6° Congresso Monotematico SIF 2002

Farmacologia Cardiovascolare dei Donatori di Ossido di Azoto (NO): Prospettive Terapeutiche

9.00	Saluti di benvenuto e apertura dei lavori P. MANTEGAZZA (Rettore Emerito, Università degli Studi di Milano) V. CUOMO (Presidente SIF)

Ia Sessione (9.15-12.40) - Moderatori: F. BERTI, E. ONGINI

9.15	The role of nitric oxide in cell respiration: physiology and pathophysiology S. MONCADA The Wolfson Institute of Biomedical Research, University College, London, UK
10.00	Ossido d’azoto e protezione cellulare S. FIORUCCI Department of Clinical and Experimental Medicine, University of Perugia, Italy
10.20	Nitric oxide and angiogenesis M. ZICHE Institute of Pharmacological Sciences, School of Pharmacy, Siena, Italy

10.40	Coffee break

11.00	Nitric oxide as a natural antithrombotic agent P. GRESELE Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy
11.20	Experimental models of cerebral ischemia: role of eNOS E. TREMOLI Department of Pharmacological Sciences, University of Milan, Italy
11.40	Nitric oxide and experimental ischemia-reperfusion injury G. ROSSONI Department of Pharmacological Sciences, University of Milan, Italy
12.00	Nitric oxide and renal damage G. REMUZZI “Mario Negri” Institute for Pharmacological Research, Negri Bergamo Laboratories, Bergamo, Italy
12.20	Ruolo dei nitrati organici nel trattamento della cardiopatia ischemica A. SALVIONI Centro Cardiologico “I. Monzino”, Milano, Italy

12.40	Colazione di lavoro

Visita e Discussione dei Posters (14.00-15.00)

IIa Sessione (15-17) - Moderatori: F. BERTI, E. ONGINI, M. ZICHE

15.00	Antiangiogenic properties of selected ruthenium(III) complexes that are nitric oxide scavengers *L. MORBIDELLI, S. DONNINI, L. LUSINI, S. FILIPPI, L. MESSORI#, M. ZICHE** Institute of Pharmacological Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, and *Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, and #Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy
15.15	Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor 3 (SSTR3) mediated regulation of endothelial NOS and MAP kinase activities T. FLORIO-1,3, V. VILLA-1,4 , M. MORINI-2 , S. ARENA-1,4 , A. CORSARO-1,4 , S. THELLUNG-1,4 , D. NOONAN-2 , A. ALBINI-2, G. SCHETTINI-1,4 Pharmacology and Neuroscience (1) and Molecular Biology (2), Natl. Inst. Cancer Research (IST) Genova; (3) Dept. Biomedical Sci. Univ. G. D’Annunzio Chieti (4) Dept. Biol., Oncol. and Genetics, Univ. Genova, Italy.
15.30	Effect of NCX 4016 or aspirin on endothelial modifications occurring in diabetic rats: a biochemical and structural study *M.V. AMBROSINI§, G. MARIUCCI§, M.G. RAMBOTTI§, M. TANTUCCI§, C. PASSERI§, G. BASTA, C. COVARELLI#, L. DE ANGELIS#, A. MONOPOLI1, P. DEL SOLDATO1** §Dept. Exp. Med. & Biochem. Sci., *DIMISEM, University of Perugia, #Perugia General Hospital, Perugia, Italy; 1Nicox Research Institute, Milano, Italy
15.45	Il monossido di azoto modula il consumo di ossigeno in cellule muscolari cardiache B. ZANELLA, N. CALONGHI, E. PAGNOTTA, L. MASOTTI, E. GIORDANO, M. ZINI, C. GUARNIERI Dipartimento di Biochimica “G. Moruzzi“, Università degli Studi di Bologna, Via Irnerio 48, 40126 Bologna, Italia
16.00	Nitric oxide release and distribution following oral administration of nitroaspirin (NCX 4016) in the rat M. CARINIa, G. ALDINIa, G. ROSSONIb, M. ORIOLIa, R. MAFFEI FACINOa a Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy; b Dipartimento di Scienze Farmacologiche, University of Milan, Italy
16.15	Diabetes and estrogenic control of inducible nitric oxide synthase in rat aortic smooth muscle cells A. CIGNARELLA, A. BRUSADELLI, C. BOLEGO, A. MAGGI, L. PUGLISI Department of Pharmacological Sciences, via Balzaretti 9, 20133 Milan, Italy
16.30	Effects of vitamin c supplementation on human aortic endothelial cells redox status and nitric oxide production A. R. SMITH, F. VISIOLIa, T. M. HAGEN Linus Pauling Institute and Dept. of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331; a Department of Pharmacological Sciences, University of Milan. Italy.

16.45	Conclusioni F. BERTI, E. ONGINI