via A. da Giussano 10, Busto Arsizio (VA), Italy
3 Department of Biomedical Sciences, University of Teramo, 64100 Teramo, Italy

37. EFFECTS OF THE IL-6 RECEPTOR SUPERANTAGONIST SANT7 ON TGF-B-INDUCED CELL PROLIFERATION AND MAP KINASE PHOSPHORYLATION IN PRIMARY CULTURES OF FIBROTIC HUMAN LUNG FIBROBLASTS
Gallelli Luca, Falcone Daniela, Renda Teresa, Pelaia Girolamo, Maselli Rosario, Savino Rocco, De Sarro Giovambattista
Department of Experimental and Clinical Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro, Italy

38. EFFECTS OF SIMVASTATIN AND BETAMETHASONE ON HYDROGEN PEROXIDE INDUCED MAPK ACTIVATION, IL-8 PRODUCTION AND CELL PROLIFERATION IN PRIMARY CULTURES OF HUMAN SQUAMOUS LUNG CANCER CELLS
Fratto Donatella1, Gallelli Luca1, Renda Teresa1, Pelaia Girolamo2, Maselli Rosario2, De Sarro Giovambattista1
1Chair of Pharmacology, and 2Chair of Respiratory Diseases, Department of Experimental and Clinical Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro, Italy

39. PKCd ISOENZYME IS INVOLVED IN GROWTH AND ANGIOGENESIS OF PROSTATE CANCER
Betti Niccolò1, Morbidelli Lucia1, Corti Federico2, Mochly-Rosen Daria3 and Ziche Marina1
1 Pharmacology section, Dept Molecular Biology, University of Siena. 2 Proteomic section, Dept Molecular Biology, University of Siena. 3 Molecular pharmacology, School of Medicine, Stanford University

40. TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND INHIBITS ANGIOGENESIS STIMULATED BY HUMAN GLIOBLASTOMA CELLS
Scuderi Mariagrazia Rita, Albini Adriana 1, Lempereur Laurence, Pennisi Giuseppa 2, Bernardini Renato, Giuseppina Cantarella
Department of Experimental and Clinical Pharmacology; and Department of Chemical Sciences; University of Catania, 95100 Catania, Italy; Laboratory of Molecular Oncology, Istituto Tumori, 16100 Genova, Italy

41. ANTIANGIOGENIC AND ANTITUMOUR EFFECTS OF METRONOMIC IRINOTECAN (CPT-11)
Fioravanti Anna1, Orlandi Paola1, Falcone Alfredo2, Danesi Romano1, Del Tacca Mario1, Bocci Guido1
1Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, 2Oncology Unit; General Hospital, Livorno

42. NATURAL AND SEMISYNTHETIC ANTRAQUINONES, FLAVONOIDS AND NAPHTOQUINONES EFFECTS ON CELL CYCLE IN HUMAN OVARIAN CANCER
M. Montopoli, S. Moro*, G. Cozza*, G. Zagotto*, G. Froldi, E. Ragazzi and L. Caparrotta
Department of Pharmacology and Anaestesiology, University of Padova Largo E. Meneghetti 2, 35131 Padova, Italy. * Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy

43. SNAP-25 PHOSPHORYLATION ON SERIN 187 MEDIATES NEGATIVE MODULATION OF NEURONAL CALCIUM DYNAMICS
Pozzi Davide1, Steven Condliffe1, Carlotta Grumelli1, Juri Bozzi2, Matteo Caleo2, Véronique Proux-Gillardeaux3, Masami Takahashi4, Claudia Verderio1 and Michela Matteoli1
1Department of Medical Pharmacology and CNR Institute of Neuroscience, Center of Excellence for Neurodegenerative Diseases, University of Milano, Via Vanvitelli 32, 20129 Milano, Italy. 2CNR- Institute of Neuroscience via G. Moruzzi 1, 56100 Pisa, Italy. 3Institut Jacques Monod UMR7592 Tour 43 2ème étage 2, place Jussieu, F-75251 Paris Cedex 05, France. 4Department of Biochemistry, Kitasato University School of Medicine, Kitasato 1-15-1, Sagamihara-shi, Kanagawa 228-8555, Japan

44. SELECTIVE REGULATION OF [3H]D-ASPARTATE RELEASE FROM HIPPOCAMPAL NERVE ENDINGS BY LARGE-CONDUCTANCE CA2+- AND VOLTAGE-ACTIVATED K+ (BK) CHANNELS
Martire Maria1, D’Amico M.1, Calciano S.1, Panza E.2, Iannotti F.2,3, Barrese V.2, Preziosi P.1, Annunziato L.2 and Tagliatatela M.2,3
1Inst. of Pharmacology, Catholic University of S. Heart, Rome; 2Division of Pharmacology, Dept. of Neuroscience, University of Naples Federico II, Naples; 3Dept. of Health Science, University of Molise, Campobasso; Italy

45. KCNQ CHANNELS REGULATE DEPOLARIZATION-INDUCED CHANGES IN INTRACELLULAR Ca2+ CONCENTRATIONS IN RAT CEREBROCORTICAL NERVE ENDINGS
1Rosa Luisi, 1Elisabetta Panza, 1Agnese Secondo, 2Maria Martire, 1Lucio Annunziato, and 1,3Maurizio Tagliatatela
1Div. of Pharmacology, Dept. of Neuroscience, School of Medicine, Univ. “Federico II”, Naples; 2Insitute of Pharmacology, School of Medicine, Catholic Univ. of Sacred Heart, Rome; 3Dept. of Health Sciences, Univ. of Molise, Campobasso, Italy

46. ADULT ASTROGLIA IS COMPETENT FOR NA+/CA2+ EXCHANGER-OPERATED EXOCYTOTIC GLUTAMATE RELEASE TRIGGERED BY MILD DEPOLARIZATION
1Zappettini Simona, 2Alloisio Susanna 1Raiteri Luca, 1Paluzzi Silvio, 2Nobile Mario, 1Bonanno Giambattista
1Department of Experimental Medicine - Pharmacology and Toxicology Section and Center of Excellence for Biomedical Research, University of Genoa, Italy. 2Institute of Biophysics, National Research Council, Genoa, Italy

47. MECHANISMS OF [3H]GLYCINE RELEASE FROM MOUSE SPINAL CORD SYNAPTOSOMES SELECTIVELY LABELLED THROUGH GLYT2 TRANSPORTERS
Luccini Elisa and Raiteri L.
Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genoa

48. IMPORTANCE OF PROTEIN KINASE C EPSILON FOR THE ALLOSTERIC MODULATION OF GABA EVOKED CURRENTS IN CORTICAL CULTURE AT DIFFERENT DIV
Garzon Giorgio, Baraldi Mario, Puja Giulia
Dept. of BioMedical Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy

49. a7 NICOTINIC RECEPTOR PRESENT ON MOUSE CORTICAL ASTROCYTES MODULATES ENDOGENEOUS GLUTAMATE RELEASE
Patti Laura 1, Raiteri Luca 1, Grilli Massimo 1, Robino Federica.1, Zappettini Simona 1, Bonanno Gian Battista 1,2, Marchi Mario 1,2
1 Section of Pharmacology and Toxicology, Department of Experimental Medicine, University of Genoa, Italy. 2 Center of Excellence for Biomedical Research, University of Genoa, Italy

50. THE AGONIST OF METABOTROPIC GLUTAMATE 5 RECEPTORS CHPG INVERTS THE EFFECTS OF DHK (A BLOCKER OF GLIAL GLUTAMATE UPTAKE): AN IN VIVO MICRODIALYSIS STUDY
Pintor Anita, Armida Monica, Pèzzola Antonella, Popoli Patrizia
Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Roma (Italy)

51. THE METABOTROPIC GLUTAMATE 5 (mGlu5Rs) AND THE ADENOSINE A2A RECEPTORS (A2ARs) OPPOSITELY MODULATE CB1-INDUCED REDUCTION OF SYNAPTIC TRANSMISSION IN THE RAT STRIATUM
Martire Alberto, Tebano Maria Teresa, Domenici Maria Rosaria, Popoli Patrizia
Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Roma (Italy)

52. GLUTAMATE RELEASE INDUCED BY ACTIVATION OF GAT-1 TRANSPORTERS SITED ON GLUTAMATE RELEASING SPINAL CORD GLIOSOMES AND ITS AUGMENTATION IN A MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS
1Milanese Marco, Raiteri Luca, 1Zappettini Simona, 2UsaiCesare, 1Bonanno Giambattista
1Department of Experimental Medicine - Pharmacology and Toxicology Section and Center of Excellence for Biomedical Research, University of Genoa, Italy. 2Institute of Biophysics, National Research Council, Genoa, Italy

53. THYROID HORMONES MODULATE GLUTAMATERGIC NEUROTRANSMISSION IN HIPPOCAMPUS
Puja Giulia, Losi Gabriele, Garzon Giorgio, Baraldi Mario
Dept. of BioMedical Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy

54. ROLE OF IONOTROPIC GLUTAMATERGIC RECEPTORS IN THE REGULATION OF HIPPOCAMPAL NOREPINEPHRINE OUPUT IN VIVO
Alessandra Matzeu, Laura Dazzi, Giovanni Biggio
Department of Experimental Biology, Neuroscience section, University of Cagliari, Cagliari, Italy

55. ALTERATIONS OF GLUTAMATERGIC TRANSMISSION IN A MURINE MODEL OF MULTIPLE SCLEROSIS: PRELIMINARY RESULTS
PEPICELLI Olimpia a, MARTE Antonella a, UCCELLI Antonio c, MANCARDI Luigi c, RAITERI Maurizio a,b, FEDELE Ernesto a,b
aDept. of Experimental Medicine, Pharmacology and Toxicology Section, University of Genoa; bCentre of Excellence for Biomedical Research, University of Genoa; cDept. of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy

56. MODIFICATION OF PRESSURE AND PLACENTAL PROTEIN EXPRESSION IN PREGNANT SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
1Bianco Giuseppe, Iacono A., Esposito E., Mattace Raso G., 1Autore G. and Meli R.
Department of Experimental Pharmacology, University of Naples “Federico II”, Naples, 1Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy

57. INCREASED P22PHOX EXPRESSION AND REDUCED SOD ACTIVITY ARE INVOLVED IN EARLY IMPAIRMENT OF INSULIN-INDUCED VASODILATION ON RESISTANCE VESSELS OF SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
GAGLIARDI Sara, POTENZA Maria A., MARASCIULO Flora L., MONTAGNANI Monica
Department of Pharmacology and Human Physiology - Medical School - University of Bari,
70124 Bari, Italy

58. VASODILATOR ACTIVITY OF HYDROGEN SULFIDE (H2S) IN HUMAN ISOLATED MESENTERIC ARTERIES
Materazzi Serena1, Patacchini R.2, Nassini R.1, Zagli G.1, Giannelli M.1, Bechi P.1, Nicoletti P.1, Geppetti P.1 and Harrison S.1
1Department of Critical Care Medicine & Surgery, University of Florence, Florence, Italy; and 2Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy; Florence, Italy

59. THE VASORELAXANT AND ANTI-INFLAMMATORY ACTION OF RALOXIFENE IN RAT AORTA IS PARTIALLY MEDIATED BY ESTROGEN RECEPTOR ALPHA
Valeria Pelosi1,2, Paola Sanvito1,2, Chiara Bolego1, Christian Pinna1, Alberto Corsini1, Rosa Maria Gaion2, Andrea Cignarella1,2
1 Department of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan; 2 Department of Pharmacology and Anaesthesiology, University of Padova, Largo Meneghetti 2, 35131 Padova, Italy

60. INHIBITORS OF CYSTATHIONINE-GAMMA-LYASE (CSE), PROPARGYLGLYCINE AND ß-CYANOALANINE, MODULATE ARTERIAL VASORELAXATION IN RAT AORTA
Vellecco Valentina, Di Lorenzo Annarita, De Gruttola Luana, Brancaleone Vincenzo, Roviezzo Fiorentina, Bucci Mariarosaria and Cirino Giuseppe
Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples “Federico II”

61. DIRECT EFFECTS OF TICLOPIDINE AND CLOPIDOGREL ON RESISTANCE VESSEL IN VITRO
Froldi Guglielmina, Montopoli Monica, Dorigo Paola, Caparrotta Laura

Department of Pharmacology and Anesthesiology -Pharmacology Division- Largo E. Meneghetti 2, University of Padova (Italy)

62. ASYMMETRIC DIMETHYLARGININE (ADMA) INDUCES VASCULAR ENDOTHELIUM IMPAIRMENT AND AGGRAVATES MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RATS
Bonomo Sara M. a , De Gennaro Colonna Vito a, Manfredi Barbara a , Ferrario Paolo a, Bianchi Mauro a, Berti Marco b,Guazzi Marco c, Berti Ferruccio a, Rossoni Giuseppe a
a Department of Pharmacology, Chemoterapy and Medical Toxicology, University of Milano, Via Vanvitelli 32, Italy; b Institute of Cardiology, Monzino Cardiology Center, IRCCS, Milan, Italy; c Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy

63. ANTI-INFLAMMATORY AND CARDIOPROTECTIVE ACTIVITIES OF SYNTHETIC HDL CONTAINING THE 37PA PEPTIDE
Monica Gomaraschi*, Alan Remaley#, Giuseppe Rossoni§, Guido Franceschini* and Laura Calabresi*
*Center Enrica Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Italy, #Molecular Disease Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA and §Department of Pharmacological Sciences, University of Milano, Italy
(abstract non disponibile su richiesta dell'autore)

64. HUMAN PHARMACOLOGY OF NAPROXEN SODIUM
Marta L Capone, PhD,§† S.Tacconelli, PhD,§† M.G.Sciulli, PhD,§† P.Anzellotti, PharmD, §† L.Di Francesco, PharmD, §† G.Merciaro,‡ P.Di Gregorio, MD,‡ and P.Patrignani, PhD§†
§Department of Medicine and Aging, School of Medicine, “G.d’Annunzio” University; †“G. d’Annunzio” University Foundation, Ce.S.I.; and ‡SS Annunziata Hospital, Chieti, Italy

65. DOXORUBICIN CARDIOTOXICITY AND APOPTOSIS: VARIATION OF EXPOSURE TIMES TO THE SAME CUMULATIVE DOSE
Vitelli Maria Redenta, Piegari Elena, Rodolico Gabriella, Leone Lidia, Marino Laura, Oliva Patrizia, Rossi Francesco, Berrino Liberato
Department of Experimental Medicine, Section of Pharmacology, Faculty of Medicine and Surgery, Second University of Naples – Via Costantinopoli, 16 – 80138 Napoli

66. APOPTOTIC CELL DEATH IN DOXORUBICIN-INDUCED CARDIOMYOPATHY: ROLE OF PEROXYNITRITE AND LOX-1 RECEPTOR MODULATION
Francesca Sculco1, Carolina Muscoli1,2, Ernesto Palma1, Iolanda Sacco1, Valeria Visalli1, Nicola Costa1, Domenicantonio Rotiroti1, Francesco Romeo3 and Vincenzo Mollace1,2
1Faculty of Pharmacy, University “Magna Graecia” of Catanzaro, Italy; 2San Raffaele Pisana IRCCS, Rome, Italy; 3Chair of Cardiology, University of Rome “Tor Vergata”, Rome, Italy; 4Faculty of Pharmacy, University of Messina, Italy

67. UBIQUITIN-PROTEASOME SYSTEM CONTRIBUTES TO THE INFLAMMATORY INJURY OF EXPERIMENTAL ACUTE DIABETIC MYOCARDIAL INFARCT
Di Filippo Clara1,2, Martella Raffaele3 , Rossi Francesco1,2, D’Amico Michele 1,2
1Department of Experimental Medicine, Section of Pharmacology L. Donatelli,2”Excellence Centre for Cardiovascular Disease”, and 3Department of Geriatrics and Metabolic Diseases, 2nd University of Naples, Italy

68. EFFECTS OF ORAL ESSENTIAL AMINO ACID SUPPLEMENTATION IN CACHECTIC INSULINE RESISTANCE PATIENTS WITH CHRONIC HEART FAILURE
Boschi Federica*, Verri M.*, Dossena M.*, Opasich C.°, Aquilani R.^, Gualco A.°, Pastoris O*.
*Department of Physiological & Pharmacological Sciences, University of Pavia, Pavia, Italy; ^IRCCS “S. Maugeri” Foundation, Montescano, Italy; °IRCCS “S. Maugeri” Foundation, Pavia, Italy

69. GENDER-DIFFERENCES IN NO AND EDHF MODULATION OF VASCULAR REACTIVITY IN RABBIT MESENTERIC ARTERY
Fabi Fulvia, Coletta T., Lorenzini P., Del Basso Orsini P.
Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Roma, Italy

70 . GENDER DIFFERENCES IN NITRIC OXIDE PRODUCTION BY INDUCIBLE NITRIC OXIDE SYNTHASE IN CYTOKINE-STIMULATED RABBIT CAROTID ARTERIES
Del Basso Orsini Paola, Calciano Simona, Fabi Fulvia
Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Roma, Italy

71. TIME-DEPENDENT AND SEQUENTIAL MODULATION OF SIGNALING CASCADES, CREB ACTIVATION AND BDNF EXPRESSION INDUCED BY ANTIDEPRESSANTS
Tardito Daniela1, Tiraboschi Ettore1, Barbiero Valentina S1, Moraschi Stefania2, Cattaneo Anna2, Gennarelli Massimo2, Racagni Giorgio1, Popoli Maurizio1
1 Center of Neuropharmacology, Dept of Pharmacological Sciences and Center of Excelence on Neurodegenerative Diseases, University of Milan, Italy. 2 Genetics Unit, I.R.C.C.S. “S. Giovanni di Dio”, Fatebenefratelli, Brescia, and Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy

72. CHRONIC ANTIDEPRESSANT TREATMENTS INDUCES SPECIFIC CHANGES IN BDNF EXPRESSION AND SUBCELLULAR LOCALIZATION
Maj Paola F.1, Calabrese Francesca1, Molteni Raffaella1, Cattaneo Annamaria3, Gennarelli Massimo2,3, Racagni Giorgio1, Riva Marco A.1
1Center of Neuropharmacology, Pharmacol. Sciences Dept., University of Milan, Via Balzaretti 9, 20133 Milan, Italy. 2I.R.C.C.S. San Giovanni di Dio-Fatebenefratelli, Brescia, Italy. 3Biol. and Gen. Div., Dept. Biomedicals and Biotechnology Sciences, University of Brescia

73. HUMAN ASTROCYTES CAN BE INDUCED BY IMIPRAMINE TO DIFFERENTIATE INTO CELLS WITH NEURONAL PHENOTYPE
1Cabras Stefano, 1Reali Camilla, 1Scorciapino Laura, 1Saba Francesca, 1Sirigu Rita, 2Biggio Giovanni, 1Sogos Valeria
1Department of Cytomorphology, University of Cagliari
2Department of Experimental Biology “Bernardo Loddo”, University of Cagliari

74. VAGUS NERVE STIMULATION LIKE ANTIDEPRESSANT DRUGS ENHANCES NOREPINEPHRINE RELEASE AND BDNF GENE EXPRESSION IN THE RAT BRAIN
Gorini Giorgio1,4, Biggio F.1, Caria S.1, Follesa P.1,2, Marrosu F.3, Dazzi L.1,2, and Biggio G.1,2
University of Cagliari, Dept. of Experimental Biology, Section of Neuroscience1, Cntr. of Excellence for the Neurobiology of Dependence2, Dept. of Neurological and Cardiovascular Sciences3, 09123 Cagliari, Italy; University of Sassari, Dept. of Pharmacology, Gynecology and Obstetrics, Section of Pharmacology4, 07100 Sassari, Italy

75. ESCITALOPRAM ALTERS BDNF, CREB AND CaRF GENE EXPRESSION IN DISCRETE RAT BRAIN AREAS
Benatti Cristina1, Alboni Silvia1, Capone Giacomo1, Corsini Daniela1, Caggia Federica1, Tascedda Fabio1, Blom Joan M.C.2, Brunello Nicoletta1.
1 Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2 Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy

76. ACETYL SALICYLIC ACID INCREASES THE RESPONSE OF ESCITALOPRAM IN A RAT MODEL OF DEPRESSION
Alboni Silvia1, Benatti Cristina1, Capone Giacomo1, Caggia Federica1, Corsini Daniela1, Tascedda Fabio1, Mendlewicz Julien2, Brunello Nicoletta1
1 Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Department of Psychiatry, Erasme Hospital, Free University of Brussels, Belgium

77. SYNAPTOPROTEOMICS OF AN ANIMAL MODEL OF DEPRESSION COMBINING GENETIC VULNERABILITY AND EARLY-LIFE STRESS
Mallei Alessandraa, Tiraboschi E.a, Giambelli R.a, El Khoury A.b, Mathè A.A.b, Racagni G.a, Popoli M.a
aCenter of Neuropharmacology-Department of Pharmacological Sciences, University of Milano (Italy). bNEUROTEC Department, Division of Psychiatry, Karolinska Institutet, Stockholm, (Sweden)

78. GROUP-II METABOTROPIC GLUTAMATE RECEPTOR LIGANDS AS ADJUNCTIVE DRUGS IN THE TREATMENT OF DEPRESSION: A NEW STRATEGY TO SHORTEN THE LATENCY OF ANTIDEPRESSANT MEDICATION?
F. Matrisciano a,b, I. Panaccionea, M. Zussod , P. Giustid , R. Tatarelli b, A. Carusoa, L. Iacovellia, S. Scaccianocea, A.A. Mathéc, S.H. Gruberc, D. Melchiorria, P. Girardib and F. Nicolettia,e
aDepartment of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Piazzale Aldo Moro, 5, 00185 Rome, Italy. b Department of Psychiatry and Psychological Medicine, Sant’Andrea Hospital, University of Rome “La Sapienza”; c Karolinska Institute, Department of Clinical Neuroscience - Psychiatry, Karolinska University Hospital Huddinge, Stockholm, Sweden; d Department of Pharmacology and Anesthesiology, University of Padova, Italy; eI.N.M. Neuromed, Pozzilli, Italy

79. MODULATION OF PRE-SYNAPTIC AND POST-SYNAPTIC PROTEINS AFTER PROLONGED TREATMENT WITH ANTIPSYCHOTIC DRUGS
Angelisa Frasca1, Fabio Fumagalli1, Giorgio Racagni1, Marco Andrea Riva1
1Center of Neuropharmacology, Department of Pharmacological Sciences University of Milan, Via Balzaretti 9, 20133 Milan (Italy)

80. EFFECT OF TYPICAL AND ATYPICAL ANTIPSYCHOTICS ON IN VIVO DOPAMINE TRANSMISSION IN DIFFERENT BRAIN AREAS
Ullu L.M., Valentini V., Tanda G., De Luca M.A. and Di Chiara G
Department of Toxicology, Centre of Excellence “Neurobiology of Addiction", University of Cagliari, Italy

81. AGONIST ACTIVITY OF N-DESMETHYLCLOZAPINE, A MAJOR CLOZAPINE METABOLITE, AT DELTA OPIOID RECEPTORS
MARIA C. OLIANAS, SIMONA DEDONI, LUCIANA GARAU and PIERLUIGI ONALI
Section of Biochemical Pharmacology, Department of Neuroscience, University of Cagliari, Cagliari, Italy

82. HALOPERIDOL BOTH PREVENTS AND REVERSES QUINPIROLE-INDUCED NON REGULATORY WATER INTAKE, A PUTATIVE ANIMAL MODEL OF PSYCHOGENIC POLYDIPSIA
Amato Davide1, Stasi Maria Antonietta2, Borsini Franco2, Nencini Paolo1
1Department of Human Phisiology and Pharmachology, University of Rome Sapienza, 2Research and Development Division, sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia

83. DIFFERENT ROLE OF NMDA RECEPTORS IN THE ROSTRAL AND CAUDAL PART OF THALAMIC RETICULAR NUCLEUS IN A RAT MODEL OF ABSENCE EPILEPSY, THE WAG/RIJ RAT
Citraro Rita1, Marra R2., Scicchitano F1., Russo E1., Ferreri Ibbadu G1., De Sarro G1.
1Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Italy, 2ISBAF CNR, Department of Pharmacology, Faculty of Pharmacy, University of Catanzaro, Catanzaro, Italy

84. EFFECTS OF ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS ADMINISTRATION ON SPIKE-WAVE DISCHARGE IN A GENETIC MODEL OF GENERALIZED ABSENCE EPILEPSY
R. Citraro1, G. Ferreri1, E. Russo1, M. D’Auro2, R. Ciccarelli2, G. De Sarro1
1Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, 2Chair of Pharmacology, Faculty of Medicine and Surgery, University of Chieti, Italy

85. EFFECTS OF THE FOCAL ADMINISTRATION OF MGLU2/3 RECEPTOR LIGANDS IN SELECTED BRAIN AREAS OF WAG/RIJ RAT, A GENETIC ANIMAL MODEL OF ABSENCE EPILEPSY
1De Sarro Giovambattista, 1Citrato R., 2Ngomba R., 1Russo E., 2Battaglia G., 2,3Nicoletti F.
1Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy, 2I.N.M. Neuromed, 86077 Pozzilli, Italy, 3Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy

86. HOMOCYSTEINE INDUCED AN INCREASE OF ABSENCE SEIZURES IN THE ELECTROCOGRAPHIC PATTERN OF WAG/RIJ RAT
Ferreri Ibbadu Guido1, Citraro R1., Marra R2., Siniscalchi A1,3., Russo E1., De Sarro G.1
1Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Italy, 2ISBAF CNR, Department of Pharmacology, Faculty of Pharmacy, University of Catanzaro, Catanzaro, 3Depatment of Neuroscience, Annunziata Hospital, Cosenza, Italy

87. EFFECTS OF NON-COMPETITIVE AMPA RECEPTOR ANTAGONISTS INJECTED INTO SOME BRAIN AREAS OF WAG/RIJ RATS, AN ANIMAL MODEL OF GENERALIZED ABSENCE EPILEPSY
1Ferreri I. Guido, 2Palma E., 2Marra R., 1Citraro R., 1Russo E., 1Curinga C., 3Gitto R., 3Chimirri A, 1De Sarro G
1Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro. 2National council of research institute of neurological science, Catanzaro. 3Department of Medicinal Chemistry, Faculty of Pharmacy, University of Messina, Italy

88. SELECTIVE ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS SUBTYPE 4 ENHANCES SPONTANEOUS AND EVOKED ABSENCE SEIZURES
Ines Santolini1,4, Richard Ngomba1, Francesca Biagioni1, Rita Citraro2, Alexandra Badura3, Giuseppe Battaglia 1, Valeria Bruno1,4, Francesco Ferraguti5, Gilles van Luijtelaar3, Giovanbattista De Sarro2, Ferdinando Nicoletti1,4
1I.N.M. Neuromed, Pozzilli, Italy; 2Dept. of Exp. & Clin. Med., Univ. of Catanzaro, Italy; 3Dept. of Biol. Psychol., Univ. of Nijmegen, The Netherlands; 4Dept. of Hum. Physiol. & Pharm., Univ. “La Sapienza”, Rome, Italy; 5Dept. of Pharm., Univ. of Innsbruck, Austria

89. PRENATAL ETHANOL EXPOSURE EFFECTS ON MAP-KINASES PATHWAY IN A GENETIC MODEL OF ABSENCE EPILEPSY: THE WAG/RIJ RAT
1Arbitrio Mariamena, 3Costa N., 1Vecchio I., 1Marra R., 1Iannone M.,1Strongoli M.C., 2Cuda G., 2Casadonte R., 2De Sarro G., 1,3Rotiroti D
1National Council of Research Institute of Neurological Science-Catanzaro. 2Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery-Catanzaro. 3Chair of Pharmacology, Faculty of Pharmacy-Catanzaro

90. TOPIRAMATE DOSE-DEPENDENTLY MODIFIES SLOW INHIBITORY POST SYNAPTIC POTENTIALS EVOKED IN RAT OLFACTORY CORTICAL NEURONES IN VITRO
1Russo Emilio, 1De Sarro G., 2Constanti A.
1Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy; 2Pharmacology Department, School of Pharmacy, University of London, London, UK

91. ZONISAMIDE INDUCES A SLOW DOSE-DEPENDENT HYPERPOLARIZATION IN RAT OLFACTORY CORTICAL NEURONES IN VITRO
1Russo Emilio, 1Scarfone S., 1De Sarro G.
1Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy

92. EFFECTS OF NITRIC OXIDE INFLUENCE ON EXPERIMENTALLY-INDUCED HYPEREXCITABILITY OF THE HIPPOCAMPUS: IN VIVO AND IN VITRO COMPARATIVE ELECTROPHYSIOLOGICAL STUDY IN THE RAT
Rizzo Valerio1, Ferraro G1, Sardo P1, Carletti F1, D’Agostino S1, La Grutta V1 and Cannizzaro G2
1 Dip. Medicina Sperimentale, Sez. Fisiologia umana, Università di Palermo, Italy. 2 Dip. Scienze Farmacologiche, Università di Palermo, Italy

93. CHANGES IN NEUROACTIVE STEROIDS LEVELS, GABAA RECEPTOR PLASTICITY AND SENSITIVITY TO ANXIOLYTIC DRUGS INDUCED BY NEONATAL EXPOSURE TO ESTROGEN
Calza A, Sogliano C, Marra C, Paganelli P, Santoru F, Angioni MM, Biggio G, Concas A
Department of Experimental Biology and Centre of Excellence for the “Neurobiology of Drug Dependence”, University of Cagliari, Italy

94. SUBCHRONIC ADMINISTRATION OF STATINS REDUCES PLASMA AND BRAIN CONTENT OF NEUROACTIVE STEROIDS
1Dore R. – 4Pisu M.G. – 2Muntoni S. – 134Serra M. – 134Biggio G.
1Department of Experimental Biology; 2Department of Toxicology, Unit of Oncology and Molecular Pathology; 3Center of Excellence for the Neurobiology of Dependence; 4CNR Institute of Neuroscience, Section of Cagliari, University of Cagliari

95. FLUMAZENIL-SENSITIVE DOSE-RELATED PHYSICAL DEPENDENCE IN PLANARIANS PRODUCED BY TWO BENZODIAZEPINE AND ONE NON-BENZODIAZEPINE BENZODIAZEPINE RECEPTOR AGONISTS
Robert B. Raffa a, Federica Cavallo b, Anna Capasso b
a Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA, b Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy

96. GABAERGIC DRUGS BECOME NEUROTOXIC IN CORTICAL NEURONS PRE-EXPOSED TO BRAIN-DERIVED NEUROTROPHIC FACTOR
Gemma Molinaro1, Giuseppe Battaglia1, Barbara Riozzi1, Marianna Storto1, Sergio Fucile1,2, Fabrizio Eusebi1,2, Ferdinando Nicoletti1,2 and Valeria Bruno1,2
1Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy; 2Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Rome, Italy

97. EXPRESSION PATTERNS OF PROMOTERS FOR NPY Y1 AND Y5 RECEPTORS IN Y5RITTA AND Y1RVENUS BAC TRANSGENIC MICE
Angela Longo, Alessandra Oberto, Elena Acquadro, Thorsten Busb, Rolf Sprengel and Carola Eva
Dipartimento di Anatomia, Farmacologia e Medicina Legale; Sezione di Farmacologia, Università degli studi di Torino. Department of Molecular Neurobiology Max Planck Institute for Medical Research, 69120, Heidelberg, Germany

98. MODULATION OF NEUROPEPTIDE Y AND Y1 RECEPTOR EXPRESSION IN THE AMYGDALA BY FLUCTUATIONS IN THE BRAIN CONTENT OF NEUROACTIVE STEROIDS DURING ETHANOL WITHDRAWAL IN MICE
Ilaria Bertocchi, Carola Eva, Paolo Mele, Devis Collura, Maria Giuseppina Pisu, Mariangela Serra and Giovanni Biggio
Dip.Anatomia, Farmacologia e Med Leg, Sez. Farmacologia, Università di Torino, Italy; Dip Biol Sperimentale, Sez Neuroscienze, Università di Cagliari, Italy; Centro Ecc. Neurobiol. Dipendenza, Università di Cagliari, Italy; C.N.R. Ist. Neurosci, Neuropsicofarmac., Cagliari

99. SULFORAPHANE INHIBITS 6-HYDROXYDOPAMINE-INDUCED APOPTOSIS BY UPREGULATION OF MEK/ERK AND PI3K/AKT IN HUMAN NEURONAL CELLS
Tarozzi Andrea1, Morroni Fabiana1, Merlicco Adriana1, Angeloni Cristina2, Hrelia Silvana2, Cantelli-Forti Giorgio1, Hrelia Patrizia1
1Department of Pharmacology, 2Department of Biochemistry "G. Moruzzi", Alma Mater Studiorum - University of Bologna, via Irnerio 48, 40126 Bologna

100. CHARACTERIZATION OF THE ANTIPARKINSONIAN EFFECTS OF THE NEW ADENOSINE A2A RECEPTOR ANTAGONIST ST1535: ACUTE AND SUBCHRONIC STUDIES IN RATS
Tronci Elisabetta(1), Simola N.(1), Borsini F.(4), Schintu N.(1), Frau L.(1), Carminati P.(4), Morelli M.(1,2,3)
(1)Department of Toxicology, (2)Centre of Excellence for Neurobiology of Dependence, (3)CNR Institute of Neuroscience, University of Cagliari, Italy, (4)Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Pomezia (Rome), Italy

101. EVALUATION OF THE NEUROPROTECTIVE EFFECT OF THE A2A RECEPTOR ANTAGONIST SCH58261 ON THE MPTP MOUSE MODEL OF PARKINSON’S DISEASE
Schintu Nicoletta, Carta Anna R. and Morelli Micaela
Department of Toxicology, University of Cagliari, Italy

102. MITOCHONDRIAL FACTORS INVOLVED IN PARKINSON’S DISEASE BY MPTP TOXYCITY IN MACACA FASCICULARIS AND DRUG EFFECT
Brera Francesca, Gorini Antonella and Villa Roberto F.
Dipartimento di Scienze Fisiologiche-Farmacologiche Cellulari-Molecolari Sezione di Farmacologia e Biotecnologie Farmacologiche Piazza Botta, 11 - 27100 Pavia, Università degli Studi di Pavia

103. CYP 2E1 MUTANT MICE ARE RESISTANT TO DDC-INDUCED ENHANCEMENT OF MPTP TOXICITY
P. Sgadò, C. Viaggi, F. Vaglini, C. Pardini, A. Caramelli, G. U. Corsini
Department of Neuroscience, Section of Pharmacology, University of Pisa and Center of Excellence ‘AMBISEN’ for the study of Environmental Toxins and CNS Diseases, Pisa, Italy
(Abstract non disponibile su richiesta dell'autore)

104. BEHAVIOURAL CHARACTERIZATION OF ENGRAILED MUTANT MICE AS MODEL OF PARKINSON’S DISEASE
Pontis Silvia1, Pinna Annalisa2, Paola Sgadò3, Giovanni U. Corsini3 and Micaela Morelli1,2
1 Department of Toxicology, University of Cagliari, Italy. 2 CNR Institute for Neuroscience, Cagliari, Italy. 3 Department of Neuroscience, Pisa, Italy

105. LOW AND HIGH DYSKINETIC TREATMENTS INDUCE DIFFERENT MOTOR RESPONSES AND mRNA CHANGES IN CAUDATE-PUTAMEN IN THE 6-OHDA RAT MODEL OF PARKINSON’ S DISEASE
Frau Lucia 1, Carta Anna R. 1, Pinna Annalisa 2, Pontis Silvia 1 and Morelli Micaela 1,2.
1 Department of Toxicology, University of Cagliari. 2 CNR, Institute of Neuroscience, Cagliari

106. BLOCKADE OF PALLIDAL ADENOSINE A2A RECEPTORS POTENTIATES CONTRALATERAL ROTATIONAL BEHAVIOR INDUCED BY L-DOPA AND DOPAMINERGIC AGONISTS IN HEMIPARKINSONIAN RATS
Nicola Simola a, Sandro Fenu a, Pier G. Baraldi b, Mojgan A. Tabrizi b and Micaela Morelli a
aDepartment of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy; bDepartment of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy

107. ANALYSYS OF THE MPP+ UPTAKE IN MESENCEPHALIC CELL CULTURES FROM CYP 2E1 KNOCK-OUT MICE
Caramelli Andrea, Pardini Carla, Viaggi Cristina, Vaglini Francesca, Sgadò Paola,
Corsini Giovanni U.
Dip. di Neuroscienze Sez. Farmacol. Università di Pisa
(Abstract non disponibile su richiesta dell'autore)

108. EFFECTS OF DIRECT AND INDIRECT CANNABINOID RECEPTOR AGONISTS ON LEVODOPA-INDUCED DYSKINESIAS IN A RAT MODEL OF PARKINSON’S DISEASE
Maria Grazia Morgese1,3, Tommaso Cassano1, Luigia Trabace1, Vincenzo Cuomo2, Andrea Giuffrida3
1Department of Biomedical Sciences, University of Foggia, Italy; 2Department of Pharmacology and General Physiology, University of Rome, ‘La Sapienza’, Italy; 3Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas, U.S.A

109. THE NITRIC OXIDE-RELEASING DERIVATIVE OF FLURBIPROFEN HCT1026 DECREASES VULNERABILITY OF NIGROSTRIATAL DOPAMINERGIC NEURONS TO MPTP VIA A SWITCH OF GLIA PROINFLAMMATORY PHENOTYPE: IMPLICATIONS FOR TREATMENT OF PARKINSON’S DISEASE
Francesca L’Episcopo1, Nuccio Testa1, Salvo Caniglia1, Cataldo Tirolo1, Giovanna Giaquinta1, Paolo Arcieri1, Pier-Andrea Serra2, Gianfranco Bazzu2, Morale Maria C1, Francesco Impagnatiello3, Marchetti Bianca1,2
1Neuropharmacology, OASI Institute Researc and Care (IRCCS) Troina (EN), Italy and 2Department of Pharmacology, University of Sassari, Medical School, Sassari, Italy, and 3Nicox Research Institute, Bresso, Milano, Italy

110. NEUROINFLAMMATORY RESPONSE IN THE ACUTE MPTP RODENT MODEL OF PARKINSON’S DISEASE: TIME-DEPENDENT CORRELATION WITH HISTOPATHOLOGICAL, NEUROCHEMICAL AND BEHAVIORAL RESPONSE TO NIGROSTRIATAL INJURY AND REPAIR
Francesca L’Episcopo1, Giuliana Salani 2, Pier-Andrea Serra3, Salvo Caniglia1, Cataldo Tirolo1, Giovanna Giaquinta1, Nuccio Testa1, Gaia Rocchitta3, Giammario Calia3, Antonio Manca3, Maria C Morale1 Stefano Pluchino2, Gianvito Martino3, Bianca Marchetti1,2
1Neuropharmacology, OASI Institute for Research and Care (IRCCS) Troina (EN), Italy; 2Neuroimmunology Unit, Department of Neurology and Physiology, San Raffaele Scientific Institute, Milano, and 3Dept. Pharmacology, University of Sassari Medical School, Sassari, Italy

111. S100B PROTEIN PROMOTES TAU PROTEIN HYPERPHOSPHORILATION THROUGH DKK-1 PROTEIN UP-REGULATION AND RELATIVE WNT PATHWAY DISRUPTION IN CULTURED HUMAN NEURONS
Esposito Giuseppe 1, Scuderi Caterina 1, 4, De Filippis Daniele 2, Iuvone Teresa 2, Savani Claudia 1, 5, Lu Jie 3, Sheen Volney 3 and Steardo Luca 1
1 Department of Human Physiology and Pharmacology “Vittorio Erspamer”, University of Rome “La Sapienza” - 2 Department of Experimental Pharmacology, University of Naples Federico II.
3 Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
4 Department of Pharmacological Sciences, University of Palermo. 5 Department of Human Physiology and Pharmacology, University of Bari

112. AMYLOID PRECURSOR PROTEIN AND PRESENILIN1 INTERACT WITH THE ADAPTOR GRB2 AND MODULATE ERK1,2 SIGNALING
Mario Nizzari1, Valentina Venezia1, Emanuela Repetto1, Valentina Caorsi2, Raffaella Magrassi2, Maria Cristina Gagliani3, Tullio Florio1, Gennaro Schettini1, Carlo Tacchetti3, Tommaso Russo4, Alberto Diaspro2 and Claudio Russo5
1Dip. Oncologia, Biologia e Genetica, Università di Genova, 2 Dip. Fisica, Università di Genova, 3Dip.Medicina Sperimentale, Università di Genova, 4 Dip.Biochimica, Università di Napoli Federico II, 5Dip. Scienze per la Salute, Università del Molise

113. NITRIC OXIDE AND DOPAMINERGIC SYSTEM: NEUROCHEMICAL INTERACTIONS IN ß-AMYLOID INJECTED RATS
Schiavone Stefania (a), Lanni Cristina (b), Cuomo Vincenzo (c), Trabace Luigia(a), Govoni Stefano (b)
(a) Dept. Biomedical Sciences, University of Foggia, Foggia, Italy; (b) Dept. of Experimental and Applied Pharmacology, University of Pavia, Pavia, Italy; (c) Dept. of Human Physiology and Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy

114. ALTERATIONS OF TAU PROTEIN AND EFFECT OF LITHIUM SALTS TREATMENT ON TgCRND8 MICE
Rosi Maria Cristina, Grossi Cristina, Fiorentini Anna, Luccarini Ilaria and Casamenti Fiorella
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy

115. LONG-TERM TREATMENT WITH CHF5074, A NOVEL GAMMA-SECRETASE MODULATOR, MARKEDLY REDUCES BRAIN B-AMYLOID IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASE
Imbimbo Bruno P.1, Del Giudice Elda2, Miccichè Flavia2, Colavito Davide2, D'Arrigo Antonello2, Dalle Carbonare Maurizio2, Villetti Gino1, Facchinetti Fabrizio1, Volta Roberta1, Pietrini Vladimiro,3 Baroc Maria F.3, Leon Alberta2
1Research & Development, Chiesi Farmaceutici, Via Palermo 26/A, 43100 Parma; 2Research & Innovation, Via Svizzera 16, 35127 Padua; 3Department of Neurosciences, Neurology Section, University of Parma, 43100 Parma

116. ANGIOGENESIS IN NEURODEGENERATIVE PROCESSES: LOSS OF REGULATORY AB FUNCTION CONTRIBUTES TO ENDOTHELIAL DEGENERATION
Donnini Sandra, Cantara Silvia, Giachetti Antonio, Ziche Marina
Pharmacology Section, Dept. Molecular Biology, University of Siena, Italy

117. THE BH4 DOMAIN OF BCL-XL COUNTERACTS BETA AMYLOID PEPTIDE TOXICITY ON CAPILLARY ENDOTHELIUM
RAFFAELLA SOLITO, SANDRA DONNINI, SILVIA CANTARA, ANTONIO GIACHETTI, AND MARINA ZICHE
Section of Pharmacology, Department of Molecular Biology, University of Siena

118. MITOCHONDRIAL DYSFUNCTIONS IN A TRANSGENIC MURINE MODEL OF ALZHEIMER’S DISEASE
1Cassano Tommaso, 2Serviddio G., 2Bellanti F., 2Tamborra R., 1Macheda T., 1Morgese M.G., 1Trabace L., 3Oddo S., 3LaFerla F.M., 4Cuomo V. and 2Vendemiale G.
1Dept. of Biochemical Sciences Univ. of Foggia, Italy; 2Dept. of Medical and Occupational Sciences, Univ. of Foggia, Italy; 3Dept. of Neurobiology and Behavior, Univ. of California, Irvine, U.S.; 4Dept. of Human Physiology and Pharmacology, Univ. of Rome “La Sapienza”, Italy

119. GLIA MEDIATES NEUROPROTECTION BY ESTROGEN AGAINST ß-AMYLOID TOXICITY: EFFECT AMPLIFIED BY ESTROGEN RECEPTOR OVEREXPRESSION
CARBONARO VIVIANA1, FRASCA GIUSEPPINA1, MERLO SARA1, CARACI FILIPPO2, COPANI AGATA2, SORTINO MARIA ANGELA2
Departments of 1Experimental and Clinical Pharmacology and 2Pharmaceutical Sciences, University of Catania

120. CANNABIDIOL IN VIVO SUPPRESSES Aß INDUCED REACTIVE GLIOSIS
Scuderi Caterina 1,2, Esposito Giuseppe 1, Savani Claudia 1,4, De Filippis Daniele 2, Iuvone Teresa 2, Steardo Luca 1
1 Department of Human Physiology and Pharmacology “Vittorio Erspamer”, University of Rome “La Sapienza” - 2 Department of Pharmacological Sciences, University of Palermo. 3 Department of Experimental Pharmacology, University of Naples Federico II. 4 Department of Human Physiology and Pharmacology, University of Bari

121. IN VIVO CHARACTERIZATION OF DKK-1 EXPRESSION IN TRANSGENIC ANIMAL MODELS OF ALZHEIMER’S DISEASE
Fiorentini Anna, Rosi Maria Cristina, Luccarini Ilaria, Grossi Cristina and Casamenti Fiorella
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy

122. IN VIVO EFFECT OF CLIOQUINOL TREATMENT IN A MOUSE MODEL OF ALZHEIMER’S DISEASE
Grossi Cristina, Rosi Maria Cristina, Fiorentini Anna, Luccarini Ilaria and Casamenti Fiorella
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy

123. LONG-TERM TREATMENT WITH A NEW ANTI-OLIGOMERIC B-AMYLOID VACCINE MARKEDLY REDUCES BRAIN B-AMYLOID LOAD IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASE
Imbimbo Bruno P.1, Pietrini Vladimiro,2 Baroc Maria F.2, Del Giudice Elda3, Miccichè Flavia3, Colavito Davide3, D'Arrigo Antonello3, Dalle Carbonare Maurizio3, Leon Alberta3, Villetti Gino1, Facchinetti Fabrizio1, Moretto Nadia4, Ottonello Simone4
1Chiesi Farmaceutici, Via Palermo 26/A, Parma; 2Department of Neurosciences, University of Parma, Parma; 3Research & Innovation, Via Svizzera 16, Padua; 4Department of Biochemistry and Molecular Biology, University of Parma, Viale G.P. Usberti 23/A, Parma

124. DISCOVERY OF A SERIES OF MOLECULES ACTING AS POTENT ALPHA7 NACHR AGONISTS WITH PRO-COGNITIVE AND NEUROPROTECTIVE PROPERTIES
C. SCALI1, M. GIANFRIDDO1, H. BOTHMANN1 , E. DIODATO1 , U. ZANELLI1, A. CARICASOLE1, G. GAVIRAGHI1, J. DUNLOP2, R. RONCARATI1, and G. C. TERSTAPPEN1
1Siena Biotech SpA, Siena, ITALY, 2 Wyeth Research, Princeton, NJ, USA

125. PERIAQUEDUCTAL GREY METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 7 AND 8 SHOW OPPOSITE ACTIONS ON AMINO ACID RELEASE, NOCICEPTIVE BEHAVIOUR AND ROSTRAL VENTROMEDIAL MEDULLA ON AND OFF CELL ACTIVITY
Marabese Ida, Rossi Francesca, Palazzo Enza, Vita Daniela, Maria Antonietta Scafuro, de Novellis Vito, Maione Sabatino
Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, The Second University of Naples, via Costantinopoli 16, 80138 Naples

126. ROLE OF THE TYPE 2 AND 3 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN MUSCARINIC ANTINOCICEPTION IN MICE
VIVOLI E, GALEOTTI N., NORCINI M., GHELARDINI, C., BARTOLINI A.
Department of Pharmacology – Viale G. Pieraccini, 6, 50139 – Florence

127. INVOLVEMENT OF TYPE 1 AND 3 RYANODINE RECEPTOR IN MOUSE MUSCARINIC ANTINOCICEPTION
NORCINI M., GALEOTTI N., VIVOLI E., GHELARDINI, C., BARTOLINI A.
Department of Pharmacology – Viale G. Pieraccini, 6, 50139 – Florence

128. DETECTION AND QUANTIFICATION OF ENDOGENOUS N/OFQ IN THE RAT CEREBROSPINAL FLUID, UNDER BASAL AND STIMULATED CONDITIONS
Lopetuso Giuseppe, Romualdi Patrizia, Candeletti Sanzio
Dip. Farmacologia - Università degli Studi di Bologna

129. IMPAIRED NOCICEPTION IN MICE LACKING THE PROKINETICIN RECEPTOR 2 (PKR2)
Lattanzi Roberta, Giannini Elisa, Melchiorri Pietro and Negri Lucia
Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy

130. THE CENTRAL ANTINOCICEPTIVE EFFECT OF N-ARACHIDONOYL-PHENOLAMINE (AM404): IMPLICATION OF OPIOIDERGIC AND SEROTONERGIC SYSTEMS
Ruggieri Valentina a, Vitale Giovanni a, Pini Luigi A. b and Sandrini Maurizio a
a Sect. of Pharmacology, Dept. of Biomedical Sciences, University of Modena and Reggio E. b Clinical Pharmacology Unit, University of Modena and Reggio E

131. 2-CHLORO-2’-C-METHYL-N6-CYCLOPENTYLADENOSINE, A HIGHLY SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, HAS ANTINOCICEPTIVE ACTIVITY IN THE RAT
Gatta Luisa, Palazzo Enza, de Novellis Vito, Rossi Francesco, Daniela Vita, Maione Sabatino
Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, The Second University of Naples, via Costantinopoli 16, 80138 Naples

132. 2-CHLORO-2’-C-METHYL-N6-CYCLOPENTYLADENOSINE, A HIGHLY SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, MODULATES THE ONGOING AND TAIL FLICK –RELATED ACTIVITY OF RVM ON AND OFF CELLS
Guida Francesca, Rossi Francesca, Vita Daniela, Marabese Ida, de NovellisVito, Maione Sabatino
Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, The Second University of Naples, via Costantinopoli 16, 80138 Naples

133. NGF-INDUCED NEURITE OUTGROWTH INHIBITION AND PAIN CONTROL
Restivo Alessandra, Salvati P. and Caccia C.,
Discovery, Newron Pharmaceuticals SpA, Bresso (MI), Italy

134. ANALGESIC EFFECTS OF NEW PIRIDAZIONE DERIVATIVES
Pieretti Stefano1, Colucci Mariantonella1, Di Giannuario Amalia1, Francesco Maione1,2, Giovannoni Maria Paola 3, Biancalani Claudio 3 and Dal Piaz Vittorio 3
1Department of Drug Research and Evaluation, Italian National Institute of Health, Rome; 2Department of Experimental Pharmacology, University of Naples, “Federico II”; 3Department of Pharmaceutical Sciences, University of Florence

135. THE PROTECTIVE EFFECT OF OLIVE OIL PHENOLS HYDROXYTYROSOL AND OLEUROPEIN ON MORPHINE TOLERANCE
Carolina Muscoli1,2, A Procopio1, D. Ventrice1, M. Oliverio1, M. Arbitrio3, M. Rizzo1, N. Costa1, R. Arcone1, S. Giovanni4, D. Rotiroti1, G. Nistico’5, Daniela Salvemini6 and Vincenzo Mollace1
1Dept. of Pharmacobiol. Sciences, University of Catanzaro Magna Graecia, Italy; 2San Raffaele Pisana IRCCS, Rome, Italy; 3 ISN-CNR; 4 Dept. of Chemistry, University of Calabria, Italy; 5Dept. of Biology, Univerity of “Tor Vergata”, Italy; 6 Dept. of Int. Med, Division of Pulmonary, Critical Care and Sleep Medicine, Saint Louis University, St Louis, USA

136. NEUROPEPTIDE S STIMULATES LOCOMOTOR ACTIVITY AND WAKEFULNESS AND EVOKES ANXIOLYTIC-LIKE EFFECTS IN MICE
1Vergura Raffaella, 1Rizzi Anna, 1Marzola Giuliano, 2Guerrini Remo, 2Salvadori Severo, 1Regoli Domenico and 1Calo’ Girolamo.
1Dept. of Pharmacology and 2Dept of Pharmaceutical Science, University of Ferrara, Italy

137. REPEATED RESTRAINT STRESS AND ANXIOLYTIC DRUGS DIFFERENTIALLY MODULATE LATENT INHIBITION IN C57BL6 MICE
Stefania Marcello a, Raymond Mongeau b, Jacob Sparre Andersen c, Luca Pani d,a
a Neuroscienze Pharmaness S.c.a.r.l., Cagliari. b NeuroPsychoPharmacologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France. c Tofla Teld, Copenhagen, Denmark. d Istitute of Biomedical Technologies, C.N.R., Milano

138. CENTRAL ADMINISTRATION OF NEUROPEPTIDE S (NPS) INHIBITS PALATABLE FOOD INTAKE IN THE RAT
Fedeli Amalia, Economidou Daina, Braconi Simone, Cippitelli Andrea, Massi Maurizio, Ciccocioppo Roberto
Department of Experimental Medicine and Public Health, University of Camerino, Italy

139. QUINPIROLE-INDUCED COMPULSIVE DRINKING IN RATS IS INFLUENCED BY MANIPULATION OF BEHAVIORAL COST
Milella Michele S., Amato Davide, Badiani Aldo, Nencini Paolo
Department of Human Phisiology and Pharmachology, University of Rome Sapienza

140. DISTURBANCES OF EATING BEHAVIOR DURING WORKPLACE SUFFERING
W. Milano, C. Petrella, A. Capasso*.
Mental Health Operations Unit District 44 ASL Napoli 1 and *Department of Pharmaceutical Sciences, University of Salerno, Italy

141. EFFECTS OF SYSTEMIC MPTP ADMINISTRATION ON BEHAVIOR AND DOPAMINE CHANGES IN DIALYSATE FROM THE STRIATUM OF FREELY MOVING MICE
Antonio Manca a, Gianfranco Bazzua, Giammario Calia a, Giulia Puggioni a, Gaia Rocchitta a, Sonia Dedola a, Rossana Mighelia, Pier Andrea Serra a
a Department of Pharmacology, Medical School, University of Sassari, Viale S. Pietro 43/b, 07100, Sassari, Italy

142. ROLE OF DOPAMINE D2-LIKE RECEPTORS IN THE MICROSTRUCTURE OF LICKING FOR WATER AND SODIUM CHLORIDE SOLUTIONS IN WATER DEPRIVED RATS
Paolo S. D'Aquila, Davide Carta, Maria G. Casula, Bonaria Dore, Emanuele Murgia, Gino Serra
Department of Drug Sciences, University of Sassari, Sassari, Italy

143. SINGLE, INTENSE PRENATAL STRESS CAN DIFFERENTLY AFFECT EMOTIONAL BEHAVIOUR ACCORDING TO THE NATURE OF THE TASK. INFLUENCE OF METYRAPONE
Noto Giovanna, Plescia Fulvio, Cannizzaro Emanuele, Gagliano Mauro., Provenzano Giuseppa Maria and Cannizzaro Carla
Department of Pharmacological Sciences, University of Palermo, Italy

144. MANIPULATIONS OF GLUCOCORTICOID INDUCED STRESS RESPONSE MAY DIFFERENTLY AFFECT THE ACQUISITION OF A REWARD-FACILITATED SPATIAL/VISUAL LEARNING TASK
Barrile Vita, Plescia Fulvio, Cannizzaro Gaspare, La Barbera Marco, Mantia Giacoma and Cannizzaro Carla
Department of Pharmacological Sciences, University of Palermo

145. BEHAVIOURAL EFFECTS INDUCED BY CHRONIC TREATMENT WITH EPIGALLOCATECHIN GALLATE (EGCG), THE MAJOR CATECHIN OF GREEN TEA, IN SPONTANEOUSLY HYPERTENSIVE RAT (SHR)
LEMOLI Mariangela, MONTAGNANI Monica and DE SALVIA Maria Antonietta
Dept. Pharmacology and Human Physiology, Medical School, University of Bari, Piazza G. Cesare, 70124 Bari, Italy

146. IMPACT OF ANTIPSYCHOTIC TREATMENTS OF BEHAVIORAL ALTERATIONS INDUCED BY PARADOXICAL SLEEP DEPRIVATION
Frau Roberto1, Orrù Marco1, Mereu Giampaolo3, Gessa Gian Luigi1, Marrosu Francesco2 Bortolato Marco2
1Dept. of Neuroscience “Bernard B. Brodie”. University of Cagliari, Cagliari, Italy
2Dept. of Cardiovascular and Neurological Science. University of Cagliari, Cagliari, Italy
3Dept. of Experimental Biology “B. Loddo”. University of Cagliari, Cagliari, Italy

147. ROLE OF GABAB RECEPTORS IN THE BALANCE OF EPILEPTIC AND PSYCHOTIC-LIKE PHENOMENA IN DBA/2J MICE
Bortolato Marco1, Frau Roberto2, Orrù Marco2, Piras Anna Paola2, Gessa Gian Luigi2, Castelli Maria Paola2, Mereu Giampaolo3, Marrosu Francesco1
1Dept. of Cardiovascular and Neurological Science. University of Cagliari, Cagliari, Italy
2Dept. of Neuroscience “Bernard B. Brodie”. University of Cagliari, Cagliari, Italy
3Dept. of Experimental Biology “B.Loddo”. University of Cagliari, Cagliari, Italy

148. TRAINING-ASSOCIATED EMOTIONAL AROUSAL DIFFERENTIALLY MODULATES CANNABINOID EFFECTS ON OBJECT RECOGNITION MEMORY
Patrizia Campolongo1-2, Sergio Scaccianoce1, Antonella Modafferi1, Viviana Trezza1, Benno Roozendaal3, Gustav Schelling4, James L McGaugh3 and Vincenzo Cuomo1
1Dept. of Human Physiology and Pharmacology, Univ. of Rome “La Sapienza”, Rome, Italy;
2Dept. of Biochemical Sciences, Univ. of Foggia, Foggia, Italy; 3Center for the Neurobiology of Learning and Memory, Univ. of California, Irvine, USA; 4Dept. of Anaesthesiology, Ludwig-Maximilians-University, Munich, Germany

149. GENDER-RELATED EFFECTS OF PREGS ON EMOTIONALITY, LEARNING AND MEMORY PERFORMANCE IN ADULT RATS
Diliberto Irene, Plescia Fulvio, Cannizzaro Gaspare, Mantia Giacoma, Provenzano Giuseppa Maria and Cannizzaro Carla
Department of Pharmacological Sciences, University of Palermo

150. USE OF ENERGY DRINKS IN ASSOCIATION WITH ALCOHOLIC BEVERAGES IN A COHORT OF STUDENTS OF THE SCHOOL OF MEDICINE OF THE UNIVERSITY OF MESSINA
Oteri A, Salvo F, Caputi AP, Calapai G
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina

151. GAMMA HYDROXYBUTIRATE (GHB) MODULATES NPY – Y1 RECEPTOR SIGNALLING IN THE AMYGDALA OF TRANSGENIC MICE THROUGH GABAB RECEPTOR IN A NEUROSTEROIDS INDEPENDENT MANNER
Mele P. a, Serra M. b,c,d, Pisu M.G. b,d, Eva C. a, Biggio G b,c,d.
a Dep. Of Anatomy, Pharmacology and Forensic Medicine, Section of Pharmacology, University of Turin, Italy. b Dep. of Experimental Biology, Sec. of Neuroscience, University of Cagliari, Cagliari, Italy. c Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy. d C.N.R. Institute of Neuroscience, Cagliari, Italy

152. MAPPING BRAIN ACTIVITY FOLLOWING GAMMA-HYDROXYBUTYRIC ACID ADMINISTRATION USING FUNCTIONAL MAGNETIC RESONANCE IMAGING IN RATS
Muntoni Anna Lisa1, Lu Hanbing2, Scholl Clara A.2, Pistis Marco3, Stein Elliot A.2
1CNR Institute of Neuroscience and 3Department of Neuroscience, University of Cagliari, Italy
2Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, USA

153. ENDOCANNABINOID SYSTEM AND NICOTINE WITHDRAWAL SIGNS IN MICE
Mannucci Carmen a, Pieratti Antonella a, Russo Giuseppina a, Caputi Achille P. a, Calapai Gioacchino a
a Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, School of Medicine, University of Messina, Italy

154. SMOKING CESSATION AFTER THE INTRODUCTION OF THE LAW BANNING SMOKING IN PUBLIC PLACES IN ITALY: A ONE-YEAR FOLLOW-UP STUDY
Maria Caterina Grassi*, Domenico Enea**, Paolo Nencini*
*Department of Human Physiology and Pharmacology “V. Erspamer”. **Centro Policlinico Senza Fumo, “Sapienza” University of Rome, Italy

155. SMOKING CESSATION AND BODY WEIGHT
Maria Caterina Grassi*, Domenico Enea**, Rosanna Marchetti**, Flavia Temperilli***, Francesca Villarosa***, Paolo Nencini *, Massimo Cuzzolaro ***
*Department of Human Physiology “V.Erspamer”, **Centro Policlinico Senza Fumo, ***Department of Clinical Medicine, “Sapienza” University of Rome, Italy

156. PRELIMINARY RESULTS IN PIVOTAL STUDY ON BIOMARKERS RELATED TO SMOKING HABITS
Gioacchino Calapai a, Stefania Morandi b, Carmen Mannucci a, Alfredo Nunziata b, Achille Caputi a e Antonella Bassi b
a Department of Clinical and Experimental Medicine and Pharmacology, University of Messina - b BAT Italia S.p.A. R&D Via Amsterdam147, Rome

157. ALTERED EXPRESSION OF METABOTROPIC GLUTAMATE RECEPTORS IN THE NUCLEUS ACCUMBENS DURING OPIATE DEPENDENCE AND WITHDRAWAL IN THE RAT
Modafferi Antonella M.E1., Diana Marco2, Scaccianoce Sergio1
1Dept. of Human Physiology and Pharmacology - University of Rome La Sapienza; 2 Dept. of Drug Sciences - University of Sassari

158. TIME-DEPENDENT MORPHOLOGICAL AND BIOCHEMICAL CHANGES DURING MORPHINE WITHDRAWAL IN THE RAT NUCLEUS ACCUMBENS
Vinci Stefania1, Marinelli Angela2, Olla Alessia2, Ibba Federico1, Diana Marco3, Spiga Saturnino2, Acquas Elio1,4
1Department of Toxicology and 4Centre of Excellence on Neurobiology of Addiction, University of Cagliari; 2 Department of Animal Biology and Ecology, University of Cagliari; 3Department of Drug Sciences , University of Sassari

159. RECIPROCAL EFFECTS OF RESPONSE CONTINGENT AND NON-CONTINGENT INTRAVENOUS HEROIN ON IN VIVO NUCLEUS ACCUMBENS SHELL VERSUS CORE DOPAMINE: A REPEATED SAMPLING MICRODIALYSIS STUDY
Cacciapaglia1 Fabio, Lecca Daniele1,2, Valentini Valentina1,2 and Di Chiara Gaetano1,2,3
1Department of Toxicology, 2Centre of Excellence for Studies on Addictions and 3Institute of Neuroscience, Consiglio Nazionale delle Ricerche (CNR), University of Cagliari, Italy

160. ROLE OF DOPAMINE D1 RECEPTOR IN MORPHINE- AND LITHIUM-INDUCED CONDITIONED SACCHARIN AVOIDANCE
Nicola Simola, Sandro Fenu, Emilia Rivas and Gaetano Di Chiara
Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy

161. DISSOCIATION IN THE MODULATORY EFFECTS OF ENVIRONMENT ON HEROIN-INDUCED PSYCHOMOTOR SENSITIZATION VS. HEROIN SELF-ADMINISTRATION
Michele Celentano, Daniele Caprioli, Paolo Nencini, Aldo Badiani
Department of Human Physiology and Pharmacology, University of Rome Sapienza

162. METHADONE AND BUPRENORPHINE MAINTENANCE EFFECTS ON IMMUNE SYSTEM FUNCTION: COMPARISON WITH UNTREATED HEROIN ADDICTCS
Somaini Lorenzo1, Franchi Silvia2, Leccese Vincenzo1, Gerra Gilberto3, Panerai Alberto E2, Sacerdote Paola2
1 Addiction Treatment Centre, Health Local Unit ASL 12 Biella. 2 Department of Pharmacology, via Vanvitelli 32, 20129 Milano. 3 Health Local Unit AUSL Parma

163. THE ROLE OF LIVER CYTOCHROME ISOFORMS ON BUPRENORPHINE METABOLISM AND IT’S CLINICAL RELEVANCE
Somaini Lorenzo1, Gola Mauro2
1 Addiction Treatment Centre, Health Local Unit ASL 12 Biella. 2 Laboratory of Pharmacogenetics Lugano (CH)

164. ANABOLIC ANDROGENIC STEROIDS INFLUENCE THE EXPRESSION OF BRAIN NERVE GROWTH FACTOR IN THE RAT
Carretta Maria Teresa*, D’Amico Danilo*, Pace Stefania, Modafferi Antonella M.E., Salemi Marisa, Togna Giuseppina I., Scaccianoce Sergio
Dept. of Human Physiology and Pharmacology - University of Rome La Sapienza

165. NANOMOLAR CONCENTRATIONS OF ANABOLIC-ANDROGENIC STEROIDS AMPLIFY EXCITOTOXIC NEURONAL DEATH IN MIXED MOUSE CORTICAL CULTURES
Rosamaria Orlando1*, Alessandra Caruso1*, Gemma Molinaro2, Marta Motolese1, Francesco Matrisciano 1, Giuseppina Togna1, Daniela Melchiorri1, Ferdinando Nicoletti1,2 and Valeria Bruno1,2
1Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy; 2Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Rome, Italy

166. EFFECT OF NANDROLONE AND STANOZOLOL ON PRO-INFLAMMATORY CYTOKINE PRODUCTION BY HUMAN MACROPHAGES
Trefiletti Giuliana*, Togna Anna Rita*, Pacifici Roberta**, Bacosi Antonella**, Di Carlo Simonetta** and Togna Giuseppina I.*
* Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”
** Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome

167. THE K-OPIOID RECEPTOR AGONIST U-69593 PREVENTS COCAINE-INDUCED DARPP-32 PHOSPHORYLATION AT THR34 IN THE RAT BRAIN
D'Addario C, Di Benedetto M, Candeletti S, Romualdi P
Dept of Pharmacology - University of Bologna - via Irnerio 48, 40126 BOLOGNA

168. FACILITATION OF CONDITIONED REINSTATEMENT OF COCAINE-SEEKING FOLLOWING CENTRAL ADMINISTRATION OF NEUROPEPTIDE S
Marsida Kallupi, Daina Economidou, Nazzareno Cannella, Serena Stopponi, Roberto Ciccocioppo
Department of Experimental Medicine and Public Health, University of Camerino, Italy

169. ENVIRONMENTAL MODULATION OF COCAINE AND AMPHETAMINE SELF ADMINISTRATION
Daniele Caprioli, Michele Celentano, Paolo Nencini, Aldo Badiani
Department of Human Physiology and Pharmacology, University of Rome La Sapienza

170. INCREASED TOXICITY OF COCAINE ADULTERATED WITH ATROPINE: EFFICACY OF DIAZEPAM
Zani Alessia, Braida Daniela, Rossoni Giuseppe, Gori Enzoa, CapurroValeria, Sala Mariaelvina
Department of Pharmacology, Chemotherapy and Medical Toxicology, and a Behavioural Pharmacology and Drug Dependence Center, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy

171. ROLE OF CREB IN THE PRODYNORPHIN GENE EXPRESSION REGULATION BY MDMA
Di Benedetto M, Porticella E, D´Addario C, Candeletti S, Romualdi P
Dept of Pharmacology - University of Bologna - via Irnerio 48, 40126 BOLOGNA

172. 3,4-METHYLENDIOXYMETHAMPHETAMINE (ECSTASY) INDUCES FORMATION OF REACTIVE OXYGEN SPECIES AND TAU PROTEIN PHOSPHORYLATION IN THE HIPPOCAMPUS
Carla L. Busceti1, Francesca Biagioni1, Barbara Riozzi1, Marianna Storto1, Giuseppe Battaglia1, Francesco Fornai1,3, Valeria Bruno1,5, Ferdinando Nicoletti1,5
1I.N.M. Neuromed, Pozzilli, Italy; 2Dept. of Neuropathol., Univ. of Amsterdam, The Netherland; 3Dept. of Hum. Morphol. and Applied Biol., Univ. of Pisa, Italy; 4SienaBiotech, Siena, Italy; 5Dept. of Hum. Physiol. and Pharmacol., Univ. “La Sapienza”, Rome, Italy

173. PHARMACOLOGICAL AND TOXICOLOGICAL PROPERTIES OF SMART DRUGS
Oteri A a, Calapai G a, Pichini S b, Zuccaro P b, Palmi I b, Caputi AP a,c
aDepartment of Clinical and Experimental Medicine and Pharmacology, University of Messina. bIstituto Superiore di Sanità, Rome. cIRCCS Centro Neurolesi ‘‘Bonino-Pulejo’’, Messina, Italy

174. INHIBITORY MODULATION OF THE NON-ADRENERGIC NON-CHOLINERGIC RELAXATION OF THE RAT GASTRIC FUNDUS BY NOCICEPTIN/ORPHANIN FQ AND RELATED PEPTIDES
Currò D., De Marco T., Martucci D. and Preziosi P.
Institute of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
(Abstract non disponibile su richiesta del'autore)

175. NOCICEPTIN/ORPHANIN FQ PREVENTS GASTRIC DAMAGE INDUCED BY ACUTE STRESS IN THE RAT BY ACTING IN THE PERIPHERY
Giuseppina MORINI a, Daniela GRANDI a, Elvira SOLENGHI a, Remo GUERRINI b, Carlo POLIDORI c & Maurizio MASSI c
aDepartment of Human Anatomy, Pharmacology and Forensic Medicine, University of Parma, PARMA; bDepartment of Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, FERRARA; cDepartment of Experimental Medicine and Public Health, University of Camerino, CAMERINO

176. GASTROPROTECTIVE EFFECTS OF THE SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS METHIMEPIP AND IMMETHRIDINE
1Adami Maristella, 1Guaita Elena, 2de Esch Iwan JP, 2Leurs Rob, 3Stark Holger and 1Coruzzi Gabriella
1Department of Human Anatomy, Pharmacology and Forensic Medicine, University of Parma, Italy; 2LACDR, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, The Netherlands; 3Institut für Pharmazeutische Chemie, J W Goethe-Universität, Frankfurt, Germany

177. THE GASTRIC EFFECTS OF UFP 112, A NEW NOP RECEPTOR AGONIST, IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS
Petrella Carla a, Agostini S. a, Broccardo M.a, Guerrini R. b, Improta G. a , Morini G. c
a Dept. Human Physiology and Pharmacology University of Rome “La Sapienza”, b Dept. Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, c Dept. of Human Anatomy, Pharmacology and Forensis Medicine, University of Parma –ITALY

178. EFFECTS OF CYCLOOXYGENASE INHIBITORS ON MOLECULAR MECHANISMS IMPLICATED IN GASTRIC ULCER HEALING
Colucci Rocchina1, Ghisu Narcisa1, Antonioli Luca1, Fornai Matteo1, Bernardini Nunzia2, Ippolito Chiara2, Natale Gianfranco2, Del Tacca Mario1, Blandizzi Corrado 1
1Division of Pharmacology and Chemotherapy, Department of Internal Medicine, 2Department of Human Morphology and Applied Biology, University of Pisa, Italy

179. DUAL EFFECTS OF TICLOPIDINE DURING FORMATION AND HEALING OF ETHANOL-INDUCED GASTRIC LESIONS IN THE RAT: COMPARISON WITH ASPIRIN
D. Rapetti1, F. Guidobono2, A. Soglian3, V. Locatelli1, V. De Luca2, V. Sibilia2
1Department of Experimental Medicine, University of Milano- Bicocca, Monza, Italy
2Department of Pharmacology, Chemotherapy and Medical Tossicology, University of Milan, Italy
3Medical Department, Pharmaceutical Division, Bayer HealthCare, Milan, Italy

180. INVOLVEMENT OF PKC IN THE ADAPTIVE CHANGES OF OPIOID RECEPTORS IN THE MYENTERIC PLEXUS AFTER CHRONIC SYMPATHETIC DENERVATION
1Zanetti Elena, 1Oldrini Rita, 2Pascale Alessia, 1Canciani Luca, 1Giuliani Daniela, 2Amadio Marialaura, 3Chiaravalli Annamaria, 1Giaroni Cristina, 1Lecchini Sergio, 1Frigo Gianmario.
1Clinical and Applied Pharmacology Interuniversity Centre, University of Insubria and University of Pavia; 2Experimental and Applied Pharmacology Dept, University of Pavia; 3Dept. of Surgical Pathology Ospedale di Circolo of Varese

181. ALTERED EXPRESSION AND PHOSPHORYLATION OF NMDA NR1 SUBUNITS IN THE MYENTERIC PLEXUS DURING HYPOXIA-HYPOGLICAEMIA
1Giaroni Cristina, 1Zanetti Elena, 1Giuliani Daniela, 1Oldrini Rita, 1Bianchi Francesca, 1Moro Elisabetta, 2Trinchera Marco, 1Crema Francesca, 1Lecchini Sergio, 1Frigo Gianmario
1Clinical and Applied Pharmacology Interuniversity Centre, Universities of Insubria and Pavia, 2Department of Experimental and Clinical Biomedical Sciences, University of Insubria

182. MELATONIN REVERSES LPS-INDUCED GASTRO-INTESTINAL MOTILITY DISTURBANCES THROUGH THE INHIBITION OF OXIDATIVE STRESS
De Filippis Daniele1, Esposito G3, D’Amico A1, De Man JG2, De Winter BY2, Steardo L3, Iuvone T1
1Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. 2Division of Gastroenterology, Faculty of Medicine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium. 3Department of Human Physiology and Pharmacology “Vittorio Erspamer”Faculty of Pharmacy University of Rome “La Sapienza” Piazza A. Moro 5, 00151 Roma (Italy)

183. THE CANNABINOID WIN 55212 INHIBITS PANCREATIC AMYLASE SECRETION VIA CHOLINERGIC SUPPRESSION
Agostini Simona, Broccardo M., Improta G., Petrella C., Linari G.
Dept. of Human Physiology and Pharmacology. University “La Sapienza”, Rome

184. SERA OF CELIAC PATIENTS WITH NEUROLOGICAL DISORDERS EVOKE A MITOCHONDRIAL-DEPENDENT APOPTOSIS IN HUMAN SH-Sy5Y NEUROBLASTOMA CELLS
Cervio Elisabetta*, Volta Umberto°, Verri Manuela*, Boschi Federica*, Pastoris Ornella*, Granito Alessandro°, De Giorgio Roberto ^, Tonini Marcello *
*Dept of Phys & Pharm Sci, Univ Pavia; Dept of °Int Med, Cardioangiol, Hepatol & ^Int Med & Gastroenterol, Univ of Bologna, Italy

185. EXPRESSION AND function OF THE BRADYKININ B1 RECEPTOR IN NORMAL AND INFLAMED HUMAN GALLBLADDER
Eunice Andre1, David Gazzieri1, Elisabetta Bardella1, Juliano Ferreira3, Marcelo A. Mori4, Michael Bader4, João B.Calixto5, Roberto De Giorgio6, Roberto Corinaldesi6, Pierangelo Geppetti1 and Marcello Trevisani1
1Pharmacology Unit, University of Ferrara, 3Dep. of Chemistry, Universidade Federal de Santa Maria, 4Max Delbrück Center for Molecular Medicine, Berlin-Buch, 5Dep. of Pharmacology, Universidade Federal de Santa Catarina, Florianópolis, 6 Dep. Int. Med. and Gastroent., University of Bologna

186. A COMMUNITY PHARMACIES SURVEY ON PREVALENCE OF CONSTIPATION AND RISK FACTORS FOR LAXATIVE USE IN THE LOCAL HEALTH DISTRICTS OF VERBANIA AND MESSINA
Ilaria Morreale (1), Francesco Salvo (1), Giovanni Polimeni (1), Ilaria Morreale (1), Elena Vighi (2), Laura Poggi (2), Giuliana Dossi (2), Alfina Rossitto (3), Angelina De Sarro (1), Gioacchino Calapai (1), Achille Patrizio Caputi (1)
(1) Dep. Clin Experim Med and Pharmacol, University of Messina, Italy. (2) Local Health District N. 14 (Verbano/Cusino/Ossola), Verbania, Italy

187. EXENATIDE ACHIEVED EQUIVALENT GLYCEMIC CONTROL TO INSULIN GLARGINE WITH WEIGHT REDUCTION, INDEPENDENTLY FROM BASELINE BMI, IN METFORMIN AND SULFONYLUREA-TREATED TYPE-2 DIABETES
Heine Robert J.1; Van Gaal Luc F.2; Johns Don3; Mihm Michael J. 3; Gentilella Raffaella 4; Widel Mario H. 3; Brodows Robert G.3
1 Diabetes Center, Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands; 2 Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, Belgium; 3Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA; 4Eli Lilly Italy, Florence, Italy

188. EFFECTS OF EXENATIDE COMPARED WITH TWICE-DAILY BIPHASIC INSULIN ASPART IN PATIENTS WITH TYPE 2 DIABETES USING METFORMIN AND A SULPHONYLUREA
Nauck Michael A. 1, Duran Garcia Santiago 2, Kim Dennis 3, Johns Don 4, Gentilella Raffaella 5, Festa Andreas 4, Trautmann Michael 4
1 Clinical Diabetology, Diabeteszentrum Bad Lauterberg, Germany, 2 Cátedra de Endocrinología, Hospital de Valme, Seville, Spain, 3 Amylin Pharmaceuticals, Inc., San Diego, United States, 4 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, United States; 5 Eli Lilly Italy, Florence, Italy

189. A COMPARISON OF EXENATIDE AND INSULIN GLARGINE IN PATIENTS USING A SINGLE ORAL ANTIDIABETIC AGENT
Barnett Anthony H. 1, Trautmann Michael 2, Burger Jude 3, Johns Don 3, Kim Dennis 4, Brodows Robert 3, Gentilella Raffaella 5, Festa Andreas 2, Roberts Anthony 2
1 Department of Diabetes/Endocrinology, Birmingham Heartlands Hospital, United Kingdom, 2 Eli Lilly and Company, Hamburg, Germany, 3 Eli Lilly and Company, Indianapolis, United States, 4 Amylin Pharmaceuticals, Inc., San Diego, United States; 5 Eli Lilly Italy, Florence, Italy

190. SAFETY AND EFFICACY OF EXENATIDE OVER 16 WEEKS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS USING A THIAZOLIDINEDIONE WITH OR WITHOUT METFORMIN
Zinman Bernard 1, Hoogwerf Byron 2, Duran Garcia Santiago 3, Milton Denai 4, Giaconia Joseph 4, Kim Dennis 5, Gentilella Raffaella 6, Trautmann Michael 7, Brodows Robert 4
1 Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada, 2 Department of Endocrinology, Cleveland Clinic Foundation, Cleveland, USA, 3 Cátedra de Endocrinología, Hospital de Valme, Sevilla, Spain, 4 Eli Lilly and Company, Indianapolis, USA, 5 Amylin Pharmaceuticals, Inc., San Diego, USA, 6 Eli Lilly Italy, Florence, Italy, 7 Eli Lilly and Company, Hamburg, Germany

191. BETA-CELL FUNCTION IS MARKEDLY REDUCED IN WOMEN WITH PREVIOUS GESTATIONAL DIABETES
Canu Silvia1, Franconi Flavia1, Tesi Federica2, Seghieri Giuseppe2
1Dpt. of Pharmacology, University of Sassari, Italy. 2Dpt. of Internal Medicine, Spedali Riuniti, Pistoia
(Abstract non disponibile su richiesta del'autore)

192. CONCENTRATION OF BRAIN NATRIURETIC PEPTIDE IN WOMEN WITH GESTATIONAL DIABETES
2Campesi Ilaria, 1Tesi Federica, 1Gironi Alfredo, 2Canu Silvia, 2De Bellis Alessandra, 1Anichini Roberto, 1Seghieri Giuseppe, 2Franconi Flavia
1Dpt. of Internal Medicine, Spedali Riuniti, Pistoia, 2Dpt. of Pharmacology, University of Sassari, Italy

(Abstract non disponibile su richiesta del'autore)

193. BIOCHEMICAL MECHANISMS UNDERLYING ENDOCANNABINOID DYSREGULATION IN THE PANCREAS AND ADIPOSE TISSUE OF HIGH FAT DIET-FED MICE
Isabelle Matias1, Katarzyna Starowicz1, Luigia Cristino2, Alessandro Racioppi1
and Vincenzo Di Marzo1
1,2Endocannabinoid Research Group, 1Institute of Biomolecular Chemistry and 2Institute of Cybernetics, Consiglio Nazionale delle Ricerche, Pozzuoli (NA), Italy

194. GHRELIN AND DES-ACYL GHRELIN INHIBIT ISOPROTERENOL-INDUCED LIPOLYSIS IN RAT ADIPOCYTES THROUGH ACTIVATION OF PHOSPHODIESTERASE 3B
Baragli Alessandra, Ghè Corrado, Arnoletti Elisa, Muccioli Giampiero
Division of Pharmacology, Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy

195. PHARMACOLOGICAL MODULATION OF METABOLIC, HORMONAL, AND INFLAMMATORY ALTERATIONS IN AN EXPERIMENTAL MODEL OF HEPATIC STEATOSIS
1Iacono Anna, 1,4Esposito Emanuela, 1Mattace Raso Giuseppina, 2Bianco Giuseppe, 3,4Cuzzocrea Salvatore, 1Meli Rosaria
1Department of Experimental Pharmacology, University of Naples “Federico II”, Naples; 2Department of Pharmaceutical Sciences, University of Salerno; 3Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina; 4IRCCS Centro Neurolesi "Bonino-Pulejo," Messina, Italy

196. INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN KINASES (MAPKS) DURING TESTICULAR ISCHEMIA-REPERFUSION INJURY IN NUCLEAR FACTOR-kB KNOCK-OUT MICE
Minutoli Letteria1, Bitto Alessandra1, Polito Francesca1, Fiumara Tiziana1, Squadrito Francesco1, Mioni Chiara 2, Antonuccio Pietro3, Romeo Carmelo3, Marini Herbert4, Guarini Salvatore 2Caputi Achille P.1 and Altavilla Domenica1.
1Department of Clinical and Experimental Medicine and Pharmacology, Univ of Messina 2Dept of of Biomed Sci, Univ of Modena and Reggio Emilia, 3Department of Med and Surg Pediatric Sci, 4 Dept of Biochem, Physiol and Nutr Sci, University of Messina, Italy

197. STIMULATION OF DOPAMINE RECEPTORS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS OF MALE RATS INDUCES PENILE ERECTION AND INCREASES EXTRA-CELLULAR DOPAMINE IN THE NUCLEUS ACCUMBENS: INVOLVEMENT OF CENTRAL OXYTOCIN
Succu Salvatora, Sanna Fabrizio, Melis Tiziana, Argiolas Antonio, Melis Maria Rosaria
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy

198. INFLUENCE OF A CANNABINOID CB1 RECEPTOR ANTAGONIST, SR141716, ON SEXUAL BEHAVIOR OF MALE RATS
Zanoli Paola, Zavatti Manuela, Montanari Caterina, Rivasi Marianna, Poggioli Rosanna and Benelli Augusta
Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Modena, Italy

199. HYDROGEN SULFIDE (H2S) RELAXES HUMAN AND RABBIT CORPUS CAVERNOSUM IN VITRO
Romina Nassini1, Patacchini R.2, Materazzi S.1 , Mondaini N.1, Natali A.1, Geppetti P.1 and Harrison S.1.
1Department of Critical Care Medicine & Surgery, University of Florence, Florence, Italy; and 2Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy; Florence, Italy

200. EURYCOMA LONGIFOLIA IMPROVES COPULATORY ACTIVITY OF SEXUALLY SLUGGISH RATS
Montanari Caterina, Zavatti Manuela, Zanoli Paola and Baraldi Mario
Dept. of Biomedical Sciences, Section of Pharmacology and National InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and Reggio Emilia, Modena, Italy

201. THE TIGHT-SKIN MICE AS A GENETIC MODEL OF PEYRONIE’S–LIKE DISEASE
1,2Roberta d’Emmanuele di Villa Bianca, 1,2Sorrentino R., 3Lungarella G., 1Longo N., 1Imbimbo C. 1Mirone V. 1,2Cirino G.
1Center for Preclinical and Clinical Research in Sexual Medicine (CIRMS), 2Department of Experimental Pharmacology, University of Naples Federico II, 3Departement of Physiopathology, Experimental Medicine and Public Health, University of Siena

202. PHARMACOLOGICAL ACTIVITY OF SELECTIVE COX-1 AND COX-2 INHIBITORS IN ENDOTHELIAL CELLS
Bolego Chiara, Buccellati Carola, Folco Giancarlo, Sala Angelo
Department of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan Italy

203. ROLE OF FGFR1 IN THE ANGIOGENIC RESPONSE INDUCED BY PGE2
Finetti Federica, Ziche Marina and Donnini Sandra
Pharmacology section, Department of Molecular Biology, University of Siena

204. TIME COURSE OF BRAIN PGE2 LEVEL AND SYNTHESIS PATHWAY IN LPS- FEVERED RATS
di Matteo Anna, Bartella Cristina, Mangano Giorgina, Apicella Claudia, Mancini Francesca, Coletta Isabella, Guglielmotti Angelo, Polenzani Lorenzo
Angelini Farmaceutici – ACRAF S.p.A Piazzale della Stazione S.Palomba-Pomezia Italy

205. BRAIN PROSTANOIDS PROFILE IN CONTROL AND LPS-TREATED RATS
Bartella Cristina, Garrone Beatrice, Basta Francesco, De Santi Stefano, Vitiello Marco, Coletta Isabella, Guglielmotti Angelo, Polenzani Lorenzo
Angelini Farmaceutici – ACRAF S.P.A Piazzale della Stazione S.Palomba-Pomezia Italy

206. CYSTEINYL LEUKOTRIENES IN HUMAN ENDOTHELIAL CELLS: SYNTHESIS AND ACTIVITIES
Chiara Carnini, Maria Rosa Accomazzo, Emanuele Borroni, Laura Vitellaro-Zuccarelli, Giancarlo Folco, Gianenrico Rovati, Angelo Sala
Department of Pharmacological Sciences, Department of Biomolecular Sciences and Biotechnology, and Center for Cardiopulmonary Pharmacology, University of Milan, 20133 Milan, Italy

207. NITRIC-OXIDE SCAVENGING PROPERTIES OF NOVEL ORGANIC COMPOUNDS CONTAINING COBALT(II) AND RUTHENIUM(III)
1Cantore Miriam, 2Valtancoli Barbara, 3Cinci Lorenzo, 2Bencini Andrea, 1Ciuffi Mario and 1Failli Paola
Depts. of: 1Preclinical & Clinical Pharmacology, 2Chemistry and 3Anatomy, Histology & Forensic Medicine, University of Florence, Italy

208. INHIBITION OF NITRIC OXIDE PATHWAY BY AN ACETONIC EXTRACT FROM FEIJOA SELLOWIANA BERG. FRUITS
Rossi Antonietta1,2, Pergola Carlo1, Formisano Carmen3, Guerriere Luisa3 and Sautebin Lidia1
1Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy; 2IRCCS Centro Neurolesi “Bonino-Pulejo”, University of Messina, Messina, Italy; 3Department of Chemistry of Natural Products, University of Naples Federico II, Naples, Italy

209. NCX 2057, A NITRIC OXIDE-DERIVATIVE OF FERULIC ACID, EXERTS ANTI-INFLAMMATORY ACTIVITY IN IN-VITRO AND IN-VIVO MODELS
Ronchetti Daniela, Borghi Valentina, Biondi Stefano and Impagnatiello Francesco Nicox Research Institute, Bresso, Milan, Italy
(Abstract non disponibile su richiesta dell'autore)

210. NCX 4040, A NITRIC OXIDE-DONATING ASPIRIN DERIVATIVE WITH IMPROVED ANTI-INFLAMMATORY PROPERTIES
Paola Anzellotti, Luigia Di Francesco, Stefania Tacconelli and Paola Patrignani
Department of Medicine and Center of Excellence on Aging, School of Medicine, “G. d’Annunzio” University; †“G. d’Annunzio” University Foundation, Ce.S.I

211. EVIDENCE OF CYTOKINES LEVELS MODULATION IN RAT SERUM EXERTED BY IACVITA, A NEW ANTIOXIDANT COMPUND
Ricchi Lucia, Corsi Lorenzo, Geminiani Elisa, Baraldi Mario
Dip. Scienze Biomediche Università degli Studi di Modena e Reggio Emilia
CINSPAN Consorzio Interuniversitario Nazionale per lo Studio dei Principi Attivi Naturali

212. RAPID RELEASE OF ANNEXIN A1 FOLLOWING HEAT-SHOCK RESPONSE IN LPS-STIMULATED MACROPHAGES
Michela Festa, Luca Parente, Roderick J. Flower*, Mauro Perretti*, Fulvio D’Acquisto* , Simona F. Ercolino
Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy. *William Harvey Research Institute, Dept. of Biochemical Pharmacology, Charterhouse Square, London, England

213. ESTROGEN RECEPTOR ANTAGONIST ICI 182,780 INHIBITS THE ANTI-INFLAMMATORY EFFECT OF GLUCOCORTICOIDS
1,2Salvatore Cuzzocrea, 3Stefano Bruscoli, 1Concetta Crisafulli, 1,2Emanuela Mazzon, 3Massimiliano Agostini, 1Carmelo Muià, 2,4Emanuela Esposito, 3Rosa Di Virgilio, 4Rosaria Meli, 5Elisabetta Vegeto, 5Adriana Maggi and 3Carlo Riccardi
1Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy; 2IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy; 3Department of Cinical and Experimental Medicine, Pharmacology, University of Perugia, Italy; 4Department of Experimental Pharmacology, University of Naples “Federico II”, Naples Italy; 5Department of Pharmacological Sciences, University of Milan, Italy

214. SYNERGISTIC CYTOTOXICITY AND PHARMACOGENETICS OF GEMCITABINE AND ZD6474 IN BLADDER CANCER CELL LINES
Mey Valentina, Giovannetti Elisa, Nannizzi Sara, Ricciardi Simona, Danesi Romano,
Del Tacca Mario
Division of Pharmacology and Chemotherapy, Department of Internal Medicine,
University of Pisa

215. SYNERGISTIC CYTOTOXICITY, INHIBITION OF AKT AND C-KIT PHOSPHORYLATION, MODULATION OF GENE EXPRESSION BY SORAFENIB AND GEMCITABINE IN HUMAN PANCREATIC CANCER CELLS
Simona Ricciardi, Elisa Giovannetti, Sara Nannizzi, Valentina Mey, Giuseppe Pasqualetti, Romano Danesi, Mario Del Tacca
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa

216. INHIBITION OF STAT3 INCREASES DOXORUBICIN SENSITIVITY IN A HUMAN METASTATIC BREAST CANCER CELL LINE
Roberta Molteni, Raffaella Ravizza, Marzia Bruna Gariboldi and Elena Monti
Dept. of Structural and Functional Biology, Università degli Studi dell’Insubria

217. IN VITRON STUDY OF THE INTERACTION BETWEEN GEMCITABINE AND SORAFENIB IN NON SMALL CELL LUNG CANCER (NSCLC) A549 CELL LINE
Pasqualetti Giuseppe, Ricciardi Simona, Nannizzi Sara, Mey Valentina, Elisa Giovannetti, Danesi Romano, Del Tacca Mario
Division of Pharmacology and Chemotherapy, Department of Internal Medicine - University of Pisa

218. IN VITRO AND IN VIVO ANTINEOPLASTIC EFFECTS OF A NOVEL PLATINUM BIOCONJUGATE USING A BIOCOMPATIBLE POLYMERIC MATRIX
Marzia Bruna Gariboldi, Elisabetta Gabano1, Katia Sparnacci1, Michele Laus1, Domenico Osella1, Raffaella Ravizza, Roberta Molteni and Elena Monti
DBSF – Pharmacology Section, University of Insubria, Busto Arsizio (VA). 1Dipartimento di Scienze dell’Ambiente e della Vita, Università del Piemonte Orientale “A. Avogadro”, Alessandria

219. TOXICOLOGICAL EVALUATION OF MEPACRINE AND INTERFERON a-2A ON U87-MG AND VERO CELL COLTURE
Coppi Andrea, Baggio Giosue’, Bruni Elisa and Rossi Tiziana
University of Modena and Reggio Emilia- Italy: Departmentof Biomedical Sciences-Section of Pharmacology; 287 G. Campi st 41100 Modena Italy

220. PRO-OXIDANT AND ANTITUMOR EFFECTS OF CURCUMIN AND N-ETHYLMALEIMIDE IN THE HA22T/VGH MODEL OF OVERT HEPATOCELLULAR CARCINOMA
Carina Valeria, Labbozzetta M., Poma P., Alaimo A., Maurici A., Inguglia L., Notarbartolo M., D’Alessandro N.
Dipartimento di Scienze Farmacologiche, Università di Palermo

221. HDAC INHIBITORS RESTORE THE p53 PATHWAY IN NEUROBLASTOMA CELLS
Ilaria Gnemmi, Fabrizio Condorelli, Armando A. Genazzani and Pier Luigi Canonico
DiSCAFF&DFB Center, Università del Piemonte Orientale, Novara, Italy

222. TEMPERATURE INFLUENCE ON CELLULAR UPTAKE, DNA PLATINATION AND ANTIPROLIFERATIVE ACTIVITY OF PLATINUM(II) DRUGS
Colangelo Donato a, Gabano Elisabetta b, Osella Domenico b, Viano Ilario a
aDept. Medical Sciences, Via Solaroli 17 I-28100 Novara, bDept. of Ambiental and Life Sciences, via Bellini 25/G, I-15100 Alessandria, Università del Piemonte Orientale “A. Avogadro”, Italy

223. INHIBITION OF P-GP/ATPASE ACTIVITY OF RAT SMALL INTESTINE MEMBRANE VESICLES BY THE NOVEL, DIHYDROPYRIDINE MDR REVERTER DP7
Alderighi Daniela, Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi F., Shah A., Kawasae M., Motohashi N., Molnar J., Sgaragli G
Dipartimento di scienze biomediche, Università Degli Studi di Siena via A. Moro 2, 53100 Siena

224. HIGH ENERGY SHOCK WAVES INCREASE PACLITAXEL EFFICACY IN A SYNGENIC MODEL OF BREAST CANCER
Canaparo Roberto1,2, Serpe Loredana2, Eandi Mario2, Zara Gian Paolo2, Berta Laura1, Frairia Roberto1
1Department of Clinical Pathophysiology, University of Torino, Torino, Italy. 2Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Torino, Italy

225. EVALUATION OF SYNTHETIC “TUBULYSIN U” INDUCED CYTOTOXICITY IN HL60, C6, PC12 AND ECV304 CELL LINES
Ilaria Manca, a Monica Sani, b,c Angela Sanna, a Giacomo Fossati, b Paolo Lazzari, a Florent Huguenot, b Luca Pani, a,d Matteo Zanda b
aNeuroscienze PharmaNess S.c.a r.l., c/o POLARIS, Edificio 5, Loc.Piscinamanna, 09010 Pula (CA), Italy. bC.N.R. Istituto di Chimica del Riconoscimento Molecolare, Via Mancinelli 7, 20131 Milano, Italy. cKemoTech srl, Unità Operativa di Milano, Via Mancinelli 7, 20131 Milano, Italy. dC.N.R. Istituto di Tecnologie Biomediche, Sezione di Cagliari, c/o Neuroscienze PharmaNess S.c.a r.l.

226. ANTHOCYANIDINS MODULATE THE CYTOTOXICITY OF IRINOTECAN AND OXALIPLATIN IN HUMAN COLON ADENOCARCINOMA CELLS
Cvorovic Jovana, Candussio Luigi, Maestro Alessandra, Bartoli Fiora, Decorti Giuliana
Department of Biomedical Sciences, University of Trieste, Via Giorgieri 7, Trieste

227. PRELIMINARY RESULTS ON ANTIPROLIFERATIVE EFFECT OF NEW DEACETILASE INHIBITORS ON HUMAN LEUKEMIA CELL LINES
Vitali Federica a, Turriziani Mario b, D’Alfonso Rossella b, Lombardo Marco b, Valenti Sergio c, Mai Antonello c, Tita Beatrice a
aDepartment of Human Physiology and Pharmacology, University of Rome “Sapienza”. bDepartment of Internal Medicine, University of Rome “Tor Vergata”. cDepartment of Pharmaceutical Studies, University of Rome “Sapienza”

228. TOPICAL ADMINISTRATION OF RESVERATROL AS PRE- AND ANTINEOPLASTIC AGENT
Berta GN, Mognetti B, Barberis A, Marinos L, Di Carlo F.
Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Italy

229. EFFECT OF TOPIRAMATE TREATMENT IN A PATIENT AFFECTED BY SYMPTOMATIC TRIGEMINAL NEURALGIA
Gallelli Luca,1 Siniscalchi Antonio,2 Borner Perrone Ina,1 Davoli Alessandro,1 De Sarro Giovambattista1
1Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro, Italy.
2Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy

230. PHARMACOKINETICS OF TRAMADOL AND OF ITS METABOLITE N-DESMETHYLTRAMADOL IN FASTING AND FED HORSES, AFTER SINGLE ORAL ADMINISTRATION
Buti Deanna, Saccomanni Giuseppe*, Sgorbini Micaela, Mengozzi Grazia, Manera Clementina* and Giorgi Mario
Departments of Veterinary Clinics V.le delle Piagge 2 56124 Pisa, Italy. *Pharmaceutical Science Via Bonanno 6 56126 Pisa, Italy

231. ADMINISTRATION OF ORAL SUSTAINED-RELEASE TABLET FORMULATION OF TRAMADOL IN HORSES: PHARMACOKINETICS OF THE PARENTAL DRUG AND OF N-DESMETHYLTRAMADOL
Magnani Francesca, Saccomanni Giuseppe*, Casini Lucia**, Soldani Giulio, Manera Clementina* and Giorgi Mario
Departments of Vetrinary Clinics V.le delle Piagge 2 56124 Pisa, *Pharmaceutical Science V. Bonanno 6 56126 Pisa and **Animal Productions, S. Piero a Grado, 56010 Pisa, Italy

232. HIGH HOMOCYSTEINE PLASMA LEVELS IN PATIENTS TREATED WITH ANTIEPILEPTIC DRUGS
Siniscalchi Antonio,1 Liotti Alessandra,2 Gallelli Luca,2 Davoli Alessandro,2 Marigliano Norma M,2 De Sarro Giovambattista2
1Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy
2Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro, Italy

233. PHARMACOKINETICS OF INDOMETHACIN IN CHRONIC MIGRAINE PATIENTS AFTER WITHDRAWAL OF THE OVERUSED COMBINATION OF INDOMETHACIN, PROCHLORPERAZINE, AND CAFFEINE
Ferrari Anna, Gallesi Daniela, Sances Grazia*, Pinetti Diego, Bertolini Alfio, Sternieri Emilio
Toxicology and Clinical Pharmacology Section, Headache Centre, University Centre for Adaptive Disorders and Headache, Section Modena II. University of Modena and Reggio Emilia, Italy
*Headache Unit, IRCCS C. Mondino, University of Pavia, Italy

234. VARIABILITY OF ORAL SUMATRIPTAN PHARMACOKINETICS IN MIGRAINE PATIENTS
Coccia Ciro, Pinetti Diego, Bertolini Alfio, Sternieri Emilio, Ferrari Anna
Toxicology and Clinical Pharmacology Section, Headache Centre, University Centre for Adaptive Disorders and Headache, Section Modena II. University of Modena and Reggio Emilia, Italy

235. HORMONAL INDEX OF WELL-BEING IN WOMEN AFFECTED BY MEDICATION OVERUSE HEADACHE (MOH)
Monnazzi Paola, Simeoni Simona, Martelletti Paolo* and Patacchioli Francesca Romana.
Dept Human Physiology and Pharmacology “V. Erspamer”, *Internal Medicine, 2nd School of Medicine, University of Rome La Sapienza, Italy

236. LONG-TERM EFFICACY OF ANTIHYPERTENSIVE THERAPY IN OLD-AGE PATIENTS WITH ESSENTIAL HYPERTENSION
Alicandri Carlo1, Parini Francesca1,2, Valenti Luigi P.1, Parrinello Giovanni3, Spano PierFranco2, Sigala Sandra1,2
1Division of Medicine, Istituto Clinico Città di Brescia, Brescia, Italy; 2Section of Pharmacology, Dept of Biomed Sci and Biotec, University of Brescia Medical School, Brescia, Italy; 3 Medical Statistic Unit, Dept of Biomed Sci and Biotec, University of Brescia Medical School, Brescia, Italy

237. THE ROLE OF CYP3A5 IN METHADONE METHABOLISM: A CASE REPORT
De Fazio Salvatore1, Scordo MariaGabriella2, Gallelli Luca1, Marigliano Norma M1, Ferreri Ibbadu Guido1, Rende Pierandrea1, De Sarro Giovambattista1
1Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine, University of Catanzaro, Via T. Campanella 115, 88100 Catanzaro, Italy
2Department of Medical Sciences, Clinical Pharmacology; Uppsala University, Akademiska sjukhuset, Ing. 61, 75185 Uppsala, Sweden

238. MANAGEMENT OF LITHIUM THERAPY DURING PREGNANCY
Lampus Simona, Serio Stefania, Chillotti Caterina, Del Zompo Maria, Ardau Raffaella
Clinical Psychopharmacology Center, Section of Clinical Pharmacology, Department of Neurosciences "B. B. Brodie", University of Cagliari

239. A NEW APOMORPHINE FORMULATION FOR ORAL ADMINISTRATION
Zara GP1, Cattaldo S4, Cavalli R2, Calderoni S4, Muntoni E1, Gasco MR5, Mauro A3-4, Eandi M1
1Dipartimento Anatomia Farmacologia e Medicina Legale, 2Dipartimento di Scienze e Tecnologia del Farmaco, 3Dipartimento di Neuroscienze, Università di Torino Italy - 4IRRCS Istituto Auxologico Italiano, Piancavallo Italy – 5Nanovector s.r.l. Torino Italy

240. INVESTIGATION ON THE OPPORTUNITY IN INITIATING TREATMENT FOR HEPATITIS C VIRUS (HCV) INFECTION AMONG DRUG USERS
Mattioli Francesca, Montinaro Eleonora*, Ducci Elena*, Martelli Antonietta
Department of Internal Medicine, Pharmacology Unit, University of Genoa, I-16132 Genoa, Italy
*Valbisagno Drug Dependence Service (SerT) of Genoa

241. REPORTS OF ADVERSE REACTIONS TO ANTIBIOTICS IN THE TUSCAN PHARMASEARCH DATABASE
Montagnani Sabrina 1, Tuccori Marco 1, Giustini Saffi E 2, Salvetti Andrea 2, Blandizzi Corrado 1, Del Tacca Mario1
1 Tuscan Regional Center for Pharmacovigilance - Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa – Pisa, Italy
2 Italian Society of General Medicine (SIMG) – Florence, Italy

242. RETROSPECTIVE EVALUATION OF ANTIDEPRESSANTS SIDE EFFECTS
De Fazio Salvatore, Gareri Pietro, Palleria Caterina, Gallelli Luca, De Sarro Giovambattista
Chair of Pharmacology, School of Medicine, University “Magna Graecia” of Catanzaro, “Mater Domini” University Hospital, Via T. Campanella 115, 88100 Catanzaro, Italy

243. GUIDELINES ON THE CLINICAL USE OF CLOZAPINE
Ligas Franca, Ardau Raffaella, Chillotti Caterina, Del Zompo Maria
Clinical Psychopharmacology Centre, Section of Clinical Pharmacology, Department of Neurosciences “B.B. Brodie”, University of Cagliari

244. OBSERVATIONAL STUDY COMPARING THE SAFETY OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC DRUGS IN PATIENTS AFFECTED BY DEMENTIA WITH BEHAVIOURAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA (BPSD)
A. Capuano, S. Potenza, L. Ferrante, M. Gallo, B. Rinaldi, A. Filippelli, F. Rossi
Department of Experimental Medicine, Section of Pharmacology “Leonardo Donatelli”. Center of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Medicine and Surgery, Second University of Naples, Italy

245. PRESCRIBING PATTERN OF ANTI-PARKINSON DRUGS IN SOUTHERN ITALY: CROSS-SECTIONAL ANALYSIS IN THE YEARS 2003-5
Gianluca Trifirò1,5, Rodolfo Savica2, Letterio Morgante2, Michele Tari3 , Salvatore Moretti3, Nicola Vanacore4, Edoardo Spina1,5, Vincenzo Arcoraci1 and Achille P Caputi1,5
1Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Italy; 2Department of Neuroscience, Psychiatry and Anaesthesiology, University of Messina, Italy; 3 Caserta-1 Local Health Service, Caserta – Italy;4 National Centre for Epidemiology Surveillance and Health Promotion. National Institute of Health, Rome, Italy; 5 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy

246. USE OF HERBAL PRODUCTS IN CHILDREN: RISKS AND BENEFITS
Stefano Loizzo1,2, AnnaLivia Loizzo3, Anna Capasso4, Alberto Loizzo1
1Dept of Drug Research and Evaluation and 2Dept of Cell Biology and Neurosciences, Istituto Superiore di Sanita’, Roma, Italy; 3Dept of Paediatric Neuropsychiatry, University of Roma Tor Vergata, Roma, Italy, 4Dept of Pharmacology, University of Salerno, Salerno, Italy

247. KNOWLEDGE AND USE OF HERBAL DRUGS IN PREGNANCY
1Micheli Lucia, 1Nencini Cristina, 1Franchi Gian Gabriele, 2Urso Renato and 1, 2Giorgi Giorgio
1Department of Pharmacology “Giorgio Segre”, University of Siena. 2Centro Regionale di Farmacovigilanza, Area Vasta Sud- Est (Siena), Regione Toscana

248. DRUGS AND HERBAL PRODUCTS IN HOSPITAL PRACTICE: USE AND POTENTIAL INTERACTIONS
Stocco Andrea1, Gallo Umberto2, Bano Francesca2, Bin Anna1, Grion Anna Maria2, Ori Carlo1, Gaion Rosa Maria1, Giron Maria Cecilia1
1Department of Pharmacology and Anesthesiology, University of Padova. 2Department of Pharmaceutical Care, ULSS 16 – Padova

249. KNOWLEDGES ABOUT HERBAL PRODUCTS AMONG SUBJECTS ON WARFARIN THERAPY AND PATIENT-PHYSICIAN RELATIONSHIP
Laura Cuzzolin1, Francesco Francini-Pesenti2, Silvana Zaffani1, Filippo Brocadello2, Vittorio Pengo3, Antonella Bassi4, Giuseppina Benoni1
1Department of Medicine & Public Health-Section of Pharmacology, University of Verona, Italy; 2Clinical Nutrition Unit, Hospital of Padua, Italy; 3Clinical Cardiology-Thrombosis Centre, University of Padua, Italy; 4Department of Clinical and Experimental Medicine, University of Verona, Italy

250. ATTITUDES, KNOWLEDGE AND USE OF HERBAL PRODUCTS AMONG PREGNANT WOMEN: A PILOT SURVEY IN TUSCANY
Alfredo Vannacci, Francesco Lapi, Maria Morsuillo, Martina Moschini, Fabrizio Cipollinic, Marina Di Pirro, Enrica Cecchia, Grazia Banchelli, Fabio Firenzuoli, Alessandro Mugelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy aEmergency Department, Prato Hospital, ASL 4, Italy; bCentre of Natural Medicine, ASL 11, Empoli, Italy; cDepartment of Statistical Sciences, University of Florence, Italy

251. SURVEILLANCE AND INFORMATION ON HERBAL MEDICINES USE OF IN PREGNANCY IN THE SICILY REGION
Pieratti Antonella1, Calapai Gioacchino1, Corsello Salvatore2, Mirabile Marianna2, Fava Giuseppina1, Caputi Achille P1
1) Department of Clinical and Experimental Medicine and Pharmacology, University of Messina. 2) U.O.C. of Ginecology and Obstetrics, Hospital S.S. Salvatore, Paternò, Catania

252. NEUROCHEMICAL MODULATION AND BEHAVIOURAL CHANGE AFTER NEONATAL ADMINISTRATION OF PYRETHROIDS IN ANIMAL MODEL
Nasuti Cinzia Carla1, Gabbianelli Rosita2, Di Stefano Antonio3, Cantalamessa Franco1.
1Department of Experimental Medicine and Public, University of Camerino, 62032 Camerino (MC). 2Department of Biology M.C.A., University of Camerino, 62032 Camerino (MC). 3Department of Drug Science, University of “G. D’Annunzio”, 66100 Chieti (CH)

253. ROLE OF BRAIN RENIN ANGIOTENSIN SYSTEM IN THE ACUTE HYPERTENSIVE RESPONSE TO INTRACEREBROVENTRICULAR CADMIUM
Varoni M.Vittoria, Palomba Domenico, Anania Vittorio, Demontis M.Piera
D.B.A - Division of Pharmacology, Faculty of Veterinary Medicine – University of Sassari

254. CANCER CHEMOPREVENTION: MANIPULATION OF XENOBIOTIC METABOLIZING ENZYMES BY GLUCORAPHASATIN AND GLUCORAPHENIN FOUND IN BRASSICACEAE
Barbara Bonamassa1, Jessica Barillari2, Donatella Canistro1, Laura Pozzetti1, Andrea Sapone1, Renato Iori 2, Gian Luigi Biagi1 and Moreno Paolini1
1Department of Pharmacology, Molecular Toxicology Unit, Alma Mater Studiorum - University of Bologna, Via Irnerio 48 - 40126 Bologna, Italy. 2Agricultural Research Council - Research Institute for Industrial Crops (CRA-ISCI), via Corticella 133, Bologna, Italy

255. EFFECTS OF PCB101, PCB118, PCB138 AND PCB153 ALONE AND IN MIXTURE IN MCF-7 BREAST CANCER CELLS: POSSIBLE MECHANISM OF ACTION
Chiesara Enzo, Marabini L., Radice S.
Department of Pharmacology, Chemoterapy and Medical Toxicology “E. Trabucchi”, University of Milan, Via Vanvitelli 32, 20129, Milan

256. DOES ACETYLSALYCILIC ACID INTERFERE WITH LIVER DIMETHYLBENZANTHRACENE(DMBA)- METABOLISM? STUDY IN A RAT MODEL OF DMBA-INDUCED MAMMARY CARCINOGENESIS
Racca Silvia1, Spaccamiglio Angela1, Dacasto Mauro2, Carletti Monica2, Nebbia Carlo2, Abbadessa Giuliana1, Di Carlo Francesco1
1Department of Clinical and Biological Sciences, University of Turin, Orbassano (TO); 2Department of Animal Pathology, Division of Pharmacology and Toxicology, University of Turin, Grugliasco (TO)

257. EFFECT OF ISOTHIAZOLINONES ON REDOX OMEOSTASIS OF RAT ERYTHROCYTES
*Frosali Simona, *Priora R., *Margaritis A., § Di Stefano A., *Di Giuseppe D., *Summa D., *Di Simplicio P.
* Department of Neuroscience, Pharmacology Unit, University of Siena. § Department of Molecular Biology, University of Siena

258. VERMINOSIDE AND VERBASCOSIDE FROM KIGELIA AFRICANA: CYTOTOXIC AND GENOTOXIC EFFECTS IN HUMAN LYMPHOCYTES
Santoro A., Bianco G., Picerno P., Aquino R.P., Marzocco S., Autore Giuseppina, Gazzerro P., Lioi M.B.1, Bifulco M.
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano Italy. 1Dipartimento di Scienze delle Produzioni Animali, Università della Basilicata, Potenza Italy

259. DNA FRAGMENTATION IN PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH LIVER CIRRHOSIS RELATED TO ALCOHOL ABUSE OR TO HEPATITIS B OR C VIRUSES
Grossi Sarah, Mattioli Francesca, Manfredi Valeria, Sumberaz Alessandro*, Testino Gianni*, Martelli Antonietta
Department of internal Medicine, Pharmacology Unit, University of Genoa, I-16132 Genoa, Italy. * Gastreoenterology Unit – St. Martino Hospital – Genoa

260. EFFECTS OF DP7 ON HUMAN AND RAT LIVER CYP-DEPENDENT ACTIVITIES: A KINETIC STUDY
D’Elia Paolo, Dragoni S., De Matteis F., Valoti M., Kawase M., Shah A., Motohashi N., Molnar J., Sgaragli G.
Dipartimento Scienze Biomediche, Università degli Studi di Siena, via A. Moro 2, 53100 Siena

261. FORMATION OF DNA-DAMAGING N-NITROSO COMPOUNDS FROM THE INTERACTION OF CALCIUM-CHANNEL BLOCKERS WITH NITRITE
Robbiano Luigi, Gosmar Marzia, Martelli Antonietta
Department of Internal Medicine, Pharmacology Unit, University of Genoa, I-16132 Genoa, Italy

262. LOW-LEVEL LEAD, CADMIUM AND VANADIUM: “IN VITRO” EVALUATION OF THEIR GENOTOXIC POTENTIAL AS INFLUENCED BY COPPER, ZINC OR SELENIUM
Volpe Anna R., Cesare Patrizia, Aimola Pierpaolo, and Carmignani Marco
Section of Pharmacology and Toxicology, Department of Basic and Applied Biology, University of L’Aquila, Via Vetoio 2, 67010 Coppito (L’Aquila), Italy

263. INHIBITORY ENZYMATIC ACTIVITY OF SEMICARBAZIDE
Mastrangelo Sabina1, Evandri Maria Grazia2, Maranghi Francesca3, Mantovani Alberto3, Bolle Paola1
1 Department of Human Physiology and Pharmacology, “Sapienza” University of Rome; 2 Italian Medicines Agency, Rome; 3 Department of Food Safety and Veterinary Public Health, Italian National Health Institute, Rome

264. IN VITRO EFFECTS OF TWO OVER-THE-COUNTER BLEACHING PRODUCTS ON GINGIVAL EPITHELIUM AND DENTAL RESTORATIVE MATERIAL
F. CIMINO, A. TOMAINO, A. SPECIALE, M. CRISTANI, D. TROMBETTA, A. SAIJA
1Dept. Farmaco-Biologico, School of Pharmacy, University of Messina, Italy

265. HUMAN UMBILICAL CORD-DERIVED HEMATOPOIETIC STEM CELLS IN CYTO- AND GENO-TOXICITY STUDIES: RESULTS WITH CADMIUM AND CHROMIUM COMPOUNDS
Carmignani Marco, Aimola Pierpaolo, Cesare Patrizia, Orsini Federica and Volpe Anna R.
Section of Pharmacology and Toxicology, Department of Basic and Applied Biology, University of L’Aquila, Via Vetoio 2, 67010 Coppito (L’Aquila), Italy

266. SEROTONIN TRANSPORTER 5HTTLPR POLYMORPHISM, CLINICAL VARIANTS AND SYMPTOM SEVERITY IN PATIENTS WITH IRRITABLE BOWEL SYNDROME
Ghisu Narcisa1, Colucci Rocchina1, Bellini Massimo2, Rossi Giuseppe3, Blandizzi Corrado1, Gori Giovanni1, Marchi Santino 2, Tonini Marcello4, Del Tacca Mario1
1Division of Pharmacology and Chemotherapy and 2Gastrointestinal Unit, Department of Internal Medicine, University of Pisa, Italy; 3Institute of Clinical Physiology-C.N.R., Italy; 4Department of Physiological and Pharmacological Sciences, University of Pavia, Italy

267. ADVERSE EFFECTS OF AZATHIOPRINE IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASE AND MULTILOCUS GENOTYPES OF ENZYMES INVOLVED IN THE METABOLISM OF THIOPURINES
STOCCO Gabriele1,2, MARTELOSSI Stefano1, BARABINO Arrigo3, DECORTI Giuliana2, BARTOLI Fiora1, VENTURA Alessandro1
1) University of Trieste, Department of Sciences of Reproduction and Development and I.R.C.C.S. “Burlo Garofolo” Trieste, Pediatric Clinic – 2) University of Trieste, Department of Biomedical Sciences – 3) I.R.C.C.S. “G. Gaslini”, Genova

268. CORTICOSENSITIVITY IN INFLAMMATORY BOWEL DISEASE: ROLE OF GLUCOCORTICOID RECEPTOR POLYMORPHISMS
De Iudicibus S.1, 2, Stocco G.1, 2, Drigo I.1, 2, Norbedo S.2, Bartoli F.1, Decorti G.1, 2, Martelossi S.2, Ventura A.2
1 Department of Biomedical Sciences, University of Trieste. 2 Department of Paediatrics, I.R.C.C.S. Burlo Garofolo Trieste

269. EVIDENCE OF AN INCREASE OF THE ACTIVE METABOLITES OF THIOPURINES INDUCED BY AMINOSALICYLATES IN INFLAMMATORY BOWEL DISEASE
Marino S.1, 2, Stocco G.1, 2, Pozzi E.3, Martelossi S.2, Lionetti P.3, Malusà N. 4, Decorti G.1, 2 Bartoli F.1, Ventura A.2
1 Department of Biomedical Sciences, University of Trieste. 2 Department of Paediatrics, I.R.C.C.S. Burlo Garofolo Trieste. 3 Research Children’s Hospital ‘Meyer’, Florence. 4 Department of Prevention, Azienda Sanitaria 1, Trieste

270. INFLUENCE OF THIOPURINE METHYLTRANSFERASE GENOTYPE AND PHENOTYPE ON ADVERSE EVENTS AND EFFICACY OF AZATHIOPRINE IN RHEUMATOLOGIC AND GASTROENTEROLOGIC PATIENTS
Gori Giovanni1, Colucci Rocchina1, Ghisu Narcisa1, Fornai Matteo1, Tani Chiara2, Mosca Marta2, Ceccarelli Linda3, Blandizzi Corrado1, Costa Francesco3, Marchi Santino3, Bombardieri Stefano2, Del Tacca Mario1
1Division of Pharmacology and Chemotherapy, 2Gastroenterology Unit, and 3Rheumatology Unit, Department of Internal Medicine, University of Pisa, Pisa, Italy

271. IDENTIFICATION OF MUTATIONS IN HERG AND KCNE2 GENES ASSOCIATED WITH ARRHYTHMIA IN PATIENTS TREATED WITH MACROLIDES
Pannacci Marilou1, Sullo Nikol2, Caronno Alessia1, Lucini Valeria1, Grosso Silvia1, Francesco Scaglione1
1Department of Pharmacology, University of Milan, Milan, Italy. 2Department of Experimental Medicine- Section of Pharmacology, 2nd University of Naples, Naples, Italy

272. AN ALLELIC VARIANT OF NA+/CA++ EXCHANGER PROMOTER REGION, A2689C, PLAYS A ROLE IN DIASTOLIC BLOOD PRESSURE RESPONSE TO B-BLOCKERS AND DIHYDROPYRIDINE CA++ ANTAGONISTS TREATMENT IN HYPERTENSIVE PATIENTS
Valentina Trimarco*, Alessandro Bellis**, Marina Marino**, Bruna Gigante**, Nicola De Luca**, Bruno Trimarco**, Lucio Annunziato*, Gianfranco Di Renzo*
*Division of Pharmacology, Dept. of Neuroscience, Federico II University of Naples, Naples, Italy. ** Dept. of Cardiovascular and Immunological Sciences, Federico II University of Naples, Naples, Italy

273. DISTRIBUTION OF CYP3A5 AND MDR-1 SINGLE NUCLEOTIDE POLYMORPHISMS IN CAUCASIAN LIVER TRANSPLANT PATIENTS
Provenzani Alessio1, Poma P2., Labbozzetta M2., Notarbartolo M2., Di Stefano R1., Triolo F3., Vizzini G4., Gridelli B5., D’Alessandro N2.
1Department of Clinical Pharmacy - ISMETT, 2Department of Pharmacological Sciences - Università di Palermo, 3Regenerative Medicine and Cell Therapy Unit - ISMETT, 4Department of Medicine - ISMETT, 5Department of Abdominal Surgery and Transplantation - ISMETT

274. PROLONGING THE ACTION OF RECOMBINANT HUMAN GROWTH HORMONE BY MONOPEGYLATION OF MUTEINS
Caboi Francesca*, Bossi Michele*, Crobu Davide*, Cabras Alba*, Scaramuzza Silvia* and Taylor Geoffrey*
*Bio-Ker s.r.l. c/o Scientific and technologic Park of Sardinia Polaris, Loc. Piscinamanna Pula (Cagliari)

275. NOVEL G-CSF MUTANT FOR CONJUGATION
Salis Barbara, Caboi Francesca, Pitzalis Sabrina, Maullu Carlo, Sergi Mauro, Sollai Luigi, Taylor Geoffrey
Bio-Ker s.r.l. c/o Scientific and technologic Park of Sardinia Polaris, Loc. Piscinamanna Pula (Cagliari)

276. NEW LONG LASTING PEGylated-hGH
Selis Fabio*, Scaramazza Silvia*, Contis Manuela*, Pasut Gianfranco+, Veronese Francesco+, Schrepfer Rodolfo*
*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA). + Università degli Studi di Padova, Dipartimento di Scienze Farmaceutiche

277. SILICA MICROPARTICLES FOR THE CONTROLLED RELEASE OF HUMAN GROWTH HORMONE
Sergi Mauro*, Morpurgo Margherita+, Selis Fabio*, Parisi Laura+, Concas Danilo*, Marongiu Christian*, Schrepfer Rodolfo*, Tonon Giancarlo*
*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA)
+Università degli Studi di Padova, Dipartimento di Scienze Farmaceutiche

278. INHIBITION OF NF-kB ACTIVATION BY DECOY ODN RELEASED FROM LIPOSOMES IN ACTIVATED MACROPHAGES
De Stefano Daniela1, Maiuri Maria C1., Simeon Vittorio1, De Rosa Giuseppe2, LaGuardia Valeria2, Carnuccio Rosa1
1Department of Experimental Pharmacology; 2Department of Pharmaceutical Sciences; University of Naples “Federico II”, Via D. Montesano n 49, 80131 Naples, Italy

279. OSTEOGENIC DIFFERENTIATION OF HUMAN ADIPOSE-DERIVED STEM CELLS (hASC)
de Girolamo L1;2, Sartori M1, Bastoni S3 and Brini AT1
1 Medical Pharmacology Department, Faculty of Medicine, University of Milan.
2 IRCCS Galeazzi Orthopedic Institute, Milan. 3 Orthopedic and Traumatological Institute, Faculty of Medicine, University of Milan

280. IN VITRO EFFECTS OF ANTI-INFLAMMATORY DRUGS INCORPORATED IN SOLID LIPID NANOPARTICLES ON HUMAN PERIPHERAL MONONUCLEAR BLOOD CELLS FROM IBD PATIENTS
Serpe Loredana1, Canaparo Roberto2, Daperno Marco3, Eandi Mario1, Gasco Maria Rosa4 and Zara Gian Paolo1
1Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Torino, 2Department of Clinical Pathophysiology, University of Torino, Torino, 3Department of Gastroenterology, Mauriziano Hospital, Torino, 4Nanovector s.r.l, Torino

281. PEGYLATION OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (R-H-G-CSF) PRODUCED IN ESCHERICHIA COLI: A NEW DRUG TO OVERCOME NEUTROPENIA
Bonatesta Rosa Rita *, Caboi Francesca*, Sergi Mauro*, Sollai Luigi*, Onali Pierluigi+, Schrepfer Rodolfo* and Tonon Giancarlo*
*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA). + Università degli Studi di Cagliari, Dipartimento di Neuroscienze

282. EMEA AND EMERGING THERAPIES AND TECHNOLOGIES:
ACTIVITY OF THE INNOVATION TASK FORCE
Roberto De Lisa, Daniela Ranzani, Laurent Brassart, Isabelle Moulon, Marisa Papaluca Amati
EMEA European Medicines’ Agency
(Abstract non disponibile su richiesta del'autore)

283. INDIPENDENT DRUG INFORMATION AND PRESCIBING APPROPRIATENESS: A CHANCE FOR HEALTH PROFESSIONALS AND PATIENTS
Luppino Maria R1,3, Alacqua Marianna1,3, Catania Maria A1,3, Fava Giuseppina1,3, Gentile Marianna1,3, Oteri Alessandro1,3, Polimeni Giovanni1,2,3, Russo Alessandra1,3, Aliferopulos Harilaos3, Genovese Rosalia3, Sgroi Carmela3, Silvestro Anna3, Zangla Antonella3, Caputi Achille P1,2,3
1University of Messina - 2IRCSS “Bonino-Pulejo”, Messina - 3Messina Provincial Drug Information Center